Reference on EC 4.4.1.5 - lactoylglutathione lyase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
vander Jagt, D.L.
The glyoxalase system
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
3
597-641
1989
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Rhodospirillum rubrum, Sus scrofa
-
Mannervik, B.; Aronsson, A.C.; Tibbelin, G.
Glyoxalase I from human erythrocytes
Methods Enzymol.
90
535-541
1982
Homo sapiens
Marmstal, E.; Aronsson, A.C.; Mannervik, B.
Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources
Biochem. J.
183
23-30
1979
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus, Sus scrofa
Aronsson, A.C.; Tibbelin, G.; Mannervik, B.
Purification of glyoxalase I from human erythrocytes by the use of affinity chromatography and separation of the three isoenzymes
Anal. Biochem.
92
390-393
1979
Homo sapiens
Cameron, A.D.; Olin, B.; Ridderstrom, M.; Mannervik, B.; Jones, T.A.
Crystal structure of human glyoxalase I - evidence for gene duplication and 3D domain swapping
EMBO J.
16
3395-3395
1997
Homo sapiens
-
Ranganathan, S.; Walsh, E.S.; Godwin, A.K.; Tew, K.D.
Cloning and characterization of human colon glyoxalase-I
J. Biol. Chem.
268
5661-5667
1993
Homo sapiens
Kim, N.S.; Sekine, S.; Kiuchi, N.; Kato, S.
cDNA cloning and characterization of human glyoxalase I isoforms from HT-1080 cells
J. Biochem.
117
359-361
1995
Homo sapiens
Allen, R.E.; Lo, T.W.C.; Thornalley, P.J.
Inhibitors of glyoxalase I: design, synthesis, inhibitory characteristics and biological evaluation
Biochem. Soc. Trans.
21
535-540
1993
Saccharomyces cerevisiae, Homo sapiens
Allen, R.E.; Lo, T.W.C.; Thornalley, P.J.
A simplified method for the purification of human red blood cell glyoxalase. I. Characteristics, immunoblotting, and inhibitor studies
J. Protein Chem.
12
111-119
1993
Homo sapiens
Shinohara, M.; Thornalley, P.J.; Giardino, I.; Beisswenger, P.; Thorpe, S.R.; Onorato, J.; Brownlee, M.
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis
J. Clin. Invest.
101
1142-1147
1998
Homo sapiens
Creighton, D.J.; Hamilton, D.S.
Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations
Arch. Biochem. Biophys.
387
1-10
2001
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Mitsumoto, A.; Kim, K.R.; Oshima, G.; Kunimoto, M.; Okawa, K.; Iwamatsu, A.; Nakagawa, Y.
Glyoxalase I is a novel nitric-oxide-responsive protein
Biochem. J.
344
837-844
1999
Homo sapiens
Cameron, A.D.; Ridderstrom, M.; Olin, B.; Kavarana, M.J.; Creighton, D.J.; Mannervik, B.
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue
Biochemistry
38
13480-13490
1999
Homo sapiens (Q04760), Homo sapiens
Sakamoto, H.; Mashima, T.; Kizaki, A.; Dan, S.; Hashimoto, Y.; Naito, M.; Tsuruo, T.
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis
Blood
95
3214-3218
2000
Homo sapiens
Himo, F.; Siegbahn, P.E.
Catalytic mechanism of glyoxalase I: a theoretical study
J. Am. Chem. Soc.
123
10280-10289
2001
Homo sapiens
ichter, U.; Krauss, M.
Active site structure and mechanism of human glyoxalase I-an ab initio theoretical study
J. Am. Chem. Soc.
123
6973-6982
2001
Homo sapiens
Lupidi, G.; Bollettini, M.; Venardi, G.; Marmocchi, F.; Rotilio, G.
Functional residues on the enzyme active site of glyoxalase I from bovine brain
Prep. Biochem. Biotechnol.
31
317-329
2001
Bos taurus, Saccharomyces cerevisiae, Homo sapiens
Davidson, S.D.; Milanesa, D.M.; Mallouh, C.; Choudhury, M.S.; Tazaki, H.; Konno, S.
A possible regulatory role of glyoxalase I in cell viability of human prostate cancer
Urol. Res.
30
116-121
2002
Homo sapiens
Akoachere, M.; Iozef, R.; Rahlfs, S.; Deponte, M.; Mannervik, B.; Creighton, D.J.; Schirmer, H.; Becker, K.
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts
Biol. Chem.
386
41-52
2005
Homo sapiens, Plasmodium falciparum
Antognelli, C.; Baldracchini, F.; Talesa, V.N.; Costantini, E.; Zucchi, A.; Mearini, E.
Overexpression of glyoxalase system enzymes in human kidney tumor
Cancer J.
12
222-228
2006
Homo sapiens, Homo sapiens (Q04760)
Miller, A.G.; Smith, D.G.; Bhat, M.; Nagaraj, R.H.
Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions
J. Biol. Chem.
281
11864-11871
2006
Homo sapiens
Ariza, A.; Vickers, T.J.; Greig, N.; Armour, K.A.; Dixon, M.J.; Eggleston, I.M.; Fairlamb, A.H.; Bond, C.S.
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
Mol. Microbiol.
59
1239-1248
2006
Homo sapiens (Q04760), Homo sapiens, Leishmania major (Q68RJ8), Leishmania major
Kuhla, B.; Boeck, K.; Schmidt, A.; Ogunlade, V.; Arendt, T.; Muench, G.; Lueth, H.J.
Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimers disease brains
Neurobiol. Aging
28
29-41
2007
Homo sapiens
Korybalska, K.; Wisniewska-Elnur, J.; Trominska, J.; Joerres, A.; Breborowicz, A.; Witowski, J.
The role of the glyoxalase pathway in reducing mesothelial toxicity of glucose degradation products
Perit. Dial. Int.
26
259-265
2006
Homo sapiens
Ahmed, U.; Dobler, D.; Larkin, S.J.; Rabbani, N.; Thornalley, P.J.
Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro
Ann. N. Y. Acad. Sci.
1126
262-264
2008
Homo sapiens
Kalousova, M.; Germanova, A.; Jachymova, M.; Mestek, O.; Tesar, V.; Zima, T.
A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients
Ann. N. Y. Acad. Sci.
1126
268-271
2008
Homo sapiens
Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S.
Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects
Bioorg. Med. Chem.
16
3969-3975
2008
Homo sapiens (Q04760), Homo sapiens
Sukdeo, N.; Honek, J.F.
Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal
Drug Metabol. Drug Interact.
23
29-50
2008
Escherichia coli, Escherichia coli (P0AC81), Homo sapiens, Homo sapiens (Q04760), Leishmania braziliensis, Leishmania donovani, Leishmania major, Leishmania sp., Neisseria meningitidis, Neisseria meningitidis (P0A0T3), Plasmodium falciparum, Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9HU72), Pseudomonas aeruginosa (Q9HY85), Pseudomonas aeruginosa (Q9I5L8), Pseudomonas putida, Pseudomonas putida (Q88GF8), Trypanosoma cruzi, Yersinia pestis
de Hemptinne, V.; Rondas, D.; Toepoel, M.; Vancompernolle, K.
Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB
Mol. Cell. Biochem.
325
169-178
2009
Homo sapiens
Santel, T.; Pflug, G.; Hemdan, N.Y.; Schaefer, A.; Hollenbach, M.; Buchold, M.; Hintersdorf, A.; Lindner, I.; Otto, A.; Bigl, M.; Oerlecke, I.; Hutschenreuter, A.; Sack, U.; Huse, K.; Groth, M.; Birkemeyer, C.; Schellenberger, W.; Gebhardt, R.; Platzer, M.; Weiss, T.; Vijayalakshmi, M.A.; Krueger, M.
Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity
PLoS ONE
3
e3508
2008
Homo sapiens
Inagi, R.; Kumagai, T.; Fujita, T.; Nangaku, M.
The role of glyoxalase system in renal hypoxia
Adv. Exp. Med. Biol.
662
49-55
2010
Homo sapiens
Mailankot, M.; Padmanabha, S.; Pasupuleti, N.; Major, D.; Howell, S.; Nagaraj, R.H.
Glyoxalase I activity and immunoreactivity in the aging human lens
Biogerontology
10
711-720
2009
Homo sapiens
Liu, M.; Yuan, M.; Luo, M.; Bu, X.; Luo, H.B.; Hu, X.
Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis
Biophys. Chem.
147
28-34
2010
Homo sapiens (Q04760)
Louie, B.; Rajamahanty, S.; Pyo, P.; Choudhury, M.; Konno, S.
Mode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme
BJU Int.
105
264-268
2010
Homo sapiens
Antognelli, C.; Del Buono, C.; Ludovini, V.; Gori, S.; Talesa, V.N.; Crino, L.; Barberini, F.; Rulli, A.
CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study
BMC Cancer
9
115
2009
Homo sapiens
Germanova, A.; Germanova, A.; Tesarova, P.; Jachymova, M.; Zvara, K.; Zima, T.; Kalousova, M.
Glyoxalase I Glu111Ala polymorphism in patients with breast cancer
Cancer Invest.
27
655-660
2009
Homo sapiens
Takeuchi, M.; Kimura, S.; Kuroda, J.; Ashihara, E.; Kawatani, M.; Osada, H.; Umezawa, K.; Yasui, E.; Imoto, M.; Tsuruo, T.; Yokota, A.; Tanaka, R.; Nagao, R.; Nakahata, T.; Fujiyama, Y.; Maekawa, T.
Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment
Cell Death Differ.
17
1211-1220
2010
Homo sapiens
Davies, G.F.; Juurlink, B.H.; Harkness, T.A.
Troglitazone reverses the multiple drug resistance phenotype in cancer cells
Drug Des. Devel. Ther.
3
79-88
2009
Homo sapiens
Engelen, L.; Ferreira, I.; Brouwers, O.; Henry, R.M.; Dekker, J.M.; Nijpels, G.; Heine, R.J.; van Greevenbroek, M.M.; van der Kallen, C.J.; Blaak, E.E.; Feskens, E.J.; ten Cate, H.; Stehouwer, C.D.; Schalkwijk, C.G.
Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies
J. Hypertens.
27
1399-1403
2009
Homo sapiens
More, S.S.; Vince, R.
Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors
J. Med. Chem.
52
4650-4656
2009
Homo sapiens
Helgager, J.; Li, J.; Lubensky, I.A.; Lonser, R.; Zhuang, Z.
Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents
J. Oncol.
2010
373491
2010
Homo sapiens
Bair, W.B.; Cabello, C.M.; Uchida, K.; Bause, A.S.; Wondrak, G.T.
GLO1 overexpression in human malignant melanoma
Melanoma Res.
20
85-96
2010
Homo sapiens
Karg, E.; Papp, F.; Tassi, N.; Janaky, T.; Wittmann, G.; Turi, S.
Enhanced methylglyoxal formation in the erythrocytes of hemodialyzed patients
Metab. Clin. Exp.
58
976-982
2009
Homo sapiens
Thornalley, P.J.; Waris, S.; Fleming, T.; Santarius, T.; Larkin, S.J.; Winklhofer-Roob, B.M.; Stratton, M.R.; Rabbani, N.
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance
Nucleic Acids Res.
38
5432-5442
2010
Homo sapiens
Birkenmeier, G.; Stegemann, C.; Hoffmann, R.; Guenther, R.; Huse, K.; Birkemeyer, C.
Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation
PLoS ONE
5
e10399
2010
Homo sapiens (Q04760), Homo sapiens
Thornalley, P.J.; Rabbani, N.
Highlights and hotspots of protein glycation in end-stage renal disease
Semin. Dial.
22
400-404
2009
Homo sapiens
Liu, M.; Yuan, M.; Li, Z.; Cheng, Y.K.; Luo, H.B.; Hu, X.
Structural investigation into the inhibitory mechanisms of indomethacin and its analogues towards human glyoxalase I
Bioorg. Med. Chem. Lett.
21
4243-4247
2011
Homo sapiens
Takasawa, R.; Tao, A.; Saeki, K.; Shionozaki, N.; Tanaka, R.; Uchiro, H.; Takahashi, S.; Yoshimori, A.; Tanuma, S.
Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore
Bioorg. Med. Chem. Lett.
21
4337-4342
2011
Homo sapiens
Yuan, M.; Luo, M.; Song, Y.; Xu, Q.; Wang, X.; Cao, Y.; Bu, X.; Ren, Y.; Hu, X.
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies
Bioorg. Med. Chem.
19
1189-1196
2011
Homo sapiens
Skapare, E.; Riekstina, U.; Liepinsh, E.; Konrade, I.; Makrecka, M.; Maurina, B.; Dambrova, M.
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes
Cell Biochem. Funct.
29
171-174
2011
Homo sapiens
Hanssen, N.M.; Stehouwer, C.D.; Schalkwijk, C.G.
Methylglyoxal and glyoxalase I in atherosclerosis
Biochem. Soc. Trans.
42
443-449
2014
Homo sapiens
Deponte, M.
Glyoxalase diversity in parasitic protists
Biochem. Soc. Trans.
42
473-478
2014
Homo sapiens, Leishmania braziliensis, Leishmania donovani, Leishmania infantum, Leishmania major, no activity in Entamoeba histolytica, Plasmodium falciparum, Trypanosoma cruzi, no activity in Trypanosoma brucei, no activity in Giardia lamblia
Honek, J.F.
Bacterial glyoxalase I enzymes: structural and biochemical investigations
Biochem. Soc. Trans.
42
479-484
2014
Saccharomyces cerevisiae, Clostridium acetobutylicum, Escherichia coli, Homo sapiens, Leishmania donovani, Leishmania infantum, Leishmania major, Neisseria meningitidis, Yersinia pestis, Plasmodium falciparum, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas syringae, Trypanosoma cruzi
Wortmann, M.; Peters, A.S.; Hakimi, M.; Boeckler, D.; Dihlmann, S.
Glyoxalase I (Glo1) and its metabolites in vascular disease
Biochem. Soc. Trans.
42
528-533
2014
Homo sapiens, Mus musculus
Chiba, T.; Ohwada, J.; Sakamoto, H.; Kobayashi, T.; Fukami, T.A.; Irie, M.; Miura, T.; Ohara, K.; Koyano, H.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
Bioorg. Med. Chem. Lett.
22
7486-7489
2012
Homo sapiens
Holewinski, R.J.; Creighton, D.J.
Inhibition by active site directed covalent modification of human glyoxalase I
Bioorg. Med. Chem.
22
3301-3308
2014
Homo sapiens
Hikita, K.; Yamada, S.; Shibata, R.; Katoh, M.; Murata, T.; Kato, K.; Tanaka, H.; Kaneda, N.
Inhibitory effect of isoflavones from Erythrina poeppigiana on the growth of HL-60 human leukemia cells through inhibition of glyoxalase I
Nat. Prod. Commun.
10
1581-1584
2015
Homo sapiens (Q04760), Homo sapiens
