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Literature summary for 3.1.3.1 extracted from

  • Stinson, R.A.; Chan, J.R.A.
    Alkaline phosphatase and its function as a protein phosphatase (1987), Adv. Protein Phosphatases, 4, 127-151.
No PubMed abstract available
Search for more literature for 3.1.3.1

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 10 mM, glycogen synthase phosphatase activity Homo sapiens
F- 50 mM KF, 13% inhibition of p-nitrophenyl phosphate hydrolysis, 50% inhibition of dephosphorylation of P-labelled histones Homo sapiens
heparin histone phosphatase activity Homo sapiens
levamisole
-
 Bos taurus
levamisole 10 mM, 94% inhibition of p-nitrophenyl phosphate hydrolysis, 82% inhibition of dephosphorylation of P-labelled histones Homo sapiens
phenylphosphonate 10 mM, 47% inhibition of p-nitrophenyl phosphate hydrolysis, 80% inhibition of dephosphorylation of P-labelled histones Homo sapiens
polylysine histone phosphatase activity Homo sapiens
protamine histone phosphatase activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus
Mg2+ stimulates glycogen synthase phosphatase activity Homo sapiens
Mn2+ stimulates glycogen synthase phosphatase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calf
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-
intestine
-
 Sus scrofa
-
intestine
-
 Bos taurus
-
liver
-
 Homo sapiens
-
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
placenta
-
 Homo sapiens
-
placenta
-
 Sus scrofa
-
placenta
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA:cholesterol acyltransferase + H2O
-
 Escherichia coli ?
-
 ?
dentine phosphoprotein + H2O
-
 Bos taurus ?
-
 ?
glycogen synthase + H2O
-
 Escherichia coli ?
-
 ?
glycogen synthase + H2O
-
 Homo sapiens ?
-
 ?
glycogen synthase + H2O
-
 Bos taurus ?
-
 ?
histone + H2O 32P-labelled Homo sapiens ?
-
 ?
HMG-CoA reductase + H2O
-
 Escherichia coli ?
-
 ?
NADPH-cytochrome reductase + H2O
-
 Escherichia coli ?
-
 ?
p-nitrophenyl phosphate + H2O
-
 Escherichia coli p-nitrophenol + phosphate
-
 ?
p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?
p-nitrophenyl phosphate + H2O
-
 Bos taurus p-nitrophenol + phosphate
-
 ?
phospho-Ser histone + H2O
-
 Escherichia coli ?
-
 ?
phospho-Ser histone + H2O
-
 Homo sapiens ?
-
 ?
phospho-Ser histone + H2O
-
 Bos taurus ?
-
 ?
phospho-Ser-casein + H2O
-
 Escherichia coli ?
-
 ?
phospho-Ser-casein + H2O
-
 Homo sapiens ?
-
 ?
phospho-Ser-casein + H2O
-
 Bos taurus ?
-
 ?
phospho-Tyr angiotensin + H2O
-
 Bos taurus angiotensin + phosphate
-
 ?
phospho-Tyr-casein + H2O
-
 Bos taurus ?
-
 ?
phospho-Tyr-histone + H2O
-
 Escherichia coli ?
-
 ?
phospho-Tyr-histone + H2O
-
 Bos taurus ?
-
 ?
phosphorylase kinase + H2O
-
 Escherichia coli ?
-
 ?
phosphorylase kinase + H2O
-
 Homo sapiens ?
-
 ?
phosphorylated acetyl-CoA carboxylase + H2O
-
 Homo sapiens acetyl-CoA carboxylase + phosphate
-
 ?
phosphorylated acetyl-CoA carboxylase + H2O
-
 Bos taurus acetyl-CoA carboxylase + phosphate
-
 ?
phosvitin + H2O
-
 Homo sapiens ?
-
 ?
phosvitin + H2O
-
 Bos taurus ?
-
 ?
protamine + H2O
-
 Homo sapiens ?
-
 ?
spermidine N'-acetyltransferase + H2O
-
 Bos taurus ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
56
-
-
 Sus scrofa
56
-
-
 Bos taurus
56
-
 pH 10.6, 20 min, the isoenzymes from intestine, liver/bone/kidney and from term-placenta are unstable Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 9 pH 6.0: about 30% of maximal activity, pH 9.0: about 15% of maximal activity Homo sapiens