Reference on EC 3.4.21.27 - coagulation factor XIa and Organism(s) Homo sapiens
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Scott, C.F.; Mentzer, R.L.; Budzynski, A.Z.; Colman, R.W.
Human factor XIa cleaves fibrinogen: effects on structure and function
Arch. Biochem. Biophys.
249
480-488
1986
Homo sapiens
Sinha, D.; Koshy, A.; Seaman, F.S.; Walsh, P.N.
Functional characterization of human blood coagulation factor XIa using hybridoma antibodies
J. Biol. Chem.
260
10714-10719
1985
Homo sapiens
Meijers, J.C.M.; Vlooswijk, R.A.A.; Bouma, B.N.
Inhibition of human blood coagulation factor XIa by C-1 inhibitor
Biochemistry
27
959-963
1988
Homo sapiens
Van der Graaf, F.; Greengard, J.S.; Bouma, B.N.; Kerbiriou, D.M.; Griffin, J.H.
Isolation and functional characterization of the active light chain of activated human blood coagulation factor XI
J. Biol. Chem.
258
9669-9675
1983
Homo sapiens
Sinha, D.; Seaman, F.S.; Walsh, P.N.
Role of calcium ions and the heavy chain of factor XIa in the activation of human coagulation factor IX
Biochemistry
26
3768-3775
1987
Homo sapiens
Kam, C.M.; Fujikawa, K.; Powers, J.C.
Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants
Biochemistry
27
2547-2557
1988
Homo sapiens
Saportio-Irwin, S.M.; Van Nostrand, W.E.
Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid beta-protein
J. Biol. Chem.
270
26265-26269
1995
Homo sapiens
Naito, K.; Fujikawa, K.
Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces
J. Biol. Chem.
266
7353-7358
1991
Homo sapiens
Zhang, Y.; Scandura, J.M.; Van Nostrand, W.E.; Walsh, P.N.
The mechanism by which heparin promotes the inhibition of coagulation factor XIa by protease nexin-2
J. Biol. Chem.
272
26139-26144
1997
Homo sapiens
Kalwant, S.; Porter, A.G.
Purification and characterization of human brain prolyl endopeptidase
Biochem. J.
276
237-244
1991
Homo sapiens
Badellino, K.O.; Walsh, P.N.
Protease nexin II interactions with coagulation factor XIa are contained within the Kunitz protease inhibitor domain of protease nexin II and the factor XIa catalytic domain
Biochemistry
39
4769-4777
2000
Homo sapiens
Gailani, D.; Ho, D.; Sun, M.F.; Cheng, Q.; Walsh, P.N.
Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential
Blood
97
3117-3122
2001
Homo sapiens
Baglia, F.A.; Walsh, P.N.
Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa
J. Biol. Chem.
275
20514-20519
2000
Homo sapiens
Baird, T.R.; Walsh, P.N.
The interaction of factor XIa with activated platelets but not endothelial cells promotes the activation of factor IX in the consolidation phase of blood coagulation
J. Biol. Chem.
277
38462-38467
2002
Homo sapiens
Peek, M.; Moran, P.; Mendoza, N.; Wickramasinghe, D.; Kirchhofer, D.
Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa
J. Biol. Chem.
277
47804-47809
2002
Homo sapiens
Jin, L.; Pandey, P.; Babine, R.E.; Weaver, D.T.; Abdel-Meguid, S.S.; Strickler, J.E.
Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors
Acta Crystallogr. Sect. D
D61
1418-1425
2005
Homo sapiens
Pedicord, D.L.; Seiffert, D.; Blat, Y.
Substrate-dependent modulation of the mechanism of factor XIa inhibition
Biochemistry
43
11883-11888
2004
Homo sapiens
Sinha, D.; Badellino, K.O.; Marcinkiewicz, M.; Walsh, P.N.
Allosteric modification of factor XIa functional activity upon binding to polyanions
Biochemistry
43
7593-7600
2004
Homo sapiens
Sinha, D.; Marcinkiewicz, M.; Lear, J.D.; Walsh, P.N.
Factor XIa dimer in the activation of factor IX
Biochemistry
44
10416-10422
2005
Homo sapiens
Ogawa, T.; Verhamme, I.M.; Sun, M.F.; Bock, P.E.; Gailani, D.
Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX
J. Biol. Chem.
280
23523-23530
2005
Homo sapiens
Navaneetham, D.; Jin, L.; Pandey, P.; Strickler, J.E.; Babine, R.E.; Abdel-Meguid, S.S.; Walsh, P.N.
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2
J. Biol. Chem.
280
36165-36175
2005
Homo sapiens (P03951)
Jin, L.; Pandey, P.; Babine, R.E.; Gorga, J.C.; Seidl, K.J.; Gelfand, E.; Weaver, D.T.; Abdel-Meguid, S.S.; Strickler, J.E.
Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions
J. Biol. Chem.
280
4704-4712
2005
Homo sapiens
Shi, T.; Giannakopoulos, B.; Iverson, G.M.; Cockerill, K.A.; Linnik, M.D.; Krilis, S.A.
Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318
J. Biol. Chem.
280
907-912
2005
Homo sapiens
Rezaie, A.R.; Sun, M.F.; Gailani, D.
Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity
Biochemistry
45
9427-9433
2006
Homo sapiens (P03951)
Miller, T.N.; Sinha, D.; Baird, T.R.; Walsh, P.N.
A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets
Biochemistry
46
14450-14460
2007
Homo sapiens (P03951)
Sinha, D.; Marcinkiewicz, M.; Navaneetham, D.; Walsh, P.N.
Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation
Biochemistry
46
9830-9839
2007
Homo sapiens
Schmidt, A.E.; Sun, M.F.; Ogawa, T.; Bajaj, S.P.; Gailani, D.
Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa
Biochemistry
47
1326-1335
2008
Homo sapiens (P03951)
Lazarova, T.I.; Jin, L.; Rynkiewicz, M.; Gorga, J.C.; Bibbins, F.; Meyers, H.V.; Babine, R.; Strickler, J.
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
Bioorg. Med. Chem. Lett.
16
5022-5027
2006
Homo sapiens
Smith, S.B.; Verhamme, I.M.; Sun, M.F.; Bock, P.E.; Gailani, D.
Characterization of novel forms of coagulation factor XIa. Independence of factor XIa subunits in factor IX activation
J. Biol. Chem.
283
6696-6705
2008
Homo sapiens
Lin, J.; Deng, H.; Jin, L.; Pandey, P.; Quinn, J.; Cantin, S.; Rynkiewicz, M.J.; Gorga, J.C.; Bibbins, F.; Celatka, C.A.; Nagafuji, P.; Bannister, T.D.; Meyers, H.V.; Babine, R.E.; Hayward, N.J.; Weaver, D.; Benjamin, H.; Stassen, F.; Abdel-Meguid, S.S.; Strickler, J.E.
Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants
J. Med. Chem.
49
7781-7791
2006
Homo sapiens (P03951), Homo sapiens
Mitchell, M.J.; Dai, L.; Clarke, J.B.; Bolton-Maggs, P.H.; Savidge, G.F.; Alhaq, A.
Characterisation of five factor XI mutations
Thromb. Haemost.
97
884-889
2007
Homo sapiens
Yang, L.; Sun, M.F.; Gailani, D.; Rezaie, A.R.
Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor
Biochemistry
48
1517-1524
2009
Homo sapiens (P03951)
Kravtsov, D.V.; Matafonov, A.; Tucker, E.I.; Sun, M.F.; Walsh, P.N.; Gruber, A.; Gailani, D.
Factor XI contributes to thrombin generation in the absence of factor XII
Blood
114
452-458
2009
Homo sapiens (P03951)
Kwon, M.J.; Kim, H.J.; Bang, S.H.; Kim, S.H.
Severe factor XI deficiency in a Korean woman with a novel missense mutation (Val498Met) and duplication G mutation in exon 13 of the F11 gene
Blood Coagul. Fibrinolysis
19
679-683
2008
Homo sapiens (P03951), Homo sapiens
Wang, J.; Wang, X.; Dai, J.; Ding, Q.; Fu, Q.; Wang, H.; Shen, L.; Li, D.
A case of factor XI deficiency caused by compound heterozygous F11 gene mutation
Haemophilia
15
603-606
2009
Homo sapiens (P03951)
Buchanan, M.S.; Carroll, A.R.; Wessling, D.; Jobling, M.; Avery, V.M.; Davis, R.A.; Feng, Y.; Xue, Y.; Oster, L.; Fex, T.; Deinum, J.; Hooper, J.N.; Quinn, R.J.
Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa
J. Med. Chem.
51
3583-3587
2008
Homo sapiens (P03951)
Butenas, S.; Undas, A.; Gissel, M.T.; Szuldrzynski, K.; Zmudka, K.; Mann, K.G.
Factor XIa and tissue factor activity in patients with coronary artery disease
Thromb. Haemost.
99
142-149
2008
Homo sapiens
Singh, A.; Harnett, M.J.; Connors, J.M.; Camann, W.R.
Factor XI deficiency and obstetrical anesthesia
Anesth. Analg.
108
1882-1885
2009
Homo sapiens (P03951)
Franchini, M.; Manzato, F.; Salvagno, G.L.; Montagnana, M.; Lippi, G.
The use of desmopressin in congenital factor XI deficiency: a systematic review
Ann. Hematol.
88
931-935
2009
Homo sapiens (P03951), Homo sapiens
Schumacher, W.A.; Luettgen, J.M.; Quan, M.L.; Seiffert, D.A.
Inhibition of factor XIa as a new approach to anticoagulation
Arterioscler. Thromb. Vasc. Biol.
30
388-392
2010
Oryctolagus cuniculus, Mus musculus, Rattus norvegicus, Homo sapiens (P03951), Homo sapiens
Emsley, J.; McEwan, P.A.; Gailani, D.
Structure and function of factor XI
Blood
115
2569-2577
2010
Mus musculus, Homo sapiens (P03951)
Gailani, D.; Smith, S.B.
Structural and functional features of factor XI
J. Thromb. Haemost.
7 Suppl 1
75-78
2009
Homo sapiens (P03951)
Renne, T.; Oschatz, C.; Seifert, S.; Mueller, F.; Antovic, J.; Karlman, M.; Benz, P.M.
Factor XI deficiency in animal models
J. Thromb. Haemost.
7 Suppl 1
79-83
2009
Canis lupus familiaris, Felis catus, Mus musculus, Ornithorhynchus anatinus, Didelphis sp., Homo sapiens (P03951)
Maas, C.; Meijers, J.C.; Marquart, J.A.; Bakhtiari, K.; Weeterings, C.; de Groot, P.G.; Urbanus, R.T.
Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma
Proc. Natl. Acad. Sci. USA
107
9083-9087
2010
Homo sapiens (P03951)
Livnat, T.; Tamarin, I.; Mor, Y.; Winckler, H.; Horowitz, Z.; Korianski, Y.; Bar-Zakay, B.; Seligsohn, U.; Salomon, O.
Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies
Thromb. Haemost.
102
487-492
2009
Homo sapiens
Hanessian, S.; Larsson, A.; Fex, T.; Knecht, W.; Blomberg, N.
Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
Bioorg. Med. Chem. Lett.
20
6925-6928
2010
Homo sapiens
Luszczak, J.; Undas, A.; Gissel, M.; Olszowska, M.; Butenas, S.
Activated factor XI and tissue factor in aortic stenosis: links with thrombin generation
Blood Coagul. Fibrinolysis
22
473-479
2011
Homo sapiens
Navaneetham, D.; Sinha, D.; Walsh, P.N.
Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
J. Biochem.
148
467-479
2010
Homo sapiens (P03951)
Su, Y.C.; Miller, T.N.; Navaneetham, D.; Schoonmaker, R.T.; Sinha, D.; Walsh, P.N.
The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2
J. Biol. Chem.
286
31904-31914
2011
Homo sapiens
Itakura, A.; Verbout, N.G.; Phillips, K.G.; Insall, R.H.; Gailani, D.; Tucker, E.I.; Gruber, A.; McCarty, O.J.
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes
J. Leukoc. Biol.
90
923-927
2011
Homo sapiens
Whelihan, M.F.; Orfeo, T.; Gissel, M.T.; Mann, K.G.
Coagulation procofactor activation by factor XIa
J. Thromb. Haemost.
8
1532-1539
2010
Homo sapiens
Carrieri, C.; Galasso, R.; Semeraro, F.; Ammollo, C.; Semeraro, N.; Colucci, M.
The role of thrombin activatable fibrinolysis inhibitor and factor XI in platelet-mediated fibrinolysis resistance: A thromboelastographic study in whole blood
J. Thromb. Haemost.
9
154-162
2011
Homo sapiens
Fradera, X.; Kazemier, B.; Carswell, E.; Cooke, A.; Oubrie, A.; Hamilton, W.; Dempster, M.; Krapp, S.; Nagel, S.; Jestel, A.
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors
Acta Crystallogr. Sect. F
68
404-408
2012
Homo sapiens (P03951)
Pinto, D.J.; Smallheer, J.M.; Corte, J.R.; Austin, E.J.; Wang, C.; Fang, T.; Smith, L.M.; Rossi, K.A.; Rendina, A.R.; Bozarth, J.M.; Zhang, G.; Wei, A.; Ramamurthy, V.; Sheriff, S.; Myers, J.E.; Morin, P.E.; Luettgen, J.M.; Seiffert, D.A.; Quan, M.L.; Wexler, R.R.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
Bioorg. Med. Chem. Lett.
25
1635-1642
2015
Homo sapiens
Corte, J.; Fang, T.; Hangeland, J.; Friends, T.; Rendina, A.; Luettgen, J.; Bozarth, J.; Barbera, F.; Rossi, K.; Wei, A.; Ramamurthy, V.; Morin, P.; Seiffert, D.; Wexler, R.; Quan, M.
Pyridine and pyridinone-based factor XIa inhibitors
Bioorg. Med. Chem. Lett.
25
925-930
2015
Homo sapiens
Puy, C.; Tucker, E.I.; Matafonov, A.; Cheng, Q.; Zientek, K.D.; Gailani, D.; Gruber, A.; McCarty, O.J.
Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor
Blood
125
1488-1496
2015
Homo sapiens
Cho, J.; Kim, J.; Jung, S.; Kang, N.
Characterization of binding mode for human coagulation factor XI (FXI) inhibitors
Bull. Korean Chem. Soc.
34
1212-1220
2013
Homo sapiens
-
Ataullakhanov, F.; Dashkevich, N.; Negrier, C.; Panteleev, M.
Factor XI and traveling waves: The key to understanding coagulation in hemophilia?
Expert Rev. Hematol.
6
111-113
2013
Homo sapiens
Argade, M.D.; Mehta, A.Y.; Sarkar, A.; Desai, U.R.
Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors
J. Med. Chem.
57
3559-3569
2014
Homo sapiens
Hangeland, J.J.; Friends, T.J.; Rossi, K.A.; Smallheer, J.M.; Wang, C.; Sun, Z.; Corte, J.R.; Fang, T.; Wong, P.C.; Rendina, A.R.; Barbera, F.A.; Bozarth, J.M.; Luettgen, J.M.; Watson, C.A.; Zhang, G.; Wei, A.; Ramamurthy, V.; Morin, P.E.; Bisacchi, G.S.; Subramaniam, S.; Arunachalam, P.; Mathur, A.; Seiffert, D.
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity
J. Med. Chem.
57
9915-9932
2014
Homo sapiens (P03951)
Faid, V.; Denguir, N.; Chapuis, V.; Bihoreau, N.; Chevreux, G.
Site-specific N-glycosylation analysis of human factor XI: Identification of a noncanonical NXC glycosite
Proteomics
14
2460-2470
2014
Homo sapiens
Gailani, D.; Geng, Y.; Verhamme, I.; Sun, M.; Bajaj, S.; Messer, A.; Emsley, J.
The mechanism underlying activation of factor IX by factor XIa
Thromb. Res.
133
S48-S51
2014
Homo sapiens
-
Leiderman, K.; Chang, W.C.; Ovanesov, M.; Fogelson, A.L.
Synergy between tissue factor and exogenous factor XIa in initiating coagulation
Arterioscler. Thromb. Vasc. Biol.
36
2334-2345
2016
Homo sapiens
Lu, Q.; Yang, L.; Manithody, C.; Wang, X.; Rezaie, A.R.
Expression and characterization of Gly-317 variants of factor IX causing variable bleeding in hemophilia B patients
Biochemistry
54
3814-3821
2015
Homo sapiens
Wang, C.; Corte, J.R.; Rossi, K.A.; Bozarth, J.M.; Wu, Y.; Sheriff, S.; Myers, J.E.; Luettgen, J.M.; Seiffert, D.A.; Wexler, R.R.; Quan, M.L.
Macrocyclic factor XIa inhibitors
Bioorg. Med. Chem. Lett.
27
4056-4060
2017
Homo sapiens
Meijers, J.
Prochemerin processing by factor XIa
Blood
131
275-276
2018
Homo sapiens
Ge, X.; Yamaguchi, Y.; Zhao, L.; Bury, L.; Gresele, P.; Berube, C.; Leung, L.L.; Morser, J.
Prochemerin cleavage by factor XIa links coagulation and inflammation
Blood
131
353-364
2018
Homo sapiens
Waters, E.K.; Hilden, I.; Sorensen, B.B.; Ezban, M.; Holm, P.K.
Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive
J. Thromb. Haemost.
13
2041-2052
2015
Homo sapiens
Zucker, M.; Seligsohn, U.; Yeheskel, A.; Mor-Cohen, R.
An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase
J. Thromb. Haemost.
14
2202-2211
2016
Homo sapiens
