Information on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.13.11.31
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RECOMMENDED NAME
GeneOntology No.
arachidonate 12-lipoxygenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dehydration
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dioxygenation
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oxidation
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redox reaction
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reduction
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PATHWAY
KEGG Link
MetaCyc Link
Arachidonic acid metabolism
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SYSTEMATIC NAME
IUBMB Comments
arachidonate:oxygen 12-oxidoreductase
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(12R)-lipoxygenase
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11R-lipoxygenase
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12(R)-lipoxygenase
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12(S)-lipoxygenase
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12-lipoxygenase
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-
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12-lipoxygenase
O75342
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12-lipoxygenase
P18054
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12-lipoxygenase
-
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12-lipoxygenase
-
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12-lipoxygenase
Q02759
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12-lipoxygenase
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12-LO
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12-LOX
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-
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12-LOX
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12-LOX
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12-LOX
Q02759
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12/15 lipoxygenase
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12/15 lipoxygenase
-
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12/15-lipoxygenase
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-
-
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12/15-lipoxygenase
-
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12/15-lipoxygenase
P39654
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12/15-lipoxygenase
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12/15-lipoxygenase
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12/15-LO
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12/15-LO
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12/15-LOX
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12/15LO
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12/15LO
P39654
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12/15LO
Mus musculus C57BL6
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12/15LO
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12DELTA-lipoxygenase
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-
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12R-lipoxygenase
O70582
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12R-lipoxygenase
Mus musculus A/J
O70582
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12R-LOX
O75342
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12R-LOX
O70582
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12R-LOX
Mus musculus A/J
O70582
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12R-LOX-2
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12S-lipoxygenase
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-
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12S-lipoxygenase
-
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2/15-lipoxygenase
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2/15-lipoxygenase
Mus musculus C57BL6
-
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Alox12b
O70582
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Alox12b
Mus musculus A/J
O70582
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Alox15
Q02759
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C-12 lipoxygenase
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DELTA 12-lipoxygenase
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epidermal-type lipoxygenase
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hp-12LOX
P18054
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human platelet 12-lipoxygenase
P18054
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leukocyte-type 12-lipoxygenase
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leukocyte-type 12-LOX
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leukocyte-type 12/15-lipoxygenase
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leukocyte-type lipoxygenase
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leukotriene A4 synthase M
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lipoxygenase 12
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LOX-12
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LTA4 synthase
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oygenase, arachidonate 12-lip-
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P-12LOX
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p12-LO
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p12-LOX
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platelet-type 12(S)-lipoxygenase
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platelet-type 12-human lipoxygenase
P18054
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platelet-type 12-lipoxygenase
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platelet-type 12-lipoxygenase
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platelet-type 12-LOX
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Platelet-type lipoxygenase 12
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CAS REGISTRY NUMBER
COMMENTARY
82391-43-3
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
soft coral
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Manually annotated by BRENDA team
gene ALOX15
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Manually annotated by BRENDA team
isozyme 12-hLO
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Manually annotated by BRENDA team
isozyme platelet 12-hLO
UniProt
Manually annotated by BRENDA team
isozymes P-12-LO and L-12-LO
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Manually annotated by BRENDA team
platelet-type 12S-lipoxygenase isozyme
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Manually annotated by BRENDA team
C57BL/6 mice
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Manually annotated by BRENDA team
C57Bl6 mice
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Manually annotated by BRENDA team
four 12-lipoxygenase: 1.platelet-type 12-lipoxygenase, 2. leukocyte-type lipoxygenase, 3. epidermal-type lipoxygenase, 4. 12(R)-lipoxygenase
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-
Manually annotated by BRENDA team
strain A/J
UniProt
Manually annotated by BRENDA team
Mus musculus A/J
strain A/J
UniProt
Manually annotated by BRENDA team
Mus musculus C57BL6
C57Bl6 mice
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-
Manually annotated by BRENDA team
Sprague-Dawley rats
UniProt
Manually annotated by BRENDA team
wild-type Sprague-Dawley rats and iron-deficient Belgrade rats, three isozymes: platelet, leukocyte, and epidermis isozyme, Alox15 is a leukocyte-type isozyme
UniProt
Manually annotated by BRENDA team
Zucker rat
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-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE