Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dimethyl-arginine 3-histone H4 | dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of PRMT1 by RNAi in erythroid progenitor cells prevents histone acetylation, enhancer and promoter interaction, and recruitment of transcription complexes to the active beta-globin promoter. Restoration of PRMT1 expression in PRMT1 knockout cells rescues erythroid differentiation and beta-globin transcription | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Mus musculus | H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | Mus musculus | H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview | CoA + acetylhistone H4 | - |
? | |
additional information | Mus musculus | PCAF is present in USF1/PRMT1 complexes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
PCAF and CBP | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
erythroid cell | - |
Mus musculus | - |
MEL cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview | Mus musculus | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | acetylation of Lys9 and Lys14 by PCAF. PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro | Mus musculus | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview | Mus musculus | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro | Mus musculus | CoA + acetylhistone H4 | - |
? | |
additional information | PCAF is present in USF1/PRMT1 complexes | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cbp | - |
Mus musculus |
PCAF | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mus musculus |