2.4.2.48: tRNA-guanine15 transglycosylase

This is an abbreviated version!
For detailed information about tRNA-guanine15 transglycosylase, go to the full flat file.

Reaction

Synonyms

archaeosine tRNA-guanine transglycosylase, archaeosine tRNAguanine transglycosylase, ArcTGT, multisite-specific archaeosine tRNA-guanine transglycosylase, Ta1493, TGT, transfer ribonucleic acid guanine15 transglycosylase, tRNA guanine15 transglycosidase, tRNA-guanine transglycosylase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.48 tRNA-guanine15 transglycosylase

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Results	in table
1970	AA Sequence
6	Cloned(Commentary)
2	Crystallization (Commentary)
3	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
4	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
17	Organism
2	Pathway
4	pH Optimum
1	Protein Variants
5	Purification (Commentary)
1	Reaction
14	Reference
3	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
5	Subunits
23	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 2.4.2.48 - tRNA-guanine15 transglycosylase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Pyrococcus furiosus

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the C-terminal extension of the enzyme is not required for the selection of G15 as the site of base exchange. Truncated forms of Pyrococcus furiosus TGT retain their specificity for guanine exchange at position 15. Deletion of the PUA domain causes a 4fold drop in the observed kcat and results in a 75fold increased Km for tRNAAsp compared with full-length TGT

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