Crystallization (Comment) | Organism |
---|---|
hanging drop vapour diffusion method | Homo sapiens |
hanging drop vapour diffusion method | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-[2-(3-fluoromethyl)-1,4-naphthoquinolyl]hexanoic acid | IC50: 0.0041 mM, irreversible inhibition | Homo sapiens | |
6-[2-(3-fluoromethyl)-1,4-naphthoquinolyl]hexanoic acid | IC50: 0.0064 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG, irreversible inhibition | Plasmodium falciparum | |
6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid | IC50: 0.0032 mM, uncompetitive inhibitor | Homo sapiens | |
6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid | IC50: 0.0045 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG, uncompetitive inhibitor | Plasmodium falciparum | |
menadione | IC50: 0.0275 mM | Homo sapiens | |
menadione | IC50: 0.042 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum | |
[4-(3-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetic acid | IC50: 0.0014 mM | Homo sapiens | |
[4-(3-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetic acid | IC50: 0.0077 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum | |
[4-[3-(fluoromethyl)-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl]phenyl]acetic acid | IC50: 0.0035 mM | Homo sapiens | |
[4-[3-(fluoromethyl)-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl]phenyl]acetic acid | IC50: 0.002 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH + H+ | - |
Plasmodium falciparum | glutathione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
homodimer | - |
Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Homo sapiens |
glutathione reductase | - |
Plasmodium falciparum |
GR | - |
Homo sapiens |
GR | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0014 | - |
IC50: 0.0014 mM | Homo sapiens | [4-(3-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetic acid | |
0.002 | - |
IC50: 0.002 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum | [4-[3-(fluoromethyl)-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl]phenyl]acetic acid | |
0.0032 | - |
IC50: 0.0032 mM, uncompetitive inhibitor | Homo sapiens | 6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid | |
0.0035 | - |
IC50: 0.0035 mM | Homo sapiens | [4-[3-(fluoromethyl)-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl]phenyl]acetic acid | |
0.0041 | - |
IC50: 0.0041 mM, irreversible inhibition | Homo sapiens | 6-[2-(3-fluoromethyl)-1,4-naphthoquinolyl]hexanoic acid | |
0.0045 | - |
IC50: 0.0045 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG, uncompetitive inhibitor | Plasmodium falciparum | 6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid | |
0.0064 | - |
IC50: 0.0064 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG, irreversible inhibition | Plasmodium falciparum | 6-[2-(3-fluoromethyl)-1,4-naphthoquinolyl]hexanoic acid | |
0.0077 | - |
IC50: 0.0077 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum | [4-(3-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetic acid | |
0.0275 | - |
IC50: 0.0275 mM | Homo sapiens | menadione | |
0.042 | - |
IC50: 0.042 mM, at pH 6.9 and 25°C in the presence of 1 mM GSSG | Plasmodium falciparum | menadione |