Reference on EC 4.1.1.17 - ornithine decarboxylase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hietala, O.A.; Yum, K.Y.; Pilon, J.; O'Donnell, K.; Holroyde, C.P.; Kline, I.; Reichard, G.A.; Litwin, S.; Gilmour, S.K.; O'Brien, T.G.
Properties of ornithine decarboxylase in human colorectal adenocarcinomas
Cancer Res.
50
2088-2094
1990
Homo sapiens
Steven, F.S.; Williams, L.A.; Warne, P.; Tucker, D.F.
Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine
J. Enzyme Inhib.
3
133-143
1989
Homo sapiens
Halmekyto, M.; Alhonen, L.; Wahlfors, J.; Sinervirta, R.; Eloranta, T.; Janne, J.
Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene
Biochem. J.
15
895-898
1991
Homo sapiens
Bachrach, U.; Wang, Y.C.
Cancer therapy and prevention by green tea: role of ornithine decarboxylase
Amino Acids
22
1-13
2002
Homo sapiens
Qu, N.; Ignatenko, N.A.; Yamauchi, P.; Stringer, D.E.; Levenson, C.; Shannon, P.; Perrin, S.; Gerner, E.W.
Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine
Biochem. J.
375
465-470
2003
Homo sapiens
Almrud, J.J.; Oliveira, M.A.; Kern, A.D.; Grishin, N.V.; Phillips, M.A.; Hackert, M.L.
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
J. Mol. Biol.
295
7-16
2000
Homo sapiens (P11926), Homo sapiens
Wallstrom, E.L.; Persson, L.
No role of the 5' untranslated region of ornithine decarboxylase mRNA in the feedback control of the enzyme
Mol. Cell. Biochem.
197
71-78
1999
Homo sapiens
Chabanon, H.; Aubel, C.; Larvaron, P.; Villard, C.; Carraro, V.; Brachet, P.
Ornithine decarboxylase activity is inhibited by the polyamine precursor amino acids at the protein stability level in Caco-2 cells
Biochim. Biophys. Acta
1723
74-81
2005
Homo sapiens
Stabellini, G.; Brugnoli, F.; Calastrini, C.; Vizzotto, L.; Vertemati, M.; Baroni, T.; Caramelli, E.; Marinucci, L.; Pellati, A.; Bertagnolo, V.
Ornithine decarboxylase, polyamines and CD11b expression in HL-60 cells during differentiation induced by retinoic acid
Biomed. Pharmacother.
58
401-406
2004
Homo sapiens
Linsalata, M.; Russo, F.; Berloco, P.; Caruso, M.L.; Matteo, G.D.; Cifone, M.G.; Simone, C.D.; Ierardi, E.; Di Leo, A.
The influence of Lactobacillus brevis on ornithine decarboxylase activity and polyamine profiles in Helicobacter pylori-infected gastric mucosa
Helicobacter
9
165-172
2004
Homo sapiens
Schipper, R.G.; Cuijpers, V.M.; De Groot, L.H.; Thio, M.; Verhofstad, A.A.
Intracellular localization of ornithine decarboxylase and its regulatory protein, antizyme-1
J. Histochem. Cytochem.
52
1259-1266
2004
Homo sapiens
Levin, V.A.; Jochec, J.L.; Shantz, L.M.; Koch, P.E.; Pegg, A.E.
Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine
J. Histochem. Cytochem.
52
1467-1474
2004
Homo sapiens
Young, L.; Salomon, R.; Au, W.; Allan, C.; Russell, P.; Dong, Q.
Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice
J. Histochem. Cytochem.
54
223-229
2006
Homo sapiens
Tian, H.; Liu, X.; Zhang, B.; Sun, Q.; Sun, D.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth
Acta Biochim. Biophys. Sin.
39
423-430
2007
Homo sapiens
Shantz, L.M.; Levin, V.A.
Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential
Amino Acids
33
213-223
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Hsu, P.C.; Hour, T.C.; Liao, Y.F.; Hung, Y.C.; Liu, C.C.; Chang, W.H.; Kao, M.C.; Tsay, G.J.; Hung, H.C.; Liu, G.Y.
Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2
Apoptosis
11
389-399
2006
Homo sapiens
Nilsson, T.; Bogdanovic, N.; Volkman, I.; Winblad, B.; Folkesson, R.; Benedikz, E.
Altered subcellular localization of ornithine decarboxylase in Alzheimers disease brain
Biochem. Biophys. Res. Commun.
344
640-646
2006
Homo sapiens
Dufe, V.T.; Ingner, D.; Heby, O.; Khomutov, A.R.; Persson, L.; Al-Karadaghi, S.
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane
Biochem. J.
405
261-268
2007
Leishmania donovani, Homo sapiens (P11926), Homo sapiens
Ma, Q.; Wang, Y.; Gao, X.; Ma, Z.; Song, Z.
L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma
Clin. Cancer Res.
13
7407-7412
2007
Homo sapiens
Levin, V.A.; Jochec, J.L.; Shantz, L.M.; Aldape, K.D.
Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy
Int. J. Cancer
121
2279-2283
2007
Homo sapiens
Hoeytoe, A.; Juutilainen, J.; Naarala, J.
Ornithine decarboxylase activity is affected in primary astrocytes but not in secondary cell lines exposed to 872 MHz RF radiation
Int. J. Radiat. Biol.
83
367-374
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Vanisree, A.J.; Shyamaladevi, C.S.
The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells - in vitro
Life Sci.
79
654-659
2006
Homo sapiens
Saunders, L.R.; Verdin, E.
Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors
Mol. Cancer Ther.
5
2777-2785
2006
Homo sapiens
Miao, X.P.; Li, J.S.; Li, H.Y.; Zeng, S.P.; Zhao, Y.; Zeng, J.Z.
Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions
World J. Gastroenterol.
13
2867-2871
2007
Homo sapiens
Kanerva, K.; Makitie, L.T.; Pelander, A.; Heiskala, M.; Andersson, L.C.
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
Biochem. J.
409
187-192
2008
Homo sapiens
Deng, W.; Jiang, X.; Mei, Y.; Sun, J.; Ma, R.; Liu, X.; Sun, H.; Tian, H.; Sun, X.
Role of ornithine decarboxylase in breast cancer
Acta Biochim. Biophys. Sin.
40
235-243
2008
Homo sapiens
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1
Biochem. J.
410
613-619
2008
Homo sapiens, Mus musculus
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
Antizyme-3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation
Biochem. J.
419
99-103
2008
Homo sapiens
Bekaert, M.; Ivanov, I.P.; Atkins, J.F.; Baranov, P.V.
Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs
BMC Bioinformatics
9
178
2008
Homo sapiens
Svensson, K.J.; Welch, J.E.; Kucharzewska, P.; Bengtson, P.; Bjurberg, M.; Pahlman, S.; Ten Dam, G.B.; Persson, L.; Belting, M.
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase
Cancer Res.
68
9291-9301
2008
Homo sapiens, Rattus norvegicus
Koomoa, D.L.; Yco, L.P.; Borsics, T.; Wallick, C.J.; Bachmann, A.S.
Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma
Cancer Res.
68
9825-9831
2008
Homo sapiens
Rounbehler, R.J.; Li, W.; Hall, M.A.; Yang, C.; Fallahi, M.; Cleveland, J.L.
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
Cancer Res.
69
547-553
2009
Homo sapiens
Hubner, R.A.; Muir, K.R.; Liu, J.F.; Logan, R.F.; Grainge, M.J.; Houlston, R.S.; Houlston, R.S.
Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention
Clin. Cancer Res.
14
2303-2309
2008
Homo sapiens
Wu, F.; Gehring, H.
Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation
FASEB J.
23
565-574
2008
Homo sapiens (P11926), Homo sapiens
Liao, Y.F.; Hung, H.C.; Hsu, P.C.; Kao, M.C.; Hour, T.C.; Tsay, G.J.; Liu, G.Y.
Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB
Leuk. Res.
32
1124-1140
2008
Homo sapiens
Hsu, P.C.; Hung, H.C.; Liao, Y.F.; Liu, C.C.; Tsay, G.J.; Liu, G.Y.
Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells
Leuk. Res.
32
1530-1540
2008
Homo sapiens
Liao, Y.F.; Hung, H.C.; Hour, T.C.; Hsu, P.C.; Kao, M.C.; Tsay, G.J.; Liu, G.Y.
Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells
Life Sci.
82
367-375
2008
Homo sapiens
Maekitie, L.T.; Kanerva, K.; Polvikoski, T.; Paetau, A.; Andersson, L.C.
brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimers disease
Brain Pathol.
20
571-580
2010
Homo sapiens
Zell, J.A.; Ziogas, A.; Ignatenko, N.; Honda, J.; Qu, N.; Bobbs, A.S.; Neuhausen, S.L.; Gerner, E.W.; Anton-Culver, H.
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
Clin. Cancer Res.
15
6208-6216
2009
Homo sapiens
Grimminger, P.P.; Schneider, P.M.; Metzger, R.; Vallboehmer, D.; Danenberg, K.D.; Danenberg, P.V.; Hoelscher, A.H.; Brabender, J.
Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer
Clin. Lung Cancer
11
114-119
2010
Homo sapiens
Brown, I.; Halliday, S.; Greig, H.; Heys, S.D.; Wallace, H.M.; Schofield, A.C.
Genetic polymorphism in ornithine decarboxylase and risk of breast cancer
Fam. Cancer
8
307-311
2009
Homo sapiens
Maekitie, L.T.; Kanerva, K.; Sankila, A.; Andersson, L.C.
High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads
Histochem. Cell Biol.
132
633-638
2009
Homo sapiens
Geerts, D.; Koster, J.; Albert, D.; Koomoa, D.L.; Feith, D.J.; Pegg, A.E.; Volckmann, R.; Caron, H.; Versteeg, R.; Bachmann, A.S.
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
Int. J. Cancer
126
2012-2024
2010
Homo sapiens
Billaudel, B.; Taxile, M.; Poulletier de Gannes, F.; Ruffie, G.; Lagroye, I.; Veyret, B.
Effects of exposure to DAMPS and GSM signals on ornithine decarboxylase (ODC) activity: II. SH-SY5Y human neuroblastoma cells
Int. J. Radiat. Biol.
85
519-522
2009
Homo sapiens
Ivanov, I.P.; Firth, A.E.; Atkins, J.F.
Recurrent emergence of catalytically inactive ornithine decarboxylase homologous forms that likely have regulatory function
J. Mol. Evol.
70
289-302
2010
Aedes aegypti, Ancylostoma ceylanicum, Anopheles gambiae, Aspergillus clavatus, Aspergillus fischeri, Aspergillus fumigatus, Aspergillus terreus, Bos taurus, Botrytis cinerea, Branchiostoma floridae, Caenorhabditis briggsae, Caenorhabditis elegans, Meyerozyma guilliermondii, Canis lupus familiaris, Gallus gallus, Ciona intestinalis, Coccidioides immitis, Culex pipiens, Dictyostelium discoideum, Drosophila melanogaster, Fusarium oxysporum, Fusarium verticillioides, Homo sapiens, Hydra vulgaris, Mus musculus, Neurospora crassa, Rattus norvegicus, Takifugu rubripes, Trypanosoma brucei, Xenopus laevis, Petromyzon marinus, Parastagonospora nodorum, Uncinocarpus reesii, Tetraodon nigroviridis, Dugesia japonica, Gasterosteus aculeatus, Anolis carolinensis, Schmidtea mediterranea, Nasonia vitripennis
Kucharzewska, P.; Welch, J.E.; Svensson, K.J.; Belting, M.
Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells
Exp. Cell Res.
316
2683-2691
2010
Homo sapiens, Mus musculus
Lange, I.; Geerts, D.; Feith, D.J.; Mocz, G.; Koster, J.; Bachmann, A.S.
Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation
J. Mol. Biol.
426
332-346
2014
Homo sapiens
Liu, Y.C.; Hsu, D.H.; Huang, C.L.; Liu, Y.L.; Liu, G.Y.; Hung, H.C.
Determinants of the differential antizyme-binding affinity of ornithine decarboxylase
PLoS ONE
6
e26835
2011
Homo sapiens
Kanerva, K.; Maekitie, L.T.; Pelander, A.; Heiskala, M.; Andersson, L.C.
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
Biochem. J.
409
187-192
2008
Homo sapiens
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1
Biochem. J.
410
613-619
2008
Homo sapiens (P11926)
Singh, K.; Coburn, L.A.; Asim, M.; Barry, D.P.; Allaman, M.M.; Shi, C.; Washington, M.K.; Luis, P.B.; Schneider, C.; Delgado, A.G.; Piazuelo, M.B.; Cleveland, J.L.; Gobert, A.P.; Wilson, K.T.
Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses
Cancer Res.
78
4303-4315
2018
Mus musculus (P00860), Homo sapiens (P11926), Homo sapiens
Kim, H.I.; Schultz, C.R.; Buras, A.L.; Friedman, E.; Fedorko, A.; Seamon, L.; Chandramouli, G.V.R.; Maxwell, G.L.; Bachmann, A.S.; Risinger, J.I.
Ornithine decarboxylase as a therapeutic target for endometrial cancer
PLoS ONE
12
e0189044
2017
Homo sapiens (P11926), Homo sapiens
