Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-ol | specific | Homo sapiens | |
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-yl acetate | specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions | Homo sapiens | |
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol | specific | Homo sapiens | |
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-yl acetate | specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions | Homo sapiens | |
(3S,20S)-20-N-ethylcarbamoylpregn-7-en-3beta-ol | - |
Homo sapiens | |
(3S,20S)-20-N-ethylcarbamoylpregn-7-en-3beta-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-ol | specific | Homo sapiens | |
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-yl acetate | specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions | Homo sapiens | |
(3S,20S)-20-N-propylcarbamoylpregn-7-en-3beta-ol | - |
Homo sapiens | |
(3S,20S)-20-N-propylcarbamoylpregn-7-en-3beta-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-ol | specific | Homo sapiens | |
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-yl acetate | specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions | Homo sapiens | |
lathosterol side chain amides | synthesis and compound screening, influence of different sterol amides on inhibition of the enzyme, overview, lathosterol-derived amides with larger substituents, e.g. butyl, isobutyl, tert-butyl, pentyl, at the amide nitrogen are selective inhibitors of lathosterol oxidase, overview | Homo sapiens | |
additional information | cytotoxicity and inhibitor potencies for inhibition of total cholesterol biosynthesis, overview | Homo sapiens | |
Triarimol | weak inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in the post-squalene part of cholesterol biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in the post-squalene part of cholesterol biosynthesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-DES | - |
Homo sapiens |
DELTA7-sterol-C5(6)-desaturase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00033 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-ol | |
0.00045 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-yl acetate | |
0.0007 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol | |
0.00091 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-yl acetate | |
0.00095 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-yl acetate | |
0.00105 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-ol | |
0.0011 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-yl acetate | |
0.00116 | - |
inhibition of total cholesterol production | Homo sapiens | (3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-ol |