Application | Comment | Organism |
---|---|---|
drug development | p12-LOX pathway may be an effective target of chemoprevention for skin carcinogenesis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | p12-LOX specific inhibitor, suppresses proliferation of JB6 P+ cells when cells are seeded at a low density in a culture plate by 81% | Mus musculus | |
siRNA | inhibition of p12-LOX in JB6 P+ cells by siRNA transfection, causes a significant suppression of 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation by 61% compared with that in control cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
additional information | expression of p12-LOX is significantly higher in JB6P+ cells than in JB6P- cells that are resistant to transformation | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
p12-LOX | - |
Mus musculus |
platelet-type 12-lipoxygenase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | tumor necrosis factor-alpha induces p12-LOX in the early stage of tumorigenesis, induces p12-LOX expression both in JB6P+ and JB6P- cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | p12-LOX plays an important role in tumor development, is required for tumor promotion of epidermal cells. The enzyme is involved in activation of NF-kappaB in the tumor necrosis factor-alpha-stimulated JB6 P+ cells | Mus musculus |