Information on EC 1.3.1.21 - 7-dehydrocholesterol reductase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.3.1.21
-
RECOMMENDED NAME
GeneOntology No.
7-dehydrocholesterol reductase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
cholesterol biosynthesis I
-
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
-
cholesterol biosynthesis III (via desmosterol)
-
ecdysone and 20-hydroxyecdysone biosynthesis
-
Metabolic pathways
-
plant sterol biosynthesis
-
Steroid biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
cholesterol:NADP+ DELTA7-oxidoreductase
In mammals the enzyme is part of the cholesterol biosynthesis pathway [2] and catalyses the reduction reaction. In the nematode Caenorhabditis elegans the enzyme catalyses the oxidation reaction as part of the biosynthesis of dafachronic acids that are important for control of developmental timing and longevity [3,4].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3-hydroxysterol DELTA7-reductase
-
-
3beta-hydroxysterol DELTA7-reductase
-
-
3beta-hydroxysterol-DELTA7-reductase
-
-
7-dehydrocholesterol DELTA7 reductase
-
-
7-dehydrocholesterol DELTA7-reductase
-
-
7-DHC reductase
-
-
-
-
7-DHCR
-
-
DELTA5,7-sterol DELTA7-reductase
-
-
Dhcr7
Q9UBM7
-
Dhcr7
Q88455
-
Dhcr7
Q9E2H5
-
Dhcr7-AS-1
Q9Z2Z8
-
Dhcr7-AS-2
Q9Z2Z8
-
Dhcr7-AS-4
Q9Z2Z8
-
Dwarf5 protein
-
-
-
-
Neverland
Q1JUZ2
-
Nvd
Q1JUZ2
-
reductase, 7-dehydrocholesterol
-
-
-
-
Sterol delta-7-reductase
-
-
-
-
sterol DELTA7 reductase
A4F244
-
sterol DELTA7 reductase
Mortierella alpina 1S-4
A4F244
-
-
sterol DELTA7-reductase
-
-
sterol DELTA7-reductase
-
-
sterol DELTA7-reductase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9080-21-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
enzyme Dhcr7, gene dhcr7
SwissProt
Manually annotated by BRENDA team
enzyme Dhcr7, no additional isoforms, no alternative splicing
SwissProt
Manually annotated by BRENDA team
expression in Caenorhabditis elegans
-
-
Manually annotated by BRENDA team
gene DHCR7
-
-
Manually annotated by BRENDA team
gene dhcr7, enzyme DHCR7
-
-
Manually annotated by BRENDA team
patient with Smith-Lemli-Opitz syndrome
SwissProt
Manually annotated by BRENDA team
patients with Smith-Lemli-Opitz syndrome
-
-
Manually annotated by BRENDA team
strain 1S-4
SwissProt
Manually annotated by BRENDA team
Mortierella alpina 1S-4
strain 1S-4
SwissProt
Manually annotated by BRENDA team
3 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
SwissProt
Manually annotated by BRENDA team
alternatively spliced variant 1, i.e. Dhcr7-AS-1; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7; alternatively spliced variant 2, i.e. Dhcr7-AS-2; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7; alternatively spliced variant 4, i.e. Dhcr7-AS-4; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
SwissProt
Manually annotated by BRENDA team
full-length gene, genomic DNA; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7, i.e. splicing variants Dhcr7-AS-1-5
SwissProt
Manually annotated by BRENDA team
large isoform Xdhcr7-L
-
-
Manually annotated by BRENDA team
maize
-
-
Manually annotated by BRENDA team
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
53970
-
A4F244, -
calculated from amino acid sequence