2.7.1.94: acylglycerol kinase
This is an abbreviated version!
For detailed information about acylglycerol kinase, go to the full flat file.
Word Map on EC 2.7.1.94
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2.7.1.94
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translocase
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intermembrane
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lysophosphatidic
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sengers
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phosphatidic
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monoacylglycerols
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preproteins
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tim10
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polytopic
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presequence
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lpa-induced
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medicine
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autotaxin
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diagnostics
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drug development
- 2.7.1.94
- translocase
-
intermembrane
-
lysophosphatidic
-
sengers
-
phosphatidic
- monoacylglycerols
- preproteins
- tim10
-
polytopic
- presequence
-
lpa-induced
- medicine
- autotaxin
- diagnostics
- drug development
Reaction
Synonyms
1-MGK, 1-monoacylglycerol kinase, 2-MGK, 2-monoacylglycerol kinase, acylglycerol kinase, AGK, kinase, monoacylglycerol (phosphorylating), MGK, monoacylglycerol kinase, monoglyceride kinase, monoglyceride phosphokinase, More, MULK, multisubstrate lipid kinase, sn-2-monoacylglycerol kinase, TIM22 complex
ECTree
2.7.1.94 acylglycerol kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.94 - acylglycerol kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + diacylglycerol
ADP + phosphatidic acid
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i.e. diacyl-glycerol 3-phosphate, regulation mechanism, overview
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?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
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i.e. acyl-sn-glycerol 3-phosphate, regulation mechanism, overview
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?
additional information
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lysophosphatidic acid induces the cytokine interleukin-8 correlated with angiogenesis, tumorigenicity, and cancer cell proliferation, the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
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?
additional information
?
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the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview
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?
additional information
?
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the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
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?
