2.3.1.259: N-terminal methionine Nalpha-acetyltransferase NatF

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For detailed information about N-terminal methionine Nalpha-acetyltransferase NatF, go to the full flat file.

Reaction

Synonyms

EC 2.3.1.88, N-terminal acetyltransferase, Naa60, Naa60p, Nalpha-acetyltransferase 60, NatF

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.259 N-terminal methionine Nalpha-acetyltransferase NatF

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1211	AA Sequence
1	Application
3	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
4	General Information
3	IC50 Value
3	Inhibitors
6	Localization
5	Natural Substrates/ Products (Substrates)
7	Organism
36	Protein Variants
2	Purification (Commentary)
1	Reaction
7	Reference
5	Source Tissue
18	Substrates and Products (Substrate)
1	Subunits
20	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.259 - N-terminal methionine Nalpha-acetyltransferase NatF

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:N-terminal-Met-Lys/Ser/Val/Leu/Gln/Ile/Tyr/Thr-[transmembrane protein] Met-Nalpha-acetyltransferase

N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. NatF is found only in higher eukaryotes, and is absent from yeast. Unlike other Nat systems the enzyme is located in the Golgi apparatus. It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol. NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.