2.3.1.240: narbonolide synthase
This is an abbreviated version!
For detailed information about narbonolide synthase, go to the full flat file.
Reaction
+ 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Synonyms
methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV
ECTree
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General Information
General Information on EC 2.3.1.240 - narbonolide synthase
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metabolism
the enzyme is involved in the biosynthesis of narbonomycin
physiological function
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in modular type I polyketide synthases the presence of the three processing domains, i.e. ketoreductase (KR), dehydratase (DH), and enoylreductase (ER), are varied in each module, leading to a fully reduced, partially reduced, or unreduced segment on the polyketide chain. Dehydratase PikDH2 converts D-alcohol substrates to trans-olefin products. The reaction is reversible with equilibrium constants ranging from 1.2 to 2. The enzyme activity is robust, and PikDH2 can be used for the chemoenzymatic synthesis of unsaturated triketide products. PikDH2 shows remarkably strict substrate specificity and is unable to turn over substrates that are epimeric at the beta-, gamma-, or delta-position