Information on EC 1.1.1.21 - aldehyde reductase

Word Map on EC 1.1.1.21
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.1.1.21
-
RECOMMENDED NAME
GeneOntology No.
aldehyde reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alditol + NAD(P)+ = aldose + NAD(P)H + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-galactose degradation IV
-
-
Fructose and mannose metabolism
-
-
Galactose metabolism
-
-
Glycerolipid metabolism
-
-
L-arabinose degradation II
-
-
Metabolic pathways
-
-
Pentose and glucuronate interconversions
-
-
xylose degradation II
-
-
lipid A biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
alditol:NAD(P)+ 1-oxidoreductase
Has wide specificity.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-31-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
strain VGI-II
-
-
Manually annotated by BRENDA team
strain VGI-II
-
-
Manually annotated by BRENDA team
strain Y-456
-
-
Manually annotated by BRENDA team
strain Y-456
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Euonymus sp.
distribution in various species
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain Y-488
-
-
Manually annotated by BRENDA team
strain Y-488
-
-
Manually annotated by BRENDA team
isolate 2001-S
-
-
Manually annotated by BRENDA team
strain Y-1017
-
-
Manually annotated by BRENDA team
Rattus novegicus
-
UniProt
Manually annotated by BRENDA team
strain BY4741
-
-
Manually annotated by BRENDA team
strain Y-1632
-
-
Manually annotated by BRENDA team
strain Y-1632
-
-
Manually annotated by BRENDA team
Torulopsis molishiama
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1S)-camphorquinone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
(3R,4S/3S,4R)-3,4-(cis)acetate-beta-lactam + NADPH + H+
4-hydroxyazetidine-2,3-diyl diacetate + NADP+
show the reaction diagram
-
screening of 19 individual yeast reductases for their effciency and enantioselectivity, overview
stereochemistry of products of the different enzymes, detailed overview
-
?
(S)-1-indanol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
(S)-1-teralol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
1-butanal + NADPH + H+
1-butanol + NADP+
show the reaction diagram
-
-
-
-
?
1-butanal + NADPH + H+
butanol + NADP+
show the reaction diagram
-
-
-
?
1-decanal + NADPH + H+
1-decanol + NADP+
show the reaction diagram
-
-
-
-
?
1-decanol + NADP+
decanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-dodecanal + NADPH + H+
dodecanol + NADP+
show the reaction diagram
-
-
-
?
1-heptanal + NADPH + H+
heptanol + NADP+
show the reaction diagram
-
-
-
?
1-hexanal + NADPH + H+
1-hexanol + NADP+
show the reaction diagram
-
-
-
-
?
1-hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
-
-
-
?
1-hydroxynonen-4-one + NADPH
1,4-dihydroxynon-2-ene + NADP+
show the reaction diagram
-
-
-
-
?
1-nonanal + NADPH + H+
1-nonanol + NADP+
show the reaction diagram
-
-
-
-
?
1-nonanal + NADPH + H+
nonanol + NADP+
show the reaction diagram
-
-
-
?
1-nonanol + NADP+
nonanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH
1-palmitoyl-2-(5-hydroxyvaleryl)sn-glycero-3-phosphocholine + NADP+
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH + H+
? + NADP+
show the reaction diagram
ALR2
-
-
?
1-propanal + NADPH + H+
1-propanol + NADP+
show the reaction diagram
-
-
-
-
?
1-tetradecanol + NADP+
tetradecanal + NADPH + H+
show the reaction diagram
-
-
-
?
11-deoxyisocorticosterone + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
16-ketoestrone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-bornanedione + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
2,3-butanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-heptanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-hexanedione + NADPH + H+
?
show the reaction diagram
2,3-pentanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,4-decadienal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,4-nonadienal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-D-deoxy-2-fluoro-galactose + NADPH
?
show the reaction diagram
-
-
-
-
r
2-D-deoxygalactose + NADPH
?
show the reaction diagram
2-decenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-deoxyribose + NADPH
?
show the reaction diagram
-
-
-
-
r
2-hexenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-nonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-phenyl-2-propenal + NADPH + H+
2-phenyl-1-propanol + NADP+
show the reaction diagram
-
-
-
-
?
20-isocortisol + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
20alpha-hydroxyprogesterone + NADPH + H+
?
show the reaction diagram
-
-
-
?
20alpha-isocorticosterone + NAD(P)H
?
show the reaction diagram
21-dehydrocortisol + NADPH + H+
?
show the reaction diagram
3,4-hexanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
3-deoxyglucosone + NADPH + H+
?
show the reaction diagram
3-glutathionyl-4-hydroxynonanal + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
4-hydroxy-trans-2-nonenal + NADPH + H+
1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
4-hydroxynonenal + NADPH + H+
4-hydroxynonanol + NADP+
show the reaction diagram
4-hydroxynonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylacetaldehyde + NAD(P)H
4-hydroxyphenylethyl alcohol + NAD(P)+
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylglycolaldehyde + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
show the reaction diagram
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
4-nitrobenzaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-oxonon-2-enal + NADPH
1-hydroxynonen-4-one + NADP+
show the reaction diagram
-
-
-
-
?
5-pregnene-3beta,20alpha-diol + NADPH
?
show the reaction diagram
-
-
-
?
5alpha-pregnan-20alpha-ol-3-one + NADPH + H+
?
show the reaction diagram
-
-
-
?
5alpha-pregnane-3beta,20alpha-diol + NADPH + H+
?
show the reaction diagram
-
-
-
?
8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one + NADPH + H+
? + NADP+
show the reaction diagram
fluorogenic synthetic substrate
-
-
?
acetaldehyde + NAD(P)H + H+
ethanol + NAD(P)+
show the reaction diagram
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
acetol + NADPH
propane-1,2 diol + NADP+
show the reaction diagram
-
-
-
-
?
acrolein + NADPH
2-propen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
acrolein + NADPH + H+
2-propen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
alditol + NAD(P)+
aldose + NAD(P)H
show the reaction diagram
aldose + NAD(P)H
alditol + NAD(P)+
show the reaction diagram
aldose + NADPH + H+
alditol + NADP+
show the reaction diagram
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
show the reaction diagram
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+
benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
butyraldehyde + NAD(P)H
butanol + NAD(P)+
show the reaction diagram
D-arabinose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
D-arabinose + NADPH + H+
arabitol + NADP+
show the reaction diagram
-
-
-
-
?
D-erythrose + NAD(P)H
erythritol + NAD(P)+
show the reaction diagram
D-erythrose + NADPH + H+
?
show the reaction diagram
D-fructose + NAD(P)H + H+
D-arabino-hexitol + NAD(P)+
show the reaction diagram
D-fucose + NADPH
fucitol + NADP+
show the reaction diagram
-
-
-
-
r
D-galactose + NAD(P)H
dulcitol + NAD(P)+
show the reaction diagram
D-galactose + NADPH
?
show the reaction diagram
D-galactose + NADPH + H+
?
show the reaction diagram
D-galactose + NADPH + H+
D-galactitol + NADP+
show the reaction diagram
D-glucose + NAD(P)H
sorbitol + NAD(P)+
show the reaction diagram
D-glucose + NADPH + H+
D-sorbitol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
D-glucuronate + NAD(P)H
?
show the reaction diagram
D-glucuronate + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucuronate + NADPH
? + NADP+
show the reaction diagram
D-glucuronolactone + NADPH
?
show the reaction diagram
D-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
D-lactaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
D-lactoaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-lyxose + NADPH
arabitol + NADP+
show the reaction diagram
D-mannose NAD(P)H
mannitol + NAD(P)+
show the reaction diagram
D-ribose + NAD(P)H
ribitol + NAD(P)+
show the reaction diagram
D-ribose + NADPH
adonitol + NADP+
show the reaction diagram
-
-
-
-
r
D-ribose + NADPH + H+
?
show the reaction diagram
D-ribose + NADPH + H+
D-ribitol + NADP+
show the reaction diagram
-
-
-
-
?
D-ribose 5-phosphate + NADPH
D-ribitol 5-phosphate + NADP+
show the reaction diagram
-
-
-
-
r
D-tagatose + NADPH
?
show the reaction diagram
-
-
-
-
r
D-xylose + NAD(P)H
xylitol + NAD(P)+
show the reaction diagram
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
xylitol + NADP+
show the reaction diagram
D-xylose + NADPH + H+
?
show the reaction diagram
D-xylose + NADPH + H+
D-xylitol + NADP+
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
-
?
D-xylose 5-phosphate + NADPH
D-xylitol 5-phosphate + NADP+
show the reaction diagram
-
-
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
show the reaction diagram
-
-
-
-
?
decanal + NAD(P)H
decanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
dihydroxyacetone + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
DL-glyceraldehyde + NADPH
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
glyycerol + NADP+
show the reaction diagram
-
-
-
-
?
farnesal + NADPH + H+
trans,trans-farnesol + NADP+
show the reaction diagram
specific substrate
-
-
?
geraniol + NADP+
geranial + NADPH + H+
show the reaction diagram
-
-
-
?
geranylgeranial + NADPH + H+
geranylgeraniol + NADP+
show the reaction diagram
specific substrate
-
-
?
glucose + NADPH
sorbitol + NADP+
show the reaction diagram
glutathione-4-hydroxy-trans-2-nonenal + NADPH + H+
glutathione-1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
glutathione-S-4-oxonon-2-enal + NADPH
S-(1-hydroxy-4-oxonona-3-yl)glutathione + NADP+
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
glycoaldehyde + NADPH
ethylene glycol + NADP+
show the reaction diagram
-
-
-
-
?
glycoaldehyde + NADPH + H+
ethylene glycol + NADP+
show the reaction diagram
-
-
-
-
?
glycolaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
glyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
glyoxal + NADPH + H+
?
show the reaction diagram
hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
indole-3-acetaldehyde + NAD(P)H
indole-3-ethanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
isatin + NADPH + H+
3-hydroxyisatin + NADP+
show the reaction diagram
specific substrate
-
-
?
isatin + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
isobutyraldehyde + NADPH + H+
isobutanol + NADP+
show the reaction diagram
isocaproaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
L-arabinose + NAD(P)H
L-arabitol + NAD(P)+
show the reaction diagram
L-arabinose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
L-fucose + NADPH
fucitol + NADP+
show the reaction diagram
-
-
-
-
r
L-glyceraldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
L-idose + NADPH + H+
alditol + NADP+
show the reaction diagram
L-lyxose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
L-rhamnose + NADPH
L-rhamnitol + NADP+
show the reaction diagram
-
-
-
-
r
L-ribose + NADPH
adonitol + NADP+
show the reaction diagram
-
-
-
-
r
L-sorbose + NADPH
L-sorbitol + NADP+
show the reaction diagram
-
-
-
-
r
L-threose + NADPH + H+
?
show the reaction diagram
L-xylose + NAD(P)H
L-xylitol + NAD(P)+
show the reaction diagram
malondialdehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
methylglyoxal + NADPH + H+
?
show the reaction diagram
methylglyoxal + NADPH + H+
acetol + NADP+
show the reaction diagram
-
-
-
-
?
n-pentanal + NAD(P)H + H+
n-pentanol + NAD(P)+
show the reaction diagram
nerol + NADPH + H+
?
show the reaction diagram
-
-
-
?
octanal + NADPH + H+
1-octanol + NADP+
show the reaction diagram
-
-
-
-
?
octanal + NADPH + H+
octanol + NADP+
show the reaction diagram
-
-
-
?
pentose + NADPH
pentitol + NADP+
show the reaction diagram
pentose + NADPH + H+
pentiol + NADP+
show the reaction diagram
phenyl-1,2-propanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
phenylglyoxal + NAD(P)H
?
show the reaction diagram
phenylglyoxal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
propanal + NADPH + H+
n-propanol + NADP+
show the reaction diagram
-
-
-
-
r
propionaldehyde + NAD(P)H
propanol + NAD(P)+
show the reaction diagram
pyridine-3-aldehyde + NAD(P)H
3-hydroxypyridine + NAD(P)+
show the reaction diagram
pyridine-3-aldehyde + NADPH + H+
3-hydroxypyridine + NADP+
show the reaction diagram
pyridine-3-methanol + NADP+
?
show the reaction diagram
-
-
-
?
pyridine-3-methanol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
pyridine-4-aldehyde + NAD(P)H
4-hydroxypyridine + NAD(P)+
show the reaction diagram
-
-
-
-
r
pyridine-4-aldehyde + NADPH + H+
4-hydroxypyridine + NADP+
show the reaction diagram
-
-
-
-
?
pyridinecarboxaldehyde + NAD(P)H
pyridylmethanol + NAD(P)+
show the reaction diagram
sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
succinic semialdehyde + NADH + H+
4-hydroxybutyrate + NAD+
show the reaction diagram
trans-2-buten-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-decen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-hexen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-nonen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
xylitol + NAD(P)+
D-xylose + NAD(P)H + H+
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-hydroxy-trans-2-nonenal + NADPH + H+
1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
4-hydroxynonenal + NADPH + H+
4-hydroxynonanol + NADP+
show the reaction diagram
aldose + NAD(P)H
alditol + NAD(P)+
show the reaction diagram
aldose + NADPH + H+
alditol + NADP+
show the reaction diagram
D-galactose + NADPH
?
show the reaction diagram
D-glucose + NADPH + H+
D-sorbitol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
glutathione-4-hydroxy-trans-2-nonenal + NADPH + H+
glutathione-1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
pentose + NADPH + H+
pentiol + NADP+
show the reaction diagram
sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
additional information
-
no activity with dinucleotide cofactors
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Li2SO4
Mg2+
-
required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((1-(2H-tetrazol-5-yl)methyl)-1H-pyrrol-3-yl)(phenyl)-methanone
-
40% inhibition
(1,1-dihydroxy-3-oxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)acetic acid
i.e. BiT, 1,1-dioxide-benzo[d]isothiazol-3-one alkanoic acid derivatives
(1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
IC50: 0.010 mM
(1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid ethyl ester
-
(1,3,3-trioxo-2,3-dihydronaphtho[2,3-d]isothiazol-2-yl)acetic acid ethyl ester
-
(1-(2-(2H-tetrazol-5-yl)ethyl)-1H-pyrrol-3-yl)(phenyl)-methanone
-
6% inhibition
-
(1-(2H-tetrazole-5-yl)-1H-pyrrol-2-yl)(phenyl)-methanone
-
-
-
(1-(2H-tetrazole-5-yl)-1H-pyrrol-3-yl)(phenyl)-methanone
-
-
-
(1-(3-(2H-tetrazol-5-yl)propyl)-1H-pyrrol-3-yl)(phenyl)-methanone
-
41% inhibition
-
(10-benzyl-3,4-dioxo-3,4-dihydro[1,2,4]triazino[4,3-a]benzimidazol-2(10H)-yl)acetic acid
-
-
(1H-indol-1-yl)acetic acid
-
-
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
-
-
(2,4-dioxo-5-[(6,8-dimethyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
-
-
(2,4-dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
-
-
(2,4-dioxo-5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
-
-
(2,4-dioxo-5-[(6-nitro-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
-
-
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid
-
an aldose reductase inhibitor and antioxidant of zwitterionic nature
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
-
; uncompetitive with both D,L-glyceraldehyde and NADPH
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
-
; uncompetitive with both D,L-glyceraldehyde and NADPH
(2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
(2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid
-
CC-13401
(2R)-2,3-dihydroxypropanamide
-
-
(2R)-2-hydroxypropanamide
-
-
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide
-
-
(2R,3S,4S)-2,3,4,5-tetrahydroxypentanamide
-
-
(2R,4S)-6-fluoro-2',5'-dioxospiro-[chroman-4,4'-imidazoline]-2-carboxamide
-
IC50: 570 nM, mechanism, active site binding modeling, the stereochemistry of the exocyclic amide group influences the affinity for the enzyme
(2S)-2'-methoxykurarinone
-
potent inhibitor of rat lens aldose reductase
(2S)-2,3-dihydroxypropanamide
-
-
(2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
(2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
potent inhibitor of recombinant human aldose reductase
(2S,3R,4R)-2,3,4,5-tetrahydroxypentanamide
-
-
(2S,3S)-2,3,4-trihydroxybutanamide
-
-
(2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
-
(2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
-
(3,3-dihydroxy-1-oxo-1,3-dihydro-2H-3lambda4-naphtho[1,2-d]isothiazol-2-yl)acetic acid
i.e. NiT
(3-benzothiazol-2-yl-pyrrol-1-yl)acetic acid
-
50% inhibition at 49 nM
(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid
-
-
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(3-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(4-benzothiazol-2-yl-2-benzoylpyrrol-1-yl)acetic acid
-
50% inhibition at 45 nM
(4-benzyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetic acid
-
-
(4-hydroxy-3-methoxyphenyl)acetonitrile
-
IC50: 0.0244 mM
(4-hydroxy-3-methoxyphenyl)methamine
-
IC50: 0.0634 mM
(4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM
(4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone
-
isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
-
-
(4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione
-
-
(5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid
-
IC50: 0.0017 mM
(5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid methyl ester
-
15% inhibition of ALR2 at 0.05 mM
(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-acetic acid
-
IC50: 0.00026 mM
(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-acetic acid methyl ester
-
35% inhibition of ALR2 at 0.05 mM
(5-chloro-2-[(3-nitrobenzyl)carbamoyl]phenoxy)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(5-chloro-2-[(4-cyanobenzyl)carbamoyl]phenoxy)acetic acid
-
-
(5-methylIndoleDs)1-(3-(3,4,5-trimethoxyphenyl)-3-(5-methyl-1H-indol-3-yl)propanoyl)-4-(5-methyl-1H-indol-3-yl)piperidin-2-one
-
-
(5-methylIndoleMs)1-(3-(3,4,5-trimethoxyphenyl)-3-(5-methyl-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetic acid
-
IC50: 0.00017 mM
(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetic acid methyl ester
-
12% inhibition of ALR2 at 0.05 mM
(5E)-5-[4-(4-oxo-4H-chromen-2-yl)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM
(5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM
(5Z)-5-(3-aminobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.69
(5Z)-5-(3-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.04
(5Z)-5-(3-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.97
(5Z)-5-(3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.88
(5Z)-5-(3-methylbenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.03
(5Z)-5-(3-phenoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.21
(5Z)-5-(3-{(E)-[(4-hydroxyphenyl)imino]methyl}benzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.73
(5Z)-5-(4-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.09
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.93
(5Z)-5-(4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.05
(5Z)-5-(4-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.39
(5Z)-5-(4-{(E)-[(4-hydroxyphenyl)imino]methyl}benzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.64
(5Z)-5-(naphthalen-1-ylmethylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.97
(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM
(5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM
(5Z)-5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.89
(5Z)-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.50
(6-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
IC50: 0.10 mM
(6-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid ethyl ester
-
(6-nitro-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
IC50: 0.180 mM
(6-nitro-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid ethyl ester
-
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
-
-
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
-
uncompetitive
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(9-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
IC50: 0.10 mM
(9-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid ethyl ester
-
(9-nitro-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid