Reference on EC 3.4.21.112 - site-1 protease and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Basak, A.; Chretien, M.; Seidah, N.G.
A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus
FEBS Lett.
514
333-339
2002
Homo sapiens
Toure, B.B.; Munzer, J.S.; Basak, A.; Benjannet, S.; Rochemont, J.; Lazure, C.; Chretien, M.; Seidah, N.G.
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment
J. Biol. Chem.
275
2349-2358
2000
Homo sapiens
Vincent, M.J.; Sanchez, A.J.; Erickson, B.R.; Basak, A.; Chretien, M.; Seidah, N.G.; Nichol, S.T.
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1
J. Virol.
77
8640-8649
2003
Homo sapiens
Seidah, N.G.; Mowla, S.J.; Hamelin, J.; Mamarbachi, A.M.; Benjannet, S.; Toure, B.B.; Basak, A.; Munzer, J.S.; Marcinkiewicz, J.; Zhong, M.; Barale, J.C.; Lazure, C.; Murphy, R.A.; Chretien, M.; Marcinkiewicz, M.
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
Proc. Natl. Acad. Sci. USA
96
1321-1326
1999
Homo sapiens, Rattus norvegicus (Q9WTZ3)
Basak, S.; Stewart, N.A.; Chretien, M.; Basak, A.
Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1
FEBS Lett.
573
186-194
2004
Homo sapiens
Shen, J.; Prywes, R.
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
J. Biol. Chem.
279
43046-43051
2004
Homo sapiens
Seidah, N.G.; Chretien, M.
Proprotein convertase SKI-1/SIP
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1845-1847
2004
Arabidopsis thaliana, Cricetulus griseus, Homo sapiens, Mus musculus, Oryza sativa, Rattus norvegicus
-
Sanchez, A.J.; Vincent, M.J.; Erickson, B.R.; Nichol, S.T.
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein
J. Virol.
80
514-525
2006
Homo sapiens
Stirling, J.; OHare, P.
CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P
Mol. Biol. Cell
17
413-426
2005
Homo sapiens
Lenz, O.; Ter Meulen, J.; Klenk, H.D.; Seidah, N.G.; Garten, W.
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
Proc. Natl. Acad. Sci. USA
98
12701-12702
2001
Homo sapiens
Hay, B.A.; Abrams, B.; Zumbrunn, A.Y.; Valentine, J.J.; Warren, L.C.; Petras, S.F.; Shelly, L.D.; Xia, A.; Varghese, A.H.; Hawkins, J.L.; Van Camp, J.A.; Robbins, M.D.; Landschulz, K.; Harwood, H.J.
Aminopyrrolidineamide inhibitors of site-1 protease
Bioorg. Med. Chem. Lett.
17
4411-4414
2007
Homo sapiens
De Windt, A.; Rai, M.; Bernier, L.; Thelen, K.; Soini, J.; Lefebvre, C.; Chintawar, S.; Lavigne, J.; Saarinen, L.; Kytoemaeki, L.; Munzer, J.S.; Luetjohann, D.; Pandolfo, M.; Davignon, J.; Seidah, N.G.; Laaksonen, R.
Gene Set Enrichment Analysis Reveals Several Globally Affected Pathways due to SKI-1/S1P Inhibition in HepG2 Cells
DNA Cell Biol.
26
765-772
2007
Homo sapiens
Pullikotil, P.; Benjannet, S.; Mayne, J.; Seidah, N.G.
The proprotein convertase SKI-1/S1P: Alternate translation and subcellular localization
J. Biol. Chem.
282
27402-27413
2007
Homo sapiens
Bergeron, E.; Vincent, M.J.; Nichol, S.T.
Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity
J. Virol.
81
13271-13276
2007
Homo sapiens
Bodvard, K.; Mohlin, J.; Knecht, W.
Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease
Protein Expr. Purif.
51
308-319
2007
Homo sapiens
Hawkins, J.L.; Robbins, M.D.; Warren, L.C.; Xia, D.; Petras, S.F.; Valentine, J.J.; Varghese, A.H.; Wang, I.K.; Subashi, T.A.; Shelly, L.D.; Hay, B.A.; Landschulz, K.T.; Geoghegan, K.F.; Harwood, H.J.
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals
J. Pharmacol. Exp. Ther.
326
801-808
2008
Homo sapiens (Q14703), Homo sapiens
Rojek, J.M.; Lee, A.M.; Nguyen, N.; Spiropoulou, C.F.; Kunz, S.
Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito
J. Virol.
82
6045-6051
2008
Homo sapiens
Basak, A.; Mitra, D.; Das, A.K.; Mohottalage, D.; Basak, A.
C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1
Bioorg. Med. Chem. Lett.
20
3977-3981
2010
Homo sapiens
Zandberg, W.F.; Benjannet, S.; Hamelin, J.; Pinto, B.M.; Seidah, N.G.
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1
Glycobiology
21
1290-1300
2011
Homo sapiens
Urata, S.; Yun, N.; Pasquato, A.; Paessler, S.; Kunz, S.; de la Torre, J.C.
Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease
J. Virol.
85
795-803
2011
Homo sapiens
Da Palma, J.; Burri, D.; Oppliger, J.; Salamina, M.; Cendron, L.; De Laureto, P.; Seidah, N.; Kunz, S.; Pasquato, A.
Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease
J. Biol. Chem.
289
35743-35756
2014
Homo sapiens (Q14703)
Weiss, N.; Stegemann, A.; Elsayed, M.A.; Schallreuter, K.U.; Luger, T.A.; Loser, K.; Metze, D.; Weishaupt, C.; Boehm, M.
Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
J. Invest. Dermatol.
134
168-175
2014
Homo sapiens (Q14703), Homo sapiens
Burri, D.; Pasqual, G.; Rochat, C.; Seidah, N.; Pasquato, A.; Kunz, S.
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease
J. Virol.
86
4935-4946
2012
Homo sapiens (Q14703)
Burri, D.; da Palma, J.; Seidah, N.; Zanotti, G.; Cendron, L.; Pasquato, A.; Kunz, S.
Differential recognition of old world and new world arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P)
J. Virol.
87
6406-6414
2013
Homo sapiens (Q14703), Homo sapiens
Kluender, S.; Heeren, J.; Markmann, S.; Santer, R.; Braulke, T.; Pohl, S.
Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control
J. Lipid Res.
56
1625-1632
2015
Homo sapiens, Mus musculus
Schweitzer, G.; Gan, C.; Bucelli, R.; Wegner, D.; Schmidt, R.; Shinawi, M.; Finck, B.; Brookheart, R.
A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema
Mol. Genet. Genomic Med.
2019
e733
2019
Homo sapiens
Hyrina, A.; Meng, F.; McArthur, S.J.; Eivemark, S.; Nabi, I.R.; Jean, F.
Human subtilisin kexin isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance A potential target for indirect-acting anti-dengue virus agents
PLoS ONE
12
e0174483
2017
Homo sapiens
