Information on EC 2.3.1.48 - histone acetyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.3.1.48
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RECOMMENDED NAME
GeneOntology No.
histone acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + histone = CoA + acetylhistone
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:histone acetyltransferase
A group of enzymes with differing specificities towards histone acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-51-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Artemia nauplii
3 enzyme forms: I, II and III
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
clinical isolate SC5314, ORF19.7491
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Manually annotated by BRENDA team
zMoz
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Manually annotated by BRENDA team
zMoz
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Herpes simplex virus
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Manually annotated by BRENDA team
i.e. HIV; recombinant from COS cell line and from Escherichia coli
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Mus musculus C57BL/6
C57BL/6 mice
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Manually annotated by BRENDA team
3 enzyme forms: A1, A2, B
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Manually annotated by BRENDA team
strain BY4705
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Manually annotated by BRENDA team
from infected african green monkey kidney cell line CV-1; i.e. SV40
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Manually annotated by BRENDA team
GCN5
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Manually annotated by BRENDA team
GCN5
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Zea mays Cuzco
strain Cuzco
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4 acetyl-CoA + histone H4
4 CoA + tetraacetylhistone H4
show the reaction diagram
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NuA4 randomly acetylates free and nucleosomal H4, with a small preference for lysines 5, 8, and 12 over 16
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?
acetyl-CoA + 1,4-butanediamine
?
show the reaction diagram
acetyl-CoA + 1,5-pentanediamine
?
show the reaction diagram
acetyl-CoA + 1,6-hexanediamine
?
show the reaction diagram
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enzyme form A shows low activity , B not
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?
acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1
CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1
show the reaction diagram
acetyl-CoA + c-Myc
CoA + acetylated c-Myc
show the reaction diagram
acetyl-CoA + H3 peptide
?
show the reaction diagram
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?
acetyl-CoA + histone
CoA + acetylhistone
show the reaction diagram
acetyl-CoA + histone H
CoA + acetylhistone H
show the reaction diagram
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histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
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?
acetyl-CoA + histone H1
CoA + acetylhistone H1
show the reaction diagram
acetyl-CoA + histone H2A
CoA + acetylhistone H2A
show the reaction diagram
acetyl-CoA + histone H2A
Nalpha-acetylated-histone H2A + CoA
show the reaction diagram
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?
acetyl-CoA + histone H2B
CoA + acetylhistone H2B
show the reaction diagram
acetyl-CoA + histone H3
CoA + acetylhistone
show the reaction diagram
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?
acetyl-CoA + histone H3
CoA + acetylhistone H3
show the reaction diagram
acetyl-CoA + histone H3
peptide CoA + acetylhistone H3 peptide
show the reaction diagram
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preferred substrate, the N-terminal substrate region plays an importsant role in enhanced affinity of the Gcn5/PCAF proteins for histone H3
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?
acetyl-CoA + histone H3 N-terminal tail
CoA + acetylated histone H3 N-terminal tail
show the reaction diagram
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50 mM Tris-HCl, pH 8.0, 30°C
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?
acetyl-CoA + histone H3 peptide
CoA + acetylhistone H3 peptide
show the reaction diagram
acetyl-CoA + histone H3 peptide
CoA + actylhistone H3
show the reaction diagram
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residues 1-21 of human histone H3
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acetyl-CoA + histone H3 tail peptide
CoA + acetylhistone H3 peptide
show the reaction diagram
H3 peptide substrate, amino acid sequence ARTKQTARKSTGGKAPRKQL
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?
acetyl-CoA + histone H4
CoA + acetylhistone H4
show the reaction diagram
acetyl-CoA + histone H4
CoA + diacetylhistone H4
show the reaction diagram
acetyl-CoA + histone H4
CoA + triacetylhistone H4
show the reaction diagram
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enzyme form B
mono-, di- and triacetylated products
?
acetyl-CoA + histone H4
Nalpha-acetylated-histone H4 + CoA
show the reaction diagram
acetylation of N-terminal Ser
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?
acetyl-CoA + histone H4
peptide CoA + acetylhistone H4 peptide
show the reaction diagram
acetyl-CoA + histone H4 peptide
CoA + acetylpeptide of histone H4
show the reaction diagram
residues 1-20 of histone H4
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?
acetyl-CoA + histone H4 peptide
CoA + actylhistone H4
show the reaction diagram
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residues 2-24 of human histone H4
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acetyl-CoA + NF-kB p65
CoA + acetyl-NF-kB p65
show the reaction diagram
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acetylation of the subunit at Lys310 by p300 or PCAF
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?
acetyl-CoA + non-histone chromatin high-mobility group protein
CoA + acetylated non-histone chromatin high-mobility group protein
show the reaction diagram
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or chymotryptic peptides of
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?
acetyl-CoA + p50 protein
CoA + acetyl-p50 protein
show the reaction diagram
acetyl-CoA + p53
CoA + acetyl-p53
show the reaction diagram
acetyl-CoA + p65 protein
CoA + acetyl-p65 protein
show the reaction diagram
acetyl-CoA + poly-L-lysine
CoA + N6-acetyllysine
show the reaction diagram
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enzyme form A, not enzyme form B1 and B2
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?
acetyl-CoA + protamine sulfate
?
show the reaction diagram
acetyl-CoA + protein p53
CoA + acetylprotein p53
show the reaction diagram
acetyl-CoA + spermidine
?
show the reaction diagram
acetyl-CoA + spermine
?
show the reaction diagram
acetyl-CoA + transcription factor TFIIE
CoA + acetylated transcription factor TFIIE
show the reaction diagram
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substrate is a basal transcription factor
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?
acetyl-CoA + transcription factor TFIIF
CoA + acetylated transcription factor TFIIF
show the reaction diagram
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substrate is a basal transcription factor
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?
activated RNA polymerase II transcriptional coactivator p15 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
alpha-tubulin + acetyl-CoA
acetyl-alpha-tubulin + CoA
show the reaction diagram
androgen receptor + acetyl-CoA
acetylated androgen receptor + CoA
show the reaction diagram
ATM kinase + acetyl-CoA
acetylated ATM kinase + CoA
show the reaction diagram
H4 peptide + acetyl-CoA
?
show the reaction diagram
histone + acetyl-CoA
acetyl-histone + CoA
show the reaction diagram
histone + propionyl-CoA
propionyl-histone + CoA
show the reaction diagram
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?
histone H2A + acetyl-CoA
acetyl-histone H2A + CoA
show the reaction diagram
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acetylation of the tail of the histone, the enzyme is organized in the NuA4 subcomplex acting on the nucleosome, overview
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?
histone H2B + acetyl-CoA
acetyl-histone H2B + CoA
show the reaction diagram
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acetylation of the tail of the histone, the enzyme is organized in the catalytic Ada2/Ada3/Gcn5 subcomplex of SAGA acting on the nucleosome, overview
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?
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
show the reaction diagram
histone H3 tail peptide + acetyl-CoA
acetyl-histone H3 tail peptide + CoA
show the reaction diagram
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?
histone H3.2 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
histone H4 + acetyl-CoA
acetyl-histone H4 + CoA
show the reaction diagram
histone H4 N-terminal peptide + acetyl-CoA
acetyl-histone H4 N-terminal peptide + CoA
show the reaction diagram
N-terminal peptide of histone H4 of different length and sequence, prepared in HeLa cell extract, overview, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail, substituting glutamine for lysine at Lys8 and Lys16 dramatically reduces the ability of yHat1p to acetylate the H4 tail peptide, phosphorylation of Ser1 also reduces the acetylation of H4 peptides
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?
isoform 1 of DNA polymerase zeta catalytic subunit + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform 1 of transcription factor BTF3 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform 2 of protein SET + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform long of antigen KI-67 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
nucleolin + 4-pentynoyl-CoA
?
show the reaction diagram
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?
piccoloNuA4 peptide + acetyl-CoA
acetyl-piccoloNuA4 peptide + CoA
show the reaction diagram
the peptide is part of the physiologic enzme complex, overview
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?
piccoloNuA4 peptide + propionyl-CoA
propionyl-piccoloNuA4 peptide + CoA
show the reaction diagram
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?
promyelotic leukemia zinc finger gene + acetyl-CoA
acetylated promyelotic leukemia zinc finger gene + CoA
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4 acetyl-CoA + histone H4
4 CoA + tetraacetylhistone H4
show the reaction diagram
-
-
NuA4 randomly acetylates free and nucleosomal H4, with a small preference for lysines 5, 8, and 12 over 16
-
?
acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1
CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1
show the reaction diagram
-
-
-
-
?
acetyl-CoA + c-Myc
CoA + acetylated c-Myc
show the reaction diagram
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acetylation by Tip60 increases c-Myc protein stability in transfected H-1299 human lung carcinoma cells
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?
acetyl-CoA + histone
CoA + acetylhistone
show the reaction diagram
acetyl-CoA + histone H
CoA + acetylhistone H
show the reaction diagram
-
histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
-
-
?
acetyl-CoA + histone H2A
CoA + acetylhistone H2A
show the reaction diagram
-
acetylation at Lys5 by Tip60
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?
acetyl-CoA + histone H3
CoA + acetylhistone H3
show the reaction diagram
acetyl-CoA + histone H4
CoA + acetylhistone H4
show the reaction diagram
acetyl-CoA + p50 protein
CoA + acetyl-p50 protein
show the reaction diagram
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acetylation of p50 by p300 independent of shear stress
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?
acetyl-CoA + p53
CoA + acetyl-p53
show the reaction diagram
Q9H7Z6
p53 protein-acetylation of the Lys120 residue
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?
acetyl-CoA + p65 protein
CoA + acetyl-p65 protein
show the reaction diagram
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acetylation of p65 by p300 during translocation into the nuclei in response to shear stress
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?
androgen receptor + acetyl-CoA
acetylated androgen receptor + CoA
show the reaction diagram
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receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview
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?
ATM kinase + acetyl-CoA
acetylated ATM kinase + CoA
show the reaction diagram
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ATM protein kinase regulates the cell’s response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair, suppression of Tip60 blocks the activation of ATM’s kinase activity, ATM autophosphorylation e.g. at Ser1981, and prevents the ATM-dependent phosphorylation of p53 and chk2, inactivation of Tip60 sensitizes cells to ionizing radiation, overview
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?
histone + acetyl-CoA
acetyl-histone + CoA
show the reaction diagram
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
show the reaction diagram
histone H4 + acetyl-CoA
acetyl-histone H4 + CoA
show the reaction diagram
piccoloNuA4 peptide + acetyl-CoA
acetyl-piccoloNuA4 peptide + CoA
show the reaction diagram
Q08649
the peptide is part of the physiologic enzme complex, overview
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?
promyelotic leukemia zinc finger gene + acetyl-CoA
acetylated promyelotic leukemia zinc finger gene + CoA
show the reaction diagram
-
-
-
-
?
additional information
?
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