Literature summary for 1.14.18.1 extracted from

Bu, J.; Ma, P.C.; Chen, Z.Q.; Zhou, W.Q.; Fu, Y.J.; Li, L.J.; Li, C.R.
Inhibition of MITF and tyrosinase by paeonol-stimulated JNK/SAPK to reduction of phosphorylated CREB (2008), Am. J. Chin. Med., 36, 245-263.

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Inhibitors

Inhibitors	Comment	Organism	Structure
paeonol	effects of paeonol on cell growth of B16F10 melanoma cells are shown. The effect of a high dose of paeonol (200 microM) is better than that of 2 microM hydroquinone (HQ), which acts as a positive agent. Paeonol down-regulates tyrosinase expression at mRNA and protein level. And paeonol inhibits MITF mRNA expression in B16F10 melanoma cells und the phosphorylation of CREB	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-F10 cell	B16F10 melanoma cell	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-dopa + 1/2 O2	-	Mus musculus	L-dopaquinone + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Mus musculus

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Release 2023.1 (January 2023)