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Information on EC 3.4.21.21 - coagulation factor VIIa and Organism(s) Bos taurus

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.21 coagulation factor VIIa
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Bos taurus
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa
Synonyms
factor vii, rfviia, fvii, fviia, factor viia, activated factor vii, recombinant factor viia, coagulation factor vii, fviic, novoseven, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
activated blood coagulation factor VII
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-
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blood-coagulation factor VII, activated
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-
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blood-coagulation factor VIIa
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-
-
-
Eptacog alfa
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-
-
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Serum prothrombin conversion accelerator
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
65312-43-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
benzyloxycarbonyl-Arg-p-nitrobenzyl ester + H2O
benzyloxycarbonyl-Arg + 4-nitrophenyl
show the reaction diagram
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-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
benzamidine HCl
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-
diisopropylfluorophosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19
benzyloxycarbonyl-Arg-p-nitrobenzyl ester
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-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8
benzyloxycarbonyl-Arg-p-nitrobenzyl ester
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FA7_BOVIN
447
1
48961
Swiss-Prot
Secretory Pathway (Reliability: 1)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
factor VII
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zur, M.; Nemersom, Y.
The esterase activity of coagulation factor VII. Evidence for intrinsic activity of the zymogen
J. Biol. Chem.
253
2203-2209
1978
Bos taurus
Manually annotated by BRENDA team
Radcliffe, R.; Nemerson, Y.
Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII
J. Biol. Chem.
250
388-395
1975
Bos taurus
Manually annotated by BRENDA team
Kisiel, W.; Davie, E.W.
Isolation and characterization of bovine factor VII
Biochemistry
14
4928-4934
1975
Bos taurus
Manually annotated by BRENDA team