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Literature summary for 1.11.1.6 extracted from

  • Herve-Grepinet, V.; Veillard, F.; Godat, E.; Heuze-Vourch, N.; Lecaille, F.; Lalmanach, G.
    Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide (2008), FEBS Lett., 582, 1307-1312.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information addition of non-toxic concentrations of H2O2 to cultured THP-1 cells neither influences catalase activity nor mRNA expression levels and activity of cathepsins Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-Amino-1,2,4-triazole inhibitory. Inhibition of extracellular catalase activity leads to a striking inactivation of secreted cysteine cathepsins Homo sapiens
KCN inhibitory. Inhibition of extracellular catalase activity leads to a striking inactivation of secreted cysteine cathepsins Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular constitutive, basal level of catalase activity. Inhibition of extracellular catalase activity by 3-amino-1,2,4-triazole or KCN leads to a striking inactivation of secreted cysteine cathepsins Homo sapiens
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peroxisome main localization Homo sapiens 5777
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
Homo sapiens
-