Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of T-DNA insertion gcn5 mutants, levels of accumulated miRNAs are increased in gcn5-2 mutant compared to the wild-type enzyme, targets of the increased miRNAs are e.g. DCL1 and AGO1, phenotypes, overview | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Arabidopsis thaliana | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Arabidopsis thaliana | histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
ecotype Wassilewskija, genes gcn5-1 and gcn5-2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
inflorescence | - |
Arabidopsis thaliana | - |
seedling | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation at Lys14 of histone H3 | Arabidopsis thaliana | CoA + acetylhistone H3 | - |
? | |
additional information | histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gcn5 | - |
Arabidopsis thaliana |
general control non-repressed protein5 | - |
Arabidopsis thaliana |
histone acetyltransferase | - |
Arabidopsis thaliana |
More | GCN5 belongs to the HAT family of enzymes | Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
physiological function | GCN5 has a general repressive effect on microRNAs, miRNAs, that guide sequence-specific posttranscriptional gene silencing, but is required for expression of a subset of MIRNA genes, overview | Arabidopsis thaliana |