Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chlorobenzaldehyde thiosemicarbazone | exhibits significant inhibitory potency on both monophenolase activity and diphenolase activity of tyrosinase, reversible noncompetitive inhibitor | Agaricus bisporus | |
4-chlorobenzaldehyde thiosemicarbazone | exhibits significant inhibitory potency on both monophenolase activity and diphenolase activity of tyrosinase, reversible mixed-type inhibitor | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | diphenolase activity | Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | monophenolase activity | Agaricus bisporus | L-DOPA + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
monophenol, o-diphenol:oxygen oxidoreductase | - |
Agaricus bisporus |
tyrosinase | - |
Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
2-chlorobenzaldehyde thiosemicarbazone | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
0.00125 | - |
4-chlorobenzaldehyde thiosemicarbazone | in 5 0mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00122 | - |
using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | 2-chlorobenzaldehyde thiosemicarbazone | |
0.00182 | - |
using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | 4-chlorobenzaldehyde thiosemicarbazone | |
0.0067 | - |
using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | 4-chlorobenzaldehyde thiosemicarbazone | |
0.0154 | - |
using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | 2-chlorobenzaldehyde thiosemicarbazone |