1.1.1.18: inositol 2-dehydrogenase
This is an abbreviated version!
For detailed information about inositol 2-dehydrogenase, go to the full flat file.
Reaction
Synonyms
BsIDH, cg0204, GK1898, IDH, inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, inositol dehydrogenase, iolG, iolG1, iolG2, LcIDH1, LcIDH2, MI dehydrogenase, More, myo-inositol 2-dehydrogenase, myo-inositol dehydrogenase, myo-inositol:NAD2 oxidoreductase
ECTree
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Reaction
Reaction on EC 1.1.1.18 - inositol 2-dehydrogenase
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myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
His176 and Asp172 are proposed to act as the catalytic dyad, in which His176 is proposed to be the acid/base catalyst
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myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
ordered sequential Bi-Bi mechanism in the absence of products, residues Y233, Y235, H176, and D172 are important for activity
myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
Lys97, Asp172, and His176 are the catalytic triad involved in the catalytic mechanism, overview
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