Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Caenorhabditis elegans | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Caenorhabditis elegans N2 | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Caenorhabditis elegans PL51 | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Caenorhabditis elegans N2 | - |
- |
- |
Caenorhabditis elegans PL51 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY | - |
Caenorhabditis elegans | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY | - |
Caenorhabditis elegans N2 | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY | - |
Caenorhabditis elegans PL51 | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Caenorhabditis elegans | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Caenorhabditis elegans N2 | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Caenorhabditis elegans PL51 | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCM-1 | - |
Caenorhabditis elegans |
protein L-isoaspartyl methyltransferase | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme overexpressor adult animals display increased resistance to severe thermal stress (37°C). The enzyme plays a signaling role in lifespan extension that involves the insulin/insulin-like growth factor-1 signaling pathway, but is independent of its function in overall protein repair. Enzyme overexpression extends lifespan in a DAF-16-dependent manner under mild thermal stress (25°C) | Caenorhabditis elegans |