2.4.1.236: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase
This is an abbreviated version!
For detailed information about flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.236
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2.4.1.236
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flavonoid
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bitter
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pummelo
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orang
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glycosides
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flavones
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rhamnosyltransferases
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taste
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grapefruit
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mandarin
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naringin
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flavor
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rhamnosylation
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maxima
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glycosyltransferase
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lycopene
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tasteless
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sinensis
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non-bitter
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agriculture
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nutrition
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synthesis
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food industry
- 2.4.1.236
- flavonoid
-
bitter
- pummelo
-
orang
- glycosides
- flavones
- rhamnosyltransferases
-
taste
- grapefruit
-
mandarin
- naringin
-
flavor
-
rhamnosylation
- maxima
- glycosyltransferase
- lycopene
-
tasteless
- sinensis
-
non-bitter
- agriculture
- nutrition
- synthesis
- food industry
Reaction
Synonyms
1,2-rhamnosyltransferase, 1,2RhaT, 1-2 UDP-rhamnosyltransferase, 2RT, Cit1,2RhaT, Cm1,2RhaT, flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase, flavanone-7-O-glucose-1,2-rhamnosyltransferase, rhamnosyltransferase, uridine diphosphorhamnose-flavanone 7-O-glucoside 2''-O-, UDP-rhamnose flavanone-glucoside rhamnosyl-transferase, UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase
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Substrates Products
Substrates Products on EC 2.4.1.236 - flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase
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REACTION DIAGRAM
UDP-beta-L-rhamnose + a flavanone 7-O-beta-D-glucoside
UDP + a flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]
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-
-
?
UDP-beta-L-rhamnose + naringenin-7-O-glucoside
UDP + naringenin 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]
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-
-
?
UDP-L-rhamnose + a flavanone 7-O-glucoside
UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
UDP-L-rhamnose + apigenin 7-O-glucoside
UDP + apigenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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98% of the activity with hesperetin 7-O-glucoside as substrate, highly specific for UDP-rhamnose
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-
?
UDP-L-rhamnose + diosmetin 7-O-glucoside
UDP + diosmetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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a flavone 7-O-glucoside
i.e. neodiosmin, a bitter 7-O-neohesperidoside
-
?
UDP-L-rhamnose + hesperetin 7-O-glucoside
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
UDP-L-rhamnose + luteolin 7-O-glucoside
UDP + luteolin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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99% of the activity with hesperetin 7-O-glucoside as substrate, highly specific for UDP-rhamnose
-
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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glucosylated flavanone is further rhamnosylated by a rhamnosyltransferase using UDP-rhamnose
-
-
?
UDP-L-rhamnose + a flavanone 7-O-glucoside
UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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glucosylated flavanone is further rhamnosylated by a rhamnosyltransferase using UDP-rhamnose
-
-
?
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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-
i.e. neohesperidin
-
?
UDP-L-rhamnose + hesperetin 7-O-glucoside
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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-
i.e. neohesperidin, a bitter 7-O-neohesperidoside
-
?
UDP-L-rhamnose + hesperetin 7-O-glucoside
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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enzyme catalyzes the transfer of rhamnose from UDP-rhamnose to the C-2 hydroxyl group of glucose attached via C-7-O- of naringenin or hesperetin, lower activity than with naringenin 7-O-glucoside as substrate, highly specific for UDP-rhamnose
i.e. neohesperidin
-
?
UDP-L-rhamnose + hesperetin 7-O-glucoside
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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a flavanone 7-O-glucoside
i.e. neohesperidin, a bitter 7-O-neohesperidoside
-
?
UDP-L-rhamnose + hesperetin 7-O-glucoside
UDP + hesperetin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
-
-
i.e. neohesperidin
-
?
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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-
i.e. naringin, a bitter 7-O-neohesperidoside
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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i.e. prunin, endogenous substrate, flavonoid biosynthetic pathway
i.e. naringin
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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i.e. prunin, natural substrate
-
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
-
i.e. prunin
i.e. naringin
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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i.e. prunin, natural substrate, enzyme catalyzes the transfer of rhamnose from UDP-rhamnose to the C-2 hydroxyl group of glucose attached via C-7-O- of naringenin or hesperetin, best substrate, 141% of the activity with hesperetin 7-O-glucoside as substrate, highly specific for UDP-rhamnose
i.e. naringin
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
-
a flavanone 7-O-glucoside
i.e. naringin, a bitter 7-O-neohesperidoside
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
-
-
-
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
-
i.e. prunin, endogenous substrate, flavonoid biosynthetic pathway
i.e. naringin
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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i.e. prunin
i.e. naringin
-
?
UDP-L-rhamnose + naringenin 7-O-glucoside
UDP + naringenin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
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the enzyme is involved in the flavonoid biosynthesis pathway in grapefruit
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-
?
?
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enzyme catalyzes the production of bitter flavanone-glucosides
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-
?
additional information
?
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not: flavonoid 5-O-glucosides or aglycones, naringenin, hesperetin, quercetin, UDP-glucose, UDP-galactose, UDP-glucoronic acid
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-
?
additional information
?
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the enzyyme specifically catalyzes rhamnosylation of flavanone-7-O-glucose and flavone-7-O-glucose substrates at position 2 of the glucose moiety
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-
?
additional information
?
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the enzyme also catalyzes the rhamnosylation of diosmetin 7-O-glucoside at position 2 of the glucose moiety to give neodiosmin, but Cm1,2RhaT is specific for flavonoid-7-O-glucosides and utilizes no flavonoid-3-O-glucosides
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-
?
additional information
?
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Cm1,2RhaT has glycosyl transfer activity toward UDP-xylose as well as UDP-rhamnose, it is a branch-forming rhamnosyltransferase, substrate specificity of the recombinant enzyme, overview. No activity with quercetin-3-O-glucoside
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-
?
additional information
?
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Cm1,2RhaT has glycosyl transfer activity toward UDP-xylose as well as UDP-rhamnose, it is a branch-forming rhamnosyltransferase, substrate specificity of the recombinant enzyme, overview. No activity with quercetin-3-O-glucoside
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-
?
additional information
?
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flavonoid-7-O-glucosides are the preferred substrate. The enzyme Cit1,2RhaT converts flavonoid-7-O-glucosides into bitter-tasting flavonoid-7-O-neohesperidoside
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additional information
?
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flavanone-7-O-glucosides are catalysed by 1,2-rhamnosyltransferase to form bitter flavanone-7-O-neohesperidosides, such as naringin, neohsperidin, neoeriocitrin and poncirin
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-
?