2.7.2.12: acetate kinase (diphosphate)
This is an abbreviated version!
For detailed information about acetate kinase (diphosphate), go to the full flat file.
Reaction
Synonyms
acetate kinase (PPi), acetate kinase (PPi-forming), ACK, diphosphate-specific AK, EhACK, phosphotransferase, pyrophosphate-acetate, PPi-dependent AK, PPi-ehiAK, PPi-forming acetate kinase, pyrophosphate-acetate phosphotransferase, pyrophosphate-dependent AK, pyrophosphate:acetate phosphotransferase
ECTree
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General Information on EC 2.7.2.12 - acetate kinase (diphosphate)
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
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residue Asn337 of ATP-ecoAK is particularly significant for the specificity to ATP. The five residues are highly conserved in 2625 PPi-ehiAK homologue implying that almost all organisms have ATP-dependent acetate kinase, EC 2.7.2.1, rather than diphosphate-dependent acetate kinase, EC 2.7.2.12
malfunction
AcK gene silencing does not affect acetate production in the parasites but promotes a slight decrease (10-20%) in the hexose phosphates and phosphate levels. Amoebae lacking ADP-forming acetyl-CoA synthetase activity are unable to reestablish the acetyl-CoA/CoA ratio after an oxidative stress challenge
metabolism
the enzyme does not contribute to acetate production but might be marginally involved in diphosphate and hexosephosphate homeostasis
physiological function
The enzyme does not importantly contribute to ATP and phospate supply in the amoebae. Recombinant enzyme AcK shows activity only in the acetate formation direction. Enzyme AcK does not contribute to acetate production but might be marginally involved in phosphate and hexosephosphate homeostasis
additional information
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substrate-binding site structure and comparison with ATP-dependent acetate kinase, EC 2.7.2.1, overview
