Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADP+ | Homo sapiens | - |
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
desmosterol + NADP+ | Homo sapiens | - |
7-dehydrodesmosterol + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADP+ | - |
Homo sapiens | cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
desmosterol + NADP+ | - |
Homo sapiens | 7-dehydrodesmosterol + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Dhcr7 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in the enzyme gene lead to the developmental disease Smith-Lemli-Opitz syndrome which can also result in fetal mortality | Homo sapiens |
metabolism | the enzyme exerts complex biological effects, involved in both cholesterol and vitamin D production | Homo sapiens |