Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylcholine | saturated acyl chains such as dipalmitoyl/dimyristoyl phosphatidylcholine | Bos taurus |
General Stability | Organism |
---|---|
inclusion into phospholipid vesicles stabilizes | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphosphatidyl glycerol | cardiolipin, dipalmitoyl phasphatidylcholine vesicles, 50% inhibition with 4-5 mol%, complete inhibition at 15 mol% | Bos taurus | |
phosphatidylcholine | unsaturated increasing dioleoyl/diphytanoyl phosphatidylcholine | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
11-deoxycorticosterone | dipalmitoyl-phosphatidylcholine vesicles | Bos taurus | |
0.01 | - |
11-deoxycorticosterone | dipalmitoyl/diphytanoyl-phosphatidylcholine vesicles | Bos taurus | |
0.033 | - |
11-deoxycorticosterone | dipalmitoyl phosphatidylcholine/diphosphatidyl glycerol vesicles | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | from zona fasciculata | Bos taurus | 5739 | - |
mitochondrion | reconstitution of cytochrome P45011beta, an intrinsic protein of inner membrane, into phospholipid vesicles via detergent dialysis procedure | Bos taurus | 5739 | - |
mitochondrion | from zona reticularis | Bos taurus | 5739 | - |
mitochondrion | from zona glomerulosa | Bos taurus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
without ionic detergents, ammonium sulfate fractionation, hexyl agarose | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O | cytochrome P45011beta is implicated in mineralocorticoid, synthesized and secreted from zona glomerulosa, as well as glucocorticoid, secreted primarily in zonae fasciculate and reticularis, biosynthesis with multiple catalytic activities, 11beta-/18-/19-hydroxylase and 18-/19-hydroxysteroid oxidase activities | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Bos taurus | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
19-hydroxy-11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Bos taurus | 19-oxo-11-deoxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
cortisol + reduced adrenal ferredoxin + O2 | - |
Bos taurus | cortisone + oxidized adrenal ferredoxin + ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.133 | - |
11-deoxycorticosterone | dipalmitoyl phosphatidylcholine vesicles + diphosphatidyl glycerol | Bos taurus | |
0.583 | - |
11-deoxycorticosterone | dipalmitoyl phosphatidylcholine vesicles | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | adrenodoxin and NADPH-linked adrenodoxin reductase | Bos taurus |