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Disease on EC 3.4.22.15 - cathepsin L and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Acute Coronary Syndrome
Plasma cathepsin L and its related pro/antiangiogenic factors play useful roles in predicting rich coronary collaterals in patients with coronary heart disease.
Serum and saliva levels of cathepsin L in patients with acute coronary syndrome.
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Adenocarcinoma
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Expression of cathepsin L in normal endometrium and endometrial cancer.
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma.
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Adenocarcinoma of Lung
Alterations in cathepsin L expression in lung cancers.
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Albuminuria
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Alopecia
The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.
Alzheimer Disease
Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L.
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Amyloidosis
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis.
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation.
Amyotrophic Lateral Sclerosis
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
Angina, Stable
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Angina, Unstable
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Aortic Aneurysm
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model.
Aortic Aneurysm, Abdominal
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice.
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Arteriosclerosis
Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers.
Arthritis
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Elevation of cathepsin L levels in the synovial lining of rabbits with antigen-induced arthritis.
Mode of activation of the precursor to cathepsin L: implication for matrix degradation in arthritis.
Arthritis, Experimental
Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat.
Arthritis, Rheumatoid
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.
Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase.
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment.
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.
Astrocytoma
Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Lysosomal enzymes, cathepsins in brain tumour invasion.
Atherosclerosis
Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.
Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis.
Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine.
Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques.
Peroxisome Proliferator-activated Receptor {gamma} Induces Apoptosis and Inhibits Autophagy of Human Monocyte-derived Macrophages via Induction of Cathepsin L: POTENTIAL ROLE IN ATHEROSCLEROSIS.
The association between serum cathepsin L and mortality in older adults.
Bacteremia
Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia.
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Bacterial Infections
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Immunodiagnostic/protective role of Cathepsin L cysteine proteinases secreted by Fasciola species.
Macrobrachium rosenbergii cathepsin L: Molecular characterization and gene expression in response to viral and bacterial infections.
Bone Diseases
Cathepsin L in metastatic bone disease: therapeutic implications.
Bone Diseases, Metabolic
Soluble cathepsin-L: a marker of bone resorption and bone density?
Bone Resorption
An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions.
Cathepsin B and L activities in isolated osteoclasts.
Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro.
Distinct roles of cathepsin K and cathepsin L in osteoclastic bone resorption.
Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats.
Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone.
Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast.
Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones.
Participation of cathepsin L on bone resorption.
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts.
Soluble cathepsin-L: a marker of bone resorption and bone density?
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Study of the functional share of lysosomal cathepsins by the development of specific inhibitors.
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
The mechanisms and regulation of procathepsin L secretion from osteoclasts in bone resorption.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide.
Brain Ischemia
Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia.
Brain Neoplasms
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
[Cathepsin L from human brain tumor. Purification and contents]
Breast Neoplasms
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Cathepsin L secretion by host and neoplastic cells potentiates invasion.
Cathepsin L splice variants in human breast cell lines.
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients.
Correction for Burton et al., "Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor".
Cystatins and cathepsins in breast carcinoma.
Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach.
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells.
Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines.
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L.
Novel roles of 1?,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.
Prognostic significance of cathepsins B and L in primary human breast cancer.
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
Caliciviridae Infections
Endosomal acidification and cathepsin L activity is required for calicivirus replication.
Carcinogenesis
Alterations in cathepsin L expression in lung cancers.
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.
Expression of cathepsin L in normal endometrium and endometrial cancer.
Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.
Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization.
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.
Protective role of cathepsin L in mouse skin carcinogenesis.
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
Carcinoma
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney.
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Cystatins and cathepsins in breast carcinoma.
Cysteine protease activities and tumor development in human colorectal carcinoma.
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor???mediated epithelial?mesenchymal transition.
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Expression of cathepsin L in human tumors.
Expression of cathepsin L in normal endometrium and endometrial cancer.
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Functional consequences of cathepsin L deficiency in human lung epithelial cells.
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Increase of endo-peptidases and exo-peptidases in thyroid-tumors.
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.
Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma.
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
The expression of Cathepsin L in oral lichen planus.
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
Carcinoma in Situ
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Carcinoma, Basal Cell
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Carcinoma, Hepatocellular
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Increased expression of cathepsin L: a novel independent prognostic marker of worse outcome in hepatocellular carcinoma patients.
Carcinoma, Lewis Lung
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Carcinoma, Non-Small-Cell Lung
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Carcinoma, Ovarian Epithelial
Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer.
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Carcinoma, Renal Cell
"Disrupted in renal carcinoma 2" (DIRC2) - a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L.
Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney.
Carcinoma, Squamous Cell
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Cardiac Output, Low
Ultrastructural changes in myocardial cells of rats fed a low protein diet.
Cardiomegaly
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF?/ASK1/JNK pathway.
Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.
Cardiomyopathies
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
Microarray Analysis of Polychlorinated Biphenyl Mixture-Induced Changes in Gene Expression among Atlantic Tomcod Populations Displaying Differential Sensitivity to Halogenated Aromatic Hydrocarbons.
Microarray analysis of polychlorinated biphenyl mixture-induced changes in gene expression among atlantic tomcod populations displaying differential sensitivity to halogenated aromatic hydrocarbons.
Cardiomyopathy, Dilated
Cell type-specific functions of the lysosomal protease cathepsin L in the heart.
Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy.
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
[The expression and significance of myocardial cathepsin L in dilated cardiomyopathy]
Cardiovascular Diseases
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children.
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
The association between serum cathepsin L and mortality in older adults.
Carotid Artery Injuries
Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.
OS 02-05 MYD88 ON MACROPHAGE TRIGGERS CATHEPSIN L ACTIVATION DRIVEN VASCULAR INTIMAL HYPERPLASIA.
cathepsin k deficiency
Thyroid functions of mouse cathepsins B, K, and L.
cathepsin l deficiency
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.
Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation.
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Epidermal differentiation: the role of proteases and their inhibitors.
Functional consequences of cathepsin L deficiency in human lung epithelial cells.
Impaired turnover of autophagolysosomes in cathepsin L deficiency.
Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo.
cathepsin s deficiency
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Chagas Disease
Characterisation of Trypanosoma cruzi populations by DNA polymorphism of the cruzipain gene detected by single-stranded DNA conformation polymorphism (SSCP) and direct sequencing.
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Cholesteatoma
Cathepsin L activity and its inhibitor in human otitis media.
Choroidal Neovascularization
Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization.
Clonorchiasis
Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis.
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen.
Clostridium Infections
Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen.
Coinfection
Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases.
Colonic Neoplasms
[Protease activities in gastric and colon cancer tissues]
Colorectal Neoplasms
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells.
Levels of serum cathepsin L and several glycosidases in patients operated for colorectal cancer.
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
The role of cysteine and serine proteases in colorectal carcinoma.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Common Cold
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
Coronary Artery Disease
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.
Increased Circulating Cathepsin L in Patients with Coronary Artery Disease.
Coronary Disease
Plasma cathepsin L and its related pro/antiangiogenic factors play useful roles in predicting rich coronary collaterals in patients with coronary heart disease.
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
[Association of cathepsin L with coronary heart disease and its risk factors]
Coronary Stenosis
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
[Association of cathepsin L with coronary heart disease and its risk factors]
COVID-19
Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.
Elucidating the drug repurposing spectra of COVID-19 with its analogues SARS and MERS.
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2.
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L*.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.
Roles of existing drug and drug targets for COVID-19 management.
Simultaneous Treatment of COVID-19 With Serine Protease Inhibitor Camostat and/or Cathepsin L Inhibitor?
Cysticercosis
Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis.
Utility of a protein fraction with cathepsin L-Like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosis.
Cysts
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini.
The highly antigenic 53/25 kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs.
Dermatitis, Atopic
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Diabetes Mellitus
High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells.
Neutrophil gelatinase-associated lipocalin and Cathepsin L as early predictors of kidney dysfunction in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
Immunoreactivity of cytotoxic T-lymphocyte antigen 2 alpha in mouse pancreatic islet cells.
Neutrophil gelatinase-associated lipocalin and Cathepsin L as early predictors of kidney dysfunction in children with type 1 diabetes.
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.
Diabetes Mellitus, Type 2
High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells.
Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
Structure-based development of specific inhibitors for individual cathepsins and their medical applications.
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Diabetic Nephropathies
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Diabetic Retinopathy
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy.
Echinococcosis
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Encephalitis, Japanese
Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.
Encephalomyelitis
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.
Endocarditis
Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Endometrial Neoplasms
Expression of cathepsin L in normal endometrium and endometrial cancer.
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Eosinophilia
Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden.
Epiretinal Membrane
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy.
Esophageal Neoplasms
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Fascioliasis
Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices.
Immunization with cathepsin L proteinases CL1 and CL2 secreted by Fasciola hepatica elicit a preferential type 1 response based on IgG2a antibodies in rats.
Immunological approaches for the control of fasciolosis.
Serodiagnosis of human fascioliasis by a cystatin capture enzyme-linked immunosorbent assay with recombinant Fasciola gigantica cathepsin L antigen.
The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease.
Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep.
Fatty Liver
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Fibrosarcoma
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Significance of 32-kDa cathepsin L secreted from cancer cells.
Folliculitis
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Frontotemporal Dementia
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Frontotemporal Lobar Degeneration
The lysosomal protein cathepsin L is a progranulin protease.
Gastrointestinal Stromal Tumors
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.
Giant Cell Tumors
Estrogen modulation of osteoclast lysosomal enzyme secretion.
Gingival Hyperplasia
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.
Gingival Overgrowth
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts.
Glioblastoma
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Cathepsin L in glioma progression: comparison with cathepsin B.
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids.
Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.
Cystatin F acts as a mediator of immune suppression in glioblastoma.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification.
Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7.
Lysosomal enzymes, cathepsins in brain tumour invasion.
Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells.
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
Glioma
Cathepsin L in glioma progression: comparison with cathepsin B.
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.
Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3?/CUX1 pathway.
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro.
Proteases in brain tumour progression.
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Glomerulonephritis
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
Glucose Intolerance
Cathepsin L activity controls adipogenesis and glucose tolerance.
Hemangioendothelioma
Generation and degradation of human endostatin proteins by various proteinases.
Hepatitis A
The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.
Herpes Simplex
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells.
Hidradenitis Suppurativa
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Huntington Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hydatidiform Mole
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Hypercalcemia
Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro.
Hypersensitivity
Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal.
Hypertension
Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism.
Association Between Polymorphism in the Human Cathepsin L (CTSL1) Promoter with Hypertension in the Uygur, Kazak and Han Populations in China.
Hyperthyroidism
Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle.
Hypotension
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Idiopathic Pulmonary Fibrosis
A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Infections
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites.
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Analysis of expressed sequence tags (ESTs) and gene expression changes under different growth conditions for the ciliate Anophryoides haemophila, the causative agent of bumper car disease in the American lobster (Homarus americanus).
Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function.
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae?
Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells.
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Cathepsin L Helps to Defend Mice from Infection with Influenza A.
Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai)--Purification and characterization.
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Cathepsin L of the sea cucumber Apostichopus japonicus-molecular characterization and transcriptional response to Vibrio splendidus infection.
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.
Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants.
Cathepsin S supports acid-independent infection by some reoviruses.
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini.
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors.
Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.
Cronobacter sakazakii ATCC 29544 Translocated Human Brain Microvascular Endothelial Cells via Endocytosis, Apoptosis Induction, and Disruption of Tight Junction.
Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity.
Development and validation of an RNA- and DNA-based quantitative PCR assay for determination of Kudoa thyrsites infection levels in Atlantic salmon Salmo salar.
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Dissociation of ras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants.
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Encapsulation of Cwp84 into pectin beads for oral vaccination against Clostridium difficile.
Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis.
Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants.
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses.
High genetic diversity in field isolates of Trypanosoma theileri assessed by analysis of cathepsin L-like sequences disclosed multiple and new genotypes infecting cattle in Thailand.
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells.
Human papillomavirus type 16 does not require cathepsin L or B for infection.
Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide.
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen.
Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases.
Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase.
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.
Influence of environmental conditions on the expression and the maturation process of the Clostridium difficile surface associated protease Cwp84.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity.
Loop-mediated isothermal amplification method for differentiation and rapid detection of Taenia species.
Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi.
Novel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug Discovery.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome.
Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.
Protease-mediated entry via the endosome of human coronavirus 229E.
Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L.
Rapid identification of lymnaeid snails and their infection with Fasciola gigantica in Thailand.
Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics.
Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein.
Roles of existing drug and drug targets for COVID-19 management.
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Serodiagnosis of Fasciola gigantica Infection in Buffaloes with Native Cathepsin-L Proteases and Recombinant Cathepsin L1-D.
Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19?
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
The first characterization of a cystatin and a cathepsin L-like peptidase from Aedes aegypti and their possible role in DENV infection by the modulation of apoptosis.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.
Upregulation of gut cathepsin L during Eimeria tenella infection.
Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy.
Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.
[Cathepsin L Cysteine Protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis.]
Infertility
Expression of cathepsin L in human testis under diverse infertility conditions.
Infertility, Male
Expression of cathepsin L in human testis under diverse infertility conditions.
Influenza, Human
Cathepsin L Helps to Defend Mice from Infection with Influenza A.
Intestinal Neoplasms
Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers.
Intestinal Volvulus
Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.
RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting.
Keratosis, Seborrheic
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Kidney Diseases
Increased dynamin expression precedes proteinuria in glomerular disease.
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Kidney Neoplasms
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Leg Ulcer
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Leiomyoma
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Leishmaniasis
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Improving serodiagnosis of human and canine leishmaniasis with recombinant Leishmania braziliensis cathepsin l-like protein and a synthetic peptide containing its linear B-cell epitope.
Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.
Leishmaniasis, Visceral
Canine Visceral Leishmaniasis in São Paulo, Brazil, the Most Populous City of South America: Isolation, Molecular Diagnosis, and Phylogenetic Inferences.
Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations.
Leukemia
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Epigenetic Regulation of Cathepsin L Expression in Chronic Myeloid Leukemia.
Leukemia, Myeloid, Acute
Prognostic significance of cathepsin L expression in pediatric acute myeloid leukemia.
Lichen Planus
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Lichen Planus, Oral
The expression of Cathepsin L in oral lichen planus.
Liver Cirrhosis
Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models.
Liver Diseases
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Lung Diseases
Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases.
Lung Injury
A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance.
Lung Neoplasms
Alterations in cathepsin L expression in lung cancers.
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients.
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.
Quantification of intracellular cathepsin activities in human lung tumor cell lines by flow cytometry.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Significance of 32-kDa cathepsin L secreted from cancer cells.
Lymphatic Metastasis
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Lymphoma
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Lymphoma, Non-Hodgkin
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis.
Lysosomal Storage Diseases
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Malaria
Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates.
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth.
Melanoma
Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.
Cathepsin L increases invasion and migration of B16 melanoma.
Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity.
Cloning and characterization of anti-cathepsin L single chain variable fragment whose expression inhibits procathepsin L secretion in human melanoma cells.
Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro.
Expression and prognostic significance of Cathepsin L in early cutaneous malignant melanoma.
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Heparin enhances serpin inhibition of the cysteine protease cathepsin L.
Melanoma Growth and Progression After Ultraviolet A Irradiation: Impact of Lysosomal Exocytosis and Cathepsin Proteases.
Membrane-associated cathepsin L: a role in metastasis of melanomas.
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Tumor-associated cysteine proteinase activities in human melanoma cells and fibroblasts of different origin.
Melanoma, Amelanotic
Membrane-associated cathepsin L: a role in metastasis of melanomas.
Melanoma, Experimental
Cathepsin L increases invasion and migration of B16 melanoma.
Membrane-associated cathepsin L: a role in metastasis of melanomas.
The malignant phenotype and cysteine proteinases.
Meningioma
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas.
Cathepsins B and L are markers for clinically invasive types of meningiomas.
Lysosomal enzymes, cathepsins in brain tumour invasion.
Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
Meningitis, Pneumococcal
Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis.
Mouth Neoplasms
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial-Mesenchymal Transition.
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Mucolipidoses
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Muscular Atrophy
Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt.
Conditional activation of MET in differentiated skeletal muscle induces atrophy.
Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle.
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control.
Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells.
Muscular Diseases
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Mycoplasma Infections
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Myocardial Infarction
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Myocardial Ischemia
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats].
Nasopharyngeal Carcinoma
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Neoplasm Metastasis
A micRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition.
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Cathepsin L in metastatic bone disease: therapeutic implications.
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94.
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Cathepsin L increases invasion and migration of B16 melanoma.
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Cathepsin L secretion by host and neoplastic cells potentiates invasion.
Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells.
Cathepsin L, target in cancer treatment?
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes.
Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma.
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Cysteine and serine proteases in gastric cancer.
Differential activity of cathepsin L in human placenta at two different stages of gestation.
Effect of liver macrophage depression on the development of liver metastases of HA-1 tumor in mice.
Enhanced expression of cathepsin L in metastatic bone tumors.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression.
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells.
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth.
Membrane-associated cathepsin L: a role in metastasis of melanomas.
Molecular cloning and anti-invasive activity of cathepsin L propeptide-like protein from Calotropis procera R. Br. against cancer cells.
Neuroblastoma therapy: what is in the pipeline?
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Significance of 32-kDa cathepsin L secreted from cancer cells.
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
The heparanase system and tumor metastasis: is heparanase the seed and soil?
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
The role of cysteine and serine proteases in colorectal carcinoma.
Truncated Human Cathepsin L, Encoded by a Novel Splice Variant, Exhibits Altered Subcellular Localization and Cytotoxicity.
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Neoplasms
A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.
A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation.
A micRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition.
Alterations in cathepsin L expression in lung cancers.
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
Antiprotease therapy in cancer: hot or not?
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial.
Bioprinting on Live Tissue for Investigating Cancer Cell Dynamics.
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.
Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors.
Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC.
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.
Cathepsin L in glioma progression: comparison with cathepsin B.
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94.
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Cathepsin L increases invasion and migration of B16 melanoma.
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism.
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3?/CUX1 pathway.
Cathepsin L secretion by host and neoplastic cells potentiates invasion.
Cathepsin L splice variants in human breast cell lines.
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Cathepsin L targeting in cancer treatment.
Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells.
Cathepsin L, target in cancer treatment?
Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms.
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis.
Cathepsins B and L are markers for clinically invasive types of meningiomas.
Cathepsins D, B and L in breast carcinoma and in transformed human breast epithelial cells (HBEC).
Cathepsins D, B, and L in malignant human lung tissue.
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis.
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma.
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Cystatins and cathepsins in breast carcinoma.
Cysteine and serine proteases in gastric cancer.
Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking.
Cysteine proteinases in cancer progression and their clinical relevance for prognosis.
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.
Differential activity of cathepsin L in human placenta at two different stages of gestation.
Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.
Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor???mediated epithelial?mesenchymal transition.
Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.
Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
Effect of in-situ and ex-situ biofloc on immune response of Genetically Improved Farmed Tilapia.
Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L.
Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues.
Enhanced expression of cathepsin L in metastatic bone tumors.
Enhancing effect of new biological response modifier sulfoethylated (1-->3)-beta-D-glucan on antitumor activity of cyclophosphamide in the treatment of experimental murine leukoses.
Epigenetic Regulation of Cathepsin L Expression in Chronic Myeloid Leukemia.
Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status.
Estrogen modulation of osteoclast lysosomal enzyme secretion.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Expression of cathepsin L in human testis under diverse infertility conditions.
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Expression of cathepsin L in human tumors.
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Expression of cathepsin L in normal endometrium and endometrial cancer.
Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.
Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases.
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Heparin enhances serpin inhibition of the cysteine protease cathepsin L.
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth.
Identification and characterization of a novel human cathepsin L splice variant.
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics.
Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma.
In silico investigation of heparanase-correlated genes in breast cancer subtypes.
In vivo imaging of intraperitoneally disseminated tumors in model mice by using activatable fluorescent small-molecular probes for activity of cathepsins.
Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.
Increased levels of cathepsin B and L, urokinase-type plasminogen activator and its inhibitor type-1 as an early event in gastric carcinogenesis.
Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells.
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins.
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro.
Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications.
Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein.
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth.
MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.
Modeling of Halogen-Protein Interactions in Co-Solvent Molecular Dynamics Simulations.
Molecular and cytogenetic analysis of glioblastoma multiforme.
Molecular cloning and anti-invasive activity of cathepsin L propeptide-like protein from Calotropis procera R. Br. against cancer cells.
Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines.
Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019.
Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer.
P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53.
Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors.
Phorbol ester stimulated cathepsin L expression in U937 cells.
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial-Mesenchymal Transition.
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Post-transcriptional regulation of human cathepsin L expression.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.
Prognostic significance of cathepsin L expression in pediatric acute myeloid leukemia.
Prognostic significance of cathepsins B and L in primary human breast cancer.
Prognostic significance of cysteine proteinases cathepsins B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck.
Prognostic significance of extracellular matrix degrading enzymes-cathepsin L and matrix metalloproteases-2 [MMP-2] in human pancreatic cancer.
Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma.
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Proteases and their inhibitors in human brain tumours: a review.
Proteases as prognostic markers in cancer.
Protective role of cathepsin L in mouse skin carcinogenesis.
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment.
Relation between the regulation of DNA synthesis and the production of two secreted glycoproteins by 12-O-tetradecanoylphorbol-13-acetate in 3T3 cells and in phorbol ester nonresponsive 3T3 variants.
RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells.
Secreted cathepsin L generates endostatin from collagen XVIII.
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Sequence analysis and distribution of two new human cathepsin L splice variants.
Sequential enzyme-activated macrotheranostic probe for selective tumor mitochondria targeting.
Significance of 32-kDa cathepsin L secreted from cancer cells.
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.
Splice variants of human cathepsin L mRNA show different expression rates.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells.
Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
Synthesis and evaluation of N?,N?-diacetyl-l-lysine-inositol conjugates as cancer-selective probes for metabolic engineering of GPIs and GPI-anchored proteins.
Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L.
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Targeting senescence pathways to reverse drug resistance in cancer.
Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
The anti-angiogenic activity of NSITC, a specific cathepsin L inhibitor.
The expression of Cathepsin L in oral lichen planus.
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease.
The heparanase system and tumor metastasis: is heparanase the seed and soil?
The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor.
The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy.
The major excreted protein of transformed fibroblasts is an activable acid-protease.
Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene.
Truncated Human Cathepsin L, Encoded by a Novel Splice Variant, Exhibits Altered Subcellular Localization and Cytotoxicity.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Tumor progression and metastasis in murine D2 hyperplastic alveolar nodule mammary tumor cell lines.
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.
Ultrasensitive internally quenched substrates of human cathepsin L.
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
[Cathepsin L from human brain tumor. Purification and contents]
[Characterization of an analog enzyme to cathepsin L produced by tumor cells]
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
[Protease activities in gastric and colon cancer tissues]
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Neoplasms, Germ Cell and Embryonal
Expression of cathepsin L in human testis under diverse infertility conditions.
Nephritis, Interstitial
Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2?
Nephrosis
Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis.
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin.
Nephrotic Syndrome
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin.
Role of cathepsin L in idiopathic nephrotic syndrome in children.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Neuroblastoma
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.
Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification.
Neurocysticercosis
[Cathepsin L Cysteine Protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis.]
Neurodegenerative Diseases
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Neuroinflammatory Diseases
Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-?B pathways.
Neuronal Ceroid-Lipofuscinoses
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Nevus
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Non-alcoholic Fatty Liver Disease
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Obesity
Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.
Osteoarthritis
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Osteolysis
Cathepsin K is the principal protease in giant cell tumor of bone.
Osteophyte
The relative importance of cysteine peptidases in osteoarthritis.
Osteoporosis
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Soluble cathepsin-L: a marker of bone resorption and bone density?
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Osteosarcoma
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Enhanced expression of cathepsin L in metastatic bone tumors.
Otitis Media
Cathepsin L activity and its inhibitor in human otitis media.
Ovarian Neoplasms
Cathepsin L is involved in proliferation and invasion of ovarian cancer cells.
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
Combined detection of serum matrix metalloproteinase 9, acetyl heparinase and cathepsin L in diagnosis of ovarian cancer.
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Knockdown of cathepsin L sensitizes ovarian cancer cells to chemotherapy.
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death.
Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer.
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
Pancreatic Neoplasms
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Plasma cathepsin L: a prognostic marker for pancreatic cancer.
Pancreatitis
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.
Pathophysiology of acute and infected pancreatitis.
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Parasitic Diseases
Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
Parkinson Disease
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.
Parkinson's disease involves autophagy and abnormal distribution of cathepsin L.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Periodontitis
Cathepsin B- and L-like activities at local gingival sites of chronic periodontitis patients.
COVID-19 and Periodontitis: A Reality to Live with.
Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients.
Persistent Infection
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA).
Pneumococcal Infections
Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections.
Pneumonia, Mycoplasma
Cathepsin L Helps to Defend Mice from Infection with Influenza A.
Pneumonia, Pneumococcal
Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Polycystic Kidney, Autosomal Dominant
Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1.
Prostatic Neoplasms
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial.
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Quantitative Glycoproteomic Analysis of Optimal Cutting Temperature-Embedded Frozen Tissues Identifying Glycoproteins Associated with Aggressive Prostate Cancer.
Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1.
Proteinuria
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis.
More expression, less function: cleaved dynamin in glomerular kidney disease.
Proteinuria: an enzymatic disease of the podocyte?
Proteinuria: is it all in the foot?
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Psoriasis
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Processing of cathepsins L, B and D in psoriatic epidermis.
Pulmonary Disease, Chronic Obstructive
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections.
Pulmonary Emphysema
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages.
Pyoderma Gangrenosum
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Renal Insufficiency, Chronic
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.
Reoviridae Infections
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.
Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.
Reperfusion Injury
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Sarcoma
Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.
Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.
Enzymatic detection systems for non-isotopic in situ hybridization using biotinylated cDNA probes.
Retrovirus transformation associated secretory phosphoproteins of mouse and mink cells.
Sarcoma, Ewing
Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.
Sarcoma, Yoshida
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
Schistosomiasis
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Scleroderma, Systemic
A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis.
Sepsis
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model.
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.
Sertoli Cell-Only Syndrome
Expression of cathepsin L in human testis under diverse infertility conditions.
Severe Acute Respiratory Syndrome
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites.
Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level.
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide.
Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Skin Diseases
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
The expression of Cathepsin L in oral lichen planus.
ST Elevation Myocardial Infarction
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Starvation
Coordinate upregulation of proteolytic-related genes in rat muscle during late fasting.
Effect of fasting and thyroidectomy on cysteine proteinase activities in liver and muscle.
Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work.
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
Stomach Neoplasms
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Defining the invasive phenotype of proximal gastric cancer cells.
FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L.
Variant cathepsin L activity from gastric cancer tissue.
[Protease activities in gastric and colon cancer tissues]
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Tendinopathy
Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.
Testicular Neoplasms
Expression of cathepsin L in human testis under diverse infertility conditions.
Expression of cathepsin L in human tumors.
Thrombosis
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Thyroid Neoplasms
Influence of proliferation, differentiation and dedifferentiation factors on the expression of the lysosomal cysteine proteinase cathepsin L (CL) in thyroid cancer cell lines.
Relaxin enhances the oncogenic potential of human thyroid carcinoma cells.
Toxoplasmosis
Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.
Triple Negative Breast Neoplasms
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Trypanosomiasis, African
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
Tuberculosis
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Uterine Cervical Neoplasms
Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells.
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.
Uterine Neoplasms
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Vascular Diseases
Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation.
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Vesicular Stomatitis
Characterization of the envelope glycoprotein of a novel filovirus, lloviu virus.
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Viremia
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.
Virus Diseases
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Diminished intracellular invariant chain expression after vaccinia virus infection.
Identification and characterization of the v-cath gene of the baculovirus, CfMNPV.