Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epalrestat | - |
Homo sapiens | |
additional information | phenolic hydroxyl groups are important both in C3 side chain and the core structure of quinoxalinone cores for constructing potent ALR2 inhibitors with antioxidant activity | Homo sapiens | |
[3-(2,4-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-(2,5-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | most potent activity | Homo sapiens | |
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | most active inhibitor evaluated | Homo sapiens | |
[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[3-[2-(4-hydroxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[6-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[7-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens | |
[7-methoxy-2-oxo-3-[(E)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(4-hydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00009 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | epalrestat | |
0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00016 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00017 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [7-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid | |
0.00018 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-(2,4-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00019 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00021 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00027 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [6-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid | |
0.00051 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[2-(4-hydroxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00085 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00087 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-(2,5-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid | |
0.00092 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [7-methoxy-2-oxo-3-[(E)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid | |
0.00098 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | [3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid |