Reference on EC 6.2.1.45 - E1 ubiquitin-activating enzyme and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Handley, P.M.; Mueckler, M.; Siegel, N.R.; Ciechanover, A.; Schwartz, A.I.
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1
Proc. Natl. Acad. Sci. USA
88
258-262
1991
Homo sapiens (P22314), Homo sapiens
Yang, Y.; Kitagaki, J.; Dai, R.M.; Tsai, Y.C.; Lorick, K.L.; Ludwig, R.L.; Pierre, S.A.; Jensen, J.P.; Davydov, I.V.; Oberoi, P.; Li, C.C.; Kenten, J.H.; Beutler, J.A.; Vousden, K.H.; Weissman, A.M.
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Cancer Res.
67
9472-9481
2007
Homo sapiens, Mus musculus
Tokgoez, Z.; Bohnsack, R.N.; Haas, A.L.
Pleiotropic effects of ATP*Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme
J. Biol. Chem.
281
14729-14737
2006
Homo sapiens
Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
UBE1L2, a novel E1 enzyme specific for ubiquitin
J. Biol. Chem.
282
23010-23014
2007
Homo sapiens, Homo sapiens (A0AVT1), Mus musculus
Nouspikel, T.; Hanawalt, P.C.
Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme
Proc. Natl. Acad. Sci. USA
103
16188-16193
2006
Homo sapiens
Zheng, M.; Gu, X.; Zheng, D.; Yang, Z.; Li, F.; Zhao, J.; Xie, Y.; Ji, C.; Mao, Y.
UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins
J. Cell. Biochem.
104
2324-2334
2008
Homo sapiens (Q9GZZ9)
Xu, G.W.; Ali, M.; Wood, T.E.; Wong, D.; Maclean, N.; Wang, X.; Gronda, M.; Skrtic, M.; Li, X.; Hurren, R.; Mao, X.; Venkatesan, M.; Beheshti Zavareh, R.; Ketela, T.; Reed, J.C.; Rose, D.; Moffat, J.; Batey, R.A.; Dhe-Paganon, S.; Schimmer, A.D.
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
Blood
115
2251-2259
2010
Homo sapiens, Mus musculus
Bacik, J.P.; Walker, J.R.; Ali, M.; Schimmer, A.D.; Dhe-Paganon, S.
Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme
J. Biol. Chem.
285
20273-20280
2010
Homo sapiens (Q9GZZ9), Homo sapiens
Brahemi, G.; Burger, A.M.; Westwell, A.D.; Brancale, A.
Homology modelling of human E1 ubiquitin activating enzyme
Lett. Drug Des. Discov.
7
57-62
2010
Homo sapiens (P22314), Homo sapiens
Zheng, M.; Liu, J.; Yang, Z.; Gu, X.; Li, F.; Lou, T.; Ji, C.; Mao, Y.
Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1
Mol. Biol. Rep.
37
1413-1419
2010
Homo sapiens, Homo sapiens (Q712V1)
Wee, K.E.; Lai, Z.; Auger, K.R.; Ma, J.; Horiuchi, K.Y.; Dowling, R.L.; Dougherty, C.S.; Corman, J.I.; Wynn, R.; Copeland, R.A.
Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate
J. Protein Chem.
19
489-498
2000
Homo sapiens
Xie, S.T.
Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1)
Biosci. Biotechnol. Biochem.
78
1542-1549
2014
Homo sapiens (P22314), Homo sapiens
Chang, T.; Huang, Y.; Ou, Y.
The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity
J. Funct. Foods
7
462-470
2014
Homo sapiens
-
Bialas, J.; Groettrup, M.; Aichem, A.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation
PLoS ONE
10
e0120329
2015
Homo sapiens
Ungermannova, D.; Parker, S.J.; Nasveschuk, C.G.; Wang, W.; Quade, B.; Zhang, G.; Kuchta, R.D.; Phillips, A.J.; Liu, X.
Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (E1)
PLoS ONE
7
e29208
2012
Homo sapiens, Schizosaccharomyces pombe
Qin, Z.; Cui, B.; Jin, J.; Song, M.; Zhou, B.; Guo, H.; Qian, D.; He, Y.; Huang, L.
The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis
Atherosclerosis
247
142-153
2016
Homo sapiens (P22314)
Wu, C.; Liu, Y.; Gu, X.; Zhu, T.; Yang, S.; Sun, W.
LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6
Biochem. Biophys. Res. Commun.
478
1442-1448
2016
Homo sapiens (A0AVT1)
Oweis, W.; Padala, P.; Hassouna, F.; Cohen-Kfir, E.; Gibbs, D.R.; Todd, E.A.; Berndsen, C.E.; Wiener, R.
Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 complex
Cell Rep.
16
3113-3120
2016
Homo sapiens (Q9GZZ9)
Liu, X.; Zhao, B.; Sun, L.; Bhuripanyo, K.; Wang, Y.; Bi, Y.; Davuluri, R.; Duong, D.; Nanavati, D.; Yin, J.; Kiyokawa, H.
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Nat. Commun.
8
14286
2017
Homo sapiens (A0AVT1), Homo sapiens (P22314)
Liu, X.; Sun, L.; Gursel, D.B.; Cheng, C.; Huang, S.; Rademaker, A.W.; Khan, S.A.; Yin, J.; Kiyokawa, H.
The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
Oncotarget
8
87480-87493
2017
Homo sapiens (A0AVT1), Homo sapiens
