1.1.1.313: sulfoacetaldehyde reductase (NADPH)

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For detailed information about sulfoacetaldehyde reductase (NADPH), go to the full flat file.

Reaction

Synonyms

isethionate formation, reductase D, IsfD, IsfD2, NADPH-dependent sulfoacetaldehyde reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.313 sulfoacetaldehyde reductase (NADPH)

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Results	in table
344	AA Sequence
2	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
26	General Information
2	Inhibitors
2	kcat/KM [mM/s]
5	KM Value [mM]
3	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
12	Organism
3	Pathway
12	PDB ID
2	pH Optimum
1	pH Range
1	pH Stability
12	Protein Variants
2	Purification (Commentary)
1	Reaction
10	Reference
4	Source Tissue
16	Substrates and Products (Substrate)
3	Subunits
24	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.313 - sulfoacetaldehyde reductase (NADPH)

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

F191A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

F249A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

I142A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, the mutant shows 33.6% of wild-type activity

762706

I186A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, the mutant shows 25.8% of wild-type activity

762706

Q244A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

R195A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

R36A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

R37A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

S141A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

T13A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, the mutant shows 7.8% of wild-type activity

762706

Y148A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706

Y154A

Klebsiella oxytoca

D3U1D9

site-directed mutagenesis, inactive mutant

762706