1.1.1.299: malate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about malate dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.299
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1.1.1.299
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maldhs
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dehydrogenases
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l-lactate
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nad-dependent
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l-malate
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hyperthermophilic
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archaeon
- 1.1.1.299
- maldhs
- dehydrogenases
- l-lactate
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nad-dependent
- l-malate
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hyperthermophilic
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archaeon
Reaction
Synonyms
LDH-like MalDH, MDH II, NAD(P)-dependent malate dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.299 - malate dehydrogenase [NAD(P)+]
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REACTION DIAGRAM
(S)-malate + NADP+
oxaloacetate + NADPH + H+
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oxaloacetate + NADH + H+
(S)-malate + NAD+
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the enzyme strongly prefers oxaloacetate by three orders of magnitude compared to pyruvate
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enzyme shows pro-R stereospecificity for hydrogen transfer at the C4 position of the nicotinamide moiety of the coenzyme. No substrates are: D-malate, malonate, L-glutamate, L-aspartate, D,L-2-hydroxybutanoate, D,L-3-hydroxybutanoate, citrate, maleate, succinate, L-tartrate, L-threonine, L-serine, L-hydroxymalonate, D-glutamate, 2-oxocaproate, 2-oxoisovalerate, glyoxylate, 2-oxoglutarate, 2-oxobutanoate
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additional information
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enzyme shows pro-R stereospecificity for hydrogen transfer at the C4 position of the nicotinamide moiety of the coenzyme. No substrates are: D-malate, malonate, L-glutamate, L-aspartate, D,L-2-hydroxybutanoate, D,L-3-hydroxybutanoate, citrate, maleate, succinate, L-tartrate, L-threonine, L-serine, L-hydroxymalonate, D-glutamate, 2-oxocaproate, 2-oxoisovalerate, glyoxylate, 2-oxoglutarate, 2-oxobutanoate
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additional information
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no substrate: pyruvate
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