Crystallization (Comment) | Organism |
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comparison of crystal structures of the active sites of Escherichia coli KAS I with human cytosolic acetoacetyl-CoA thiolase and bacterial thiolase, overview | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
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Escherichia coli | P0A953 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | catalytic active site residues are Cys163 and His333, the active site contains two oxyanion holes, stabilizing the thioester oxyanion of acetylated CoA and of acetylated Cys92, respectively | Escherichia coli |
Subunits | Comment | Organism |
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More | comparison of crystal structures of the active sites of Escherichia coli KAS I with human cytosolic acetoacetyl-CoA thiolase and bacterial thiolase, active sites with four highly conserved loop structures, overview | Escherichia coli |
Synonyms | Comment | Organism |
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beta-ketoacyl ACP synthase I | - |
Escherichia coli |
KAS I | - |
Escherichia coli |
More | the enzyme belongs to the superfamily of condensing enzymes which includes thiolases | Escherichia coli |