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Information on EC 1.11.1.6 - catalase and Organism(s) Pseudomonas aeruginosa

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.6 catalase
IUBMB Comments
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
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This record set is specific for:
Pseudomonas aeruginosa
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Word Map
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
2
=
+
2
2
=
+
2
Synonyms
catalase, cat-1, catalase a, manganese catalase, polyethylene glycol-catalase, catalase-1, cat-a, catpo, catalase p, haem catalase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
caperase
-
-
-
-
CAT
-
-
-
-
catalase-peroxidase
-
-
-
-
equilase
-
-
-
-
optidase
-
-
-
-
polyethylene glycol-catalase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
hydrogen-peroxide:hydrogen-peroxide oxidoreductase
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-05-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2O2
O2 + H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
H2O2
O2 + H2O
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
-
3-amino-1H-1,2,4-triazole
-
-
hydroxylamine
-
-
NaCN
-
50% inhibition at 12 mM
additional information
-
detailed comparison of inhibitors
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AnkB
-
the periplasmic ankyrin-like protein is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
biofilm cultures
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A8G5UAF0_PSEAI
709
0
77898
TrEMBL
-
A0A8G7F282_PSEAI
379
1
42658
TrEMBL
-
A0A0K3ADN6_PSEAI
294
0
31587
TrEMBL
-
A0A8G6ZRR7_PSEAI
517
0
57380
TrEMBL
-
A0A8G6DA21_PSEAI
709
0
77947
TrEMBL
-
A0A8G7IIF4_PSEAI
482
0
55559
TrEMBL
-
A0A8G3ZUD9_PSEAI
709
0
78018
TrEMBL
-
A0A2R3J4Y2_PSEAI
517
0
57397
TrEMBL
-
A0A080VD75_PSEAI
709
0
77959
TrEMBL
-
A0A8G1VE77_PSEAI
517
0
57379
TrEMBL
-
A0A8G4CRS5_PSEAI
379
1
42716
TrEMBL
-
A0A8G4DDB1_PSEAI
379
1
42761
TrEMBL
-
A0A8G2QNW4_PSEAI
379
1
42766
TrEMBL
-
A0A5F1BHB2_PSEAI
379
1
42774
TrEMBL
-
A0A8G5ID08_PSEAI
709
0
77975
TrEMBL
-
A0A643J3U8_PSEAI
481
0
54386
TrEMBL
-
A0A8G5LY05_PSEAI
709
0
77947
TrEMBL
-
A0A7L5F5E4_PSEAI
482
0
55605
TrEMBL
-
A0A8G2VEZ3_PSEAI
482
0
55531
TrEMBL
-
A0A8G7B8N9_PSEAI
709
0
77944
TrEMBL
-
A0A8G4NAK2_PSEAI
379
1
42726
TrEMBL
-
A0A8G6DII6_PSEAI
709
0
77949
TrEMBL
-
A0A8G7HIA8_PSEAI
513
0
57130
TrEMBL
-
A0A071L4H2_PSEAI
482
0
55589
TrEMBL
-
A0A2R3IS75_PSEAI
482
0
55600
TrEMBL
-
A0A8G4J0V7_PSEAI
517
0
57386
TrEMBL
-
A0A8G3TDF9_PSEAI
513
0
57159
TrEMBL
-
A0A8G7A3Y6_PSEAI
379
1
42702
TrEMBL
-
A0A485HPY1_PSEAI
386
0
43223
TrEMBL
-
A0A8G3JZQ5_PSEAI
709
0
77920
TrEMBL
-
A0A5E5R0Q8_PSEAI
513
0
57132
TrEMBL
-
A0A8G3PCZ2_PSEAI
379
1
42758
TrEMBL
-
A0A8G7GSS8_PSEAI
379
1
42703
TrEMBL
-
A0A3S0IWU9_PSEAI
513
0
57124
TrEMBL
-
A0A8G1JEX1_PSEAI
482
0
55590
TrEMBL
-
A0A8G7PQ25_PSEAI
709
0
78018
TrEMBL
-
A0A8G7IFB9_PSEAI
379
1
42785
TrEMBL
-
A0A8G2K522_PSEAI
709
0
77889
TrEMBL
-
A0A072ZCQ2_PSEAI
513
0
57131
TrEMBL
-
A0A8G6HLH3_PSEAI
709
0
77977
TrEMBL
-
A0A8G7I7E7_PSEAI
379
1
42773
TrEMBL
-
A0A2U2XQ17_PSEAI
379
1
42770
TrEMBL
-
A0A8G2RC91_PSEAI
482
0
55590
TrEMBL
-
A0A2R3IW62_PSEAI
709
0
77857
TrEMBL
-
A0A8G3SKQ0_PSEAI
513
0
57073
TrEMBL
-
A0A8G4ARC2_PSEAI
379
1
42747
TrEMBL
-
A0A6A9K8F3_PSEAI
379
1
42771
TrEMBL
-
A0A8G5UMF0_PSEAI
482
0
55603
TrEMBL
-
A0A8G4JVQ6_PSEAI
517
0
57444
TrEMBL
-
A0A8G2QQZ9_PSEAI
379
1
42828
TrEMBL
-
A0A8G2KD28_PSEAI
379
1
42744
TrEMBL
-
Q1W506_PSEAI
482
0
55519
TrEMBL
-
A0A8G7TG98_PSEAI
709
0
77929
TrEMBL
-
A0A424XBK0_PSEAI
709
0
77857
TrEMBL
-
A0A4U9SC11_PSEAI
379
1
42715
TrEMBL
-
A0A8G6YIC9_PSEAI
709
0
77960
TrEMBL
-
A0A1Y0GE77_PSEAI
379
1
42771
TrEMBL
-
A0A8G3DEA2_PSEAI
513
0
57103
TrEMBL
-
A0A8G4KG03_PSEAI
379
1
42656
TrEMBL
-
A0A8G4AKZ3_PSEAI
482
0
55541
TrEMBL
-
A0A8G4H152_PSEAI
482
0
55677
TrEMBL
-
A0A8G7KIZ9_PSEAI
379
1
42768
TrEMBL
-
A0A485IJW5_PSEAI
709
0
77871
TrEMBL
-
A0A8G7LJ99_PSEAI
709
0
77949
TrEMBL
-
A0A8G7GB63_PSEAI
709
0
77937
TrEMBL
-
A0A8G3Z7Z1_PSEAI
513
0
57154
TrEMBL
-
A0A077JWW4_PSEAI
379
1
42744
TrEMBL
-
A0A8B5BIR1_PSEAI
709
0
77906
TrEMBL
-
A0A8G4LMS5_PSEAI
709
0
77964
TrEMBL
-
A0A8G2RV12_PSEAI
709
0
78054
TrEMBL
-
A0A8G6XEG8_PSEAI
379
1
42819
TrEMBL
-
A0A8G3YA44_PSEAI
709
0
77987
TrEMBL
-
A0A8F9V713_PSEAI
482
0
55575
TrEMBL
-
A0A0A8RA21_PSEAI
482
0
55619
TrEMBL
-
A0A8G6GET3_PSEAI
709
0
77928
TrEMBL
-
A0A8G2W580_PSEAI
379
1
42737
TrEMBL
-
A0A8G5UMD1_PSEAI
379
1
42758
TrEMBL
-
A0A8G2QM73_PSEAI
482
0
55560
TrEMBL
-
A0A485HPZ1_PSEAI
113
0
11692
TrEMBL
-
A0A8G2L122_PSEAI
513
0
57145
TrEMBL
-
A0A8G4FCQ8_PSEAI
379
1
42790
TrEMBL
-
A0A5E5QT13_PSEAI
709
0
77863
TrEMBL
-
A0A7M3AP53_PSEAI
513
0
57162
TrEMBL
-
A0A8G7KSS0_PSEAI
709
0
77930
TrEMBL
-
A0A8G2NQF0_PSEAI
709
0
77987
TrEMBL
-
A0A8G6JNZ8_PSEAI
379
1
42674
TrEMBL
-
A0A8G5WGG3_PSEAI
709
0
77864
TrEMBL
-
A0A8G6YA91_PSEAI
379
1
42829
TrEMBL
-
A0A5E5QTN4_PSEAI
379
1
42834
TrEMBL
-
A0A8F9VAG0_PSEAI
513
0
57117
TrEMBL
-
A0A8B5A9W3_PSEAI
709
0
77931
TrEMBL
-
A0A8G6ZU17_PSEAI
513
0
57131
TrEMBL
-
A0A8B5BD01_PSEAI
379
1
42784
TrEMBL
-
A0A8G4TJ99_PSEAI
513
0
57159
TrEMBL
-
A0A8B5ABM0_PSEAI
513
0
57161
TrEMBL
-
A0A4P0UMD3_PSEAI
294
0
31549
TrEMBL
-
A0A509JI12_PSEAI
709
0
77933
TrEMBL
-
A0A8G5CDL8_PSEAI
379
1
42802
TrEMBL
-
A0A8G2QT66_PSEAI
709
0
77990
TrEMBL
-
A0A8F9NQ01_PSEAI
709
0
77902
TrEMBL
-
A0A485GWZ0_PSEAI
517
0
57369
TrEMBL
-
A0A8G4N813_PSEAI
482
0
55509
TrEMBL
-
A0A8G3SYS2_PSEAI
379
1
42786
TrEMBL
-
A0A8G6HJR6_PSEAI
379
1
42745
TrEMBL
-
A0A2R3IRN3_PSEAI
513
0
57168
TrEMBL
-
A0A8G4I294_PSEAI
379
1
42787
TrEMBL
-
A0A2R3J4D7_PSEAI
379
1
42846
TrEMBL
-
A0A659B9P3_PSEAI
379
1
42774
TrEMBL
-
A0A8G3XCX4_PSEAI
709
0
78005
TrEMBL
-
A0A8G3AU87_PSEAI
482
0
55615
TrEMBL
-
A0A8G3P146_PSEAI
709
0
77993
TrEMBL
-
A0A6A9JXC8_PSEAI
513
0
57173
TrEMBL
-
A0A8G6YJS0_PSEAI
482
0
55617
TrEMBL
-
A0A8G5PX94_PSEAI
482
0
55617
TrEMBL
-
A0A5E9JV40_PSEAI
379
1
42701
TrEMBL
-
A0A8H1AG58_PSEAI
709
0
77961
TrEMBL
-
A0A8G2Q4R3_PSEAI
513
0
57121
TrEMBL
-
A0A3S3XGY1_PSEAI
709
0
77976
TrEMBL
-
A0A367MCB7_PSEAI
519
0
56795
TrEMBL
-
A0A8G4C164_PSEAI
379
1
42756
TrEMBL
-
A0A8G7K936_PSEAI
379
1
42769
TrEMBL
-
A0A8G2UVN6_PSEAI
379
1
42754
TrEMBL
-
A0A485I6Y6_PSEAI
485
0
56027
TrEMBL
-
A0A3S0L5F9_PSEAI
517
0
57412
TrEMBL
-
A0A8G3WYZ4_PSEAI
482
0
55605
TrEMBL
-
A0A8G2YSI1_PSEAI
709
0
77923
TrEMBL
-
A0A8G4CRE6_PSEAI
482
0
55520
TrEMBL
-
A0A367LTJ1_PSEAI
73
0
8275
TrEMBL
-
A0A8G3NVT6_PSEAI
513
0
57097
TrEMBL
-
A0A8G4JDG4_PSEAI
379
1
42834
TrEMBL
-
A0A8G4N992_PSEAI
709
0
77991
TrEMBL
-
A0A8G3X6V0_PSEAI
709
0
77945
TrEMBL
-
A0A8G3NCA6_PSEAI
709
0
77974
TrEMBL
-
A0A8F9NNL4_PSEAI
709
0
77959
TrEMBL
-
A0A8G3KGM0_PSEAI
709
0
77979
TrEMBL
-
A0A8G2RY90_PSEAI
513
0
57287
TrEMBL
-
A0A8F9KLY2_PSEAI
709
0
77947
TrEMBL
-
A0A8G7CG84_PSEAI
513
0
57163
TrEMBL
-
A0A8G2QBF1_PSEAI
709
0
77871
TrEMBL
-
A0A8G7D2E1_PSEAI
709
0
78004
TrEMBL
-
A0A8G4N6M2_PSEAI
379
1
42800
TrEMBL
-
A0A241XKW7_PSEAI
709
0
77990
TrEMBL
-
A0A509JDF3_PSEAI
379
1
42774
TrEMBL
-
A0A8G3ESA0_PSEAI
513
0
57212
TrEMBL
-
A0A8G6ZW77_PSEAI
709
0
77990
TrEMBL
-
A0A8G4ETK5_PSEAI
482
0
55530
TrEMBL
-
A0A7M3AT05_PSEAI
709
0
77933
TrEMBL
-
A0A8G8GEF7_PSEAI
379
1
42704
TrEMBL
-
A0A5F1BG98_PSEAI
709
0
77989
TrEMBL
-
A0A8G7P867_PSEAI
379
1
42756
TrEMBL
-
A0A8G7MPF8_PSEAI
709
0
77905
TrEMBL
-
A0A367M369_PSEAI
379
1
42656
TrEMBL
-
A0A6B1YEM7_PSEAI
709
0
77963
TrEMBL
-
A0A0E1KSY7_PSEAI
709
0
77933
TrEMBL
-
A0A8B4ZA65_PSEAI
379
1
42730
TrEMBL
-
A0A8G6ZJT9_PSEAI
517
0
57410
TrEMBL
-
A0A6A9JWD0_PSEAI
709
0
77934
TrEMBL
-
A0A643J5I8_PSEAI
482
0
55504
TrEMBL
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
228000
-
gel filtration
57000
-
4 * 57000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
-
4 * 57000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
overexpression of cyanide-insensitive terminal oxidase leads to failure to produce temperature-inducible catalyse KatC without affecting transcription of katC. Presence of an intact disulfide bond formation system is required for KatC activity, and enzyme is predicted to contain two cysteine resiudes
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3
-
inactivation
661985
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
58
-
1 h, 83% reduction in activity
60
-
1 h, complete loss of activity
65
-
half-life: 3 s
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to homogeneity, chromatography techniques
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression analysis in strain PAO1 of biofilms of Pseudomonas aeruginosa
-
expression in Escherichia coli
-
katB, expression in Escherichia coli
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Elkins, J.G.; Hassett, D.J.; Steward, P.S.; Schweizer, H.P.; McDermott, T.R.
Protective role of catalyse in Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide
Appl. Environ. Microbiol.
65
4594-4600
1999
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Switala, J.; Loewen, P.C.
Diversity of properties among catalases
Arch. Biochem. Biophys.
401
145-154
2002
Aspergillus niger, Bacteroides fragilis, Bordetella pertussis, Bos taurus, Saccharomyces cerevisiae, Brucella abortus, Escherichia coli, Helicobacter pylori, Homo sapiens, Listeria seeligeri, Micrococcus luteus, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas syringae, Serratia marcescens, Xanthomonas campestris
Manually annotated by BRENDA team
Brown, S.M.; Howell, M.L.; Vasil, M.L.; et al.
Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide
J. Bacteriol.
177
6536-6544
1995
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Howell, M.L.; Alsabbagh, E.; Ma, J.F.; et al.
AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide
J. Bacteriol.
182
4545-4556
2000
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Mossialos, D.; Tavankar, G.R.; Zlosnik, J.E.; Williams, H.D.
Defects in a quinol oxidase lead to loss of KatC catalase activity in Pseudomonas aeruginosa: KatC activity is temperature dependent and it requires an intact disulphide bond formation system
Biochem. Biophys. Res. Commun.
341
697-702
2006
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Yuan, Z.C.; Zaheer, R.; Finan, T.M.
Phosphate limitation induces catalase expression in Sinorhizobium meliloti, Pseudomonas aeruginosa and Agrobacterium tumefaciens
Mol. Microbiol.
58
877-894
2005
Agrobacterium tumefaciens, Pseudomonas aeruginosa, Sinorhizobium meliloti
Manually annotated by BRENDA team
Driffield, K.; Miller, K.; Bostock, J.M.; O'Neill, A.J.; Chopra, I.
Increased mutability of Pseudomonas aeruginosa in biofilms
J. Antimicrob. Chemother.
61
1053-1056
2008
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Baert, B.; Baysse, C.; Matthijs, S.; Cornelis, P.
Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa
Microbiology
154
127-138
2008
Pseudomonas aeruginosa
Manually annotated by BRENDA team