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Information on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Drosophila melanogaster
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3.1.3.16 protein-serine/threonine phosphataseIUBMB Comments
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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Word Map
- 3.1.3.16
-
cyclosporine
- phosphatases
- tacrolimus
-
rejection
-
okadaic
- mycophenolate
-
allograft
- cardiac
- steroid
-
corticosteroid
- mofetil
- rapamycin
-
nephrotoxicity
- nfat
- sirolimus
- agonist
- t-cells
- creatinine
- hypertrophy
- mapks
- glycogen
- synaptic
- mtor
-
glomerular
- pkc
- platelet
-
ca2+-dependent
- hypertension
- episode
- erk
-
atopic
- cardiomyocytes
- nephropathy
-
everolimus
- dermatitis
- myocytes
-
trough
-
hyperphosphorylation
- azathioprine
-
posttransplant
-
prophylaxis
-
allogeneic
- proteinuria
- camkii
-
post-transplantation
- graft-versus-host
- rituximab
- cyclophilins
-
biopsy-proven
- prednisone
- diagnostics
- analysis
- drug development
- medicine
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
calcineurin, protein phosphatase, pac-1, dusp1, dusp6, serine/threonine phosphatase, pp2ac, ppm1d, phosphoprotein phosphatase, laforin, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
-
-
-
-
Aspergillus awamori acid protein phosphatase
-
-
-
-
BCKDH phosphatase
-
-
-
-
branched-chain alpha-keto acid dehydrogenase phosphatase
-
-
-
-
calcineurin
-
-
-
-
Calcineurin A1
-
-
-
-
Calcineurin A2
-
-
-
-
CaM-kinase phosphatase
-
-
-
-
CaMKPase
-
-
-
-
casein phosphatase
-
-
-
-
DRES10
-
-
-
-
Fibroblast growth factor inducible protein 13
-
-
-
-
FIN13
-
-
-
-
Flap wing protein
-
-
-
-
HMG-CoA reductase phosphatase
-
-
-
-
Magnesium-dependent calcium inhibitable phosphatase
-
-
-
-
MCPP
-
-
-
-
Microtubule star protein
-
-
-
-
phosphatase 2A
-
-
-
-
phosphatase 2B
-
-
-
-
phosphatase C-II
-
-
-
-
Phosphatase esp1
-
-
-
-
phosphatase H-II
-
-
-
-
phosphatase I
-
-
-
-
phosphatase IB
-
-
-
-
phosphatase II
-
-
-
-
phosphatase III
-
-
-
-
phosphatase IV
-
-
-
-
phosphatase SP
-
-
-
-
phosphoglycerate mutase 5
-
PGAM5 lacks PGAM activity and instead associates with signal-regulating kinase 1 and acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1, PGAM5 is a protein Ser/Thr phosphatase unrelated to the other known families of Ser/Thr phosphatases
phosphoprotein phosphatase
-
-
-
-
phosphopyruvate dehydrogenase phosphatase
-
-
-
-
phosphospectrin phosphatase
-
-
-
-
PK-Pase
-
-
-
-
polycation modulated (PCM-) phosphatase
-
-
-
-
PP-1A
-
-
-
-
PP-1B
-
-
-
-
PP-1G
-
-
-
-
PP2A-alpha
-
-
-
-
PP2A-beta
-
-
-
-
PP2C
-
-
-
-
PP2C-alpha
-
-
-
-
PP2C-beta
-
-
-
-
PP2C-delta
-
-
-
-
PP2C-gamma
-
-
-
-
Pp4
PP5
PP6
-
-
-
-
PPEF
-
-
-
-
PPN
-
-
-
-
PPT
-
-
-
-
protein D phosphatase
-
-
-
-
protein phosphatase
-
-
-
-
Protein phosphatase 1A
-
-
-
-
Protein phosphatase 1B
-
-
-
-
Protein phosphatase 1C
-
-
-
-
Protein phosphatase magnesium-dependent 1 delta
-
-
-
-
Protein phosphatase magnesium-dependent 1 gamma
-
-
-
-
Protein phosphatase with EF calcium-binding domain
-
-
-
-
PSPase
-
-
-
-
Retinal degeneration C protein
-
-
-
-
Suppressor protein SDS21
-
-
-
-
additional information
-
the enzyme belongs to the phosphoprotein phosphatase family
Pp4
-
-
-
-
PP5
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY
9025-75-6
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
very low activity
-
-
?
phosphophosphorylase kinase + H2O
phosphorylase kinase + phosphate
-
specific for alpha-subunit
-
-
?
phosphorylated apoptosis signal-regulating kinase 1 + H2O
apoptosis signal-regulating kinase 1 + phosphate
-
PGAM5 acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1 by dephosphorylation of inhibitory sites (phosphorylation of Thr-838), PGAM5 serves as a specialized activator of apoptosis signal-regulating kinase 1
-
-
?
phosphorylated INAD-protein + H2O
INAD-protein + phosphate
-
INAD-protein is inactivation no afterpotential D-protein
-
-
?
phosphorylated phosphorylase alpha + H2O
phosphorylase alpha + phosphate
-
-
-
-
?
phosphorylated p53 + H2O
p53 + phosphate
-
the B56-containing PP2A acts partly through p53 suppressing apoptosis
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, circadian rhythm and cancer, overview, knockout of the PP2A regulator alpha4 causes p53-regulated apoptosis correlated with increased phosphorylation of p53 and JNK, PP2A is involved in regulation of PERIOD degradation and de/phosphorylation important in cricadian rhythm, overview
-
-
?
additional information
?
-
-
the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe
-
-
?
additional information
?
-
-
GST-tagged PGAM5 does not dephosphorylate phospho-Tyr peptides (like END-pYINASL or DADEpYLIPQQG)
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphorylated p53 + H2O
p53 + phosphate
-
the B56-containing PP2A acts partly through p53 suppressing apoptosis
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of diverse cellular processes and signaling pathways including embryonic development, cell proliferation, cell death, circadian rhythm and cancer, overview, knockout of the PP2A regulator alpha4 causes p53-regulated apoptosis correlated with increased phosphorylation of p53 and JNK, PP2A is involved in regulation of PERIOD degradation and de/phosphorylation important in cricadian rhythm, overview
-
-
?
additional information
?
-
-
the holoenzyme plays a role in organelle assembly and is essential for maturation of the centrosome, phylogenetic tree and PPP phosphome, overviewe
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Drosophila melanogaster protein phosphatase inhibitor-2
-
IC50: 0.5-1 nM
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0000005 - 0.000001
Drosophila melanogaster protein phosphatase inhibitor-2
Drosophila melanogaster
-
IC50: 0.5-1 nM
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
-
PGAM5 is an evolutionarily conserved activator of apoptosis signal-regulating kinase 1
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). HZG_DROME
352
0
40326
Swiss-Prot
other Location (Reliability: 1)
PP2B2_DROME
570
0
63101
Swiss-Prot
Mitochondrion (Reliability: 4)
PP2B3_DROME
584
0
64285
Swiss-Prot
Mitochondrion (Reliability: 5)
PPY_DROME
314
0
35980
Swiss-Prot
other Location (Reliability: 1)
PP11_DROME
327
0
37370
Swiss-Prot
other Location (Reliability: 3)
PP2A_DROME
309
0
35469
Swiss-Prot
other Location (Reliability: 1)
PP2B1_DROME
622
0
69133
Swiss-Prot
Mitochondrion (Reliability: 4)
PP1B_DROME
330
0
37740
Swiss-Prot
other Location (Reliability: 3)
PHLPP_DROME
954
0
107092
Swiss-Prot
other Location (Reliability: 3)
PTC71_DROME
314
0
34838
Swiss-Prot
Mitochondrion (Reliability: 2)
PTPM1_DROME
200
0
23156
Swiss-Prot
other Location (Reliability: 5)
PP4C_DROME
307
0
35341
Swiss-Prot
other Location (Reliability: 1)
DUSK3_DROME
411
0
45792
Swiss-Prot
other Location (Reliability: 2)
DUSK4_DROME
387
0
43742
Swiss-Prot
other Location (Reliability: 4)
PP12_DROME
302
0
34542
Swiss-Prot
other Location (Reliability: 2)
RDGC_DROME
661
0
75511
Swiss-Prot
other Location (Reliability: 5)
Y0417_DROME
662
0
72370
Swiss-Prot
other Location (Reliability: 1)
PGAM5_DROME
289
0
33166
Swiss-Prot
Mitochondrion (Reliability: 4)
SSH_DROME
1045
0
114997
Swiss-Prot
other Location (Reliability: 2)
CNEP1_DROME
243
0
28486
Swiss-Prot
Secretory Pathway (Reliability: 1)
PP13_DROME
302
0
34558
Swiss-Prot
other Location (Reliability: 2)
PPP6_DROME
303
0
34759
Swiss-Prot
other Location (Reliability: 1)
RPAP2_DROME
143
0
16330
Swiss-Prot
other Location (Reliability: 3)
Q9VZS1_DROME
371
0
41009
TrEMBL
other Location (Reliability: 1)
B4F4X2_DROME
302
0
34558
TrEMBL
other Location (Reliability: 2)
M9PJJ5_DROME
315
0
34613
TrEMBL
other Location (Reliability: 2)
X2JG90_DROME
307
0
35341
TrEMBL
other Location (Reliability: 1)
Q9XZ16_DROME
320
0
37320
TrEMBL
other Location (Reliability: 2)
D3PFH9_DROME
1045
0
114997
TrEMBL
other Location (Reliability: 2)
M9NFW6_DROME
170
0
19341
TrEMBL
other Location (Reliability: 1)
A0A0B4LFR7_DROME
314
0
35980
TrEMBL
other Location (Reliability: 1)
E1JIW2_DROME
1046
0
115370
TrEMBL
other Location (Reliability: 5)
Q8SXF8_DROME
206
0
23329
TrEMBL
Mitochondrion (Reliability: 4)
C0MKX3_DROME
302
0
34559
TrEMBL
other Location (Reliability: 2)
Q8SY34_DROME
741
0
80610
TrEMBL
other Location (Reliability: 2)
A0A0B4K7Q3_DROME
332
0
36941
TrEMBL
other Location (Reliability: 1)
A0A0B4K833_DROME
170
0
19267
TrEMBL
other Location (Reliability: 1)
X2JEB8_DROME
235
0
26832
TrEMBL
other Location (Reliability: 5)
M9NEL1_DROME
584
0
64285
TrEMBL
Mitochondrion (Reliability: 5)
M9PFW0_DROME
411
0
45792
TrEMBL
other Location (Reliability: 2)
O77294_DROME
324
0
37107
TrEMBL
other Location (Reliability: 3)
Q8T0U6_DROME
461
0
51311
TrEMBL
other Location (Reliability: 2)
Q9W4H8_DROME
1427
0
153906
TrEMBL
other Location (Reliability: 5)
A8JUQ2_DROME
226
0
25702
TrEMBL
other Location (Reliability: 5)
Q8MQY2_DROME
896
0
99331
TrEMBL
other Location (Reliability: 2)
M9PCH3_DROME
471
0
51851
TrEMBL
Mitochondrion (Reliability: 2)
Q9XZ28_DROME
524
2
58011
TrEMBL
other Location (Reliability: 2)
Q9V3L4_DROME
509
0
58432
TrEMBL
other Location (Reliability: 4)
X2JDI1_DROME
309
0
35469
TrEMBL
other Location (Reliability: 1)
Q5LJN2_DROME
313
0
35854
TrEMBL
other Location (Reliability: 2)
Q86NN3_DROME
339
0
38782
TrEMBL
other Location (Reliability: 4)
Q9VAK1_DROME
368
0
40955
TrEMBL
other Location (Reliability: 1)
Q7KMQ6_DROME
514
0
58953
TrEMBL
other Location (Reliability: 4)
Q9W0Q0_DROME
352
0
38530
TrEMBL
other Location (Reliability: 1)
M9NE01_DROME
570
0
63101
TrEMBL
Mitochondrion (Reliability: 4)
A0A0B4LHX7_DROME
369
0
39487
TrEMBL
Mitochondrion (Reliability: 4)
X2JCV6_DROME
240
0
28098
TrEMBL
Secretory Pathway (Reliability: 1)
Q9W173_DROME
280
1
31395
TrEMBL
Secretory Pathway (Reliability: 5)
C6SUY6_DROME
342
0
38525
TrEMBL
other Location (Reliability: 2)
Q9VQL9_DROME
336
0
38322
TrEMBL
other Location (Reliability: 2)
Q8SWU9_DROME
330
0
37773
TrEMBL
other Location (Reliability: 3)
D8FT19_DROME
469
0
51681
TrEMBL
Mitochondrion (Reliability: 2)
H5V895_DROME
330
0
37740
TrEMBL
other Location (Reliability: 3)
Q9Y0B6_DROME
418
0
48067
TrEMBL
other Location (Reliability: 4)
Q9VZS0_DROME
253
1
29432
TrEMBL
Secretory Pathway (Reliability: 1)
Q95TV5_DROME
317
0
35705
TrEMBL
other Location (Reliability: 2)
Q9W3Q1_DROME
475
0
53551
TrEMBL
other Location (Reliability: 5)
Q5K375_DROME
309
0
35394
TrEMBL
other Location (Reliability: 2)
Q9VR62_DROME
651
0
72887
TrEMBL
other Location (Reliability: 3)
Q95V52_DROME
306
0
35317
TrEMBL
other Location (Reliability: 2)
M9PHZ3_DROME
194
0
22572
TrEMBL
other Location (Reliability: 4)
A8QI94_DROME
317
0
36784
TrEMBL
other Location (Reliability: 4)
A1A6V5_DROME
142
0
16202
TrEMBL
other Location (Reliability: 3)
A0A0B4K6V6_DROME
622
0
69133
TrEMBL
Mitochondrion (Reliability: 4)
Q8IMK7_DROME
371
0
41387
TrEMBL
other Location (Reliability: 1)
A0A1B2AL60_DROME
143
0
16330
TrEMBL
other Location (Reliability: 3)
Q9W2A5_DROME
346
0
39045
TrEMBL
other Location (Reliability: 4)
X2JEK6_DROME
182
0
21423
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0B4KHS9_DROME
327
0
37370
TrEMBL
other Location (Reliability: 3)
Q9NGL1_DROME
203
0
22848
TrEMBL
Mitochondrion (Reliability: 3)
E2QC56_DROME
662
0
72370
TrEMBL
other Location (Reliability: 1)
M9PGI3_DROME
303
0
34759
TrEMBL
other Location (Reliability: 1)
Q6NNT3_DROME
337
0
38409
TrEMBL
other Location (Reliability: 2)
M9PFV2_DROME
635
0
68544
TrEMBL
other Location (Reliability: 2)
Q961C5_DROME
374
0
41629
TrEMBL
other Location (Reliability: 1)
Q9W3R1_DROME
374
0
41367
TrEMBL
other Location (Reliability: 1)
A0A0B4LHI3_DROME
292
0
31424
TrEMBL
other Location (Reliability: 1)
Q9VHV8_DROME
476
0
51271
TrEMBL
other Location (Reliability: 3)
Q9VWN2_DROME
206
0
23299
TrEMBL
Mitochondrion (Reliability: 4)
Q9W147_DROME
880
0
97358
TrEMBL
other Location (Reliability: 1)
Q9VH81_DROME
520
0
59264
TrEMBL
other Location (Reliability: 1)
Q9VWE4_DROME
195
0
22733
TrEMBL
other Location (Reliability: 4)
Q9W272_DROME
308
0
33669
TrEMBL
other Location (Reliability: 3)
Q95V51_DROME
309
0
35297
TrEMBL
other Location (Reliability: 2)
M9NDG3_DROME
236
0
27476
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4D6K293_DROME
339
0
38817
TrEMBL
other Location (Reliability: 3)
X2JC94_DROME
288
0
33038
TrEMBL
Mitochondrion (Reliability: 4)
Q9W0E2_DROME
321
0
34449
TrEMBL
Mitochondrion (Reliability: 2)
Q7KVM5_DROME
324
0
37093
TrEMBL
other Location (Reliability: 3)
Q8SXA5_DROME
324
0
37079
TrEMBL
other Location (Reliability: 3)
A0A0B4K6N5_DROME
596
0
66304
TrEMBL
Mitochondrion (Reliability: 4)
A0A4D6K426_DROME
677
0
77210
TrEMBL
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
several catalytic subunit and regulatory subunit forms, properties and interactions, overview
additional information
-
the enzymes are monomers or heterodimers, the different serine/threonine protein phosphatases are formed by different catalytic subunits forming the different isozymes
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
knockout of PP2A subunits using dsDNA, and of the two B56 genes leaving A(B56)C and A(PR72)C heterotrimers intact activates caspases and cause apoptosis
additional information
-
PP4 gene disruption by P element mutagenesis leads to a centrosomes-minus-microtubule-homozygous strain which has semi-lethal phenotype with early embryos exhibiting a decreased amount of PPP4c catalytic subunit mRNA and about 25% reduced wild-type PP4 protein
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation, phenyl Sepharose column chromatography, and Q Sepharose column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Orgad, S.; Dudai, Y.; Cohen, P.
The protein phosphatases of Drosophila melanogaster and their inhibitors
Eur. J. Biochem.
164
31-38
1987
Drosophila melanogaster
Szoor, B.; Gross, S.; Alphey, L.
Biochemical characterization of recombinant Drosophila type 1 serine/threonine protein phosphatase (PP1c) produced in Pichia pastoris
Arch. Biochem. Biophys.
396
213-218
2001
Drosophila melanogaster
Chinkers, M.
PP5: the TPR phosphatase
Topics in Current Genetics (Arino, J. , Alexander, D. R. Eds. ) Springer
5
107-130
2004
Drosophila melanogaster, Neurospora crassa, Plasmodium falciparum, Rattus norvegicus, Trypanosoma brucei
-
Gallego, M.; Virshup, D.M.
Protein serine/threonine phosphatases: life, death, and sleeping
Curr. Opin. Cell Biol.
17
197-202
2005
Drosophila melanogaster, Lingulodinium polyedra, Homo sapiens, Mus musculus, Neurospora crassa
Cohen, P.T.; Philp, A.; Vazquez-Martin, C.
Protein phosphatase 4 - from obscurity to vital functions
FEBS Lett.
579
3278-3286
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
Vereshchagina, N.; Ramel, M.C.; Bitoun, E.; Wilson, C.
The protein phosphatase PP2A-B subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
J. Cell Sci.
121
3383-3392
2008
Drosophila melanogaster
Wang, N.; Leung, H.T.; Pak, W.L.; Carl, Y.T.; Wadzinski, B.E.; Shieh, B.H.
Role of protein phosphatase 2A in regulating the visual signaling in Drosophila
J. Neurosci.
28
1444-1451
2008
Drosophila melanogaster, Homo sapiens
Takeda, K.; Komuro, Y.; Hayakawa, T.; Oguchi, H.; Ishida, Y.; Murakami, S.; Noguchi, T.; Kinoshita, H.; Sekine, Y.; Iemura, S.; Natsume, T.; Ichijo, H.
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
Proc. Natl. Acad. Sci. USA
106
12301-12305
2009
Caenorhabditis elegans, Drosophila melanogaster
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