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Information on EC 3.1.3.1 - alkaline phosphatase and Organism(s) Sus scrofa
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EC Tree
3.1.3.1 alkaline phosphataseIUBMB Comments
Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase)
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Word Map
- 3.1.3.1
- osteoblast
- osteocalcin
-
osteogenic
- collagen
- aminotransferase
- bilirubin
- women
- mesenchymal
- albumin
- pancreatitis
- marrow
- parathyroid
- phosphorus
- urinary
- cholesterol
- osteoporosis
- creatinine
- resorption
- arterial
- fracture
- children
-
alt
- necrosis
- pain
- femoral
- spine
- transaminase
-
osteogenesis
-
lumbar
- biliary
-
morphogenetic
- osteopontin
- anterior
- bile
- femur
- periodontal
-
radiological
-
gamma-glutamyl
- calcification
- dental
-
postoperative
-
biocompatibility
- gg
-
preoperative
- transpeptidase
- ligament
-
admission
-
postmenopausal
- trabecular
-
hepatoprotective
- biotechnology
- agriculture
- medicine
- food industry
- environmental protection
- analysis
- molecular biology
- diagnostics
- synthesis
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
ap, alkaline phosphatase, bone alkaline phosphatase, placental alkaline phosphatase, alpase, apase, intestinal alkaline phosphatase, tnsalp, phosphomonoesterase, secreted alkaline phosphatase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alkaline phenyl phosphatase
-
-
-
-
alkaline phosphohydrolase
-
-
-
-
alkaline phosphomonoesterase
-
-
-
-
ALP
-
-
-
-
AP-TNAP
-
-
-
-
APase
-
-
-
-
APASED
-
-
-
-
BC6
-
-
-
-
EAP
-
-
-
-
Germ-cell alkaline phosphatase
-
-
-
-
glycerophosphatase
-
-
-
-
H-AP
-
-
-
-
High molecular weight phosphatase
-
-
-
-
IAP
-
-
-
-
L-AP
-
-
-
-
Liver/bone/kidney isozyme
-
-
-
-
Low molecular weight phosphatase
-
-
-
-
M-ALP
-
-
-
-
Nagao isozyme
-
-
-
-
non-specific alkaline phosphatase
-
-
-
-
phosphatase, alkaline
-
-
-
-
phosphomonoesterase
-
-
-
-
PLAP-like
-
-
-
-
RAN1
-
-
-
-
Regan isozyme
-
-
-
-
TNSALP
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphate-monoester phosphohydrolase (alkaline optimum)
Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase)
CAS REGISTRY NUMBER
COMMENTARY
9001-78-9
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-(2-nitrophenyl)-1-benzothiophene-3-carbaldehyde
-
with 0.4 mM 78% remaining activity
2-(3-formyl-1-benzothiophen-2-yl)benzonitrile
-
with 0.4 mM 79% remaining activity
2-(3-methoxy-1-benzothiophen-2-yl)benzonitrile
-
with 0.4 mM 79% remaining activity
2-(pyridin-3-yl)-1-benzothiophene-3-carbaldehyde
-
with 0.4 mM 79% remaining activity
2-[3-(4-chlorophenoxy)-1-benzothiophen-2-yl]benzonitrile
-
with 0.4 mM 79% remaining activity
4-[(1-oxido-1-benzothiophen-3-yl)oxy]benzonitrile
-
with 0.4 mM 67% remaining activity
6-(1-benzothiophen-3-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
-
with 0.4 mM 19% remaining activity
6-(1-benzothiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole
-
with 0.4 mM 11% remaining activity
methyl 3-(1-benzothiophen-3-yl)-N-benzoylalaninate
-
with 0.4 mM 74% remaining activity
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.192 - 0.408
6-(thiophen-3-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
0.8
3-(thiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C, value higher than 0.8 mM
0.8
3-(thiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C, value higher than 0.8 mM
0.8
6-(thiophen-2-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C, value higher than 0.8 mM
0.8
6-(thiophen-2-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C, value higher than 0.8 mM
0.26
6-(thiophen-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C
0.331
6-(thiophen-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C
0.192
6-(thiophen-3-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C
0.408
6-(thiophen-3-yl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C
0.8
6-(thiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C, value higher than 0.8 mM
0.8
6-(thiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C, value higher than 0.8 mM
0.042
6-(thiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C
0.084
6-(thiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C
0.8
6-(thiophen-3-yl)imidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 10.4, 37°C, value higher than 0.8 mM
0.8
6-(thiophen-3-yl)imidazo[2,1-b][1,3]thiazole hydrochloride
Sus scrofa
-
pH 7.8, 37°C, value higher than 0.8 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A480UBK2_PIG
573
0
63271
TrEMBL
other Location (Reliability: 2)
A0A5G2QFR6_PIG
469
0
50597
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1RMZ4_PIG
469
0
51152
TrEMBL
Secretory Pathway (Reliability: 1)
Q8HYZ5_PIG
252
0
27223
TrEMBL
other Location (Reliability: 2)
A0A8D1VS84_PIG
533
0
57601
TrEMBL
Secretory Pathway (Reliability: 1)
A0A480LVI6_PIG
600
0
66013
TrEMBL
other Location (Reliability: 2)
A0A8D1DXS5_PIG
563
0
60336
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1SQB4_PIG
459
0
50097
TrEMBL
Secretory Pathway (Reliability: 1)
A0A480K8S1_PIG
535
0
58831
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D2CE12_PIG
533
0
57702
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0WVP3_PIG
534
1
57858
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1KYM4_PIG
534
1
57681
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MIA2_PIG
563
0
60497
TrEMBL
Secretory Pathway (Reliability: 1)
A0A286ZUK3_PIG
500
0
54354
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MMW8_PIG
470
0
51387
TrEMBL
Secretory Pathway (Reliability: 1)
A0A480PVF7_PIG
405
0
44527
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D2BM92_PIG
439
0
47595
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D2CE50_PIG
520
0
56067
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0NGK2_PIG
368
0
40418
TrEMBL
other Location (Reliability: 3)
A0A8D1BS27_PIG
470
1
50784
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ZQV9_PIG
530
1
57875
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1TEN8_PIG
534
0
58144
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1AYP0_PIG
656
1
69745
TrEMBL
Mitochondrion (Reliability: 2)
A0A8D1I2H9_PIG
648
0
69800
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0J9S1_PIG
434
0
47415
TrEMBL
other Location (Reliability: 3)
A0A8D1ITM7_PIG
833
0
91132
TrEMBL
other Location (Reliability: 2)
A0A480ZPT1_PIG
321
0
35111
TrEMBL
other Location (Reliability: 1)
A0A8D1MLW8_PIG
534
0
58265
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1DLW4_PIG
530
1
57828
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0QKQ7_PIG
395
0
43530
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ZSU2_PIG
456
0
49154
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0WV68_PIG
495
0
54056
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ARU2_PIG
534
1
57726
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0JGL5_PIG
498
0
54293
TrEMBL
other Location (Reliability: 3)
A0A4X1W3F8_PIG
524
0
57611
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8D1L0L6_PIG
533
0
58056
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ZMD6_PIG
469
0
50731
TrEMBL
Secretory Pathway (Reliability: 1)
A0A481D7U6_PIG
500
0
55267
TrEMBL
Secretory Pathway (Reliability: 2)
A0A480ZP29_PIG
237
0
26145
TrEMBL
other Location (Reliability: 1)
A0A8D1DLA2_PIG
469
1
51278
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1WF37_PIG
835
0
91449
TrEMBL
other Location (Reliability: 2)
A0A287A6H7_PIG
564
0
61233
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MKY4_PIG
512
0
55008
TrEMBL
Mitochondrion (Reliability: 2)
A0A8D1MK33_PIG
493
0
53429
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MKA6_PIG
470
1
50840
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ZXZ7_PIG
469
1
51325
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MLV7_PIG
531
0
57936
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MFZ3_PIG
437
0
47322
TrEMBL
Secretory Pathway (Reliability: 1)
Q8HYZ6_PIG
173
0
18683
TrEMBL
Secretory Pathway (Reliability: 2)
A0A4X1SPG8_PIG
461
0
49688
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5G2QTH8_PIG
563
0
60427
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1BMG5_PIG
833
0
91178
TrEMBL
other Location (Reliability: 2)
A0A8D1BJ77_PIG
533
1
57382
TrEMBL
Mitochondrion (Reliability: 2)
A0A2I6SB91_PIG
171
0
18838
TrEMBL
other Location (Reliability: 2)
A0A8D0WXM1_PIG
537
0
57557
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0REV8_PIG
319
0
35016
TrEMBL
other Location (Reliability: 2)
A0A8D1D2K3_PIG
533
1
58108
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1AW80_PIG
469
1
51262
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1VRQ2_PIG
533
0
58164
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1SPQ3_PIG
522
1
56764
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1TH14_PIG
470
0
51265
TrEMBL
Secretory Pathway (Reliability: 1)
A0A287BSC3_PIG
834
0
91253
TrEMBL
other Location (Reliability: 2)
A0A8D1L1G8_PIG
527
0
57278
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1DVN1_PIG
533
0
57419
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1AVI8_PIG
530
1
57779
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1VRL7_PIG
469
0
51179
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1RJZ1_PIG
530
0
57824
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1DLF9_PIG
541
1
58914
TrEMBL
Mitochondrion (Reliability: 4)
A0A8D1C8V2_PIG
501
1
54195
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0JGN5_PIG
500
0
54189
TrEMBL
Mitochondrion (Reliability: 2)
A0A8D1VUY3_PIG
530
0
57807
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1I1P2_PIG
528
0
57392
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D2CEC7_PIG
533
1
58204
TrEMBL
Secretory Pathway (Reliability: 1)
F1SMT7_PIG
533
0
58030
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1SQU6_PIG
533
0
57567
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1KXY4_PIG
470
1
50709
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0LPP4_PIG
458
0
50150
TrEMBL
other Location (Reliability: 5)
A0A8D1WFA5_PIG
573
0
63299
TrEMBL
other Location (Reliability: 2)
A0A8D1AZ79_PIG
536
1
56970
TrEMBL
other Location (Reliability: 2)
A0A4X1VYS3_PIG
446
0
49029
TrEMBL
other Location (Reliability: 5)
A0A8D1DXU5_PIG
469
0
50506
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1DL58_PIG
532
1
57814
TrEMBL
Mitochondrion (Reliability: 2)
A0A8D1C8X1_PIG
473
0
50678
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0WYL3_PIG
517
0
55839
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MLK8_PIG
534
1
57753
TrEMBL
Secretory Pathway (Reliability: 1)
A0A4X1SPK5_PIG
541
0
58672
TrEMBL
Mitochondrion (Reliability: 2)
A0A480NX00_PIG
405
0
44554
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1RKC6_PIG
533
0
58030
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1I0J5_PIG
584
0
62921
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1DMH7_PIG
533
1
58157
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1VSK6_PIG
469
0
50630
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1B278_PIG
532
1
57765
TrEMBL
Mitochondrion (Reliability: 2)
A0A8D1ZJR4_PIG
563
0
60620
TrEMBL
Secretory Pathway (Reliability: 1)
I3LHU5_PIG
533
0
57509
TrEMBL
Secretory Pathway (Reliability: 1)
A0A480ZY54_PIG
405
0
44555
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1VTT2_PIG
533
0
58136
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1BFF8_PIG
534
1
57696
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D0RAM3_PIG
255
0
28137
TrEMBL
other Location (Reliability: 2)
A0A8D1VT31_PIG
535
0
57914
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1MHY1_PIG
533
0
57551
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8D1ZRC6_PIG
534
0
57667
TrEMBL
Secretory Pathway (Reliability: 1)
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
56
65
-
50% inactivation of the placental enzyme after 0.91 min, 50% inactivation of the liver enzyme after 0.65 min
56
-
50% inactivation of the placental enzyme after 9.7 min, 50% inactivation of the liver enzyme after 3.5 min
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stinson, R.A.; Chan, J.R.A.
Alkaline phosphatase and its function as a protein phosphatase
Adv. Protein Phosphatases
4
127-151
1987
Bos taurus, Escherichia coli, Homo sapiens, Sus scrofa
-
Stadtman, T.C.
Alkaline phosphatases
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
5
55-71
1961
Bos taurus, Escherichia coli, Sus scrofa
-
Goldstein, D.J.; Harris, H.
Human placental alkaline phosphatase differs from that of other species
Nature
280
602-605
1979
Bos taurus, Canis lupus familiaris, Cavia porcellus, Felis catus, Ovis aries, Homo sapiens, Macaca mulatta, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa
Li, L.; Chang, L.; Pellet-Rostaing, S.; Liger, F.; Lemaire, M.; Buchet, R.; Wu, Y.
Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases
Bioorg. Med. Chem.
17
7290-7300
2009
Bos taurus, Sus scrofa
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