Reference on EC 2.5.1.1 - dimethylallyltranstransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zaehringer, U.; Ebel, J.; Mulheirn, L.J.; Lyne, R.L.; Grisebach, H.
Induction of phytoalexin synthesis in soybean. Dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase from elicitor-induced cotyledons
FEBS Lett.
101
90-92
1979
Glycine max
Lee, S.L.; Floss, H.G.; Heinstein, P.
Purification and properties of dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58
Arch. Biochem. Biophys.
177
84-94
1976
Claviceps
Chamovitz, D.; Misawa, N.; Sandmann, G.; Hirschberg, J.
Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme
FEBS Lett.
296
305-310
1992
Escherichia coli, Pantoea ananatis
Reed, B.C.; Rilling, H.C.
Crystallization and partial characterization of prenyltransferase from avian liver
Biochemistry
14
50-54
1975
Gallus gallus, Saccharomyces cerevisiae, Sus scrofa
Barnard, G.F.; Popjak, G.
Human liver prenyltransferase and its characterization
Biochim. Biophys. Acta
661
87-99
1981
Homo sapiens, Sus scrofa, Dialysis
Eberhardt, N.L.; Rilling, H.C.
Prenyltransferase from Saccharomyces cerevisiae. Purification to homogeneity and molecular properties
J. Biol. Chem.
250
863-866
1975
Saccharomyces cerevisiae
Attucci, S.; Aitken, S.M.; Gulick, P.J.; Ibrahim, R.K.
Farnesyl pyrophosphate synthase from white lupine: molecular cloning, expression, and purification of the expressed protein
Arch. Biochem. Biophys.
321
493-500
1995
Arabidopsis thaliana, Lupinus albus, Saccharomyces cerevisiae, Homo sapiens, Rattus
Narita, K.; Ohnuma, S.I.; Nishino, T.
Protein design of geranyl diphosphate synthase. Structural features that define the product specificities of prenyltransferases
J. Biochem.
126
566-571
1999
Geobacillus stearothermophilus
Heide, L.; Berger, U.
Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures
Arch. Biochem. Biophys.
273
331-338
1989
Lithospermum erythrorhizon
Clastre, M.; Bantignies, B.; Feron, G.; Soler, E.; Ambid, C.
Purification and characterization of geranyl diphosphate synthase from Vitis vinifera L. cv. muscat de frontignan cell cultures
Plant Physiol.
102
205-211
1993
Vitis vinifera
Burke, C.C.; Wildung, M.R.; Croteau, R.
Geranyl diphosphate synthase: cloning, expression, and characterization of this prenyltransferase as a heterodimer
Proc. Natl. Acad. Sci. USA
96
13062-13067
1999
Mentha spicata
Bouvier, F.; Suire, C.; d'Harlingue, A.; Backhaus, R.A.; Camara, B.
Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells
Plant J.
24
241-252
2000
Arabidopsis thaliana, plant, Arabidopsis thaliana (P34802)
Wiedemann, M.; Misawa, N.; Sandmann, G.
Purification and enzymatic characterization of the geranylgeranyl pyrophosphate synthase from Erwinia uredovora after expression in Escherichia coli
Arch. Biochem. Biophys.
306
152-157
1993
Pantoea ananatis, Escherichia coli
Burke, C.; Croteau, R.
Geranyl diphosphate synthase from Abies grandis: cDNA isolation, functional expression, and characterization
Arch. Biochem. Biophys.
405
130-136
2002
Abies grandis, Escherichia coli, Taxus, Taxus canadensis, Abies grandis (Q8W1R9)
Burke, C.; Croteau, R.
Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate
J. Biol. Chem.
277
3141-3149
2002
Escherichia coli, Mentha, Abies grandis, Abies grandis (Q8W1R9), Taxus canadensis, plant
Burke, C.; Klettke, K.; Croteau, R.
Heteromeric geranyl diphosphate synthase from mint: construction of a functional fusion protein and inhibition by bisphosphonate substrate analogs
Arch. Biochem. Biophys.
422
52-60
2004
Escherichia coli, Mentha spicata, Mentha x piperita
Engprasert, S.; Taura, F.; Kawamukai, M.; Shoyama, Y.
Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq
BMC Plant Biol.
4
18
2004
Plectranthus barbatus
Fukusaki, E.I.; Nishikawa, T.; Kato, K.; Shinmyo, A.; Hemmi, H.; Nishino, T.; Kobayashi, A.
Introduction of the archaebacterial geranylgeranyl pyrophosphate synthase gene into Chlamydomonas reinhardtii chloroplast
J. Biosci. Bioeng.
95
283-287
2003
Chlamydomonas reinhardtii
Tholl, D.; Kish, C.M.; Orlova, I.; Sherman, D.; Gershenzon, J.; Pichersky, E.; Dudareva, N.
Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases
Plant Cell
16
977-992
2004
Antirrhinum majus, Clarkia breweri, Escherichia coli, Mentha x piperita
Turner, G.W.; Croteau, R.
Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase
Plant Physiol.
136
4215-4227
2004
Mentha, Mentha spicata, Mentha x piperita
Gilg, A.B.; Bearfield, J.C.; Tittiger, C.; Welch, W.H.; Blomquist, G.J.
Isolation and functional expression of an animal geranyl diphosphate synthase and its role in bark beetle pheromone biosynthesis
Proc. Natl. Acad. Sci. USA
102
9760-9765
2005
animal
Schulbach, M.C.; Brennan, P.J.; Crick, D.C.
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl disphosphate synthase in Mycobacterium tuberculosis
J. Biol. Chem.
275
22876-22881
2000
Mycobacterium tuberculosis
Schulbach, M.C.; Mahapatra, S.; Macchia, M.; Barontini, S.; Papi, C.; Minutolo, F.; Bertini, S.; Brennan, P.J.; Crick, D.C.
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis
J. Biol. Chem.
276
11624-11630
2001
Mycobacterium tuberculosis H37Rv
Kavanagh, K.L.; Dunford, J.E.; Bunkoczi, G.; Russell, R.G.; Oppermann, U.
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J. Biol. Chem.
281
22004-22012
2006
Homo sapiens, Mammalia
Ament, K.; Van Schie, C.C.; Bouwmeester, H.J.; Haring, M.A.; Schuurink, R.C.
Induction of a leaf specific geranylgeranyl pyrophosphate synthase and emission of (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene in tomato are dependent on both jasmonic acid and salicylic acid signaling pathways
Planta
224
1197-1208
2006
Solanum lycopersicum, Solanum lycopersicum (Q1A7S9), Solanum lycopersicum (Q1A7T0)
Vandermoten, S.; Charloteaux, B.; Santini, S.; Sen, S.E.; Beliveau, C.; Vandenbol, M.; Francis, F.; Brasseur, R.; Cusson, M.; Haubruge, E.
Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity
FEBS Lett.
582
1928-1934
2008
Myzus persicae, Escherichia coli
Schmidt, A.; Gershenzon, J.
Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies)
Phytochemistry
69
49-57
2008
Picea abies, Abies, Arabidopsis thaliana
van Schie, C.C.; Ament, K.; Schmidt, A.; Lange, T.; Haring, M.A.; Schuurink, R.C.
Geranyl diphosphate synthase is required for biosynthesis of gibberellins
Plant J.
52
752-762
2007
Arabidopsis thaliana, Solanum lycopersicum
Hsiao, Y.Y.; Jeng, M.F.; Tsai, W.C.; Chuang, Y.C.; Li, C.Y.; Wu, T.S.; Kuoh, C.S.; Chen, W.H.; Chen, H.H.
A novel homodimeric geranyl diphosphate synthase from the orchid Phalaenopsis bellina lacking a DD(X)2-4D motif
Plant J.
55
719-733
2008
Phalaenopsis bellina, Saccharomyces cerevisiae, plant
Vandermoten, S.; Santini, S.; Haubruge, E.; Heuze, F.; Francis, F.; Brasseur, R.; Cusson, M.; Charloteaux, B.
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase
Insect Biochem. Mol. Biol.
39
707-716
2009
Acyrthosiphon pisum (Q1X877)
Lewis, M.J.; Prosser, I.M.; Mohib, A.; Field, L.M.
Cloning and characterisation of a prenyltransferase from the aphid Myzus persicae with potential involvement in alarm pheromone biosynthesis
Insect Mol. Biol.
17
437-443
2008
BRENDA: Myzus persicae (Q1X876), Myzus persicae
Textmining: Aphididae
Nagaki, M.; Musashi, T.; Hirano, Y.; Tanaka, H.; Ichita, J.; Maki, Y.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases of Bacillus stearothermophilus and porcine liver with allylic substrate homologs having vinyl or ethynyl group
J. Mol. Catal. B
59
163-167
2009
Sus scrofa
-
Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Endo, T.; Maki, Y.; Koyama, T.
Substrate specificities of wild and mutated farnesyl diphosphate synthases: Reactivity of allylic substrate homologs having hydrophilic groups at omega-position
J. Mol. Catal. B
59
225-230
2009
Geobacillus stearothermophilus, Sus scrofa
-
Nagaki, M.; Kanno, H.; Musashi, T.; Shimizu, R.; Maki, Y.; Sagami, H.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases from Bacillus stearothermophilus and porcine liver with cyclic substrate homologs
J. Mol. Catal. B
60
186-190
2009
Geobacillus stearothermophilus, Sus scrofa
-
Gilg, A.B.; Tittiger, C.; Blomquist, G.J.
Unique animal prenyltransferase with monoterpene synthase activity
Naturwissenschaften
96
731-735
2009
BRENDA: Ips pini (Q58GE8), Ips pini
Textmining: animal, Scolytinae, Transformation
Orlova, I.; Nagegowda, D.A.; Kish, C.M.; Gutensohn, M.; Maeda, H.; Varbanova, M.; Fridman, E.; Yamaguchi, S.; Hanada, A.; Kamiya, Y.; Krichevsky, A.; Citovsky, V.; Pichersky, E.; Dudareva, N.
The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta
Plant Cell
21
4002-4017
2009
Antirrhinum majus, Nicotiana tabacum
Chang, T.H.; Hsieh, F.L.; Ko, T.P.; Teng, K.H.; Liang, P.H.; Wang, A.H.
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation
Plant Cell
22
454-467
2010
Mentha x piperita
Schmidt, A.; Waechtler, B.; Temp, U.; Krekling, T.; Seguin, A.; Gershenzon, J.
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies
Plant Physiol.
152
639-655
2010
Picea abies (D2IT07), Picea abies
Li, S.M.
Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives
Phytochemistry
70
1746-1757
2009
Escherichia coli, Saccharomyces cerevisiae, Bacteria, Fungi, Aspergillus fischeri, Aspergillus fumigatus
Dolzhenko, Y.; Bertea, C.M.; Occhipinti, A.; Bossi, S.; Maffei, M.E.
UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Mentha x piperita L.)
J. Photochem. Photobiol. B Biol.
100
67-75
2010
Mentha x piperita (Q6WAU0), Mentha x piperita
Breitenbach, J.; Visser, H.; Verdoes, J.C.; van Ooyen, A.J.; Sandmann, G.
Engineering of geranylgeranyl pyrophosphate synthase levels and physiological conditions for enhanced carotenoid and astaxanthin synthesis in Xanthophyllomyces dendrorhous
Biotechnol. Lett.
33
755-761
2011
Phaffia rhodozyma
Mann, F.M.; Thomas, J.A.; Peters, R.J.
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis
FEBS Lett.
585
549-554
2011
BRENDA: Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551
Textmining: Bacteria
Artz, J.D.; Wernimont, A.K.; Dunford, J.E.; Schapira, M.; Dong, A.; Zhao, Y.; Lew, J.; Russell, R.G.; Ebetino, F.H.; Oppermann, U.; Hui, R.
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites
J. Biol. Chem.
286
3315-3322
2011
Plasmodium
Nagegowda, D.
The small subunit of geranyl diphosphate synthase: A tool to improve aroma and flavour by metabolic engineering
J. Biosci.
35
167-169
2010
BRENDA: Antirrhinum majus, Clarkia breweri (Q6QLU5), Mentha x piperita (Q9SBR4)
Textmining: Aroma
Thabet, I.; Gregory Guirimand, G.; Guihur, A.; Lanoue, A.; Courdavault, V.; Papon, N.; Bouzid, S.; Giglioli-Guivarch, N.; Simkin, A.; Clastre, M.
Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus
Mol. Biol. Rep.
39
3235-3243
2012
Catharanthus roseus, Catharanthus roseus (Q42698), Escherichia coli, Catharanthus, plant
Schmidt, A.; Nagel, R.; Krekling, T.; Christiansen, E.; Gershenzon, J.; Krokene, P.
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies)
Plant Mol. Biol.
77
577-590
2011
Picea abies
Frick, S.; Nagel, R.; Schmidt, A.; Bodemann, R.R.; Rahfeld, P.; Pauls, G.; Brandt, W.; Gershenzon, J.; Boland, W.; Burse, A.
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway
Proc. Natl. Acad. Sci. USA
110
4194-4199
2013
Phaedon cochleariae
Dolzhenko, Y.; Bertea, C.; Occhipinti, A.; Bossi, S.; Maffei, M.
UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Menthapiperita L.)
J. Photochem. Photobiol. B
100
67-75
2010
Mentha x piperita
Martin, D.M.; Chiang, A.; Lund, S.T.; Bohlmann, J.
Biosynthesis of wine aroma: transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewuerztraminer grapes
Planta
236
919-929
2012
Aroma
Zhou, J.; Wang, X.; Kuang, M.; Wang, L.; Luo, H.; Mo, Y.; Wu, R.
Protonation-triggered carbon-chain elongation in geranyl pyrophosphate synthase (GPPS)
ACS Catal.
5
4466-4478
2015
Mentha x piperita (Q9SBR3 and Q9SBR4)
-
Kato, S.; Takaichi, S.; Ishikawa, T.; Asahina, M.; Takahashi, S.; Shinomura, T.
Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis
BMC Plant Biol.
16
4-15
2016
Euglena gracilis, Euglena gracilis (A0A0U5ARE7)
Kato, S.; Takaichi, S.; Ishikawa, T.; Asahina, M.; Takahashi, S.; Shinomura, T.
Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis
BMC Plant Biol.
16
4-4
2016
Euglena gracilis, Euglena gracilis (A0A0U5ALI9)
Pockrandt, D.; Li, S.M.
Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring
ChemBioChem
14
2023-2028
2013
Aspergillus fischeri
Heider, S.A.; Peters-Wendisch, P.; Beekwilder, J.; Wendisch, V.F.
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum
FEBS J.
281
4906-4920
2014
BRENDA: Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Textmining: bacterium
Rivera-Perez, C.; Nyati, P.; Noriega, F.G.
A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity
Insect Biochem. Mol. Biol.
64
44-50
2015
Aedes aegypti (Q17F78)
Liu, Z.; Zhou, J.; Wu, R.; Xu, J.
Mechanism of assembling isoprenoid building blocks 1. elucidation of the structural motifs for substrate binding in geranyl pyrophosphate synthase
J. Chem. Theory Comput.
10
5057-5067
2014
Mentha x piperita (Q9SBR3 and Q9SBR4)
Rai, A.; Smita, S.S.; Singh, A.K.; Shanker, K.; Nagegowda, D.A.
Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis
Mol. Plant
6
1531-1549
2013
Catharanthus roseus (B2MV87), Catharanthus roseus
Liebhold, M.; Li, S.M.
Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase
Org. Lett.
15
5834-5837
2013
Aspergillus fumigatus
Tata, S.K.; Jung, J.; Kim, Y.H.; Choi, J.Y.; Jung, J.Y.; Lee, I.J.; Shin, J.S.; Ryu, S.B.
Heterologous expression of chloroplast-localized geranylgeranyl pyrophosphate synthase confers fast plant growth, early flowering and increased seed yield
Plant Biotechnol. J.
14
29-39
2016
plant
Xi, J.; Rossi, L.; Lin, X.; Xie, D.Y.
Overexpression of a synthetic insect-plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis
Planta
244
215-230
2016
BRENDA: Myzus persicae
Textmining: Camelina sativa, plant
Chen, W.; He, S.; Liu, D.; Patil, G.B.; Zhai, H.; Wang, F.; Stephenson, T.J.; Wang, Y.; Wang, B.; Valliyodan, B.; Nguyen, H.T.; Liu, Q.
A sweetpotato geranylgeranyl pyrophosphate synthase gene, IbGGPS, increases carotenoid content and enhances osmotic stress tolerance in Arabidopsis thaliana
PLoS ONE
10
e0137623
2015
Arabidopsis thaliana
Alcaino, J.; Romero, I.; Niklitschek, M.; Sepulveda, D.; Rojas, M.C.; Baeza, M.; Cifuentes, V.
Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors
PLoS ONE
9
e96626
2014
Phaffia rhodozyma, Phaffia rhodozyma (X5DUM0)
Keeling, C.I.; Chiu, C.C.; Aw, T.; Li, M.; Henderson, H.; Tittiger, C.; Weng, H.B.; Blomquist, G.J.; Bohlmann, J.
Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases
Proc. Natl. Acad. Sci. USA
110
18838-18843
2013
BRENDA: Dendroctonus ponderosae (I1VJ84), Dendroctonus ponderosae
Textmining: Dendroctonus jeffreyi
Zhou, J.; Wang, C.; Yoon, S.; Jang, H.; Choi, E.; Kim, S.
Engineering Escherichia coli for selective geraniol production with minimized endogenous dehydrogenation
J. Biotechnol.
169
42-50
2014
Escherichia coli str. K-12 substr. MG1655
Betterle, N.; Melis, A.
Heterologous leader sequences in fusion constructs enhance expression of geranyl diphosphate synthase and yield of beta-phellandrene production in cyanobacteria (Synechocystis)
ACS Synth. Biol.
7
912-921
2018
Cyanobacteria
Kim, E.M.; Eom, J.H.; Um, Y.; Kim, Y.; Woo, H.M.
Microbial synthesis of myrcene by metabolically engineered Escherichia coli
J. Agric. Food Chem.
63
4606-4612
2015
Escherichia coli
Lin, P.; Saha, R.; Zhang, F.; Pakrasi, H.
Metabolic engineering of the pentose phosphate pathway for enhanced limonene production in the cyanobacterium Synechocystis sp. PCC 6803
Sci. Rep.
7
17503-17512
2017
Abies grandis, plant
Liu, W.; Zhang, R.; Tian, N.; Xu, X.; Cao, Y.; Xian, M.; Liu, H.
Utilization of alkaline phosphatase PhoA in the bioproduction of geraniol by metabolically engineered Escherichia coli
Bioengineered
6
288-293
2015
Escherichia coli, Abies grandis
Li, J.; Liu, S.; Wang, J.; Li, J.; Liu, D.; Li, J.; Gao, W.
Fungal elicitors enhance ginsenosides biosynthesis, expression of functional genes as well as signal molecules accumulation in adventitious roots of Panax ginseng C. A. Mey
J. Biotechnol.
239
106-114
2016
Aspergillus niger, plant
Yang, L.; Jiang, L.; Li, W.; Yang, Y.; Zhang, G.; Luo, Y.
A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli
J. Ind. Microbiol. Biotechnol.
44
1431-1441
2017
Camptotheca acuminata (A0A2H4ULH9), Camptotheca acuminata
Kim, S.; Kim, E.J.; Park, J.B.; Kim, S.W.; Kim, K.J.
Crystal structure of geranylgeranyl pyrophosphate synthase (crtE) from Nonlabens dokdonensis DSW-6
Biochem. Biophys. Res. Commun.
518
479-485
2019
Nonlabens dokdonensis DSW-6, Nonlabens dokdonensis DSW-6 (L7W5I6), Flavobacterium
Chen, Z.; Xu, N.; Chong, D.; Guan, S.; Jiang, C.; Yang, Z.; Li, C.
Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart
Cardiovasc. Res.
114
965-978
2018
Mus musculus, Mus musculus (Q9WTN0)
Petrova, T.E.; Boyko, K.M.; Nikolaeva, A.Y.; Stekhanova, T.N.; Gruzdev, E.V.; Mardanov, A.V.; Stroilov, V.S.; Littlechild, J.A.; Popov, V.O.; Bezsudnova, E.Y.
Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans
Extremophiles
22
877-888
2018
archaeon, Escherichia coli, Geoglobus, Geoglobus acetivorans, Geoglobus acetivorans (A0A0A7GEY4)
Rubat, S.; Varas, I.; Sepulveda, R.; Almonacid, D.; Gonzalez-Nilo, F.; Agosin, E.
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase
FEMS Yeast Res.
17
fox032
2017
Saccharomyces cerevisiae
Feng, Y.; Morgan, R.M.L.; Fraser, P.D.; Hellgardt, K.; Nixon, P.J.
Crystal structure of geranylgeranyl pyrophosphate synthase (CrtE) involved in cyanobacterial terpenoid biosynthesis
Front. Plant Sci.
11
589
2020
Arabidopsis thaliana
Picard, M.E.; Nisole, A.; Beliveau, C.; Sen, S.; Barbar, A.; Shi, R.; Cusson, M.
Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana Implications for inhibitor design
Insect Biochem. Mol. Biol.
92
84-92
2018
Choristoneura fumiferana (Q1XAB1)
Lee, J.S.; Pan, J.J.; Ramamoorthy, G.; Poulter, C.D.
Structure-function studies of Artemisia tridentata farnesyl diphosphate synthase and chrysanthemyl diphosphate synthase by site-directed mutagenesis and morphogenesis
J. Am. Chem. Soc.
139
14556-14567
2017
Artemisia spiciformis, Artemisia spiciformis (Q7XYS8)
Lacbay, C.M.; Waller, D.D.; Park, J.; Gomez Palou, M.; Vincent, F.; Huang, X.F.; Ta, V.; Berghuis, A.M.; Sebag, M.; Tsantrizos, Y.S.
Unraveling the prenylation-cancer paradox in multiple myeloma with novel geranylgeranyl pyrophosphate synthase (GGPPS) inhibitors
J. Med. Chem.
61
6904-6917
2018
Homo sapiens, Homo sapiens (O95749)
Han, S.; Li, X.; Xia, Y.; Yu, Z.; Cai, N.; Malwal, S.R.; Han, X.; Oldfield, E.; Zhang, Y.
Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells
J. Med. Chem.
62
10867-10896
2019
Homo sapiens (P14324)
Huang, D.; Liu, W.; Li, A.; Wang, C.; Hu, Z.
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