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Literature summary for 2.4.1.B72 extracted from

  • Lopez-Gutierrez, B.; Cova, M.; Izquierdo, L.
    A Plasmodium falciparum C-mannosyltransferase is dispensable for parasite asexual blood stage development (2019), Parasitology, 146, 1767-1772 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.B72

Protein Variants

Protein Variants Comment Organism
additional information CRISPR/Cas9 technology is used to generate a Pf DPY19 null mutant. Pf DPY19 gene disruption is not associated with a growth phenotype, not even under endoplasmic reticulum-stressing conditions that could impair protein folding Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum C0H4S1 1.2B line
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information several thrombospondin type 1 repeat (TSR) domain-containing proteins of Plasmodium falciparum can be C-mannosylated in vivo Plasmodium falciparum ?
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Synonyms

Synonyms Comment Organism
Dpy-19-like C-mannosyltransferase UniProt Plasmodium falciparum
Pf DPY-19
-
 Plasmodium falciparum
PF3D7_0806200 locus name Plasmodium falciparum

General Information

General Information Comment Organism
evolution Plasmodium falciparum DPY19 exhibits a different acceptor specificity than the mammalian enzymes Plasmodium falciparum
malfunction Pf DPY19 gene disruption is not associated with a growth phenotype, not even under endoplasmic reticulum-stressing conditions that could impair protein folding Plasmodium falciparum
physiological function Plasmodium falciparum C-mannosyltransferase (Pf DPY-19) is demonstrated to modify thrombospondin type 1 repeat (TSR) domains in vitro, exhibiting a different acceptor specificity than their mammalian counterparts. The Plasmodium falciparum C-mannosyltransferase is dispensable for parasite asexual blood stage development Plasmodium falciparum