>O28964|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)|Swiss-Prot
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNA
KNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKA
GVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVV
GRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
>Q8THA9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)|Swiss-Prot
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAAKIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVVVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDINKVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDVREVAEQFINALNKPEIDQFRVMTDF
>Q0W644|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)|Swiss-Prot
MYQIGEALIGEGNEVAHIDLLIGDKNGPVGIAFANGMTQLSMGHTPLLAVVRPNLIPKPA
TLIVPKVTVKNMGQAAQIFGPAQAAVAKAVADAVEEGVVPKDLCEDVVIIVSVFIHPEAQ
DPTKIYKYNYGATKLALTRAMEKFPGVDKVTYEKDRGVHAIMGYKITRLWDAPYLQIAID
APDLGVVERVLKNVPKNDHLIIEAGTPLIKRYGLSVISKIREIRKDAFIVADLKTLDTGN
LEARMAADNLADAVVCSGLAPIATIEKFIEEARKVGIYSIIDTLNVENPAKLIAALKVKP
DIVELHRGIDTESQSAEHAWGNIPEIKKAAGGKKLLVAVAGGVKVENVETALKGGADILV
VGRSITNAKDIEGESRRFLQAMKKDEIDQYRIMTDF
>A7I6C9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)|Swiss-Prot
MYLVGEALIGEGAELAHIDLLLGSKEGPVGSAFANAVSQLSMGHTPLLAVVRPNLLTKPA
TVIIPKVTLKDMEQVNEMFGPVQAAVAKAIADSLEEGAFKDIDIEGIAIIASAFVHPEAK
DYNRIYRYNYGATKLALHRALDKFPDEKTLVYEKDRAAHGIMGFKVQRLWDPPYLQVAMD
LVDMGKVAQVLKEVPQNDHVIIEAGTPLIKKFGLNVIGEIRKLRPNAFIIADMKILDTGN
LEARMAADATADAVVVSGLAPTSTIEKAISEARKVGIYSIIDMLNVQNPAKLIEKLKVKP
DIVELHRAIDTEETAHAWGDIPAMKKAAGGKLLVATAGGIRVEVVKDALKAGADILVVGR
SITASKDIGHATDEFLDQLNREEIDQFRIMTDF
>Q46DY5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri (strain Fusaro / DSM 804)|Swiss-Prot
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALGGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISRIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKIAPKILVAVAGGVRLDKVPVALGQGADILVVGRA
ITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
>Q12UK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)|Swiss-Prot
MMLIGEALIGEAPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPVLSVIRPNLPTKPS
TLIVPKVTVKGMDQASQIFGPAQAAVSKAVADAVEEGLIPKEKAEDLVIIASVFIHPQAV
DYNRIYRYNYGATKLALKRALDGFPDIDTVLHEKDRAAHAVMGFKISKLWDAPYLQVALD
NPNLPVILNIIKQLPKSDHLILEAGTPLIKRYGVDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATLNKVIEEAHKTGIYAVMDTLNTPDPVAVLEQLDVLP
DVVELHRAIDIEGTAHAWGSIEGIKALAVKRSSKVLVAVAGGVRVDTISDALGAGADILV
VGRAITNSKDVRQAADRFIEGLNKPEIDQFRIMTDF
>Q2FQ74|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)|Swiss-Prot
MYLIGEALIGEGSELAHVDLIVGDKNGPVGMAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKNEGQVNQMFGPVQAAVAKAVADAVEEGLFGDININDICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEEFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDLGKLRSVLSSLPENDHLIIEAGTPLIKKFGLNVISEIRAVKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>Q58842|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)|Swiss-Prot
MIKFGEAVLGNEIKAIVNVALGKGELIENTFTNALTRGNCVFANLRPNLIVKPLTLVVPR
HNIESEIQDELFQGVIQYAVAKAVADLDLDEDLKVVVSVNVPEVPITNLNKRKLFQYFYA
SAKLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
QTIPNSDHIILEAGTPLIKKFGLEVIEIMREYFDGFIVADLKTLDTGRVEVRLAFEATAN
AVAISGVAPKSTIIKAIHECQKCGLISYLDMMNVSEPQKLYDSLKLKPDVVILHRGIDEE
TFGIKKEWKFKENCLLAIAGGVGVENVEELLKEYQILIVGRAITKSKDPGRVIRMFINKM
GYDIDTYRLYFDEDEDIGEEL
>Q8PXE1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)|Swiss-Prot
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A3CUG8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)|Swiss-Prot
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANSISQLSKGHTPLLAVVRPNLPTKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSIEEGVFEGVDIEDTVIMASVFVHPTAQ
DYNKIYRFNYGAMKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMNRVLDELPQNDHLIIEAGTPLIKKFGLSIISEIRERRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVIDMLNVKDPVAVVKQLKVKP
DVVELHRGIDVEDTAYAWGDIPAIKKAGGERLLVATAGGIRQGVVKDARKAGADILVVGR
AITASKNIQHAAEEFLEELSTEEIDQFRIMTDF
>B8GGX9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)|Swiss-Prot
MYQIGEALVGDGAELAHIDLIIGEKSGPVGIAFANGLSQLSAGHTPLLAVIRPNLLTKPA
TLIIPKVTLKNQTQVTEMFGPVQAAIAKGIADCIEEGTFKEYDIEDLVILASVYLAPEAK
DYNKIYRYNYGAIKLALNRALEGFPPEKTILYEKDRGAHAVMGFKVQRLWDAPYLQVAMD
LVDMGKVAKVLKEVPDNDHVIIEAGTPLIKRFGLSVISEIRKLRPNAFIIADMKILDTGN
LESRMAADASADAVVISGLAPASTIEKAIEETKKTGIYSIIDMLNVPNPVELIASLKIKP
DIVELHRAIDCETSCHAWGDIVAIKKAAGGKLLVATAGGVRVEVVKEALASGADILVVGR
AITASKDIRHATEEFLEQLHKDEIDQFRVMTDF
>Q2NE86|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)|Swiss-Prot
MSDIYEIGEALIGDGPELAHIDLIVGSKQGPVGTAFATNMASMSVGHTPLLSVIRPNLPT
KPATLIVPKVTVQNLDDASKIFGPAQTAVGRAVADAVEEEIIPKDIVEDIVLMVNVFIDP
SAKDYRKIYQYNYGATKLAIKRAFDKYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQV
ALDLDNEDRMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLD
VGRVEVKMAADETADAVAISGLGTNESIEKAIHECSKQGIYSILDMMNVSDIPSKLEELK
LKPNIVLLHRNIDSETMRDNDGEQQSEWGNIKDIKSKLGKRGLIAVAGGVTPEKVDTALA
NGANIIIAGRYIIGSSDVRRAAEDFLRYLPQDSDTMRLALDEDEKI
>O27518|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)|Swiss-Prot
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0B7U9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)|Swiss-Prot
MFLVGEALIGKEPEVAHIDLLIGDKNGPVGIAFANGLTQLSAGHTPLLSVIRPNLLAKPS
TLIVPKVTVKNMEQAAIIFGPAQTAVAKAVADAVEEGVIPKERAEELVIIVSVFIHPDAK
DYDAIYRYNYGATKLAIQRAMEGFPDVDKVLYEKERSVHPVMGYRVMRLWDPPYLQIAFD
IVDLAEVKRVLSEIPESDHLLIEMGTPLVKMHGVQVVREVRRARPGSFVVLDLKTLDTGN
LEVRLAADASADAVVISGLAPRKTIELAIKEAKKTGIYSIVDMLNVRDPVEVLRSLSVLP
DVVELHRAIDMENSEHAWQSIPEIKSLGGKILVAVAGGIRVDNVRDALRAGADIIVVGRA
ITRSKDVRDMTEQFLSQLKKSEIDQYRIMTDF
>Q46AU8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri (strain Fusaro / DSM 804)|Swiss-Prot
MFIKYAEVLNLVKNILKSMVGEALIGSGPEVAHIDLVIGPRGGSVEAAFMNSLAMPRQGH
TPLLAVLEPNIQPKPTTLIVNKVTIKNVSQAALMFGPAQAAVAKAVMDSVADGVLPEEQA
DDIFIIVSVFIEWDAKDKDKVYEFNYEATKLAIARAMEGRPTVEEALAKKDSANHPFA
>Q9FA38|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)|Swiss-Prot
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAMAVQDAVAEGIIPADEADDLYVLVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKASVVTEQRKSATHPFAANA
>A0A6J5DNH8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Burkholderia paludis|TrEMBL
MTASQPRQLYIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIAQP
GVPTKPLTLYVNKAQIAGDFHGNATWGASQAGIAKAVAEALENGTLPPEAENDWVVVSAN
WVNPQTDDLDAVFENNYRACRNAIVAAMEGLPHRDAVFAAARDVSNPFYTPKKN
>A0A7C0X0G6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Syntrophoarchaeum butanivorans|TrEMBL
MFKVGEALVGEGAELAHVDLVIGSKSSPVGIAFANSMAQLSAGHTPLFAVIRPNLPVKPS
TLIVPKVTIKNLDQASKVFGPAQTGVAKAIADAMEEGIIQKDEAEDQVIIVSVFIHPDAK
DYNKIYRYNYGATKLALKRALSGFPDADKVLYEKDRSTHPVMGFKVTKLWDPPYLQVALD
VPDWDLTSRVLAQIPKNDHLILEAGTPLIKRYGLDVITRIREIKPDAFIVADLKTLDTGN
LEARMAADLTADAVVISGLAPIETIDKAIEEAKKTGIYAVIDMLNVEDPVEVLKRLKTLP
EVVELHRAIDVELYGEGSNYAWGDIGAIKSLGDILVGVAGGIREDTLEIALKSGADILIV
GRAITKSKDVEAACRRFLRGLKKEEIDQYRVMTDF
>A0A660HSE2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina flavescens|TrEMBL
MFQIGEALIGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSIGHTPLLSVIRPNLPSKPS
TLIIPKVTVKNMEQASKIFGPAQTAVAKAVADSVEEGIISKDQVEDIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPSINTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLESVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQPDSISILKQLKVMP
DVIELHRGIDIESTEHAWGNIEEIKKVAPRALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAKQFINSLNKPEIDQFRVMTDF
>D3E107|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)|TrEMBL
MVKKDDTMFIGEALIGDGDELAHVDLLIGRKDGPVGNAFANGLSQLSVGHTPLLSVIRPN
LMTKPATIIIPKVTVGDLDDASKIFGPAQTAVGRAVADAVEEGIIPKNKAEEWVINASVL
ISPAAEDYRKIYQYNYAATKLAIKRALDGYPDMKKVLYEKDRGTHAIMGFKAIKLYEPPY
LQVALDLDNEEAMARIIKQLPNRERILLEAGTPLVKKFGVGIVGKIRELAPSAFIIADLK
TLDVGRVEVKMAADETADAVAISGLGTIESIEKAIHETRKQGIYSILDMMNVDNFTEKLQ
QINKDLMPDIVLLHRNVDLESKLRAEGKNLDDISAWGNIKEIKEITGGLAAVAGGITPEK
AEEAFEKGADIIIAGRYIIGSGDPRRAAEDFLAHMPVDPNHMRVVMEDDEQI
>A0A822ITM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGEAPELAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGVIPEDQVEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIIEARKTGIYAVIDMLNVDKPLSVIKGLSVKP
HVVELHRAIDTEGKAEHAWGDISAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>A0A2I0PJH1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriales archaeon HGW-Methanobacteriales-1|TrEMBL
MYKIGEALIGSGNEIAHVDLIIGDKESPAGAAFVNGMTQLSLGHTPLLSVIRPNLMTKPA
TLIIPKVTVGDLKDANKIFGPAQTAVGRAVADAVSEGIIPEDQAEDLVIMASVFIHPEAE
DFRKIYQYNYGATKLAIQRAMDGYPSMKKVMAEKDRGSHPIMGFKAIKLWNPPYLQVALD
LDNMDEMERIINTLPDRERILLEAGTPLVKKFGVGIVSKIRELRKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTIESIEKAIHEAQKQGIYSILDMMNVDNFVEKLKSLNFMP
NIVLLHRNVDLETMKAERGEEAGEMTEWGNIGEIKETLGANGLVAVAGGITPNKVEQALD
SEADIIVVGRYIIGSRDVRRSAEDFLEHMPQDPDTMRLALDEDESI
>A0A853B8C2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Amycolatopsis endophytica|TrEMBL
MTFAPTALVGESFVGTGVNAAHTNIVLGRKGGPVETAWATALATPSAGHVPFVAVLRPSV
PVKPLTLFVTKAAASGDLHERATWGSAQAGLAQGVADAAGHGLIPAAELDELLIIAAIWV
NPGVDDLDESFRNQRAAAFGALRAAVAGTPTADEVLAAARAGAANPFYEPGAALLAESAP
EAAR
>A0A833DR14|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus profundus|TrEMBL
MRIGEALIGQGYEVAHIDLIIGSKDGPVGYAFANALSQLSAGHTPLLAVLRPNLITKPPA
IIVPKVTIKDMKQAELIFGPAQAAVAKAIADAVEEGIIPKEEAENLVVIVSVFIHPKAKD
KNKIYYYNYGATKLALKRAMSGFPDVDTVLYEKDRAFHPLVGRKMTKLWDPPYLQIAFDL
TSLDEVLNVMKQIPESDHIIYEVGTPLAKKYGAEVILKLREIKPDAFYILDLKTLDVGKL
EARMAADATANAIVISGLAPIKTIIEGIKETDKTGIYAIVDMLGVEDPIKRLEKIKEAGY
LPNVVELHRAIDEEDAKPPWGLAKDIKEKFNVLVAVAGGIRPENVPEVIQAGADILVVGR
AITRARDVEGAVRRFLNYMKPD
>A0A2R5F384|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Novimethylophilus kurashikiensis|TrEMBL
MSIFDKILGLFGGGSSEAAPAAKPVAAGSRVIDRVLVGESLVIDNRPDGSGLDLLNVAHI
DLIIGPRGSAAERAFTRTLTTQRKGVNGLLAVVAPNMMTKPATVMFNKVTIKNGKQAVQM
FGPAQRGVAMAVMDSVAEGVIPANEADDVFICVGVFIDHKADIDERIQDWNYRATKEAIK
RAVNREPKVGDVVQTYKDPTVSHPFQAK
>A0A2I0PZ25|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriales archaeon HGW-Methanobacteriales-2|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAEDMVLIISVFIHPEAS
DYRKIYQYNYGATKLALRRAMGGYPSVNKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRALKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTGKLETLNYKP
DIVLLHRNVDLETMKAERGEEQADMTEWGNINQIKDLLGKNGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDEAI
>K2R6Z7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium formicicum (strain DSM 3637 / PP1)|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGAAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPKEDAEDMVLIISVFIHPEAS
DYRKIYQYNYGATKLALRRAMEGYPSVNKVLAEKDRGAHPVMGFKVTRLWKPPYLQVALD
LDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIISKIRELKKDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTEKLETLNLKP
DIVLLHRNVDLETMKAERGEEQAAMTEWGNINQIKDILGDNGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRHAAEDFLEKMPQDPDTMRLALDEDESI
>A0A257MFT9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. NSP1|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKEGPVATAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADSVAEGIIPKDRAEELLVIVSVFIHPQAK
DYDAIYRYNYGATKLALERAMAGFPDVDLMLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLAALPESDHILIEVGTPLVKMLGISVVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVPDPLAVLKGLEVLP
DVVELHRAIDMEKSAHAWSNIGEIQALAKDGRRLLVAVAGGIRVDTEAAALAAGANILVV
GRAITRSKDIRDMAEQFLTGLKQTEIDQYRVMTDF
>T2GJH4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. CaT2|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A2D3C6N3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus portucalensis|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEEADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAVDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLNELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGANILVVGRA
ITNSKDIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A133VT97|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|candidate division MSBL1 archaeon SCGC-AAA833F18|TrEMBL
MIKDEFSVGEALVGEEPELAHIDLAIGRKNSKIGQAFMDSLAQPRQGHTPILAVIRPNLP
VKPSTLILPKVTIRSLEDADKIFGPAQSAVAKAVADVVEEGVIPKEEAESLVIVASVFVH
PRGKDYSRIYRYNYGATKLAIKRAMEKFPSIDKVLEEKDKATHGVIGFRMNNLKNPPYLE
VALDIPDWRRVEGIIRSLPRSDSLIIEAGTPLIKRYGVEVVQKIRQLRPESVILADLKTL
DTGNIEARMAGDATANVVACSGLAPVNTMEKFIEECEKVGALSLIDTLNLSDPKTVLGKL
TVKPNIVELHRAIDVEEEEEARWGNIEEIRKVCGDDTLIAVAGGIRTKNAKKALDAGADI
IVVGRAITGAKDVAGAARAFLQQMGVEEVDQFRVMTDF
>A0A2S6S0T5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alphaproteobacteria bacterium MarineAlpha6_Bin4|TrEMBL
MFFKRLFNLGGIMAKINKVLVGESLVGDGNEVAHIDLLIGPRGSAAEAAFCNTLTNNKDG
FTSLLAVVAPNLPCKPNTVMFNKVTIKGAKQAVQMFGPAQAAVARAVADSVEDGTIPSGE
ADDVFVSVGVFIHWDAKSDQKIYDYNYQAVKESIERAIKGEPKAKDVVSQKASAEHPFGN
VKV
>F2KNT8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus veneficus (strain DSM 11195 / SNP6)|TrEMBL
MDIDMRVGEALIGEGYEVAHVDLLIGDKRGPVGTAFANALSQLSAGHTPLLAVVRPNLIT
KPPAVIVPKVTVRDLEQAELIFGPAQAAVAKAIADAVEEGVIPKEAAEDLVVIVSVFIHP
KAKNKHKIYYYNYGATKLALRRAMRGFPDVDKVLYEKDRSAHPFVGRKLTKLWDPPYLQI
ALDLTSLEEVIRVLQQIPESDHIIYEVGTPLAKRYGAEVILKLREVKPNAFFVLDLKTLD
TGNLEARMAADATANAVVISGLAPVQTIVKAIKEAEKTGIYSVVDMLNVEEPVKRLEKIS
EAGVMPNVVELHRAIDVEGIAPPPWTYAKEVKEKFNVLVGVAGGLRPENMGEAIAAGADI
LVVGRAITRARDIEGAARRFLVAMKPDTDQFRIMTDF
>A0A1F5DDZ6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon RBG_13_38_9|TrEMBL
MYLIGEALVGKEPEIAHVDLVIGTKDGPVGQAFANNIGNYSAGHTPLLAVVRPNLAAKPY
TLVIPKVTVQDISDAAKIFGPAQAGVGKAVVDAVEEGVIPKDVLDDWVILCSVFVHPDAK
DYRKIYQYNYGATKLAIKRALTKYPSLEKIMFDKDRATHPIMGFRIPRLWMPPYLQIALD
IPDLERTKRIITEVPKSDRVIFEAGTPLIKKYGASVIQELRDVAKNVFIVADLKTLDVGQ
VEVDLAFDETADAVVASGLASLQTLDNFIYETKRLGIYAYVDMMDVSSPVKVLESLKELP
DVIILHRGIDAERGSKTRWDLIKEIKTKFKDAKLLVAVAGGIEPSNVTNALKAGADILIV
GRYITQSKDIEHSAEEFLTQIGLDMDLFRIHTE
>A0A832NQD2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYLVGEALVGEGAELAHVDVLVGDLEGVLGSSLAQAMARVRMGHTPLPGVIRPNLLVKPF
TLIVPKVDLKNFSDVARVFGPVQYAVAKAVADAVEEGLIPVGDLDGIAVICGVYVDPEAR
DVNRLFHYNYSAVKLALKRAMSGFPSVERLLSEKDRSRHPLTRFRAPRLWMPPYLQVALD
NPDIEAIKRVVSQLPRSDRIILEAGTPLIKRYGLDAVRELRSMARDNFLIADLKTLDSGR
IEVDEAMEAGADGVVVSGLAPRDVLEEFIYEAERIGVYPILDMTDIPDPVRLLSNLKVLP
RVVIIHRGIDQEASTRIRWNLLGDLKARFSRILVAAAGGITPESIPAALSSGADILIVGR
YITQARDPRRAALEFLRRIGLDMDQLRIHVE
>A0A256XGZ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon ex4484_96|TrEMBL
MFKIGEALVGSGNEVAHVDLMIGEKEGVVGEAFANGLTQLSRGHTPLLSVIRPNLPAKPY
TLVVPKVTVQGMEDAEKIFGPAQAAVAKAIADSVEDRLIPENKIEDWVVIVSVFIHPEAK
DYRKIYQYNYGATKLALKRALLDYPNADKIKYDKDRAVHPIMGFKVPRLPRWNTPYLQIA
LDVPDISRVKNVIEQVPKSDKIILEAGTPLIKKYGAQVIKEIREVTKSDFVIADLKTLDV
GQVEVDLAYDEGADAVVASGLAAPEVLDKFIYEAHRLGIYAVVDTMNVEEPVSLVKELKE
APDIVILHRCVDAEGRQQPRWHLIKELKKNNPKLMVAVAGGIDPHSAPKAIKEGADIVIV
GRSITQSRDVEGSVRQFLDFMGGDIDLKRVHVE
>A0A7J4L1J2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocellales archaeon|TrEMBL
MYLLGEALIGEEPEIAHIDLVIGDKNGPVGMAFVNAMSHMSAGHTPLLAVIRPNLPTKPS
TLVVPKVTVQNLEQAAQVFGPAQTAIAKAVADAVEEGLIPKGKAEDLVLIVSVFIHPEAE
DYSKIYRYNYGATKLAIQRAMEGFPPVDKILYEKDRSIHPIMGFKIAKLWDPPYLQVALD
IPNMESTKKVLEELPESDHLILEAGTPLIKRYGLD
>A0A522V7B2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedens sp|TrEMBL
VKNILKQIPQSDHLIIEAGTPLIKRYGVEVVQSIREVRPNAFVVADLKTLDTGNLEARMV
ADATADAIVISGLAPVSTIEKAIKEAKKTGIYAVIDMLNVDKPLAVLKTLTVKPDVVELH
RAIDTEGKAEHAWGEVPAMKKLSERLLVAVAGGIRVDTVKDALKAGADIVVVGRAITKAK
DVRSMTEQFIEELKQPEIDQYRIMTDF
>A0A1D2X1A3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. WGK6|TrEMBL
MYEIGEALIGDGPELAHIDLIIGDKEGPVGTAFATNMASMSVGHTPLLAVIRPNLTAKPA
TLIIPKVTVQNLDDASKIFGPAQTAVGRAVADAVEEEIIPSDIVEDIVIMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRAFDKYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADQTADAVAISGLGTNESIEKAIHECSKQGIYSILDMMNVQDIPEKLEQLNLKP
NIVLLHRNIDSETMRDNDNEQASEWGNISEIKSKLGKRGLVAVAGGVTPEKVNKALSNGA
DIIIAGRYIIGSSDVRRAADDFLRYMPQDSDTMRVALDEDEEI
>A0A7R7AHD0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methyloprofundus sp|TrEMBL
MSILDKVFSFFSEGNSSMAKINNLRVGESLNGDGNEVAHIDLMMGPRGSAAESAFANCLT
NNKDGFSSLLAVVAPNLMVKPATVMFNKVTIKGSKQAVQMFGPAQRGVAMAVADCVEDGT
IPADEADDIFISVGVFIHWLAEDDAAIEKNNYDAVKASIKNAVAGTPTAAEVVAQKSTSE
HPFAANKV
>A0A839U7Z4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Phyllobacterium trifolii|TrEMBL
MAKINKVMVGESLIGDGNEVAHIDLLIGPRGSAVETAFCNALTNNKDGFTSLLAVIAPNM
ACKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVQDSVADGTIPADEADDLFICVGVFI
HWEAEDDAKIQDFNYRATKEALQRAVTGKPTAAEATAQRDSVKHPFSA
>A0A7J2ZGQ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Micrarchaeota archaeon|TrEMBL
MNIKIVSAKLNRGAILKSLSNPPYLQVALDIPDIEKVKRIVSELPKSEKIILEAGTPLVK
MYGCGVVSELRKVRDAFIVADLKTLDVGALEARIACEGKADGAVVSGLAFPLTIKEFVEE
ARRVGVCSFVDMMNVPNPLKVLKDAGALPDVVLLHRGIDAELSSKHAWGYLKGIKEKLRG
KALVGIAGGLELEQVKKSLQNGADVVVVGRYITKSSDVASAANSILELMR
>A0A832YWL7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGRDITAIVNVVLGKGETIDTVFTNALTRVPTPILANLRDNLIVKPLTLVVP
RNTLNSDIQCNLLHGPIQYGVAKAVVDLDLDEDLKLIVTVSVPDVPYTTLNKRKLFQYYY
GATRLAISRALNDYPSKEKIKREKYRALHPLVGFRDIRLERPPYLQVALDVPSMENVEYV
LESLPPSDRIIVEAGTPLIKKYGIEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGIMSYLDTINVRDPFGLYNSLELKPDVLLLHRAIDE
EEKVPMKEYRDVKRREKLLLGIAGGVTLENIEKLKNRYHIIVVGRGITKSRDPGRVARAI
VNKLGDDIDQYRLYLEEDEDVPIR
>A0A5E4J2U6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MIYPFVGTLVGEALVGEGPEIAHIDLVIGPSGGYVEQTFVHALASPAKGHTPLLAVLEPN
LPAKPSTLMVNKVTIKNAAQAILMFGPAQAAVAKAVMDCVGEGTIPEMLAEELFIIVSVF
IEWDAADKKKVYEYNYQATKLAIERAVARKPVASEVLARKDTAKHPFA
>A0A1V4V440|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaB.Bin039|TrEMBL
MFLIGEALIGKEPEIAHIDLIIGDKEGPVGAAFANGLTQLSAGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMDQAAQIFGPAQTAVARAVADCVAEGIIPRDQVEKLVVVVSVFIHPEAK
DYDALYRYNYGATKLALRRAMEGFPEIEKVLYEKDRSTHPIMGFRVTRLWDPPYLQVALD
LVDLSEVRRVLSSIPDSDHVLIEVGTPLVKMLGVSVVREVRAARPGSFVILDLKTLDTGN
LEVRLAADASADAVVISGLAPVKTIELAVREAKKTGIYSIIDMLNVKDPLAVLSGLEVLP
DVVELHRAIDMESSGHAWQDIPQIKALQKDGGRVLVAVAGGIRADTVKDALSAGADIVVA
GRAITRSKDIRDMAEQFLTQLKQSEIDQYRIMTDF
>A0A5K7X2R1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Lacipirellula parvula|TrEMBL
MSMFIGEALAGEGNEIAHIDLLIGDKAGPVGVAFANALARQSEGHSNLLAVLTPNLAVKP
ATVMITKVTIKGAKQAVQMFGPAQAAVAKAVADSVANGVIKKGDVENLVIVCGVFIHWEA
ADDKKIYDYNYEATVMAIKNAMEGKPNVDEMLAGKDAAAHPFRGF
>A0A1S9D0H1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Chromatiales bacterium USCg_Taylor|TrEMBL
MAVVDRVLVGESLVGDGNEIAHVDLIMGPRGSAVEATFCNALTNQKDGCSTLLALVSPNL
PCKPNTILFNKVTIKGAAQAVQMFGPAQRAVAMAVVDSVQSGIIPASEAEDIFICVGVFI
HWEAKDNKKIQDFNYQATKESIERAVKRLPKAMDVVAKKNTAHPFADHV
>A0A520KS82|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoliparum thermophilum|TrEMBL
MELRDDDFLYLVGEALVGEGDEVAHIDLIIGDKRGAVGDAFANGLVNLSKGHTPLLSVIR
PNLPPKPSTLIIPKVTIRDMNDANKIFGPAQSAVAKAVADCVEEGVIPKKDVERIVIIAS
VFIHPNAKDYEKIYRYNYGATKLAINRALSSFPDIDTVLYEKDRSINPIMGFSVQRLWNP
PYLQVALDLPELRRMQEVVEQLPDSDHIIIEIGTPLIKRYGIDVIDKIREKKPGLFIVAD
LKTLDTGNLEARIVADASGDAIVISGLAPIKTIEKAIYEAKKTGIYSVIDMLNVKDPISV
LSSLSIKPNVVEIHRAIDNESIEKEDWIIVKEIKSKFKNILVGVAGGLRPENVQKALDSG
ADILIVGRGITASKDVEGETRKFLKHLNTEEIDQYRVKTDF
>A0A8J8C0R8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Theionarchaea archaeon|TrEMBL
MIMKIGEALVGDGLEVAHIDLIIGEKDSAVGQAFVSSLAQPSHGHTPMLGVIRPNLPPKP
STLIVPKVTIRGFKDAGKMFGPAQAGVAKAVADAVEEGLIPREHCEDWVVIVSVFVHKDA
SDYRKIYQYNYGATKLAIKRAMDNYPSVDKVMKEKDRATHPIMGFRVYRLWNPPYLQVAL
DLTSEEQVRKIIEKLPLRERLLLEAGTPLIKNCGIEIVEKIRAMRQESFIIADLKTLDVG
RLEVKMAADATADAVCISGLGPNASIEKSIQEAYRQGIYSIVDFMNVPDIEEKLKSLKYK
PDIALIHRNVDVETAARERGEEPETKWGNITPIKKLVKLVSVAGGITPQTCGEALTKGAD
IIVVGRYIIRSYDPYQASRDFLEKMPPDPDTMRLILDEDEVVGT
>A0A7J4EJP4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MIGDKEGPVGIAFANSFSQLSAGHTPLLSVIRPNLPCKPNTLIVPKVTVKNMEQASKIFG
PAQTAVAKAVADAVEEGIINKESAEDLIVVVSVFIHPNAKDYNKIFRYNYGATKLAIQRA
MEGFPDVDTVLYEKDRAVHPVMGFKVTRLWDPPYLQIALDIPNIKFIKKVLRQLPENDHL
ILEAGTPLIKRYGVEVINQLREAKQNSFIVADLKILDTGNLEARMVADSSADAVVISGLA
PIPTIDKAIKEAKKTGIYSVIDMLNVEDPLKVLKSIKEYPEVVELHRAIDLENREHAWWQ
IKDIKALSKKMLVAVAGGIRVNTMQDALKAGADILIVGRAITKAKDVRLVAEQFLEELKK
PEIDQFRIMTDF
>A0A1V4Z4F5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocella sp. PtaU1.Bin125|TrEMBL
MYLIGEALIGEGNEIAHVDLLIGDKDGPVGTAFANGLTQLSPGHTPLLAVVRPNLIPKPA
TLIVPKVTVKTMTQVNQIFGPAQAAVAKAIADAVEEGVVPKDQLENVVIIASVFIHPDAE
DTARIYKYNYGATKLALTRAMDKFPSADKVTYEKDRGVHAIMGYKITRLWDPPYLQIAID
APDLGVVERVLRNVPKNDHLIIEAGTPLIKRYGLAVISKIRELRKDAFVVADLKTLDTGN
LEARMAADATADAVVCSGLAPLATIEKFIEEARKVGIYSIIDTLNVDNPAKLIASLKVKP
DIVELHRGIDTEGKAEHAWGNIAEIKKAAGGRKLLVAVAGGVKVENAATALKGGADILVV
GRAITNAKDIEGVSREFLEALHKEEIDQYRIMTDF
>A0A2S6S4V1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alphaproteobacteria bacterium MarineAlpha6_Bin2|TrEMBL
MFFKNLFKLGGISMAKINKVLVGESLVGDGNEVAHIDLIIGPRGSAAETAFCNTLSNNKD
GFTSLLAVVAPNLPTKPNTVMWNKVTIKGATQAVQMFGPAQTAVARAVSDSVEDGTIPSG
EADNVFILVGVFIHWDAKNDQKIYDYNYQAVKESIERAIKDEPKAKDVVAQKASAEHPFG
KVKI
>A0A284VSH1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedens nitroreducens|TrEMBL
MFLVGEALIGEEPELAHIDLIIGEKTGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVQEGVIPEDQVEDLAVVVSVFIHPEAK
DYNKIYRYNYGATKLAVERAMQGFPDTKTLMYEKDRTMHPIMGFKVIRLWNPPYLQVAID
IPDVDAVKSIIKQIPQSDHLIIEAGTPLIKRYGVNIVQAIREVRPNAFVVADLKTLDTGN
LEARMVADATADAVVISGLAPASTIEKAIKEAKKTGIYAVIDMLNVEKPLSVLKALGIKP
DVVELHRAIDTENKAEHAWGDIPAMKKLSERMLVAVAGGIRVDTVREALKSGADIIVVGR
AITKAKDVRSMTEQFLEELRQPEIDQYRIMTDF
>D3S0L9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Ferroglobus placidus (strain DSM 10642 / AEDII12DO)|TrEMBL
MEMRIGEALVGVGNEVAHIDLMIGTKDSPVAQAFANALSQLSAGHTPLLAVIRPNLITKP
PAVIIPKVTIKDMKQAELIFGPAQMAVAKAIADAVEEGIIPKEKAEDYLVVVSVFIHPKA
ENKHKIFYYNYSATKLALKRAMQNFPDVDTVLYEKDRSSHPLVGRKMTKLWDPPYLQIAI
DIPDLGEVKKVLAQIPESDHIIYEVGTPLAKRYGAEVILELREIKPNAFFVLDLKTLDTG
NLEARMAADATANAVVISGLAPISTIVKAIKEADKTGIYSVVDMLNVEDPLKRLEKIKEA
GVFPNVVELHRAIDSESEKPPWMLAKEIKKKYNVLVAVAGGIRPENVEEVISYGADIIVV
GRAITKAKDVEGAARRFLNYMKPDTDQFRIMTDF
>E3GYI9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)|TrEMBL
MYRIGEALIGKGNEVAHIELIIGKKDGKVGDAFVKGFTNASIGHVPLLSVIRPNLMTKPA
TLIIPKVTIRDMDDANKIFGPAQMAVGRAIADAVEEGIIPKEKVEELVVIVSVFVHPDAK
DYRKIYQYNYGATKLALRRAIEGYPPIDKILSEKDRSVHPIMGFKVPKLWNPPYIQVALD
MNDLNEMKRVINELPKRERLILEAGTPLIKKYGVHVVNEIRKLRKDAFIVADLKTLDVGR
LEVKMASDETADAVAISGLASIESIEKAIHETQRQGVYSILDMMNVSDIEGKLKKLRYKP
DIVLLHRSVDVETVKAERGEKIGEVTEWGNIKRIKSITNALVAVAGGITPDNVQKAIKSG
ADIIVVGRYITGSKDVRRASQEFLDQLPPDPDTMRLPLDEDESI
>A0A5S9NEQ1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Starkeya sp. HF14-78462|TrEMBL
MAKINKVLIGESLVGDGNEVAHIDLIIGPRGSAAESAFVNALTNNKDGFTSLLAVVTPNL
LAKPNTILFNKVTIKDARQAVQMFGPAQYAVAKAVVDSVAEGVIPEEEADDLFISVGVFI
HWEAADDAKIQQFNYQATKEALKRAVDGEPKIKDVLSQAASAKHPFAA
>A0A842MBH4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
TAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAEDYQKIYHYNYGATKLAIRRAMEG
YPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALDLESIEEMERIVDSLPPRERILLE
AGTPLVKKFGVGIVDKIRKLRKDAFIIADLKTLDVGRMEVKMAADETADAVAISGLATKA
TIEKAVHEARKQGVYSVLDMMNVENVPEKLEELRYKPDIVLLHKNIDVGAAEVSEWGDIP
KIKEIIGERGLVAVAGGITPSKTKKALESGADIIVVGRYITGSKDPRRAAEDFLEELPPD
PDTMRLPHEEDEAI
>A0A520K368|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon ANME-1-THS|TrEMBL
MISGGFLVGEALVGEEPEIAHIDLIIGNKRDAAGLAFATSFAQPRQGHTPILAVVRPNLP
VKPSTLLVPKVSIRNLQDAEKIFGPAQSAVAKAVVDAVEEGIIPRAEVEELVVIVSAFIH
PRGKDYQRIYRYNYAATKLALTRAMQQFPCIDKILEEKDKSIHAMIGFRMNNLKKPPYLE
VALDIPDWRRVEGIIRALPRTDALIIEAGTPLIKRYGVEVVQKIHQLRPETVVVADLKTL
DTGNLEARMAGDATADVVGFSGLAPLETMEKFIEECKKVGALSLMDTLNVHEPLEVLTKL
PVKPDIIELHRAIDIEKTQNLESEWGDIKLIKQVCENKILVAVAGGVRVSKVEKALNAGA
DILVVGRAITVAKDVNGAARAFLQKMGVEEVDQFRIMTDF
>A0A2V3JHI5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKTGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTLKNMEQASLIFGPAQAAVAKAVADAVEDGIVPTKQAEELVIVASVFIHPDAK
DYNRIYRYNYGAMKLALARAMDGFPGIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVKTLPDSDHLILEAGTPLIKRYGVDVIARLREVKPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPIPTIVNAIKEAHKTGIYAIIDTLNLPDPLPLLRELGEIG
TLPDVVELHRAIDAEKTEYQWGSIPEIKVISSKILVAVAGGIRADTIGAARDAGADVLVV
GRAITNAKDVRQAAEMFIEGLSKDEIDQFRVMTDF
>A0A843HFZ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
VIRPNLITKPATIIIPKVTVGDLDDASKIFGPAQTAVGRAVADCVEEGIIPKDKVEDWVI
NASVFISPAAQDYRKIYQYNYAATKLAIKRALKGYPDIDKVLYEKDRGTHAIMGFKAIKL
YEPPYLQVALDLDNEEAMARIIKQLPNRERILLEAGTPLVKKFGVGIVGKIRELAPSAFI
IADLKTLDVGRVEVKMAADETADAVAISGLGTIESIEKAIHETQKQGIYSILDMMNVDNF
TDKIKQLNPEFMPDIVLLHRNVDLESKLRAEGKNLDDVSAWGNIKEIKELTGGLAAVAGG
ITPEKAEEAFEKGADIIIAGRYIIGSGDPRRAAEDFLAHMPVDPNHMRVVMEDDEQI
>R7PUQ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter smithii CAG:186|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPSAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A7G9YSS0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon ANME-1 ERB6|TrEMBL
MTDERDELLIGEALVGEEPEIAHIDLIIGSKRGAAGAAFASSIAQPRQGHTPILGVIRPN
LPTKPMTLIVPKVSIRNLADAEKIFGPAQSAIAKAVADAVEEGVIRKSQAEEFVVIVSVF
IHPRGKDYQRIYRYNYAATKLALSRAVEKFPNIDKVLEEKDKSIHAMIGFRINNLKKPPY
LEVALDIPDWRRVEGIVRALPKSDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVFADLK
TLDTGNLEARMAGDATADVVGFSGLAPVSTMEKFIEECKKVGALSLMDTLNVPNPVKVLK
KLKVTPDIVELHRAIDVEQAQGSEWRNIGAVRKVCGNNVLVAVAGGIRVDKVEKALKAGA
DILVVGRAITAAKDVTGAARAFLQRMGVEEVDQFRVMTDF
>A0A7Y9U814|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Sphaerotilus montanus|TrEMBL
MAKIDRMMVGESLVGDGNEVAHIDLIIGPRGSAAETAFANALTNNKDGFTSLLAVVAPNL
LTKPATVMFNKVTIKGAKQAVQMFGPAQRGVAMAVADCLEAGTIPMDEADNLFISVGVFI
HWLAADDAKIQDYNYAATKEALERAVAGLPTPAQVVAGKASATHPFAAHA
>A0A679KI10|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium bullatum|TrEMBL
MSERIILRAGEALVAGGPPNTASEPEVIIGELDGPVGTALATLTGDQVVGHSRVFALLNT
DIMVRPVTLCVSKVSVTESKYTSILMGTVQFAIANGVLDAVRLGYIPKEKANDLGIICSV
WLSPGVIEAETVDHKALFEIQRKGMTEAIRKAMTNEPSIDWLLENQDKIIHKYYQMGLDG
KI
>A0A7K3YMT9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Crenarchaeota archaeon|TrEMBL
DLLIGDKNGPVGQAFANGITTLSAGHTPLLAVVRPNLPPKPHTLIVPKVTVKNMEDTGKI
FGPAQAAVAKAIADSSEEGIIPTVKLDEWVIIASVFIHPQATDYRKIYQYNYGATKMALQ
RALKKYPTIDKVNYEKDRAKHPIMGFKVPRLWRPPYLQIALDAPSIEGAKKVIEALPGSD
RIILEVGTPFIKRYGTKGINELRQMAKDKFIIADLKTLDVGKVEVDIAYEDTADAVVAAG
LAPAETLDATVQEAKRLGVYAVIDMLNVEDVLAKLKSIKDFPDIVILHRGIDQETGRSSG
LERIKMIREAFPNKKFLIAVAGGIVPETAKEALDKGADILIVGRYVTQSRDVERAVRDFL
ELTPAMREDIDLYRVHTE
>A0A2I0NMD0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon HGW-Methanomicrobiales-6|TrEMBL
MYLIGEALVGDGAELAHIDLLIGNKEGAVGQAFANSISQLSKGHTPLLAVVRPNLPTKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGIDIEDTVIMASVFVHPTAQ
DYNKIYRFNYGAMKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMQKVLEQLPQNDHLIIEAGTPLIKKFGLSIISEIRERRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVIDMLNVENPVAVIEQLKVKP
DVVELHRGIDVEETAYAWGDIPAIKKAGGERLLVATAGGIRQNVVKDARKAGADILVVGR
AITASKNIQHAAEEFLEELSTEEIDQFRIMTDF
>A0A0G3CCL7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri CM1|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFLHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKVAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A7T9HGG0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolinea sp|TrEMBL
MYLVGEALVGDGPELAHIDLIIGEKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKEGQVREMFGPVQAAVAKAVADFVEEGAFGTHDLESLVVLASVYLDPGAA
DFNRIYRFNYGAMKLALRRAMEGFPDRATILYEKDRSAHAVMGFKVQRLWDPPYLQVAID
LVEMKKVASVLSELPENDHLLIEAGTPLIKKFGLQVISEIRKIRPNAFIIADMKVLDTGN
LEARMAADSSADAVVISGLAPLQTLEKAIAEAKKTGIYSFVDMLNVADPVKVLKSLKAKP
DVVELHRAIDAEDTAHAWGDIPALKKAAGGKLLVATAGGIRVDVVRDAVRAGADIIVVGR
AITASKDPHTQADLFLEQLNREEIDQFRVMTDF
>A0A7C5K1V7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedenaceae archaeon|TrEMBL
MFLVGEALIGEAPELAHVDLIIGEKDGAAGTAFATGMAQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVKNMEQVAQIFGPAQNAVALAVADSVENGVIPVERVEDLVVVASVFIHPDAR
DYSKIYRYNYGATRLALERAMEEFPDIKTVIDEKDRAAHPIMGFKVTRLWDPPYLQVAID
IPEIGYVQRILKEMPESDHLIIEAGTPLIKRYGVNVVEQIREARPNAFIVADLKTLDTGN
LEARMVADATADAVVISGLAPTSTIEKAIREAKKTGIYSVIDMLNVKDPMKLLKSLAVKP
EVVELHRAIDLENTGALGLDVISEIKELSDKILVAVAGGVRVDKLSPTDQTIDEALQAGA
DIIVVGRDITKAKDVRLKTEQFLERMKKPEIDQYRVMTDF
>A0A7J3I1I4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
ALRRALQAYPPLEKVMYDKDRAVHPIMGFKVPRLWRPPYLQIALDNPSLEQALRVVSELP
KSDMIILEAGTPLIKRHGVSAVSKLREVAPDTFIVADLKTLDTAQVEVDLAYEETADGVV
ASGLASKESIDKFIYEAKRLGIYAFLDMMDVPDPIEKLKSLKELPDVLIIHRAIDTESSG
RRSRWELINEINNAFKGKKMLFAVAGGIVPETADEALDSGAHILIVGRYITQSKDVKRSV
REFLEILKKRIPGEPGDVDLLRIHVE
>A0A7J3J2G9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSGKDVKKPESREEFLRILTEAAKKEVEARSLLSGKPAKPTVSGTAKVLGVHRDTLYSWL
KEFDVDFEKATEGISAAEVSEIRQVSRGYTYLIGEALVGEGSEVAHIDLLIGDKDGPVGE
AFANGLAHLSMGHTPLLAVIRPNLPPKPHTLLVPKVTIRNLEDANKVFGPAQAAVAKAIA
DAVEEGIIPKDKVDDWVVVCSVFVHPKASDYRKIYHYNYSATKLALKRALAKYPPLEKVF
YDKDRAKHPMLGYRVPRLWRPPYLQISLDIPDLERTKKIIMQIPRSDRIILEAGTPLIKR
YGTKVISDLREVAKDIFIIADLKTLDVGKVEVDIAYEETADGVIAAGLAPTETLNAFIYE
AKRLGIYAAIDMLNVEDPIRKLKALKDFPDLVIIHRGIDEETGKTIGLELIQELRQTFRD
KRFLIAVAGGIIPETAKEALEKGADIIIVGRYVTQSKDIERAVREFLELTPEMREDIDLY
RVHVE
>A0A509EJV4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium symbioticum|TrEMBL
MSEIWFRTGEATVLAAEGQYTDAMPEVLIGSTRGPVGQAFASMMGQVQGHTRMFVVRDLN
QLVRPATMMTTKATIHTAEYVELLGGVVQAATGDAIVDCIIEGILPKEGLDELCMIIMIW
LDPRCADHDDLDQKDLYRTNYEATKLAIARALKGEPTVEELIANRKTVKHYALEDVIEY
>A0A1V5AUP8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaU1.Bin060|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGEKEGPVGTAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADAVAEGVIPKEKVEELVVIVSVFIHPAAK
DYDAIYRYNYGATKLALQRAMEGFPDIEKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDLAEVKRVLAALPESDHILIEVGTPLVKMLGINVVKEIRAVRPGAFVILDLKTLDTGN
LEVRLAADSAADAVVISGLAPKKTLELSINEARKTGIYSVIDMLNVPDPVAVLKELAVLP
DVVELHRAIDMEKSAYAWQNIPQIKELAKDGRRLLVAVAGGIRVDNESQALKAGADILVV
GRAITRSRDIRDAAEQFLAGLKQTEIDQYRIMTDF
>A0A8B6M1S7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylocella tundrae|TrEMBL
MAGLTIDRVLVAEALVGEGNELAHIDLIMGPRGSAAEIAFCNTLTNQKRGDNALLALVAP
NLMAKPMTLMFNKVEIKNATQATQMFGPAQRGVAKAVVDSVKAGIIPEAEAENVFICVGV
FIHWEAKDNTKIQDWNYEATKIAIARAVKGEPKIAEVIAQEDVMPHPLAAHV
>A0A7W6AHT2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium brachythecii|TrEMBL
MATINKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPAAEADDLFILVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKAATVTEQRNSAQHPFAANA
>A0A7L4RDU3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Micrarchaeota archaeon|TrEMBL
MLRTLDNPPYLQVALDTPDIESVKRVVSKLPKSDRILIEAGTPLIKRYGSEVISQLREIR
DDSFIVADLKTLDVGALEVRIAQQGGADAAVVSGLAFPLTIKEFINEAKKVGICSFVDMM
NVPDPLKALKDAQAVPNAVLLHRGIDSEAVAKHSWDNLKNVKEKLAGKALVGVGGGIELE
LAKKSIENGADIIIVGRYITGSSDVESAANSILKFMR
>D1J962|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MMNVGEALIGDGEEIAHIDLMIGDKSGPVGMAFTNALSQMSAGHTPVFAVIRPNLPVKPS
TVVVPKVTVRNMKEAEKIFGPAQSAIAKAVADSVEEGVIPEDKTEELVVIVSVFMHPHAD
DYNKIYRYNYGATKLALKRAMDGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALD
IPNWGHMERVVKDLPSNDHLIIEAGTPLIKRYGVDIVAKIKEIKSDTFVIADLKTLDTGN
LEVRMVADAGADAVVISGLAPLRTMEKAIEEARKTGIYSSLDMLNVKKPLAVLKELSVGG
MMPDVVELHRAIDVEQEERHAWGDIAEIKRIGGKMLVAVAGGIKEDTAPEAITGGADIII
VGRGITNSKDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A842T1D1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MPKTEFYIGEALIGDAPNLAHVDVMVGSKDGPVGYAFSQSLSQPSVGHGSLLAVIRPNLV
PKPQTLIIPKVTIKKMEEANKIFGPAQSAVAKAVADAVEEGIVPMDKLDDWVIIVNVFIH
PEGDDYRKIYQYNYGAVKLALRRALKNYPPIEKIFYDKDRAKHPVAGIKAPKLWRPPYLQ
VALDHPSIEHQTKVIQRLPKSDRIILEAGTPFLKKYGMDAITKIRELEPNKYIVADLKTL
DVGKLEVDDAFNAGADGVVCSGLASSASIDKFLLEAERLGIDGIIDMMEVPDPVQKLKSL
KQIPRVVILHRGIDAEQSTATSGSDEAQKKKWGFVPKIKELYAGNKLASGRDRVLVAVAG
GITPETADDALSMGADILIVGRFITSSKDIKNSTRRIINKLPGYSDVDLKRIHSEDDDEE
ALQKQLKENETTKP
>A0A223Z322|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. EMTCatA1|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A0E3NIA7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina thermophila CHTI-55|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIVPKVTVKNMEQASKIFGPAQTAVAKAVADSVEEGIISKDLVEDIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPSIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLESVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMP
DVIELHRGIDIENTEHAWGNIEEIKKVAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAEQFIMSLNKPEIDQFRVMTDF
>A0A498GSM2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. MSH10X1|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPSKPS
TLIIPKVTVKNMEQAAKIFGPAQTAVAKAVADSVEEGIISKDQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPNINTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNIEFVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISILKQLKVMP
DVIELHRGIDIESTEHAWGNIEEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVRDVAEQFINSLNKPEIDQFRVMTDF
>D9PTW9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTSLSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADAVEEGIIPEEKVEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMENYPSARKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSIEEMERIIDALPNRERILLEAGTPLVKKFGVGVVSRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLRYKP
DIVLLHRNVDLETLRAERGEDIGEMSEWGNIREIKDILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDESI
>A0A0E3NMQ6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. WH1|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQASKIFGPAQSAVAKAVADSVEEGVITKDQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNIEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPIFVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKVAPKALIAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDIREMAEQFINSLNKPEIDQFRVMTDF
>A0A2P0QNA2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured bacterium|TrEMBL
MAKINKVLIGESLVGEGNEIAHIDLMVGPRGSAAESAFANALTNNKDGFSTLLAVVAPNL
MVKPATILFNKVTIKGSKQAVQMFGPAQRAVAMAVADCVEDGTIPADEADDLFISVGVFI
HWQAEDDALIEKFNYQATKEALKRAVAGSPTAAEVVAAKSTAKHPFAVNNEG
>A0A7C3YHS3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Geoglobus ahangari|TrEMBL
MFRIGEALVGTGNEVAHIDLLIGSKDGPVGYAFANALSQLSAGHTPLLAVIRPNLITKPP
AVIIPKVTIKDMKQAELIFGQAQMAVAKAIADAVEDGIIPKDKAEDLVVIVSVFIHPKAE
NKEKVFYYNYSATKLALKRAMEGFPDVDKVIWEKDRSFHPLVGRKLTRLWDPPYLQIAID
IPDLDEVFKIIRQIPESDHIIFEVGTPLAKRYGAEVILELRKERPDAFYVLDLKTLDTGN
LEARMAADATANAVVISGLAPLNTIKKAIEEVKKLGIYSVVDMLNVEDPVKRLDKIVETG
ILPDVVELHRAIDSETEEPPWKFAKEIKEKYNVLVAVAGGIRPENVEEVIREGADILIVG
RAITKARDIEGATRKFLKYMKPDTDQFRIMTDF
>A0A0F8KBF0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A497IK68|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLVGEALIGEAPELAHVDLIIGEKDGAAGTAFATGMAQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVKNMEQVAQIFGPAQNAVALAVADSVENGVIPVERVEDLVVVASVFIHPDAR
DYSKIYRYNYGATRLALERAMEGFPDIKTVIDEKDRAAHPIMGFKVTRLWDPPYLQVAID
IPEIGYVQRILKEMPESDHLIIEAGTPLIKRYGVNVVEQIREARPNAFIVADLKTLDTGN
LEARMVADATADAVVISGLAPTSTIEKAIREAKKTGIYSVIDMLNVKDPMKLLKSLDVKP
EVVELHRAIDLENTGALGLDVISEIKELSDKILVAVAGGVRVDKLSPTDQTIDEALQAGA
DIIVVGRDITKAKDVRLKTEQFLERMKKPEIDQYRVMTDF
>A0A1V4Y9Y7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomethylovorans sp. PtaU1.Bin093|TrEMBL
MLLVGEALIGEEPELAHVDLIIGDKNGPVGLAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIVPKVTVKNMGQAAQIFGPAQAAVAKAVADAVEEGVIDKKDVEDLVIVASVFIHPEAT
DYNRIYRYNYGATKLALKRAMEGFPSVETVMKEKDRAAHGIMGFKVTRLWDAPYLQVALD
NPNIAAIRSIVAQIPKSDHVILEAGTPLIKRYGVDVISQLREVRPDAFIVADLKTLDTGN
LEARMVADATADAIVISALAPVSTLQKAIEEAHKTGIYAVMDTLNCEDPVAVLSELKKMG
SLPDVVELHRGIDIEETEHAWGNIADIKAFSTESHKVLVAVAGGIRIDTMPVALEAGADI
LVVGRAITNAKDVRQVAEKFIEGMNKSEIDQFRVMTDF
>A0A7L4P242|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
MYLIGEALIGNGNEIAHIDLVIGDKNGPAGTAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPKDNAEDMVLIISVFIHPDAT
DYRKIYQYNYGATKLALRRAMEGYPSVDKVLAEKDRGTHPIMGFKVTRLWKPPYLQVALD
LDNLQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELRKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTPESIEKAIHEAQKQGIYSILDMMNVENFTEKLETLNYKP
DIVLLHRNVDLETLKAERGELQEEMTEWGNISQIKDILGERGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRHAAEDFLEKMPQDPDTMRLALDEDESI
>A0A832YY78|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus profundus|TrEMBL
MRVGEALIGQGYEVAHIDLIIGSKDGPVGYAFANALSQLSAGHTPLLAVLRPNLITKPPA
IIVPKVTIKDMKQAELIFGPAQAAVAKAIADAVEEGIIPKEEAENLVVIVSVFIHPKAKD
KNKIYYYNYGATKLALKRAMSGFPDVDTVLYEKDRAFHPLVGRKMTKLWDPPYLQIAFDL
TSLDEVLSVIKQIPESDHIIYEVGTPLAKKYGAEVILKLREIKPDAFYILDLKTLDVGKL
EARMAADATANAIVISGLAPIKTIIEGIKEADKTGIYAIVDMLGVEDPIKRLEKIKEAGY
LPNVV
>A0A257MKG6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. ASM2|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKEGPVATAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADSVAEGIIPKDRAEELLVIVSVFIHPQAK
DYDAIYRYNYGATKLALERAMAGFPDVDLMLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLAALPESDHILIEVGTPLVKMLGISVVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVPDPLAVLKGLEVLP
DVVELHRAIDMEKSAHAWSNIGEIQALAKDGRRLLVAVAGGIRVDTEAAALAAGANILVV
GRAITRSKDIRDMAEQFLTGLQQTEIDQYRVMTDF
>D1Z2Q4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)|TrEMBL
MYLVGEALIGEGNEVAHIDLLVGDKAGPVGMAFANGMTNMSAGHTPLLAVVRPNLIPKPA
TLIVPKVTVKNLEQAAQIFGPAQAAVAKAVADAVEEGIIPKDQVESIVIIVSVFVHPAAK
DYTRIYKYNYGATRLALVRAMESFPPVDKVTFEKDRGTHAIMGYKIMRLWDPPYLQIAID
APDLGVVERVLMQAPKNDHIIIEAGTPLIKRYGLEVISKIRAIKKDAFIVADLKTLDTGN
LEARMAADATADAVVCSGLAPLETIEKFCEEARKVGIYSIIDMLNVDNPAKVVEALKHKP
DIVELHRGIDTEGQKAEHAWGNIAGIKKAAGGKKLLVAVAGGVKVENVEVAMKGGADILV
VGRAITNAKDIEGATRAFLRAMHKDEIDQYRIMTDF
>A0A833Q3P4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Burkholderia gladioli|TrEMBL
MTATPRKSLYIGEGFEGPGVNLAHINVLIGPREGPAGQAFSTALATPSAGHAPFVVIAQP
GVPTKPLTLYVNKAQIANDFHGNATWGASQAGIAKAVAEALESGTLPPEAENDWVVVTAN
WVNPQTDDLDAVFENNYRACRNAIVAAMEGLPLRGKVFAAAREVSNPFYTPNKS
>A0A7C1DTS1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp|TrEMBL
MYFIGEALVGEGAELAHIDLLIGDKSGAVGTAFANAASQMSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKEQQVNQMFGPVQAAVAKAVADALEEGIFGDVDVEDVVILASAFLHPDAS
DYNRIYRYNYGATKLAITRAFGGFPDTATLIKEKDRAAHAVMGFKVARLWDPPYLQVAMD
LVEMKQVEAVLTALPKNDHLLIEAGTPLIKQFGLSIIAEIRRMRPDAFIIADLKTLDTGN
LEARMAANSSADAVVISGLAPIATLEKAITEAKKTGIYSVIDMLNVPNPVDIVSELAERG
VLPDVVEMHRAIDTEGEEYNWGDIPAIRKAAGDRILIATAGGIRQHVVKDALGAGADIIV
VGRAITASKNIQNAAEGFLDEMNKPEIDQFRVMTDF
>A0A842XY73|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedenaceae archaeon|TrEMBL
MFLVGEALIGQEPELAHIDLIIGEKTGPVGQAFANGFTQLSQGHTPLLSVIRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVQEGIIPEDKLEELSIVVSVFIHPDAK
DYSKIYRYNYGATKLAIERAFSGFPDSDTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAID
IPEINAVKRILSQIPASDHVIIEAGTPLIKRYGVDVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAVVISGLAPVPTLEKAIKEAKKTGIYAVIDMLNVHNPVEVVKQLSVKP
DVIELHRAIDTEGAEAKHAWGDIPELKKLSERMLVAVAGGIRVDTVKDALKSGADIIVVG
RAITNSKDVRSMAEQFIEELKQPEIDQYRIMTDF
>A0A846UBX6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Rhizobacter sp. SG703|TrEMBL
MAKIDRMMVGESLVGDGNEVAHIDLLIGPRGSPAESAFANALTNNKDGFTSLLAVVAPNL
LTKPATVMFNKVTIKGAKQAVQMFGPAQRGVAMAVADCVEDGTIPMAEADNLFVCVGVFI
HWLAEDDKKIQDYNYRAVKESIKRAVAGSPTASEVVAKKGSSAHPFAAA
>A0A498H3B3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus taiwanensis|TrEMBL
MYLIGEALVGEGAELAHIDLIIGDKNGAVGQAFANAFSQLSAGHTPLLGVVRPNLMTKPA
TLVIPKVTLKKEAQVNQMFGPMQAAVAKAVADSVEEGVFEGIDLEDIVILASVFMHPSAE
DYNRIYRFNYGAMKLAVRRALDKFPDTGTLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDMRQVERVLSELPQNDHLLIEAGTPLIKKFGLSVIGEIRKLRPNAFIIADLKTLDTGN
LEARMAADAGADAVVISGLAPVSTIEKAISDTKKTGIYTVVDMLNVEDPVGLIASLAVKP
DIVELHRAIDVEGTEHAWGNIPAIKEAGGKRLLVATAGGIRQHVVKKALASGADILVVGR
AITASKNIQHAAEEFLEELSQEEIDQFRIMTDF
>A0A7C3U843|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MFAVGEALIGSGGEVAHVDLLVGDKNGPVGQAFANGMAQPSQGHTPLLAVIRPNLLTKPC
TLIIPKVTVKDLEQAAKVFGPAQYAVAKAIADSVEEGVIPADKLDEWVIICGVFVHPEAK
DYRKIYQYNYGATKLALKRALENYPSVDKIMYEKDRAVHPIMGFRVPRLWKPPYLQVALD
IPDIEHVKQVIRQIPSSDQLILEAGTPLIKKYGLRVVREIREVAGNAFIIADLKTMDVGQ
VEVDLAFEETADAVVVSGMASKQTIEKFVDEAKKCGIYAFLDLSNVEDPISLLKSLKEPP
EVVLVHRPIDTEHEAKQRWELIEDLKKAVDKKILVAVAGGITPENVQKVLKLGADIIVVG
RYITQSRDVTHAAREFLQYMGGDIDLFRVHYATE
>A0A832TKQ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MANENVERTGKAYLIGEALLGEGNELAHVDLLIGDKDGPVGKAFAQGLTNLSAGHTPLLA
VIRPNLPPKPYTLLVPKVTVKNMEDAGKIFGPAQAAIAKAVADSVEEGIIPRDKLDEWVI
VCSVFIHPQASDFRRVYQYNYGATRLALKRALTGYPSLDKMLYDKDRAKHPIMGFKVPRL
WRPPYLQISLDAPEIEKAKKVLAEIPGSDRIIIEVGTPLIKRYGTRVINELRQTNKDAFM
VADMKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLDAFVHEAKRLGIYGVIDMLNVENP
IEKLKSLKEFPEIVILHRGIDQETGRTSGLERIQIIRKTFTDKKFLIAVAGGIVPETAKE
ALEQGADILIVGRYVTQSKDVERAIRDFLELTPKMREDIDLFRVHVE
>A0A3R7AR29|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLVNAAKKEVEARSILKGKRAKPTISGTAKILNVHRDTLYSWLKEFNVDFKEVVNGLTQS
LSVGKYTYLIGEALVGEGNEVAHVDLLIGDKDGPVGEAFAAGLAHLSMGHTPLLAVIRPN
LPPKPHTLLVPKVTVKNLEDANKVFGPAQAAVAKAVADAVEEEIIPKDKVDDWVIICSVF
VHPQAKDYRKIYHYNYSATKLALKRALAKYPSLEKIFYDKDRAKHPIMGFRVPRLWRPPY
LQISLDIPDLERTKKIIEQIPKSDRIILEVGTPLIKRYGTKVINQLREVAKDVFFIADLK
TLDVGKVEVDLAYEETAEAVVAAGLAPPETLNAFIYEAKRLGIYAAVDMLNVENPVKKLK
TLKEFPDIVILHRGIDQETGRTIGLENIQKLRQAFKDKKFLIAVAGGIVPLTAKEALEKG
ADIIIVGRYITQSKDVERAVREFLEITPTMREDVDLFRVHVE
>A0A5B9M5C9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. KEPCO-1|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTSLSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADAVEEGIIPEEKVEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMENYPSARKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSIEEMERIIDALPNRERILLEAGTPLVKKFGVGVVSRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLRYKP
DIVLLHRNVDLETLRAERGEDIGEMSEWGNIREIKDILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDESI
>A0A6A2FBF8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedens sp|TrEMBL
MFLIGEALIGEAPELAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGVIPEDQVEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIIEARKTGIYAVIDMLNVDKPLSVIKGLSVKP
HVVELHRAIDTEGKAEHAWGDISAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>A0A0E3QFT1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri str. Wiesmoor|TrEMBL
MGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPSTLIIPKVT
VKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFIHPDAQDYNKIYRY
NYGATKLAIKRALGGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFDNPDIEFVQ
SAISQIPKSDHVIIEAGTPLIKRYGMDVISRIREVRPDAFIVADLKTLDTGNLEARMVAD
AAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRG
IDIEATEHAWGNIAEIKKIAPKILVAVAGGVRLDKVPVALGQGADILVVGRAITNSKDVR
EVAEQFINSLNKPEIDQFRVMTDF
>A0A0H2M8B9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Variovorax paradoxus|TrEMBL
MTHPYLFHAGEATVLAKEGQFTDAMPEILIGATDGPVGQAFANMMAQSKGHTAMFAIRAC
NQLVRPATIMVPKVTLKDVANIDLFGGVVQSATADAVVDCLIEGIIPREYANTLCIISLV
WIDPRCAKDQDLDKKDMYRTNYEATKLAIRRALNNEPSVDELIANRHRIKHDMDDWS
>A0A842TJ25|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MYLIGEALLGQGNEVAHIDIMIGDKNGPVGNAFANALSQLSAGHTPLLAVIRPNLPPKPY
TVIIPKVTVKNMDDANKIFGAGQSAVAKAVADSVEEGIIPKDKVDDWVLIVSVFIHPQAS
DLRKIYNYNYGATKLAISRAINKKPDLDRILWDKDRAKHPILGFNVPRLWRPPYLQIAFD
ITSYKRIENIVNSIPDSDRVIVEIGTPLLKKYGTKVISKLREIAKDSFMVCDLKTLDVGR
IEVLLAFEETADAVVASGLANTKTLDVFIDEAKRLGIYSFIDMMNVSDPVELLKTLKNLP
DVVILHRGIDTEEENAKPRWDLIGDIKALNKKILVAVAGGISPITMDDALKKGADIIIVG
RYITQAKDPERAVREFLHGFESVLSEVTKEWGEVDQFRVNLDVD
>A0A5E6PZR0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas fluorescens|TrEMBL
MKTLDLYIGEGFEGPGVNAAHINILIGPRNGPAGQAFANSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAEISSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGTPYTAQLADVVNHISNPFYTPKA
>A0A8J8CM41|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Asgard group archaeon|TrEMBL
MADFFIGEALQGKGDELAHIDLMIGDKDGPVGHAFANGMTQLSQGHTPLLALIKPNLCPH
PRTLIVPKVTIDNLEQAGKIFGPAQMAVAKAVADAAAEGDIPQSKLFDYVVIVSVFIHPK
ATDESKIYYYNYGATRLAIKRALSDYPPMKKLIAEKDRARHPVMKFRPQTLWNPPYLQVA
LDVGSLSAAVKIVEQLPRSDRIIIEIGTPYIKKYGIEDTIGRMRQIKPGAYIIADMKTMD
VGRAEVGAAADATANAVVVSGIAPAQTITEFIRECNKRGVHAWIDSLNTKQTELITMLEG
LKEKPKVVILHRGIDQEEGTKKEGTSASRSVWGDIKKIKKITGGLAAVAGGLKPGKPLSD
ALKADADIVIVGRYIYRSSDPHRAAMRFLDDMEIEADTMRLFDKLDY
>A0A0F8D922|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 2.H.T.1A.6|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A2P0QMN3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured bacterium|TrEMBL
MVKPATILFNKVTIKGSKQAVQMFGPAQRAVAMAVADCVEDGTIPADEADDLFISVGVFI
HWQAENDALIEKFNYQATKEALKRAIAGSPTAAEVVAAKSTA
>A0A7C4G3J0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MNREEAFYVGEALIGIGDEVAHIDLIIGHKNGPAGIAFTNALTNISAGHTPLLAVIRPNL
AVKPSTIVIPKVTVKSLEDANKIFGPAQAAVAKAVADAVEEGIIPMDKCEDWVIIASVFV
HPKAKDYRKIYQYNYGAAKLAIRRALQGYPDALKVLREKDRAIHPIMGFKISKLWNPPYL
QVALDIDSLEQVEKIIKELPVRERIIYEAGTPLIKAYGVYSVVDKIREYRRDAFIIADLK
TMDVGRMEVKEAADATANAVCILGVASKATIERAIQEAKKQGIYAVLDMMEVKNVKARLE
TLSIKPDIVVLHRSVDVEREIAERGLKPETEWGDIKGIKDEFKCKVAVAGGITPETAIKA
LNGGADIIVVGRYIVRSHDPRRAAEQFLDQMPPDADTMRLILDEDEVIGE
>A0A7G9Y7E1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MLIGEALIGEEPELAHVDLIIGEKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLLTKPAA
LIVPKVTVKNMEQAARIFGPAQSAVAKAIADALGEGILPKEEVEDLVIVASVFIHPDAKD
YNRIYRYNYGATKLALKRAMDGFPDVDTVLEEKDRSTHAIMGFKVSRLWDPPYLQVALDN
PNITQILGVVEALPDSDHLILEAGTPLIKRYGVDVIAKLREAKPNAFIVADLKTLDTGNL
EARMVADATADAVVISALAPTSTIEKAITEAHKTGIYAVIDTLNLPDPLPKLVELDKLGA
LPDVVELHRAIDIEETEHQWGSIPAIKELSDKILIAVAGGIRTDTIHDAITAGADILVVG
RAITNAKDVRQVAERFIEGLSKDEIDQFRVMTDF
>A0A2H6JXD9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon BMS3Bbin15|TrEMBL
MYNMFIGEALIGEGYEVAHIDLIMGDKNGVVGQAFASGLSHLSSGHTPLLSVIRPNLPPK
PYTLVVPKVTVKAMGDVEKIFGPAQAAVAKAVADSVEEGIIPMEKLDEWVIVVSVFIHPE
ATDYRRIYHYNYSGTKLAIKRAMTNYPSWDKIKFDKDRATHPIMGFKVPRLWRPPYLQIA
LDVPNIDNAKNVIKNIPKNDRIILEAGTPLLKRYGTKVINDLREVAKDSLFIADLKTLDV
GKIEVDLAYDETADAVVVSGLATSQTIDKFIYEARRLGIYAVVDMLNVESPLDRLKSIKE
LPDVVILHRAIDAESEEDQRWKWVRMIKEEFKGEKILIAVAGGITPQTASEALKNGADIL
IVGRYITQSKDVRKSTIDFLDVLSRELPKEPGDIDLFRVHVE
>A0A520KN52|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanonatronarchaeia archaeon|TrEMBL
MFKVGEALIGEEPELAHIDLVIGDKSGPAGQAFLNGLTNLSEGHTPLLGVIKPNLPAKPS
TLIVPKVTIRDMNDTEKIFGPAQEAVSKAVADSLEEGIIGEEEAEDIVIIASVFIHPEAS
DFQKIYRYNYGATKLAIKRALDGFPEPSKVIEEKDRGGHPIMGNRITRLSSPPYLQVALD
TTDFNHVEKILREVPENDHVIFEVGTPLVKKYGVDVVSRMREIREDAFIVVDLKTLDTGN
LEARMVADAGGDGVVVAGIASKPTIEGVIEEADKTGIYSIIDTINMEHPLQMVKELDKKP
DIVELHRAIDLEDEAEHAWGDIPGIKKELDSGLVSVAGGLKSQNVSQAIKSGADILVVGR
AITGAKDPEGAAREIIDEMQTTEVDQFEIKTDL
>A0A3N5C088|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter gottschalkii DSM 11977|TrEMBL
MDPMYKIGEALIGDGPELAHIDLLIGDKFGPIGQAFANGLSNLSVGHTPLTSVIRPNLMT
KPATLIIPKVTVGDLDDAGKIFGPAQTAVARAVADAVEDGYIPKEIVEDIVINVSVFIDP
SAKDYRKIYQYNYGATKLAIRRAMEDYPSIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQV
ALDLDNEDAMERIINDLPDNDRILLEAGTPLVKKFGVGIIGKIRALRPDAFIIADLKTLD
VGRVEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAGFEEKLAKLP
KDLKPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKSMLGDKGLVAVAGGIRPNNA
EEAIEKGANIIIAGRYIIGSKDVRRAAQDFLEHFEPDPDNMRLAMDEDENIEVKDD
>A0A8F7ZKM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylovirgula sp. HY1|TrEMBL
MAARKIDSVLVGEALVGDGHEVAHIDLIMGPRGSAAEAAFCNTLTNQKVGDNALLALVAP
NLMTKPATVMFNKVDIKNGDQAGKMFGPAQRGVGKAVIDSVKSGVIPKNEAADVFICVGV
FIHWEAKDDAKIQDWNYQATKLAIERAVKGEPSIDDVISKEDVELHPLAAHG
>A0A811TBS9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Argoarchaeum ethanivorans|TrEMBL
MFLIGEALIGSAPELAHIDLVIGDKNGPVGSAFAAGMTQLSAGHTPVLSVIRPNLLTKPA
TLIVPKVTMKKTEQVNQIFGPAQNAVALAIADSVEEELIPQDKAEEWVVIASVFIHPDAK
DYSKIYRYNYGATKLAIQRAMEQFPSINTVLDEKNRAAHPVMGFKVTRLWDPPYLQVAID
VPDIDYVQQILKEMPQSDHLIIEAGTPLIKRYGVDVIEKIREARNNPFIVADLKTLDTGN
LEVRMAADATADAVVISGLAPTSTIEKAIKEAKKTGVYSVIDMLNVKDAAGLIDNLSVKP
NIVELHRAIDLENTVATGWDSIQKIKKISGKILVAVAGGIRIDKLKPSDHTVDEALAAGA
DIIVVGRDITKAKDVRLKTEQFLEHMKKPEIDQYRIMTDF
>A0A843EXA9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
AIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALDLDSKEAMAKILNDLP
DKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLDVGRVEIKMAADATADAVA
ISGLGTIESIKKAIHETQKQGIYAILDMMNVSDFEDKLSQLPDDLKPDIVLLHRNVDLET
YKAEKGEDVSEMTEWGNIKKIKEILGGGLIAVAGGITPDNVEEAIDKGADVIIAGRYIIG
SRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN
>A0A133U6F6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|candidate division MSBL1 archaeon SCGC-AAA259D14|TrEMBL
MFKVGEALVGDEPNLAHIDLVIGEKDGPAGQAFLNSLSKPSQGHTPLLSVIRPDLPAKPS
TLLVPKVTIRDMEDADKAFGPVQEAVSRAVADSVEEGVIPKEQAEELVVIVSVFIHPEAD
DFQKLSRFNYGATRLAIRRAMEGFPDVDKVLEEKDKGGHPIMGTRTVKLRNPPYLQIAMD
KPAIEQQLNLMEQLPESDHLIVEAGTPLIKKYGIKVIEELRKKDEDAFIIADLKTLDTGH
LEAEIAADAGADGVVISGLADVNTIEKAAREADKCGIYCILDTLNVENPVDLLEKLEDKP
HIVELHRGIDEEYAGKEHSAWGDIPAIKEMTKEKLVAVAGGITQETIGEAIGAGANILVV
GRAIANSKDPESKTRDFLESMGKAWSESEKEKFGDIEQFRWRTDF
>A5UMJ0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPAAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A520KV38|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanolliviera hydrocarbonicum|TrEMBL
MYLIGEALIGEGDELAHVDLMIGGKEGPVGMAFTNGMVNLSRGHTPLLSVIRPNLPTKPS
TLIVPKVTIQDMEDANKIFGPAQTAVAKAVADSVEEGVIPRDIVEKIVVVVSVFVHPAAK
DYEKIYRYNYGATKLAIQRAFESFPDVDTVLYEKDRSTHPIMGFRVTKLWDPPYLQVALD
LTDIDKALSVVSQLPDSDHLILEAGTPLIKRYGIDVVNRLRENKPGIFIVADLKTLDTGN
LEVRMTADASADAVVISGLAPVSTIEKSIKEAKKTGIYSVIDMLNVKDPLGVLKSLSMNP
DVVEIHRAIDNESSEKERWDLIEKIKKEFSDILVGVAGGIRPENCQEALESGADILIAGR
AITAAKDVEGAARKFLKMFKGEIDQFRIKTDF
>A0A2I0PG59|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon HGW-Methanomicrobiales-3|TrEMBL
MYLVGEALIGDGAELAHIDLLMGDKEGPIGSAFANSVSQLSMGHTPLLAVVRPNLLTKPA
TLVIPKVTLRDMSQVNEMFGPVQAAVAKAVADCVEEDLFKGIDIESVVIMVSAFVHPDAK
DYNKIYRYNYGATKLALHRALDKFPDTKTLVFEKDRAAHGIMGFKVTRLWDAPYLQVAMD
LVDMGKVAEVLKSVPQNDHVIIEAGTPLIKKFGLSVIGEIRKLRPNAFIIADMKILDTGN
LEARMAADATADAVVVSGLAPMSTIEKAISEARKVGIYSIVDMLNVTSPVKLIQSLKVKP
DIVELHRAIDVEESAHAWGDIPALKKAAGGKLLVATAGGIRVDVVKDALKAGADILVVGR
AITASKDIGHAAEEFLDKLNKEEIDQFRVMTDF
>A0A1D2R448|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon WOR_SM1_86-2|TrEMBL
MYKIGEALVGKDNEIAHIDLLIGDKEGYVGQAFAQGLVNLSKGHTPLLGVIRPNLPPKPH
TLIIPKVTVEDMGDAGKIFGPAQSGVAKAVADAVEEGIIPEDKIDDWVIIASVFIHPEAK
DYRKIYQYNYGATKLALRRAISDYPSLNKINYEKDRATHPIMGFKVPRLPRWNTPYLQIA
LDVGSSKTAEGIVKKLPPSDKIILEIGTPLIKAEGVKAVSKLREAAPNAFIIADLKTLDV
GQVEVDLAFDETADAVVASGLAGTEMLREFIYEAHRLGIYAMVDTMNVPDPVKLLKSISE
DSKEKYDASIPKAPKPPQMPDIMLLHRGISGESEKEVGAEWDRINEIKEFAKKKGKDLLV
AVAGGIEAQNAREALDKGADIIVVGRYITQSKDVERSVRAFLYEMGAKASDIDLKREHIE
>A0A7C3TKZ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Nitrososphaerales archaeon|TrEMBL
MTDFLVGEALIGEEPEIAHIDLIIGKKDSSVGIAFANSIAQPRMGHTPILGVIRPNLPTK
PSTLIVPKVTIRNLGDAEKIFGPAQSAVAKAVADAVEEGIIPKERSEEFVVIVSVFIHPR
GKDYQRIYRYNYAATKLALRRAMENFPSIDKVLEEKDKAIHGMIGFRINNLKKPPYLEVA
LDIPDWRRVEGIIRALPRSDAIVIEAGTPLIKRYGVEAVQKIHQLRPESVVIADLKTLDT
GNLEARIAGDATADVISFSGLAPINTMEKFMEECKKIGSLSLMDTINVPNPVEILKKLKN
KPDIVELHRAIDVEHEEYAWGNIKEIREVCGNVLIAVAGGIRVSNVKNALKAGADIIVVG
RAITAAKDVTGAARAFLQEMGVEEVDQFRVMTDF
>A0A831PGQ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp|TrEMBL
MFLIGESLEGEGAELAHIDLMIGDKNGPVGMAFANAASQLSAGHTPLLAVIRPNLLTKPA
TLIIPKVTLKKEEQVNAIFGAVQAAVAKAVADSVEEGIFDGMDLEETVILASAFLHPTAA
DYNRIYRYNYGATKQAIQRAIAGFPDKQTLIHEKDRAGHAVMGFKVHRLWDPPYLQVAMD
LVDMKSVERVLRNVPENDHVLIEAGTPLIKQFGLSVIGEIRKYRPEAFIIADLKTLDTGN
LEARMAANASADAVVVSGLAPISTIEKFIIEAKKTGIYSVIDMLNVENPAQLVAELARRG
AVPSIVELHRAIDAEGDEHNWGDIPAIKKAAGGKLLVATAGGIRQHVVKDALKAGADILV
VGRAITASKNICNAAEGFLEELNSEEIDQFRIMTDF
>A0A0E3P9P7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina siciliae HI350|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNLDQAAKIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVVVASVFIHPEAQ
DYNKIYRYNYGATKLAIRRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISRIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKAMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDVREVAEQFINALNKPEIDQFRVMTDF
>F8AJM9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)|TrEMBL
MIKFGEAILGKDLKAVVNVIIGKGNEIDIAFSNALTRTPSPIFANLRDNLIVKPLSIVVP
RHNIDNEIQAELLHGVIQYGAAKAIADLDLDEDLKIVITVSVPDVPYTTLNKRKLFHYYY
GATKLAITRALNEYPSKEKIKKEKYRALHPLVGFRDVRLERPPYLQVALDVPTVENMEFI
IESLPKTDRIIIEAGTPLIKKYGIEIIEHIRELYDGYIVADLKTIDTGRVEVRMAFECTA
NAVVLSGVAPKATILKGIHECEKCGIMSYLDTINIENPLKLYNSLELKPDVLMVHRGIDE
ETFNKDRLYLDTDNEKDKKLILGVAGGVSIDNIDELKNKYDILVVGRGITKSRDPGRVAR
AIVNKLGDDIEQYRLYLDEDEDINL
>A0A842R4Z9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MVDFFIGEALLGKGSELAHIDLMMGDKGGPVGQAFATALVNLSKGHTPILGVIRPNLPPK
PHMVIVPKVTVQSLSDANKIFGPAQAGCAKAVADAVEEGIIPIEKVDDWVIVCSVFIHPE
ASNTRKIYKNNYSATRLSIKRAMANYPPIDKIMYDKDRAKHPVSGIRMPRLWRPPYLQIA
LDSPSLSKAIRVIKECPRSDRIILEAGTPLIKKHGVDVIKELRKEAPDAFFIADLKTLDV
GKVEVDMAFDADADAAVASGVAPNESIDKFLMEADRVGIYGIVDMLNVEDPIAKLKGLKQ
RPRVIILHRGIDTESTGAKTRWELIQEIKALYAGIKPPVLCAVAGGIRPKNCLEAIKNHA
DILIVGRYITQSQDVERAIRNFINLIPGPSDIDLFRYHTDDDDVVKP
>A0A7J3QSG3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTDAVRKEVEARSLLSGKPAKPTVSGTAKILGVHRDTLYSWLREFNVDFDEVARSVSAV
EVSGVRQPPRGYTYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFANGLAHLSMGHTPLL
AVIRPNLPPKPHTLLVPKVTVRNLEDANKVFGPAQAAVAKAIADAVEEGIIPKDKVDDWV
VVCSVFVHPKASDYRKIYHYNYSATKLALKRAMAKYPSLEKVFYDKDRAKHPILGYRVPR
LWRPPYLQISLDIPDLERTKKIIMQIPRSDRIILEAGTPLIKRYGTKVISELREVAKDIF
FMADLKTLDVGKVEVDIAYEETADGVIAAGLAPTETLDAFIYEAKRLGIYAAVDMLNVED
PIKKLKSLRDFPDVVIIHRGIDEETGRTIGLELIQELRQTFKDKKFLIAVAGGIIPETAK
EALEKGADIIVVGRYVTQSKDIERAVREFLELTPEMREDIDVYRVHVE
>A0A523ZZE2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MGSTRRGGAFLIGEALVGEGNEVAHIDLLIGDKQGPVGLSFAHSLANLSAGHTPLLAVIR
PNLPPKPHTVIIPKVTVKNMEDAAKIFGPAQSAVAKAVADAVEDGIIPRAIIDDWVVIAS
VFIHPQAEDERKIWHYNYSATKLALSRALQSYPSWEKLMYDKDRARHPFMGFRAPRLWRP
PYLQIALDNPNIEMIKRVIRQIPKNDNIILEAGTPLIKRYGVGVIRQLREVRADSFVIAD
LKTMDVGKVEVDMAFDETADAVCCAGAASSATIDEFVYETKRLGVYSFVDLMQVEDPVAK
LKSLERLPDGVILHRAIDVEQRGGETRWEYISTIREAFKDKKLLIAVAGGIRPNTAKFAL
DAGADILIVGRYITQSRDVERSVREFLPLLQGDIDLFRVHVE
>A0A550GA82|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MEQIPTDEPAKPSASGSTYLIGEALLGEGNEIAHVDLMIGDKQGIVGTAFASGMSNLSVG
HTPLLAVIRPNLPPKPYTLLVPKVTVKNMEDAGKIFGPAQAAIAKAVADSVEEGIIPRDK
VDDWVIICSVFIHPQATDFRKVYMYNYSATKLALKRALIKYPSLEKMLYDKDRAKHPIMG
FKVPRLWRPPYLQISIDNPDLERAKKVIAQLPGSDRIIIEVGTPLIKRYGTRVMNELRQT
NKDAFMVADLKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLDSFVHEAKRLGIYGIIDM
LNVEDTVAKLKSL
>A0A7K4B6N3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALIGEGAELAHVDLIVGDKNGPVGMAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKHEGQVNQMFGPVQAAVAKAVADSVEEGLFGKSDINEICILASVFLHPSAK
DYNRIYRYNYGATKLAISRAFEQFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDMGKLRAVLSALPENDHLIIEAGTPLIKKFGLQVISEIRAIKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPTSTIEKAIIEARKTGIYSVIDMLNVDDPVALITGLKVKP
DVVELHRAIDAEHTSHAWGNIGNIKKAAGGKFLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A842XFH3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MINGGFLVGEALVGEEPEIAHIDLIIGSKKDAAGIAFVTSFAQPRQGHTPILAVVRPNLP
AKPSTLLVPKVSIRNLEDAEKIFGPAQSAVAKAVADAVEEGIIPKAEAEELVIIVSVFIH
PRGKDYQRIYRYNYAATKLALTRAMQKFPGIDTILEEKDKSIHAMIGFRMNNLKNPPYLE
VALDIPDWRRVEGVVRALPRTDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVVADLKTL
DTGNLEARMAGDATADVVGFSGLAPLKTMEKFIAECKKVGALSLMDTLNVQEPLEVLTKL
PVKPDIIELHRAIDVEQIQNLESEWGDIKEIKQVCDNNILVAVAGGIRVDKVEKALNAGA
DILVVGRAITVAKDVNGAARAFLQRMGVEEVDQFRIMTDF
>A0A7C1M3G3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon|TrEMBL
MAKNDYFIGEALIGEPPNMAHIDMIIGSKDGPVGISFANALSTPSKGHGGLLAAIRPNLL
AKPISLIVPKVTISDMADANKIFGPAQAAVAKGIADSVEEGLIPMNKLDEWLIIASVFIH
PEAKDYRKIYQYNYGATKLAIQRALKSYPPIEKIFYDKDRAKHPVAGIRVPRLWRPPYIQ
VALDAPNLEKQVKVVKQLPKSDRIILEVGTPFLKKYGVESIKQIRAVAREKFIVADLKTL
DVGKLEVDFAFDATADGVVASGLAATASLNKFILEAHRLGIHAFVDTMEVQDPIEKLRTL
KEIPDVVILHRAIDVEQSSAGDKSPDAEQRQRWALIPKIKELYADKKKASGKDRVLVAVA
GGIEPTTATYALGQGADILIVGRFIASAKDVEFAMRRILTVLPGYQDIDLKRIHSEDDDS
SVENGGGPRWD
>A0A662WBR4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobales archaeon|TrEMBL
MELDMRVGEALIGEGYEVAHVDLLIGDKKGPVGQAFANALSQLSAGHTPLLAVIRPNLIT
KPPAIIVPKVTVKDLEQAELVFGPAQAAVAKAIADAVEEGVIPKEIAEDLVVIVSVFIHP
KAKNKHKIYYYNYGATKLALRRALKGFPDVEKVLYEKDRSAHPFVGRKLTKLWDPPYLQI
AFDLTSLEEVVKVLKQIPESDHIIYEVGTPLAKRYGAEVILKLREVKPNAFFVLDLKTLD
TGNLEARMAADATANAVVVSGLAPIPTIVKAIKEAEKTGIYSVVDMLNVEEPIKRLEKIS
EAGVLPNVVELHRAIDVEGIAPPPWNYAKEVKEKFNVLVGVAGGLRPENLNEAIAAGADI
LVVGRAITRARDVEGAARRFLTVMKPDTDQFRIMTDF
>A0A847V354|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLIGEALMGDEPELAHIDLLIGDKDGPVGTAFASGLAQLSAGHTPLLSVIRPNLPPKPA
TLIVPKVTVKNMEQAAAIFGPAQNAVAKAVADSVAEGVIPKAEVENLVVIASVFIHPQAR
DYDAIYRYNYGATKLAVKRAMEGFPDIDTVLFEKDRSTHPIMGFRVIRLWDPPYLQVALD
LVDLAVVRRVLSQLPDSDHLLIEVGTPLVKKFGASVVKEIRTVRPSSFVVLDLKTLDTGN
LEVRLAADATADAVVISGLAPKKTLELAIQEARKTGIYSVIDMLNVPDPLAVLRSLSALP
DVVEMHRAIDQEAERHNWEAIAEIKRMAATSDRKILVAVAGGIRVDTVASALSSGADIVV
SGRAITGSKDVKDAAEQFLSELKQTEIDQYRVMTDF
>A6UUM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)|TrEMBL
MKILFEDIMIKFGEAILGTDLKAIVNVIIGKGTEIDTAFTNALTRRPSPIFANLRDNLIV
RPLTIVVPQNDINSEIQVELLNGVIQYGVAKAIADMGEKEGIDNDLKAVITVSVPDVPFT
TINKRKLFQYYYGATKLAINRALSEYPSAEKIKKEKYRALHPLVGFRDIKLERPPYLQVA
LDVPTIESMENIVESLPQSDRIIIEAGTPLIKKYGIEVIEQIREIFDGFIVADLKTLDTG
RIEVRMAFEATANAVVLSGLAPKSTILKGIHECQKCGIMSYLDTINLNNPVELYNKLELK
PDVLMVHRGIDEEINKDNNKNRSSLSKEDFDNNIILGVAGGVSAETVEDLKNKYDILVVG
RGITKSREPARVARSIVNKLGDDIEQYRLYLDEDEDIAY
>A0A0E3R8H3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei SarPi|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A1I6X148|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina thermophila|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIVPKVTVKNMEQASKIFGPAQTAVAKAVADSVEEGIISKDLVEDIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPSIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLESVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMP
DVIELHRGIDIENTEHAWGNIEEIKKVAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAEQFIMSLNKPEIDQFRVMTDF
>A0A523TIR0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Heimdallarchaeota archaeon|TrEMBL
MADFFIGEALQGKGNELAHVDLMIGDKDGPVGHAFANGMTQLSQGHTPLLALIKPNLTPH
PRTLIVPKVTIDSLDQAEKIFGPAQMAVAKAVADAAEEGDIPQSKIFEYVVIVSVYIHPK
AEDESKIYYYNYGATRLAIKRALSNYPSMKKLIAEKDRAKHPVMKFRPQTLWDPPYLQVA
LDVGSLSAAVKIVEELPKSDRVIIEIGTPYIKKYGIEETIGRMRALKPGAYIIADMKTMD
VGRAEVNAAADATANAVVVSGIAPIATVAEFIRACNKRGVHAWVDSLNTKQTELLATLEG
LKEKPKVVILHRGIDQEIAQKEGAAKKEGTSASRSVWGDIKRIKKITGGLAAVAGGLKPG
KPLADALKAGADIVIVGRYIYRSSDPHRAAMRFLDEMEIEADTMRLFDKLDY
>A0A1Q9N594|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Odinarchaeota archaeon (strain LCB_4)|TrEMBL
MDYFIGEALLGTDAEVAHIDLLVGDKNGPVGAAFANGLTQLSQGHTPLLAVIRPNLPPKP
MTLIVPKVTVQNLEQANKVFGPAQAAVAKAVADAVEEGLIPQDKLEDWVIIVSVFIHPAA
KDDRKIYHFNYSATKLALKRALIKYPPLEKILYEKDRARHPIMGFKVPRLWRPPYLQIAL
DVPSIESCKNLIKSIPQSDRIILEAGTPLIKRYGVDVIRELREVAKDVFIIADLKTLDVG
NVEVDMAFEATADAVVASGLASNETLDKFIYEAQRMGIYAFIDMMNVADPLERVKQLKEK
PDVIILHRSVDAEQYGKAAPKWEALKPIREYYQSRKQKILIAVAGGIQPSTALEALKTEA
DILIVGRYITQAKDPERAVREFIHIFEQQELWSDIDLFRSHVE
>A0A7J3NUS6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
AAVAKAVADAVEEGIIPRDKIDDWVIICSAFVHPEAKDYRKLYHYNYGATKLAIRRALSG
YPSLEKVFYEKDRATHPIMGFKVPRLWRPPYLQISLDIPDLEKTKKVIAQIPRSDRIILE
AGTPLIKRYGTKVISDLREVAKDIFIIADLKTLDVGKVEVDIAYEETADGVIAAGLAPKE
TLDAFIYEARRLGIYAAIDMLNVENPIDKLKSLKELPDIVIIHRGIDQETGKTIGLELIQ
ELKKTFEGKKFLVAVAGGIIPETAKEALEKGADIIIVGRYITQSKDVERAVREFLELTPE
MREDIDLYRVHVE
>A0A520JXD1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MISIGEALIGEAPELAHVDLMIGDKDGPVGQAFATGMTQMSEGHTPLLSVIRPNLLTKPA
TLIVPKVTVKNMDQAALIFGPAQAAVAKAIADAVEAGIVPKKQTEELVIVASVFIHPQAA
DYNRIYRYNYGATKLALERAMSGFPGIDTVLKEKDRGTHAIMGFKVSRLWDPPYLQVALD
NPNIDQILGVIKSLPDSDHLILEAGTPLIKRYGVDVIAKLREVAPNAFIVADLKTLDTGN
LEARMVADATADAVVVSALAPTSTIDKVIEEAHKTGIYAVIDTLNMPDPMPMLKKLKVLP
DVVELHRAIDVEETEYQWGSIPDIKALAEKQSKNMLIAVAGGVRVDNISDALGAGADILV
VGRAITNAKDVYQTAEMFIEGLAKDETDQFRVMTDF
>A0A662RDT9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKTGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMEQASLIFGPAQAAVAKAVADAVEDGIIPEEQAEELVIVASIFIHPDAK
DYNRIYRYNYGATKLALARAMDGFPGIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVKTLPDSDHLILEAGTPLIKRYGVDVIARLREVKPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPIPTIVNAIREAHKTGIYAIIDTLNLPDPLPLLRELGEIG
ALPDVVELHRAIDAEKTEYQWGSIPEIKALSSKILVAVAGGIRADTIRAARDAGADVLVV
GRAITNAKDVRQAAERFIEGLSKEEIDQFRVMTDF
>A0A7J4NUJ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGEEPELAHVDIIIGDKNGPVGQAFATGFTQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVQNMDGAARIFGPAQSAVARAVADAMDEGIIPKEQAEDLVIVASVFIHPQAE
DYSKIYRYNYGATKLAVQRAMEGFPDVDTVMEEKDRTMHPIMGFNVTRLWDPPYLQVAID
IPDMDFVKNVLKQLPQSDHLIIEAGTPLIKRYGLDVVSKIREARPNAFIVADLKTLDTGN
LEARMVADATADAIVISGLA
>A0A7K4HR41|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis tationis|TrEMBL
MYLIGEALVGTGAELAHVDLVMGDKEGPVGMAFANSISQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKGEQVKEMFGPVQAAVAKAVADSVEEGVFEGIDIENTVILASVYLAPEAQ
NYNMIYRYNYGATKLAIRRALQQFPDVETLVYEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDLKRVEQVLTAVPENDHVLFEAGTPLIKQFGLNVLAEIRRIRPNAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPKATIEKAIEETKKTGIYSVIDMLNVDDPAALVAALKVKP
DIVELHRAIDAEGDEYAWGNIPAIKKAAGGKLLVATAGGIRQDVVSKAVASGADILVVGR
AITASKDIRHAAEEFIEKLDSEEIDQFRVMTDF
>A0A8J7XA92|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeota archaeon|TrEMBL
MYKIGEALVGKGNEVAHIDIMVGDKEGIVGQAFANSLSQLSAGHTPLLSVIRPNLPCKPY
TVVVPKVTINDMEDVTKIFGPAQAGVAKAVADAVEEGIIPRDKVDDWVIICSVFIHPEAE
DFRKIYQYNYGATKLALKRALGDYPNLDKIMFDKDRATHPIMGFKVPRLPKWNAPYLQIA
LDNPDLEYIKRVIKELPQSDKIILEAGTPLIKKYGVKVIAELRDVAKSSFMIADLKTLDV
GQVEVDMSFDEGADAVVASGLATNEVLDKFIYEAKRLGIYAFIDTMNVDNPLVKLKALKN
LPDVVILHRAIDSEKTQEHKWSQIGKIKKEFPNLYVAVAGGIDPSTAPLALKEGADIIIV
GRYITQSKDVERSTREFIRLVGGDIDLKRVHVE
>A0A842M6H4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
MYRIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIGEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNKIRELRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGVYSILDMMNVENVPEKLEELRYKP
EIVLLHKNIDVGAAEVSEWGNIPEIKKIIGERGLVAVAGGITPSKTRRALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDEPI
>A0A843EYP3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
TPLTSVIRPNLMTKPATLIIPKVTVGDLDDASKIFGPAQTAVARAVADAVEDGYIPKDIV
EDIVINVSVFIDPSAEDYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGF
RVQKLWSPPYLQVALDLDSKEAMAKILNDLPDKERVLIEAGTPLVKKFGVGVVEDIRALR
PSAFIIADLKTLDVGRVEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMM
NVADFEDKLSQLPDDLKPDIVLLHRNVDLETYKAEKGEDVSEMTEWGNIKKIKEILGGGL
IAVAGGITPDNVEEAIDKGADVIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDED
EQVN
>A0A7W6CXT0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Hansschlegelia beijingensis|TrEMBL
MAKITKTLIGESLVGDGNEVAHIDLIIGPRGSTAESAFVNALTNNKDGFTSLLAVVTPNL
LAKPNTILFNKVTIKDARQAVQMFGPAQYGVAKAVVDSVAEGVIPEDEADDLFISVGVFI
HWEAADDAKIQQYNYEATKEALKRAVTGEPKAKDVVAQAATAKHPFAANA
>A0A2S6RN46|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alphaproteobacteria bacterium MarineAlpha6_Bin5|TrEMBL
MFFKNLFNLGGIMAKINKTLVGESLVGDGNEVAHIDLLIGPKGSAAESAFCNTLTNNKDG
FTSLLAVVAPNLPCKPNTVMFNKVTIKGAKQAVQMFGPAQAAVARAIADSVEDGTIPSGE
ADDVFVCVGVFIHWDAKNDQKIYDYNYQATKESLERAIKNEPKAKDVVAQKASAEHPFGN
VKV
>A0A1F5CRI6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon RBG_13_46_16b|TrEMBL
MYEKNVGFPEKTYLIGEALIGEGNEVAHIDLLMGDKNGPVGEAFAAGLTNLSAGHTPLLA
VIRPNLPPKPHTLLVPKVTVKNFEDVGKIFGPAQAAVAKAVADAVEEEIVPKDKADDWVI
VCSVFIHPQATDFRKIYHYNYSATKLALKRAMSKYPTLEKIFYDKDRAKHPIMGFKVPRL
WRPPYLQIALDAPELERSKKILEQLPGSDRIIIEVGTPLIKRYGTKVINDLRQVAKDIFV
VADLKTLDVGKVEVDLAYDETADAVVAAGLAPAETLDAFVHEAKRLAIYAIVDMLNVEDP
MKKLRSLKEFPDVVILHRGIDQETGRTLGLDLIQEMRETFKDKKFLVAVAGGIVPETAKE
ALQKGANILIVGRYVTQSRDIERAVRDFLEATPEMREDVDLFRVHVE
>A0A497S4G0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MYKIGEALVGKDNEVAHIDLIIGDKEGNVGEAFANGLAKLSAGHTPVLSVIRPNLPSKPY
TLVIPKITIKDMEDANKIFGPAQAAVAKAVADAVEEGIIPRDKIEDWVIICSVFVHPEAK
DFRKIYQYNYGATKLALKRALQDYPSLDKIMFDKDRATHPIMGFRVPRLPKWNRPYLQIA
LDIPDLERTKKIIREIPKSDKIILEAGTPLIKKYGTKVINELREVAKSDFIIADLKTLDV
GQVEVDLAFDDGADAVVASGLATVEVIDKFIYEAKRLGIYAILDMMNVEDPVKRLKSLKE
LPHIVILHRAIDSEKSEKHRFGLIRDIKKEFPDLYVAVAGGIEPETVPLALKEGVDIIIV
GRFITQSKDIERSTRLFINQLGGDIDLKRVHVE
>A0A7J2YUU0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MPTVNEEKEDLGPVYLIGESLVGEGNEVAHVDLLIGDKSGPVGQAFANGLTSLSAGHTPL
LAVIRPNLPPKPHTLIVPKVTVKNMEDTGKIFGPAQAAVAKAIADSAEEGVIPLDKLDDW
VIIASVFIHPQATDFRKIYQYNYGATKMALQRALKKYPSLDKIIYDKDRAKHPIMGFKVP
RLWRPPYLQIALDAPSLEGAKKVIEALPGSDRIILEVGTPLIKRYGTRVINELRQVAKDK
FIIADLKTLDVGKVEADIAYEDTADAVVAAGLAPPETLDSTVSEAKRLGIYAVIDMLNVE
DVMAKLKSLKDLPDVVILHRGIDQESGRTCGLERIQMIRKAFPNKKLLIAVAGGIVPETA
KEALEQGADILIVGRYVTQSKDVERSVREFLELTPAMREDVDLYRVHTE
>A0A7J2J6G9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKEYNVKFEEIARELISPKEILEKPEKPVYLIGEALVGSGNEVAHVDLLIGDKDGPVGEA
FAHSLSNMSAGHTPLLAVIRPNLPPKPHTVVVPKVTIRNMEDASKVFGPAQAAVAKAVAD
AVEEGIIPKDKIEDWVIVCSVFVHPEAKDYRRIYHFNYGATKLALKRALTKYPPLEKIMY
DKDRATHPIMGFRVPRLWRPPYLQIALDIPSLERTKNIIRQIPRSDRIILEVGTPLLKRY
GTKVIRELREEVKDVFMIADLKTLDVGKVEVDIAYEETADAVVASGLADISTLDKFIYEA
KRLGIYAFVDLMYVENPIEKLKQLKDFPDVVIIHRAIDVETGRTLGLDLIPKLRKEFKDK
KFLIGVAGGIIPETAREALQKGADILIVGRYITQSKDIERAVREFLEITKEMREDIDLYR
VHVE
>A0A7J2I4Q5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MVRAPGRITREQYEFLEEEVKKGKYASISEAVRAAINVYREHAAGKPTPTYLIGEALVGE
GPEVAHVDLVIGDKWGPVGQAFVHALSNPTKGHTPLLAVIRPNLPPKPFTLMIPKVTIRN
LKDADKIFGPAQYAVGKAVADAVEEGIIPEDKVDDWVIICSVFIHPQASNYRKIYHYNYS
ATKLALKRAMMGYPTLDKIMYDKDRAKHPILGYRVQRLWNPPYLQIALDIPDIKRIKKVV
SQIPKSDRIILEAGTPLIKRYGTRVIRELREVAEETFIVADLKTLDVGKVEVDVAFDETA
DGVVASGLASKQTLDDFIYEAKRLGIYAFVDMMGVPDPVARLKELKQPPDVVILHRGIDM
EKAGAKLHFKVIKEIREE
>A0A842MUM4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
FGFWVDEGATKLALKRALAKYPPLQKILYDKDRATHPIMGFKVPRLWRPPYLQISLDIPD
LERTKKIIRQIPRSDRIILEAGTPLIKRYGTKVISELREVAKDIFIIADLKTLDVGKVEV
DIAYEETADGVIAAGLAPKETLDAFIYEAKRLGIYAAVDMLNVENPVEKLKSLKEFPDII
IIHRGIDQETGRSIGFERIQELKETFKDKKFLVAIAGGIIPETAKEALERGADIIVVGRY
ITQSKDIERAVREFLRLTPEMREDIDLHRVHVE
>A0A841A226|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylorubrum rhodesianum|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPADEADDLYILVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKASVVTEQRNSAQHPFAANA
>A0A7W6RPJ3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Rhizobium mongolense|TrEMBL
MAKISKVMVGESLVGEGNEVAHIDLLIGPRGSAVETAFCNALTNNKDGFTSLLAVIAPNL
ACKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVQDSVAEGIIPADEADDVFICVGVFI
HWEAEDDAKIQDYNYRATKEAIERAVSGKPTAAEATAQRDTVKHPFSA
>A0A839F8H2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Phyllobacterium sp. P30BS-XVII|TrEMBL
MQIINRVMVGESLVGEGNEVAHIDLLIGPRGSAVETAFCNALTNNKDGFTSVLAVIAPNL
PCKPNTVMYNKVTIRGAGQAVQLFGPAQSGIAKAVRDSVADGIIPQNEADNLFICVGVFI
HWQARDDAKIHDYNYQATREAIQRAVSGHPTAAETLAAAG
>A0A2V3JBM4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MYVGEALIGEGPEVAHIDLMIGDKYGPVGVAFTNALSQLSAGHTPVFAVIRPNLPVKPPT
LIVPKVTVQNMKDADKIFGPAQSAVAKAVADSVEEGIIQADKAEDFVVIASVFVHPKARD
YNKIYRFNYGAAKLAIKRAMTGFPDVKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALDI
PNWNHMERVVKELPRNDHLIIEAGTPLIKRYGVDIVGKIKEIKPETFVVADLKTLDTGNL
EARMVADSGADAVVISGLAPLRTIEKAIEEARKTGIYSSLDMLNVRSPIELLKELSIGGL
MPDVVELHRAIDVEELGEEHAWGNIEEIKRIGGNILVAVAGGIREENAPEALKGGADILI
VGRGITNSKDVEGTARRFLRLMKEEIDQYRVMTDF
>A0A832UFV8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocalculus sp|TrEMBL
MYSIGEALVGDGPELAHIDLLVGDKNGPVGSAFANALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTLKKGEQVKEMFGPVQAAVAKAVADCLEEGLFNGINIDEIVIIASVYLAPDAE
DYNRIYRYNYGAMKLSLSRAFESFPDEKTIIHEKDRAAHGVMGFKVQRLWNPPYLQVAMD
LVDMNQVGRVLTELPQNDHLIIEAGTPLIKQFGLSVIGEIRKMRPSAFIIADLKTLDTGN
LETRMCANASADAVVISGLAPISTIEKAVLEARKTGIYAVVDMLNVSSPLNLVKELAKIN
ALPHVIEMHRAIDAEGSDYAWGDIPAIKKAAGGKILVATAGGIRVNVAKKALASGADILV
VGRAITASKNIHHAAEEFLEEIDSEEIDQFRIMTDF
>A0A832VZV4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina acetivorans|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAAKIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVVVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDINKVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDVREVAEQFINALNKPEIDQFRVMTDF
>A0A2V2MYZ0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum lacunae|TrEMBL
MYLIGEALIGDGAELAHIDLLIGDKNGPVGTAFANSLSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKSGAQVTQMFGPVQAAVAKAVADCVEEGVFAGQDLNDLVILASAFLSPEAK
DYNRIYRFNYGAVKLALNRAFEQFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDLGKLKSVLSALPENDHLIIEAGTPLIKKFGLNVLNEIRAVKPNSFIVADMKILDTGN
LEARMAADASADAVVMSGLAPKSTIEKAIEEARKTGIYSVIDMLNVSDPVGLIKSLAVKP
DIVELHRAIDAESSAHAWGNIKDMKAAAGGKLLVATAGGIRVPVVKEALKSGADILVVGR
AITASKDVHHAAEEFLEQLNKEEIDQFRIMTDF
>A0A166CLI6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter cuticularis|TrEMBL
MYKIGEALIGDGNELAHIDLIIGDKESAAGSAFANGMSQLSIGHTPLLSVIRPNLMTKPA
TLIVPKVTVGDLDDASKIFGPAQTAVGRAVADAVEEGLIPKDQSEDLVIIISVFIHPEAK
DYRKIYQYNYGATKLAIRRAMGDYPSIDKVLAEKDRGTHPIMGFKVTRLWSPPYLQVALD
LDNLDTMEKIIAAIPDRERVLLEAGTPLIKKFGVGVVNKIRELRPDAFIIADLKTLDVGR
VEVKMAADETADAIAISGLGTIESIEKAIHEAQKQGIYSILDMMNVSNFTDKLNQINENL
KPDIVLLHRNVDLETSKAEKGEDTSSMTEWGNIKEIKNLIGNGLVAVAGGITPAKVEEAI
DSGADIIVVGRYIIGSRDVRRSAEDFLSHLPQDPDNMRLALDEDESAN
>A0A5E4L374|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MSNRIAKSLIGEALVGSGPEIAHIDLVIGPKGGAVETAFMNSLAMPRFGHTPLLAVLEPN
LQPKPATLMINKVTIRKASQALLMFGPAQAAVAKAVMDSVEEGLINKNEAEDVLIIVSVF
IEWDAADKDKVYEFNYEATKLALKRAIEGEPTVGEALSKKDKAKHPFA
>A0A1V4ZPK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregula sp. PtaU1.Bin051|TrEMBL
MYLIGEALIGDGAELAHIDLIIGEKDGPVGAAFANALSQLSMGHTPLLAVVRPNLLTKPA
TLVIPKVTLKNITQVNEMFGPVQAAVAKAVADCVEEGVFTRAGVDVENIVILASAFLHPD
AEDYNRIYRYNYGSTKLAINRAFEKFPDTKTLIFEKDRAPHVIMGFKVQRLWDPPYLQVA
IDLVDMGKVAAVLTQVPANDHVLIEAGTPLVKKFGLGVINEIRKLRPNAFIIADLKILDT
GNLEARMAADASADAVVVSGLAPISTIEKAINEARKVGIYSIIDTLNVQNPVKLLEKLKV
KPDIVELHRAIDTDDAAHAWGDIPALKKACGNKLLIATAGGIRVPNVKEALKAGADILVV
GRAITASKDISHAAEQFIEELEKEEIDQFRVMTDF
>A0A7W3JUD0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alpinimonas psychrophila|TrEMBL
MTFHIGESFIGSGVNAAHINTVYGHRDGPAGVAWASALATPSQGHVPFVVVLQPSLPVKP
MTLFVTKAAAASDLHGNLIWGAAQAGVAGGVADAVAAGDIPSETVDEFAIICAVWVNPQA
DDEQAVFDNNRRATAEALSNGVKNLPRLEDVLNNRSRPFNPFFAAKE
>A0A219AMW8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. 87.7|TrEMBL
MYNIGEALIGDGDELAHVDLIIGDKEGPAGTAFATSLTNLSVGHTPLLTVIRPNLMTKPA
TAIIPKVTVGNLDDASKVFGPAQTAVGRAVADAVEEGLIPKDIVDDIVILVSVFIGPGAE
DYRKIYQYNYGATKLAIRRAMNGYPDMKKVLAEKDRGTHPIMGFKVQRLWNPPYLQVALD
LDNLDAVERIMNALPQRERILIEAGTPLVKKFGVGVVSKIRELRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTIESIEKAIHETQKQGIYSILDMMNVDDFTGKLKQIKPEL
KPDIVLLHRNVDLETSKAEKGEDTSDMTEWGNIKEIKKILGNGLIAVAGGITPEKVEEAT
SKGADIIIAGRYIIGSRDPRRAADDFLAHFPVDPDNMRLALDEDETI
>A0A1V5ASH1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaU1.Bin055|TrEMBL
MFLIGEALMGDEPELAHIDLLIGDKDGPVGTAFASGLAQLSAGHTPVLSVIRPNLPPKPA
TLIVPKVTVKNMEQAAAIFGPAQNAVAKAVADSVAEGVIPKAEVENLVVIASVFIHPQAR
DYDAIYRYNYGATKLAVKRAMEGFPDIDTVLFEKDRSTHPIMGFRVIRLWDPPYLQVALD
LVDLAVVRRVLSQLPDSDHLLIEVGTPLVKKFGASVVKEIRTVRPSSFVVLDLKTLDTGN
LEVRLAADATADAVVISGLAPKKTLELAIQEARKTGIYSVIDMLNVPDPLAVLRSLSALP
DVVEMHRAIDQEAERHNWEAIAEIKRMAATSDRKILVAVAGGIRVDTVASALSSGADIVV
SGRAITGSKDVKDAAEQFLSELKQTEIDQYRVMTDF
>A0A7C4NHE4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MERGFYVGEALIGSGYEVAHVDVVLGEKSGAAGLAFVNALSNPSAGHTAMLAVLRPNLPV
KPSTLIVPKVTVRSMEDSEKVFGPAQAAVAKAIADAVEEGVIPRDKCENWVVIVSVFVHP
KARDFRRIYQFNYAATKLAVRRALKEYPTVEKVLKEKDRAVHPIMGFRVKKLWSPPYLQV
ALDLSSLEKALEIVKQLPRSERVILEAGTPLIKAYGVKAIEKIREVWRDAFIVADLKTMD
VGRVEVKEAADATADAVCILAAASKTTIDKAILEARKQGVYSILDTMEVSDPIAKIETLE
YKPDVVLLHVSADVERMTAESGKTVEYKWNEIAEIKSRFKVLLAVAGGITPKTSVEALKN
GADIVVVGRYI
>A0A7C3RBL1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus|TrEMBL
MEFRIGEALVGEGFEVAHVDLIIGTKDGPAGIAFANALANLSAGHTPLLAVLRPNLITKP
PAVIIPKVTVKNMEQAELIFGPAQAAVAKAVADAVEEGIIPKEKADEYVVIASIFIHPNA
ANRHKIYYYNYGATKLAIRRAMQNFPDVDTVMYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLNEVLRVLEQIPESDHIIFEIGTPLVKKYGSEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPISTIVKGIREAEKTGILSYVDMMNVEDPLKRLEEIKKA
GVLPNVVELHRAIDSEESEPPWMLAGKIKENYRVLIAVAGGIRPENVEEVINAGADIVVV
GRAVTKAKDVEGAVRRFMRYMKPDTDQFRIMTDF
>A0A0F8LR80|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A6J5JYB6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia phenoliruptrix|TrEMBL
MAKINRVLIGESLVGDGNEVAHIDLLMGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
LAKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPADEADDLFLCVGVFI
HWQAEDDKKIQEYNYKATREAIQRAVRGEPTAAEVVSKKSSVAHPFAPN
>A0A842KPY2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomethylovorans sp|TrEMBL
MLLVGEALIGEEPELAHVDLIIGDKNGPVGLAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIVPKVTVKNMGQAAQIFGPAQAAVAKAVADAVEEGVIDKKDVEDLVIIASVFIHPEAK
DYNRIYRYNYGATKLALKRAMEGFPSVETVMKEKDRAAHGIMGFKVTRLWDAPYLQVALD
NPNITVIRNIVSQIPKSDHVILEAGTPLIKRYGMDVISQLREVRPDAFIVADLKTLDTGN
LEARMVADATADAIVISALAPVSTLHKAIEEAHKTGIYAVMDTLNCLDPVTVLSELKKMG
SLPDVVELHRGIDVEDTEHAWGSIDDIKAFSTESHKILVAVAGGIRIDTMPLALKAGADI
LVVGRAITNAKDVRQVAEKFIEGLNKPEIDQFRIMTDF
>A0A849PGU9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKNGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMEQAALIFGPAQAAVAKAVADAVEDGVVPTEQAEELVIIASVFIHPDAK
DYNRIYRYNYGATKLALKRAMDGFPWIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVKTLPDSDHLILEAGTPLIKRYGVDVIARLREAKPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPIPTIVNAIKEAHKTGIYAIIDTLNLPDPMPKLRELGELG
ALPDVVELHRAIDAEKTEHQWGSIPEIKALSSKILVAVAGGIRADTIQDALAAGADILVV
GRAITNAKDVRQAAEMFIEGLSKEEIDQFRVMTDF
>A0A7L4QWI3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMFIGEALIGEAPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVAKAIADAVEEGIVPKDQAEDLVVIASVFIHPQAV
DYNRIFRYNYGATKLALKRALDNFPSIDTVLEEKDKSSHAIMGFKVSRLWDAPYLQVALD
NPNIDAIRNVVKQLPKSDHLILEAGTPLIKRYGVDVITKLREIKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATLNKAIAEAHKT
>A0A1H9Z6L8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcoides vulcani|TrEMBL
MMFIGEALIGEEPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQAAQIFGPAQAAVAKAVADAVEEGIVPTEQVEDLVIIASVFIHPQAV
DYNRIFRYNYGATKLALKRALDNFPDIDTVLEEKDKSAHAIMGFKVSRLWDAPYLQVALD
NPNIGAITNVVKQLPKSDHLILEAGTPLIKRYGVDVISKLREIKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATLNKAIAEAHKTGIYAVMDTLNQPDPVAVLEQLDELP
DVVELHRAIDIEETAHAWGSIDGIKAVGEKRNKKILVAVAGGVRVETIPDALGAGADILV
VGRAITNSKDVKQAADQFIEGLNKPEIDQFRVMTDF
>A0A7K4DPU1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium subterraneum|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAEDMVLIISVFIHPEAS
DYRKIYQYNYGATKLALRRAMEGYPSINKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRALKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTGKLETLNYKP
DIVLLHRNVDLETMKAERGEEQADMTEWGNINQIKDLLGKNGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDEAI
>A0A0A7GGL8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Geoglobus acetivorans|TrEMBL
MEYRIGEALVGTGNEVAHIDLMIGTKDSPVGEAFANALSQLSAGHTPLLAVLRPNLITKP
PAVIIPKVTVKDMFQAELIFGPAQMAVAKAISDAVEEGIIPKDMVEDYLVIVSVFIHPKA
RNKEKVFYYNYSATKLAIKRAMSSFPDVDTVLYEKDRSFHPFAGRKLTKLWDPPYLQIAI
DIPDLNEVQRVLRYIPDSDHIIFEVGTPLAKRHGAEVILKLREERPDAFFVLDLKTLDTG
NLEARMAVDATANAVVISGLAPINTIKKAINEAQKLGIYCVVDMLNVEDPVSRLDRIVEA
GVKPDVVELHRAIDSEHEEPPWKFAKPIKERHNVLVAVAGGIRPENVEAAISGGADILVV
GRAITRARDIEGAARRFLASMKPDTDQFRVMTDF
>A0A8J7N971|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeota archaeon|TrEMBL
MAERETRETFLIGEALIGKGNEVAHIDLMIGHKNGPVGQAFTNGLTQLSKGHTPLLAVIR
PNIIPKPATLVIPKVTVQNMEDAGKIFGPAQAAVAKAVADAVEEGIIPKEYLEDYVVVTS
VFIHPEAEDYEKIYRYNYSATKLSLKRAMTRYPDLNKINFEKDRATHPIAGVKMTRLWRP
PYLQVAIDVTNLDAIRHVITELPHNDMIILEAGTPFIKEHGVKGIREIRKMRPDAFIIAD
LKTLDVGKVEVDMAYDETADAVVVAGLANKATIDSVIYEAHRLGIYAIVDMMNVSDPKKV
LHTLSDLPDMVNLHRNIDEERAEGQSGQATDSRWQLIKEIKKDFPDKRVLFAVAGGVVPQ
TAKHALVNGADILVVGRYITQSKDVERATREFLNFLGEDTDLFRVHWE
>A0A7J3S802|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
MYKIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISIGHTPLISVIRPNLMTKPA
TLMIPKVTISCLKDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIISIFIHPEAK
DYQKIYHYNYGATKLAIRRAMEGYPSIEKVLSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDVLPPRERILLEAGTPIVKKFGVGIVNKIRELRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKKTIEKAVHEARKQGIYSILDMMNVENITEKLEELRYKP
DIVLLHKNIDVGTAEVSEWGNIHEIKEILGKRGLVAVAGGITPSKTRKALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDESI
>A0A483CY45|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis fontis|TrEMBL
MYLIGEALVGTGPELAHVDLVMGDKEGPVGMAFANSVSQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKKGEQVTEMFGPVQAAVAKAVADSVEEGIFDGIDIENTVILASIYLAPDAA
DYNRIYRYNYGATKLAIRRAIQQFPDTETLLYEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDMRKVEQVLTSVPENDHVIIEAGTPLIKQFGLAALAEIRKVRPNAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPKATIEKAIEETHKTGIYSVIDMLNVEDPVALVASLRIKP
DIVELHRAIDAEGDEYSWGNIPAIKKAAGGKLLVATAGGIRQEVVGKALASGADILVVGR
AITASKDIRHAAEEFLERLNSEEIDQFRVMTDF
>A0A524Q7A9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon|TrEMBL
MLLYAQLGIYRWPLKICIWEKSKMIPQFNLTEINRRAFDDATEEMIKYTEIKGNPPYLQV
AIDIPDINTLKAILKQIPQSDHLIIEAGTPLIKKYGVGVVQSIREVRPNAFVVADMKTLD
TGNLEAGIVADATADAIVISGLAPISTIEKAIKEARMRGIYAVIDMLNVDKPLSVLKALT
IKPDIVEFHRAIDIEGKAEHAWSDIPAMKKLSERMLIAVAGGIRLDMVKDALKAGADIVV
VGRAITEAKDVRSITEQFIEEMKQPEIDPYRIMTDF
>A0A101IZF2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon 53_19|TrEMBL
MYSIGEALVGDGPELAHIDLLVGDKNGPVGSAFANALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTLKKGEQVKEMFGPVQAAVAKAVADCLEEGLFNGINIDEIVIIASVYLAPDAE
DYNRIYRYNYGAMKLSLSRAFESFPDEKTIIHEKDRAAHGVMGFKVQRLWNPPYLQVAMD
LVDMNQVGRVLTELPQNDHLIIEAGTPLIKQFGLSVIGEIRKMRPSAFIIADLKTLDTGN
LETRMCANASADAVVISGLAPISTIEKAVLEARKTGIYAVVDMLNVSSPLNLVKELAKIN
ALPHVIEMHRAIDAEGSDYAWGDIPAIKKAAGGKILVATAGGIRVNVAKKALASGADILV
VGRAITASKNIHHAAEEFLEEIDSEEIDQFRIMTDF
>A0A564FRM9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium dankookense|TrEMBL
MSERIILRAGEALVAGGPPNTASEPEVIIGELDGPVGTALATLTGDQVVGHSRVFALLNT
DIMVRPVTLCVSKVSVTENKYTSILMGTVQYAIANGVLDAVRAGYIPKEKANDLGIICSV
WLSPGVIQAESVDHKALFEIQRKGMTEAIRKAMTNEPSIDWLLENQDKIVHKYYQMGLDG
KI
>A0A1J5QCN1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MSILDRILGFFGSKESVASASAPAKPRSGPVIDRVLVGEALVIDNRPDGSGLDLLNVAHI
DLIIGPRGSAAERSFTRALTTQRKGVNGLLAVVAPNMMAKPSTVMFNKVTIKNGKQAVQM
FGPAQRGVSMAVMDCVADGTIPAEEADDVFICVGVFIDHKADIDERIQDWNYKATKQAIK
SAVAGEPRAADVVRKYKDPMNAHPFQAK
>A2SS59|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)|TrEMBL
MKSLYPPGANTTAEIIPMFLIGEALVGDGAELAHIDLMIGDKNGPVGMSFANGLTQLSAG
HTPLLGVIRPNLLPKPAVLIVPKVTLKHTEQVTQIFGPAQAAVSKAIADALEDGVFAGMD
VEENVIVASVFIDPSAKDFNKLYRFNYGATRLALSRALDKFPDTTTVLKEKDRAAHGVMG
FKVQRLWNPPYLQVAMDLVDMKQVERVLTGVPQNDHVIFEAGTPLIKQFGLSVINEIRKI
RPNCFIVADLKTLDTGNLEARMVSNAGGDAAVVSGLAPVETIAAFIKEAKKCGIYAIIDM
LNVEEPAKLIESLGQMGGAALLPQYVEMHRAIDKESTGDYSWGDIKKIKEVAKTYDAKIL
VATAGGIRQPVVKKAIAAGADIVVVGRAITASKDIKNAAESFLEELDSEEIDQFRIMTDF
>A0A2H6AYQ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|bacterium HR40|TrEMBL
MPKIDRMLVGEALVGEGNEVAHIDLIIGPRGTPAETAFALTLTNQKEGVNALLAVLEPNL
MVKPATVMFNKVTIKNAKQATQMFGPAQRAVAMAVADCVAEGTIPADEAEDLFISVGVFI
HWEASDDAKIQQYNYEATKLAIERAVAGQPTAARMVALKDKTRHPFQAG
>A0A2S6SCJ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alphaproteobacteria bacterium MarineAlpha8_Bin1|TrEMBL
MAKITKMLVGESLVGDGNEVAHIDLIIGPRGSAAETAFANSLTNNKDGFTALLAVVAPNL
MTKPATCMFNKVTIKGAKQAVQMFGPAQHGVAKAVMDCVEEGTIPADEADDLFISVGVFI
HWLAEDDKKIQEYNYQATKESIERAVSGEPKAKDVVSAKDSAEHPFAAK
>A0A1U7CSP2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paludisphaera borealis|TrEMBL
MSGRIVLRTGEALVEGAEDHLCAEPEIVIGELDGPVGQALANLIGDQVKGHSRVFAILAS
DVQVRPATIMVSKVTVKSKKYTNILMGTVQAAIAHGVLDAVREGVIPKEKVNDLGIIYSV
WLDPAVTDVDDLDHKALFAVHREATLKVIRKALNNAPSIDWLLENQDKVEHYFHKLGVDG
EL
>A0A7J2TH64|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus|TrEMBL
IANLSAGHTPLLAVLRPNLITKPPAIIVPKVTVKNMEQAELVFGIAQAAVAKAIADAVEE
GYIPKEKADDYVIIVSVFVHPLAKNKHKIYYYNYGATKLAIKRAMSNFPDVETMLYEKDR
SVHPLVGRKLTKLWDPPYLQIAFDIPDLEEVISIISQIPESDHIIFEIGTPLLKKYGCEV
VLKLRDVKPNAFFILDMKTLDVGNLEARMAADATANAVVISALAPISTIVKGINEAKKTG
IMAFLDMLNVENPISRLEEISKEVLPDVVELHRAIDSEHSRPPWDIAREIKDKFRVLVAV
AGGIRPENVSEVISSGVDIIIVGRAITKAKDVEGAVRRFMVHLKPDTDQFRIMTDF
>A0A1G9CEG9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus thermophilus|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANSLSQLSKGHTPLLAVVRPNLLTKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGIDIEDTVILASVFLHPTAQ
DYNKIYRFNYGAMKLAIRRALDRFPDVETLMHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDKNHMRKVLESLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMAADAGADAVVISGLAPLSTIEKAIEDTRKTGIYTVVDMLNVEDPRAVIEQLKVKP
DVVELHRGIDIEETTHAWGDIPAIKKAGGERLLVATAGGIRQDVVKDALKAGADILVVGR
AITASKNIRHAAEEFLEELNTEEIDQFRVMTDF
>A0A0P0RHI3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia caribensis MBA4|TrEMBL
MSTTEKQLYIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALSTPSAGHAPFVVIARPG
VPTKPLTLYVNKAQIEGDFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSANW
VNPKTDDLDAVFENNYRACKNAILAAMKGLPHKEEVFAAAREVSNPFYTPKQR
>A0A7J2JLY2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MYKIGEALVGKGNEVAHVDLLIGDKEGFVGQAFANGISHLSSGHTPLLSVIRPNLPCKPY
TLVIPKVTMKDMEDVTKVFGPAQAAVAKAIADAVEEGIIQRDRIDDWVIICSVFIHPEAK
DFRRIYQYNYGATKLALKRALQDYPSLDKIMFDKDRATHPIMGFKVPRLPKWNRPYLQIA
LDIPDVERTKKIISEIPHSDKIILEAGTPLIKKYGTKVISELREVAKDSFIIADLKTLDV
GQVEVDVAFDETADAVIASGLASVEVIDKFIYEAKRLGIYAIIDTMNVPDPINLLKSLKE
LPDIVILHRGIDVEKKERPRFELIRKIKREFPDIYVAVAGGIEPDTAPLALKEGADIIIV
GRFITQSKDIERSTRLFVNILGGDIDLKRVHVE
>A0A7J3W6P3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MCGRLELGFYVGEALVGVGYEAAHVDIVIGEKNGPVGLAFTNALSNPSAGHTAILAVLRP
NLPVKPSTLIVPKVTVKSMEDSEKVFGPAQAAVAKAIADAVEEGIIPRDKCEDWVIVVSV
FVHPKARDYRKIYQFNYAATKLATRRALKGYPSIDKILKEKDRAVHPIMGFRVRRLWSPP
YLQVALDLSSLEKALEVVKQLPRSERIILEAGTPLIKAHGVGVIGRIREVWRDAFIVADL
KTMDVGRVEVKEAADATADAVCILAVASKTTIDKAVLEAQKQGVYSILDMMEVSNPIAKI
EALEYKPDVVLLHVSADVERKAVESGKPVEFRWNEISEIKNRFKVLVAVAGGITPSSAIE
ALKSGADVIVVGRYIVGSGDPRRASEQFLNLMPPEPDVMRLTLDEDESIGEI
>A0A7K3ZPD4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSTAGDEADQCSGPAYLIGESLVGEGNEVAHVDLMVGDKTGPVGQAFAMGLTTLSAGHTP
LLAVVRPNLPPKPHTLIVPKVTVKNMEDTGKIFGPAQAAVAKAIADAAEEGVIPAAKLDE
WVVVVSVFIHPQAKDYRKIYQYNYGATKMALQRALKKYPTLDKVNYDKDRAKHPIMGFKV
PRLWRPPYLQIALDAPNLEGAKKVIEQLPGSDRIILEVGTPMIKRYGTRVINDIRQIAKD
KFVIADLKTLDVGKVEVDIAYEDTADAVVAAGLGPAETLDATVQEARRLGIYAVVDMLNV
EDVLAKLKSIKDFPDIVILHRGIDQETGRSSGLERIKMIREAFPNKKFLIAVAGGIVPET
AKEALEKGADILIVGRYVTQSRDVERAVRDFLELTPAMREDIDLYRVHTE
>A0A842XUJ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEALVGEGNEVAHVDLLVGDKEGPVGEAFAAGLSNLSMGHTPLLAVIRPNLPPKPHTLL
VPKVTVKNMEDTNKIFGPAQSAVAKAVADAVEEGIFPKDKVDEWVIVCSVFVHPKAKDYR
KIYHYNYSATKLALKRALTNYPPLEKVLYDKDRARHPIMGFKVPRLWRPPYLQIALDIPD
LGRNKKIIASLPRSDRIILELGTPLIKRYGTKVISELREIARDVFFVADLKTLDVGKVEV
DLAYDETADAVVAAGLAPVETLNAFIHEAKRFGIYAVVDMLNIEDPVKKLRMLKEFPDIV
VLHRGIDQETGRTLGLERIQELRQTFKDKRFLIAVAGGIVPETAKEALEKGADILIVGRY
VTQSKDVERAARELLKLTPEMRKDIDLFRVHVE
>A0A497F2X7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Verstraetearchaeota archaeon|TrEMBL
MYLIGEALVGEGNEVAHIDLILGDKNGPVGEAFASGLAHMSAGHTPLLAVIRPNLPPKPH
TLIVPKVTIKNMEQANAIFGPAQAAVAKAVADAVEEGILPRDKVDDWVIICSVFIHPDAK
DYRKIYHYNYGATKLALKRAMAKYPSLEKIFYDKDRATHPIMGYRVPRLWRPPYIQIALD
IPSLEQTKRIIMQIPKSDRIILEVGTPLIKKYGTKVIRDLREVAKDMFMVADLKTLDVGK
VEVDLAYEDTADAVVAAGLAPTETLDGFIYEAKRLGIYAVIDMLNVDDPIKKLKSLKEFP
DVVIIHRGIDQETGRTIGLELIEKLRETFKDKRFLIAVAGGIVPETAKEALEKKADIIIV
GRYVTQSKDIERAVREFLTLTPEMREDIDLFRVHVE
>A0A550GD26|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTESTKKTTLEKAARKTKPTKPTLSATAKALNIHRDTLYTWLKDLNVDFKTIIKQIPTD
EPAKPSASSSTYLIGEALLGEGNEIAHVDLMIGDKQGIVGTAFASGMSNLSVGHTPLLAV
IRPNLPPKPYTLLVPKVTVKNMEDAGKIFGPAQAAIAKAVADSVEEGIIPRDKVDDWVII
CSVFIHPQATDFRKVYMYNYSATKLALKRALIKYPSLEKMLYDKDRAKHPIMGFKVPRLW
RPPYLQISLDNPDLERAKKVIAQLPGSDRIIVEVGTPLIKRYGTRVMNDLRQTNKDAFMV
ADLKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLDSFVHEAKRLGIYGIIDMLNVEDIV
AKLKSLKEFPDAVILHRGIDQETGRTSGLERIKIIRQAFSNKKFLIAVAGGIVPETAKEA
LQLGADIIIVGRYVTQSKDIERAVRDFLELTPTMREDIDLYRVHTE
>A0A842XK21|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MREFGVEFADVGERELSVEAVKKREEFAYLIGEALMGEGSEVAHIDLIIGDKAGPVGEAF
ASGLSTLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMEQAGKIFGPAQAAVAKAVADA
VEEGVIPEDKLDDWLIICSVFVHPEAKDYRRIYQYNYGATKLALRRALDKYPPLKKIMYD
KDRAKHPIMGFKVPRLWRPPYLQIALDIPSVERTKKIISELPESDRIILEVGTPLLKKYG
VKVIRDLREVAKETFIVADLKTLDVGKVEVDLAFEETADAVVVAGLAAPETIDKFIYEAK
RLGIYAVVDMMNVEDPLKKLQALKIFPDIVILHRAIDVEERTGKTRWGLIKEMRQIFQRE
RFLVAVAGGITPETAPEALANGADIIIVGRYITQSRDVERAVREFLKCTREMAMDIDLFR
VHVE
>A0A523TBN7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MREFDVDFSDVDERELLFEEATKRKETTYLIGEALMGEGTEVAHVDLLIGDKDGPVGQAF
ANGLSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMEQIGKIFGPAQAAVAKAVADS
VEEGIIPEDKVDDWVIICSVFIHPQAKDYRSIYHYNYGATKLALSRALENYPSLKKIMYD
KDRAKHPIMGFKVPRLWRPPYLQVALDVPNLERVKKIINELPESDRIILEVGTPLLKKYG
VNVIRDLRKVAKDMFIVADLKTLDVGKVEVDLAFEETADAVVVAGLATPETIDKFIKEAK
RLGIYAIMDLMNVDDPIGKLRSLKRLPDVAILHRAIDAEKTGKTRWDIIKEMRQTFQGKK
FLVAVAGGITPETAPEALANGADIIIVGRYITQSKDVERATREFLKSTKDMAQDIDLFRV
HVE
>A0A2U0RVD8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKSKESTYLIGEALMGEGNEIAHVDLLIGDKTGPIGQAFANGLSNLSAGHTPLLAVIRPN
LPPKPHTLLVPKVTVKNMDDTGKIFGPAQAAVAKAVADSVEEGIIPEDKVDDWVIICSVF
IHPQAKDYRSIYHYNYGATKLALQRALDNYPTLKKIMYDKDRAKHPIMGFKVPRLWRPPY
LQIALDNPNVEGIKKVVSELPESDRIILEVGTPLLKKYGVNVIRDLRKIAKDMFIVADLK
TLDVGKVEVDMAYEETADAVVVAGLATPETIDKFIKEAKRLGIYAIMDLMNVDDPVAKLK
SLKRLPDVAILHRAIDAEKTGKSRWELIKEMKQTFPNQKFLIAVAGGITPDTAPEALANG
ADIIIVGRYITQSKDVERATREFLKSTREMAQDIDLFRVHVE
>A0A550GPK5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSGINRKKPESREELITIILDAGKKELDDKKFKKAKSLKPTISGTAKILDIHRDTLYTWL
REFDVDFKELFTDINISSKIKSVAENGRAYLIGEALLGAGNELAHVDLLIGDKDGPVGKA
FANGFSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMKDAGKIFGPAQAAVAKAVAD
SVEEGIIPKDKVDEWVIVCSVFIHPQANDYHRIFQNNYSATKLALTRAMKKYPSLEKMLY
DKDRAKHPIMGFKVPRLWRPPYLQ
>A0A509EDG8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium symbioticum|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAESAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPADEADDLYILVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKAATVTEQRNSAQHPFAANA
>A0A1V5AH83|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon PtaU1.Bin222|TrEMBL
MYLIGEALVGDGPELAHVDLVLGDKEGPVGAAFAHALSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLRKGAQIQEMFGPVQAAVAKAVADCVEEGLFGTQDLESLVILASIYLDPAAA
DYNRIYRYNYGATKLALSRAMEKFPDRKTLLYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVEMQKVHSVLAELPKNDHLIIEAGTPLIKRFGLSIISEIRKIRPNAFIIADMKILDTGN
LEARMAADASADAVVISGLAPQPTLEKAIAEARKTGIYSVIDMLNVPEPLKVLKSLKVKP
DVVELHRAIDAESTAHAWGDIPAMKKAAGGKLLVATAGGIRVDGVKKAFASGADIIVVGR
AITASKDVHTAADLFLEQMNKEEIDQFRVMTDF
>A0A849R1W0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MMNLGEALIGDGEEIAHIDLMIGDKSGPVGMAFANALSQMSAGHTPLFAVIRPNLPVKPS
TVVVPKVTVRNMKEAEKIFGPAQSAIAKAVADSVEEGVIPEDKTEELVVIVSVFMHPHAD
DYNKIYRYNYGATKLALKRAMDGFPDIKKVLYEKDRSRHPSLGMKMTKLWDPPYLQVALD
IPNWGHMERVVKDLPSNDHLIIEAGTPLIKRYGVDIVAKIKEIKPDTFVIADLKTLDTGN
LEVRMVSDAGADAVVISGLAPLRTMEKAIEEARKTGIYSSLDMLNVKKPLAVLKELSVGG
MMPDVVELHRAIDVEQEERHAWGDMAEIKRIGGKMLVAVAGGIKEDTAPEAINGGADIII
VGRGITNSKDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A6J5G8V2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia caffeinitolerans|TrEMBL
MKALEVYIGEGFAGPGVNAAHINIMIGPRSGPVGQAFTNSLSSPSQGHVPFMVVAQPNVP
VKPATLYVNKADIRGDLHGNATWGASQAAIAKAVTEAMLDSTLPPEAENEWCIVTANWVN
WSCDDLDAVYENNYAACKTAIRAAMNGLPALHDVAKIKDQISNPFYTPKAKAA
>A0A833A2E1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGRDIIAIVNVVLGKGETIDTIFTNALTRVPTPILANLRDNLIVKPLTLVVP
RNTLSSDIQCNLLHGPIQCGVAKAVADLDLDEDLKLIVTVSVPDVPYTNLNKRKLFQYYY
GATRLAINRALNDYPSKEKIKKEKYRALHPLVGFRDIRLERPPYLQVALDVPSMENVEYV
LESLPPSDRIIVEAGTPLIKKYGIEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGIMSYLDTINVRDPFALYNSLELKPDVLLLHRAIDE
EGRVPMREYREVKRREKPLLGIAGGVTLDNIEELKERYHIIVVGRGITKSRDPGRVARAI
VNKLGDDIDQYRLYLEEDEDVPIR
>D5E9B6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAVDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIPTLEKAISEAHKTGIYAVMDTLNQPDPMAVLKELNELP
DVVELHRAIDVEDTAYAWGSIDAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSKDIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A843K173|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKGPEVAHIDLIIGEKEGPVGTAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMDQAAQIFGPAQTAVAKAVADSVAEGVIPKDRAEELLVIVSVYIDPKAT
DYDAIYRYNYGATKLAVARAMAGFPDIDKVLYEKERSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPDSDHILIEVGTPLVKMLGMSVVKEIRAIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTIELSINEARKTGIYSIIDMLNVTDPLAVLKGLDVLP
DVVELHRAIDMEKSAHAWQNIPDIKALAEEGRRLLVAVAGGIRTDTQGAALAAGADILVV
GRAITRSRDIRDMAEQFLTGLKQTEIDQYRVMTDF
>A0A7K4D4A7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGEKDGPVGTAFACGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKSMDQAAQIFGPAQMAVAKAVADSVAEGIIPKEKAEELVVVVSVFIHPQAK
DYDAIYRYNYGATKLALQRAMEGFPDVDKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDLEEVRRVLAALPESDHILIEVGTPLVKMLGINIVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIDEARKTGIYSVIDMLNVPNPLAVLKDLDVLP
DVVELHRAIDMEKSAHAWQNIREMQALAKPGRRLLVAVAGGIRVDTEAQALAAGADILVV
GRAITRSKDIRDMAEQFLAGLKQTEIDQYRIMTDF
>A0A7W5NI48|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. WP4_3_2|TrEMBL
MKALEVYIGEGFAGPGVNAAHINIMIGPRNGPVGQAFTNSLSSPSQGHVPFMVVAQPNVP
VKPATLYVNKADIRGDLHGNATWGASQAAIAKAVTEAMLDGTLPPEAENEWCVVTANWVN
WSCDDLDAVYENNYAACKTAIHAAMNGLPKLDDIAKIKDQISNPFYTPKAKAA
>A0A151B958|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Bathyarchaeota archaeon (strain B24)|TrEMBL
MEEGFYVGEALVGSGYEVAHVDLVIGSKRGAAGIAFVNALSQLSAGHTPMLAVIRPNLPA
KPNTVIVPKVTVKTMEDADKIFGPAQAAVAKAVADAVEEGLIPRDKCEDWVIIASVFIHP
KAKDYRKIYQYNYGATKLAIRRALKGYPSAEKVLKEKDRAVHPIMGFKVRRLWNPPYLQV
ALDLRSVDRALEVVKLLPKRERLILEAGTPLIKAQGVGVVEKIRSVWRDAFIVADLKTMD
VGRVEVKEAADATADAVCILAVASDTTVDKAILEAQKQGIYSVLDMMEVSDPIARLERLT
YKPDIVLLHVSADVERAAAEAGKPLETRWGNISEIKRRFKVLVAVAGGVTPTTAGEALRS
GADIIVVGRYIVRSGDPRRAAEQFLDLMPPDPDTMRLILDEDERVGEI
>A0A5E7QYB4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas fluorescens|TrEMBL
MKALDLYIGEGFEGPGVNAAHINILIGPRNGPAGQAFANSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAAIGSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGKPETAQLADVVNHISNPFYTLKA
>C7P8E8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)|TrEMBL
MIKFGEAVLGNDEAKAIVNVALGKGKEIDEVFTNALTRGSCIFANLRPNLIVKPLTLVVP
RHNIESSIQDELFHGVVQYAVAKAVADLDLDEDLKVVVSVNVPELPLTNLTKRKLFQYFY
ASARLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFL
LQTIPKSDHIILEAGTPLIKKFGLEVVEVMREYFDGFIVADLKTLDTGRVEVRLAFEATA
NAVAISGVAPKSTIIKAIHECQKCGLISYLDMMNVPNPQELYDSLKLKPDVVILHRGIDE
ETFGVKKEWKFKGDCMLAIAGGVGVENVEELLKECQILIVGRAITKSRDPGRVIRMFINK
MGYDIDTYRLYFDEDEDIDI
>A0A843JW56|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum sp|TrEMBL
MYLIGEALIGEGSELAHVDLIVGDKNGPVGMAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKNEGQVNQMFGPVQAAVAKAVADAVEEGLFGDININDICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEEFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDLGKLRSVLSSLPENDHLIIEAGTPLIKKFGLNVISEIRAVKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A101DCK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus|TrEMBL
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNA
KNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKA
GVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVV
GRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
>A0A662RRU4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MIDEGFMIGEALVGEEPEIAHIDLIIGSKKEAVGTAFACSIAQPRQGHTPILGVIRPNLP
TKPTTLIVPKVSIRNLADAEKMFGPAQSAVAKAIADAVEEGVIPKAEVEELAVIVSVFIH
PRGRDYQRIYRYNYAATKLALSRAIQKFPDIDKVLEEKDKSIHAMIGFKMNNLKKPPYLE
VALDIPDWRRVEGIIRALPRSDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVFADLKTL
DTGNLEARMAGDATADVAGFSGLAPIGTMEKFIEECKKVGTLSLMDTLNVPDPVEVLRKL
KVKPDIVELHRAIDVELYQNRGQEQESEWGNIGEVREVCGNEVLVAVAGGIRLKKVKKAL
KAGADIIVVGRAITAAKDVTGAARGFLQQMGVEDVDQFRVMTDF
>A0A6J4MGC2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured Gemmatimonadaceae bacterium|TrEMBL
MAADFFIGESLVGDGNEVAHIDLIIGSKSGPAGAAFVNALSNQKDGFSTLLAVVSPNLPA
KPDTILFNKVTIKGAKQAVQMFGPAQAAVARAVVDSVESGIIPRDKADDYVILVGVFIHW
DASDDQKIYSYNYQATKESIQRALGNKPSVSEVLSQSKSAKHPFASDAERKHGESSGSAG
GKQMQGANI
>A0A822IN53|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MVYIRSMIGEALAGDGNEIAHIDLVIGPRGGPVETAFMNSLAMPREGHTPLLAVLEPNLQ
PKPCTLMVNKVTIKNADQAVLMFGAGQAAVAKAVIDSVEEGVIAKSDAEDLLIIVSVFIH
WEAKDKQKIYDYNYEATKLAIKRAIASEPSVGEALARKDKAKHPFA
>A0A839ET97|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Phyllobacterium myrsinacearum|TrEMBL
MDKPLGNSLGRNLAVVKINKVMVGESLVGDGNEVAHIDLLIGPRGSAVETAFCNALTNNK
DGFTSLLAVIAPNLACKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVQDSVADGTIPA
DEADDLFICVGVFIHWEAEDDAKIQDFNYRATKEALERAVTGKPTAAEATAQRDSVKHPF
SA
>A0A811TGQ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Argoarchaeum ethanivorans|TrEMBL
MFLIGEALIGSAPELAHIDLVIGDKNGPVGSAFAAGMTQLSAGHTPVLSVIRPNLLTKPA
TLIVPKVTMKKTEQVNQIFGPAQNAVALAIADAVEEELIPQDKAEEWVVIASVFIHPDAK
DYSKIYRYNYGATKLAIQRAMEQFPSINTVLDEKNRAAHPVMGFKVTRLWDPPYLQVAID
VPDIDYVQQILKEMPQSDHLIIEAGTPLIKRYGVDVIEKIREARNNPFIVADLKTLDTGN
LEVRMAADATADAVVISGLAPTSTIEKAIKEAKKTGVYSVIDMLNVKDAAGLIDNLPVKP
NIVELHRAIDLENTVATGWDSIQKIKKISGKILVAVAGGIRIDKLKPSDHTVDEALAAGA
DIIVVGRDITKAKDVRLKTEQFLEHMKKPEIDQYRIMTDF
>A0A1D2WWC2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. A14|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFLHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKVAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A0E3S053|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina lacustris Z-7289|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGFTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTIKNMEQASRIFGPAQSAVAKAVADSVEEGVISKDQAEDLVIIASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPGIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPDIEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISRIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAVVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIDEIKKVAPKSLVAVAGGVRLDKVPIALSQGADILVVGRA
ITNAKDIREMAEQFINSLNKPEIDQFRVMTDF
>A0A075WCQ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus DSM 8774|TrEMBL
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNA
KNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKA
GVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVV
GRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
>A0A832RUU1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methermicoccus shengliensis|TrEMBL
MLLVGEALIGEEPELAHIDLMIGDKDGPVGEAFAAGLSTLSMGHTPLLAVIRPNLLTKPA
TLIVPKVTVRSMEDAAKVFGPAQSAVALAVADSVQAGIIPRDKVEELVMVVSVFIHPEAK
DFDRLYRYNYGATKLAIARAMEGFPSIDKVLEEKDRDVHPIMGYRVLKLFDPPYLQIAID
IPDIAHVERVLREVPHSDHVIFEAGTPLIKRYGLSIIERMRAVRRDAFIMADLKTLDTGN
LEARMAADAAADGVVVSGLAPLSTIESAISEAKKTGIYSCIDMLNVKEPAGLLGRLSIKP
DIVELHRAIDAEGAESHAWERITEVKEASPTSLIAVAGGIRMDNMQQALDAGADILVVGR
AITKSKDIRNTAEMFLSGLKVSEIDQFRIKTDF
>A0A2V2MR66|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum stamsii|TrEMBL
MYLIGEALIGEGAELAHVDLIVGDKNGPVGMAFANALSNLSAGHTPLLAVIRPNLLTKPA
TVVIPKVTLKHEGQVNQMFGPVQAAIAKAVADSVEEGAFGKSDINEICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEQFPDEKTLINEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDMGKLRAVLSSLPENDHLIIEAGTPLIKKFGLQVISEIRAIKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPSSTIEKAIVEARKTGIYSVIDMLNVEDPVGLIAGLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A832PES9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp|TrEMBL
MYRISEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESVEEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNRIRKLRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGIYSILDMMNVENVAEKLEELRYKP
EIVLLHKNIDVGAAEVSEWGDIPKIKEIIGERGLVAVAGGITPSKTRRALESGADIIVVG
RYITGSKDPRRAAEDFLEELPPDPDTMRLPHEEDEPI
>A0A679JA22|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium bullatum|TrEMBL
MSEIWFRTGEATVLAADGQYTDAMPEVLIGSTRGPVGQAFAGMMGQVQGHTRMFVVRDLN
QLVRPSTMMTTKATIHTAEYVNLLGGVVQAATGDAIVDCVIEGILPKDGLDELCMIIMIW
LDPRCAEDANLDQKDLYRTNYEATKLAIARAIKGEPTIDELIANRKTVKHYALEDIIEY
>A0A679JNW7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium bullatum|TrEMBL
MGRECAGHSDIEKDMSMSERIILRAGEALVAGGPPNTASEPEVIIGELDGPVGTALATLT
GDQVVGHSRVFALLNTDIMVRPVTLCVSKVSVTESKYTSILMGTVQFAIANGVLDAVRLG
YIPKEKANDLGIICSVWLSPGVIEAETVDHKALFEIQRKGMTEAIRKAMTNEPSIDWLLE
NQDKIIHKYYQMGLDGKI
>A0A2I0PQ92|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon HGW-Methanomicrobiales-1|TrEMBL
MYLVGEALVGDGAELAHIDLLMGDKEGPIGTAFANAISQLSAGHTPLLAVVRPNLLTKPV
TLVIPKVTLKDMAQVNEMFGPVQAAVAKAVADCVEEGLFNGIDLEKVAILASVFVHPDAK
DYNRLYRYNYGATKLALNRALAAFPDAKTLVFEKDRAAHAVMGFKVQRLWDAPYLQVAMD
LVDMGKVAQVLKELPENDHLIIEAGTPLIKKFGLGVISEIRKLRPNAFIIADMKILDTGN
LEARMAADATADAVVVSGLAPASTMEKAISEARKVGIYSIVDMLNVQNPAKVIASLKVKP
DIVELHRAIDTEETAHAWGDIQAIKKAAGGKLLVATAGGVRVNVVKDALKAGADILVVGR
AITASKDIGHAADEFLEQLDREEIDQFRIMTDF
>A0A843LEC0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp|TrEMBL
MYLIGEALVGDGAELAHVDLIMGNKEGPVGQAFANALSQLSKGHTPLLAVVRPNLPAKPS
TIIIPKVTLKKEYQVNQIFGPVQSAVAKAVADLVEEGAFEGIDIEDIVIMASVFVHPTAE
DYNKLYRFNYGATKLAIRRALDRFPDVDTLLHEKDRATHAVMGFKVQRLWNPPYLQVAMD
LVDRNHMRKVLEELPESDHLILEAGTPLIKKFGLSIISEIHEIRPGSFIVADLKTLDTGN
LEARMAADAGADAVVISGLAPLSTIEKAIQEARKTGIYSVLDTLNVSDPVAVIGQLKVKP
DVVELHRAIDIEDTDYAWGDIPAIRKAGGERMLIATAGGIRQHVVKEALRAGADILVVGR
AITASKNIKHAAEEFLEELNTEEVDQFRIMTDF
>A0A2U0RY54|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MREFDVDFSDVDEKDLVSEASKQSTYLIGEALMGEGTEVAHVDLMIGDKDGPVGMAFANG
MTNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMADTGKIFGPAQAAVAKAVADSVEE
GVIPWDKVDDWVIVCSVFIHPQATDYRSIYHYNYGATKLAISRALQNYPTLDKVMYDKDR
AKHPIMGFKVPRLWRPPYLQIALDNPNLEAIKKIITELPESDRIILEVGTPLLKKYGVNV
IRELRKTAKDMFIVADLKTLDVGKIEVDMAFEETADAVVVAGLATAETIDKFIKEAKRLG
IYAIMDLMNVDDPIAKLKSLKRLPDVAILHRAIDAEKTGKTRWEIIKEMKQTFQGQKCLV
AVAGGINPQTAPEALASGADIIIVGRYITQSKDVERATREFLKATKEMAEDIDLFRVHVE
>A0A497ERY4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Verstraetearchaeota archaeon|TrEMBL
MYLIGEALVGEGNEVAHIDLILGDKNGPVGEAFASGLAHMSAGHTPLLAVIRPNLPPKPH
TLIVPKVTIKNMEQANAIFGPAQAAVAKAVADAVEEGILPRDKVDDWVIICSVFIHPDAK
DYRKIYHYNYGATKLALKRAMAKYPSLEKIFYDKDRATHPIMGYRVPRLWRPPYIQIALD
IPSLEQTKRIIMQIPKSDRIILEVGTPLIKKYGTKVIRDLREVAKDMFMVADLKTLDVGK
VEVDLAYEDTADAVVAAGLAPTETLDGFIYEAKRLGIYAVVDMLNVDDPIKKLKSLKEFP
DVIIIHRGIDQETGRTIGLELIEKLRETFKDKRFLVAVAGGIVPETAKEALEKKADIIIV
GRYVTQSKDIERAVREFLTLTPEMREDIDLFRVHVE
>A0A8J7RCP8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis sp. W23|TrEMBL
MYLIGEALVGTGAELAHIDLIMGDKNGPVGMAFANGMSQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKNGEQVNEIFGPAQAAVAKAVADSVEEGVFEGIDLDETVILASVFIAPDAE
DYSKIYRYNYGATKLAIRRALKKFPDTETLLYEKDRSTHAVMGFKVQRLWNPPYLQVAMD
LVDMARVEAVLTAVPKNDHVVFEAGTPLIKQFGLNVLSEIRKIRPDAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPTATIEKAIEETKKTGIYSVIDMLNVKDPVALIKELKVKP
DIVELHRAIDTEGDEYSWGNIPAIKEAAGGKLLVATAGGVRQHVVQKALDSGADILVVGR
AITGSKDIGHAADEFLERMNAPEIDQFRIMTDF
>D7EB20|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)|TrEMBL
MLLVGEALIGEEPELAHVDLMVGDKDGPVGQAFATGMTQLSAGHTPMLSVIRPNLPAKPS
TLIVPKVTVQNMKQAEQVFGPAQAAVAKAVADSVEDGVIPKDKAEELVLVASVFIHPKAS
DYNKIYRYNYGATKLALKRAMDGFPDVDTMCEEKDKSMHAIMGFKVTRLWDPPYLQVALD
NPNLDAVKNIISQLPQSDHLILEAGTPLIKRYGVDVVSRLREVKPDAFIVADLKTLDTGN
LEARMVSDATADAIVVSALAPVSTINKAINEAHKTGIYVVMDTLNEPDPMSILKQLDELP
DVVELHRAIDVEETEYAWGSIDAIKELSPKIMVAVAGGIRVDTIPDALKAGADIVVAGRA
ITNAKDVRQVSEKFLDVLNKPEIDQYRVMTDF
>A0A7G9Z6M9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MMNVGEALIGNGEEIAHIDLMIGDKSGPVGMAFTNALSQMSAGHTPLFAVIRPNLPVKPS
TVVVPKVTVRNMKEAEKVFGPAQSAIAKAVADSVEEGVIPEDKAEELVVIVSVFIHPHAD
DYNKIYRYNYGATKLALKRAMDGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALD
IPNWEHMERVVKDLPSNDHLIIEAGTPLIKRYGVDIVAKIKEIKPDTFVIADLKTLDTGN
LEVRMVSDAGADAVVISGLAPLRTMEKAIEEARKTGIYSSLDMLNVEKPLDVLKELSVGG
MMPDVVELHRAIDVEQEERHAWGDMAEIKRIGGKMLVAVAGGIKEDSAPEAINGGADIII
VGRGITNSKDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A7U7EL29|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas carbonaria|TrEMBL
MKQLALYIGEGFEGPGVNAAHINILLGPRNGPAGQAFASSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAPIGGDLHANATWGASQAGIAKAVTEALLDGTLPAEAEDEWAVVTANWVN
PACDDLDAVYLNNYNACRTAIRAALACKPERAQLADVVGQIANPFYTPKA
>A0A2H4VI84|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. MZ-A1|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAEDMVLIISVFIHPEAS
DYRKIYQYNYGATKLALRRAMEGYPSINKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRALKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTGKLETLNYKP
DIVLLHRNVDLETMKAERGEEQADMTEWGNINQIKDLLGKNGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDEAI
>A0A0Q1CK63|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. SDB|TrEMBL
MFLIGEALIGDEPELAHIDLLIGDKDGPVGMAFANGLAQLSAGHTPLLSVIRPNLPPKPA
TLIVPKVTVKNMDQAATIFGPAQTAVAKAVADSVAEGIIPRADVENLVLIVSVFIHPQAR
DYDAIYRYNYGATKLAIKRAMEGFPDIGTVLYEKDRSTHPVMGFRVIRLWDPPYLQVALD
LVDLSVVRKVLSQLPDSDHLLIEVGTPLVKKFGAQVVKEIRNVRPSSFVVLDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIREARKTGIYSVIDMLNVPDALAVLRSLSALP
DVVEMHRAIDQEAEKHNWEVIGEIKELAAGSDRKILVAVAGGIRVDTVASALKSGADIVV
TGRAITGSKDVKDAAEQFLAELKQTEIDQYRVMTDF
>A0A0E3WYL5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcoides methylutens MM1|TrEMBL
MFIGEALIGEEPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPST
LIVPKVTVKNMDQAAQIFGPAQAAVAKAVADAVEEGVVPTDQVEDLVIIASVFIHPQAVD
YNRIFRYNYGATKLALKRALDNFPDIDTVLDEKDKSSHAIMGFKVSRLWDAPYLQVALDN
PNIGAITNVVKQLPKSDHLILEAGTPLIKRYGVDVITKLREIKPDAFIVADLKTLDTGNL
EARMVADATADAIVVSALAPIATLNKAIAEAHKTGISAVMDTLNQPDPVAVLEQLDELPD
VVELHRAIDIEETAHAWGSIEGIKAIGEKRNKKILVAVAGGVRVDTISDALGAGADILVV
GRAITNSKDIKQAADQFIEGLNKPEIDQFRVMTDF
>A0A524QH14|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
AEGIIPKDKAEELLIIVSVFIHPQAKDYDAIYRYNYGATKLALERAMIGFPDVDLMLYEK
DRSTHPIMGFRVTRLWDPPYLQVAFDLVDLAEVRRVLTALPDSDHILIEVGTPLVKMLGI
SVVKEIRAIRPGAFVILDLKTLDTGNLEVRLAADSTADAVVISGLAPKKTLELSIREARK
TSIYSIIDMLNVPDPLLVLKGLDVLPDVVELHRAIDNEKSAHAWNNIRDIQALAKDGRKL
LVAVAGGIRVDTEGAALAAGANILVVGRAITRSKDIRDMAEQFLTGLKQTEIDQYRVMTD
F
>A0A5E6VGX1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas fluorescens|TrEMBL
MKELDLYIGEGFEGPGVNAAHINILIGPRNGPAGQAFANSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAAISSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGKPETAQLADVVGHISNPFYTPKA
>A0A843C443|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Heimdallarchaeota archaeon|TrEMBL
MADFFIGEALQGKGNELAHVDLMIGDKDGPVGHAFANGMTQLSQGHTPLLALIKPNLVPH
PRTLIVPKVTINSLDQAAKIFGPAQMAVAKAVADAAEEGDIPPGKIFEYVVIVSVYIHPK
AEDESKIYYYNYGATRLAIKRALSNYPSMKKLIAEKDRAKHPVMTFRPQTLWDPPYLQVA
LDVGSLSAAVKIVEELPKSDRIIIEIGTPYIKKYGIEETIGRMRVLKPGAYIIADMKTMD
VGRAEVEAAADATANAVVVSGIAPAETIAEFIRACNKRGVHAWVDSLNTNQAELLATLQG
LKEKPKVVILHRGIDQEDAQKEGGTKKEGTSASRSVWGDIKQIKKITGGLAAVAGGLKPG
QPLADALKAGADIVIVGRYIYRSSDPNRAAMRFLDEMEIEADTMRLFDKLDY
>A0A101IFN3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix harundinacea|TrEMBL
MFLIGEALIGDEPELAHIDLLIGDKDGPVGMAFANGLAQLSAGHTPLLSVIRPNLPPKPA
TLIVPKVTVKNMDQAATIFGPAQTAVAKAVADSVAEGIIPRADVENLVLIVSVFIHPQAR
DYDAIYRYNYGATKLAIKRAMEGFPDIGTVLYEKDRSTHPVMGFRVIRLWDPPYLQVALD
LVDLSVVRKVLSQLPDSDHLLIEVGTPLVKKFGAQVVKEIRNVRPSSFVVLDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIREARKTGIYSVIDMLNVPDALAVLRSLSALP
DVVEMHRAIDQEAEKHNWEVIGEIKELAAGSDRKILVAVAGGIRVDTVASALKSGADIVV
TGRAITGSKDVKDAAEQFLAELKQTEIDQYRVMTDF
>A0A0H2M8R7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Variovorax paradoxus|TrEMBL
MAKIDRLMVGESLVGDGNEVAHIDLIIGPRGSAAETAFANALTNNKDGFTSLLAVVAPNL
LTKPATVMFNKVTIKGAKQAVQMFGPAQRAVALAVADSVEDGTIPMAEADNLFICVGVFI
HWLADDDKKIQDYNYQATREAIQRAVAGSPTAAEVVDKKGTTAHPFAAHL
>A0A662SXK5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Korarchaeota archaeon|TrEMBL
MMLIGEALVGKEPEIAHIDLVIGSKDGPVGQAFAAGLAHCSAGHTPLLAVIRPNLPCKPF
TLIIPKVTVRNMRDAEKIFGPAQAAVAKAIADAVEEGIIPRDKVDDWVIICSVFIHPQAK
DYRRIYHYNYSATKLALKRAMQAYPSLEKIMYDKDRAIHPVLGYRVPRLWNPPYLQIALD
IPSLSRIIEVVKQIPKSDTIILEAGTPLIKRYGASVIRQLREVAPDVFIVADLKTLDVGK
VEVDIAFEETADGVVASGLAPVETLNKFVYEADRLGIYSFIDMLGVSDPLSVLEKLEKLP
SGVIVHRGVDEAGRDIRWHLVKKIREAYGRKLLIAVAGGIVPENVREALRLGADIVIVGR
YITQSRDVERAVREFLMEFEKRELDIDLFREHVE
>A0A160PDL5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylorubrum populi|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPADEADDLYVLVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKAATVTEQRNSAQHPFAANA
>A0A7Z0BBC8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia bryophila|TrEMBL
MSVSTDKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSDFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSAN
WVNPSTDDLDAVFENNYRACKNAILAAMKGLPHRDEVFAAAREVSNPFYTPKQR
>A0A822J1Z3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MLEDLLIIVSVFIHWEAKDKQKIYDYNYETTKLAIKRAITGEPTVGEALARKDKAKHPFA
>A0A852YGW3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Schumannella luteola|TrEMBL
MTAGLQIGESFIGEGVNAAHVNTVLGHRDGPAGVAWATALATPSAGHVPFVTVLRPSLPV
KPLTLFVTKAAPAGDEHGLLIWGPAQAGIAAGVADAVADGIIPAEHSDTHALVAAVWVNP
GADDADTVYRNNRLSVRTALENGLRGLPALDDVVAARDAAANPFYTAPPTAASTTPGAS
>A0A850M445|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Helarchaeota archaeon|TrEMBL
MYAIGEALLGREPELAHVDLIIGDKKGNVGLAFANALSQLSKGHTPLLAVIRPNLPCKPW
TLVVPKVTVQSGTQIAKIFGSAQYAVAKAIADAAEEGIIPQGKLDDWLIIVSVFVHPGAK
NDRRIYSYNYSATKLALKRALSNYPPYDKILYDKDRAKHPILGFRVPRLWRPPYLQIALD
VPSKERTEKIIKEVPKSDRIILEVGTPLLKHYGTQLIGELRNIAKSAFIIADLKTLDVGK
VEVDLAFEETADAVVASGLASIQTLDKFIYEADRVGVYSFVDMMDVEQPIEKLKQLKQLP
NLVIIHRAIDTEATAKPRWDLIKEVKEVGVKLVAVAGGIRPQTTIDALKSGADIIIVGRY
ITQSKDIERSTREFLKIFEEKQYWSDIDLFRVHEE
>A0A850LX50|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Helarchaeota archaeon|TrEMBL
MVTKQVFEIGEALLGAGAEVAHIDLMIGDKSGPVGIAFANALSQLSMGHTPLLAVIRPNL
PPKPFTAIIPKVTVKSGEDISKIFGPAQASVAKAIADAVEEGVVPSDKLDEWVIVVSVFI
SPQAKDMRKIYHYNYGATKLALKRALTRYPDLKKIIYDKDRARHPIMGFKVPRLWRPPYL
QIAIDNPSIKMAKRVIQEMAKSDRIILEAGTPLIKRYGVSIINELRQVDGAKDIFFIADL
KTLDVGKVEVDMAYEETADGVVGSALANKESLDKFIYEAKRVGIYAIVDMMNVPDPIGKL
KSLKELPDVVILHKAIDTEAGEGSGTDKITNRAEMVAMIKQEFPKERMLIAVAGGIRPET
APEALQSGADIIIVGRYITQSRDIERSTREFVRLLAEKAPKAPGDVDLFRVHEE
>A0A839W2A5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Azospirillum sp. OGB3|TrEMBL
MPMWGGQSTKINRVLVGESLVGDGNEVAHIDLIMGPRGSAVETAFCNALTNNKDGFTALL
AVVAPNLMCKPATILFNKVTIKGAEQAVQMFGPAQHAVAKAVADCVSEGTIPQDEIDNIF
ICVGVFIHWEAKDNAKIQDYNYRATKEAIERAVASFPSAQDLMNQKDKVKHPFAA
>A0A1J5QD69|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MAVIDRVLVGEALVIDNRPDGSGLDLLNVAHIDLIIGPRGSAAEDAFCRTLTDQKEGVNG
LLAVVAPNMMTKPATVMFNKVTIKNGRQAVQMFGPAQRGVSMAVMDCVADGTIPLEEAED
VFICVGVFIDHKADMDERIQEWNYQATKQAIKSAIAREPKAADVVKNYKTSSHPFAANN
>A0A1J5Q065|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MAVIDRVLVGEALVIENRPDGGGLDLLNVAHIDLIIGPRGSPAEEAFCRTLTDQKQGVNG
LLAVIAPNMMTKPATVMFNKVTIKNGRQAVQMFGPAQRGVAMAVMDCVADGTIPEEEADD
VFICVGVFIDHKADIDERIQEWNYRATKQAIKSAVAREPKVEDVLAKYKESAHPFQA
>A0A1J5SGW0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MAVIDRVLIGEGLVIEDRPDGSGLDLKNVAHIDLIMGPRGSAAEDAFCRTLTDQKEGVNG
LLAIVAPNMMVKPNTVMFNKVTLKNSKQSVQMFGPAQRGVAMAVMDCVADGTIPVEEADD
VFICVGVFIDSKADMDDRIQDWNYRATKIAIKSAIAREPKAADLLKVYKASAHPFAAKN
>A0A832W4S2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLE
>A0A654C1T9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Burkholderia sp. 8Y|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLIIGPRGSAAETAFCHALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPADEADDLFICVGVFI
HWEAADDKKIQEFNYQATKEALQRAVAGEPKASEVVSRKSSVAHPFAAA
>A0A328S9U2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. SHI613|TrEMBL
MYEIGEALIGNGPELAHIDLIIGDKEGPVGHAFATNMANMSVGHTPLLSVIRPNLPAKPA
TLIIPKVTVQNLEDASKIFGPAQTAVGRAVADAVEEKIIPEDKVNDIVIMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRAFEGYPDVEKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTIDSIDKAIHECTKQGIYSILDMMNVDNIIEKLDSLKFKP
NIVLLHRNIDTETMQQNDDEQASEWGNIKAIKAKLGDKGLAAVAGGVTPEKVNKALENGA
DIIIAGRYIIGSSDVRRAADDFLRYLPQDSDTMRVALDEDEKI
>A0A2U1S6C6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter woesei|TrEMBL
MYNIGEALIGDGDELAHVDLIIGDKEGPAGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDANKIFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIHPAAK
NYRKIYQYNYGATKLAIRRAMSGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMEKIINDLPDKERVLIEAGTPLVKKFGVGVVSKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVDDFAEKLSELPEDL
KPDIVLLHRNVDLETYKAEKGEDTSNMTEWGNIKEIKKLIDGGLVAVAGGITPDKVEEAT
EKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A7K3Z1I6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Crenarchaeota archaeon|TrEMBL
MLTEAAKKEVDSKGKPTKPTIVGTAKEINIHRDTLYSWLKDFNVDFKEIIDRIPTTSYES
DEYPSPTYLIGESLVGEGNEVAHIDLMIGDKNGPIGQAFANGIANLSAGHTPLLAVIRPN
LPPKPHTLIIPKVTVKNMEDTGKIFGPAQAAVAKAIADSAEEGIIPLSKLDEWVIICSVF
IHPQASDYRKIYQYNYGATKMALQRALRKYPSLEKIIYDKDRAKHPIMGFKVPRLWRPPY
LQISLDAPSLEGAKKVIEALPGSDRIIIEVGT
>A0A1V4U7S7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon PtaB.Bin056|TrEMBL
MYLIGEALVGDGPELAHVDLILGDKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLAKPA
TLIIPKVTLRKGVQIKEMFGPVQAAVAKAVADCVEEGLFGKSDLESLVIMASIYLDPTAA
DYNKIYRYNYGATKLALSRAIEKFPDQKTLIYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVDMNKVHSVLAELPQNDHLIIEAGTPLIKRFGLSIIPEIRKVRPNAFIIADMKILDTGN
LEARMAADASADAVVISGLAPLPTLEKAIAEAKKTGIYSVIDMLNVPEPLKVIKALKVKP
DIVELHRAIDAESSEHAWGDIPALKKAAGGKLLVATAGGIRVDGVKKAFAAGADIIVVGR
AITASKDVHTAADLFLEQMNKEEIDQFRVMTDF
>A0A166AG45|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter filiformis|TrEMBL
MYEIGEALIGDGNELAHVDLIIGTKDSPAGTAFANGMSQLSIGHTPVLSVIRPNLMTKPA
TLIVPKVTVGNLDDASKIFGPAQTAVGRAVADAVDEGIIPKKDIEDLVIIASVFIHPEAK
DYRKIYQYNYGATKLAIKRALKKYPSIKKVLAEKDRGTHPIMGFRVTKLWKPPYLQVALD
LDNVDVMERIIEATPDRERILLEAGTPLIKKFGVGIVSKIRELRPDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTLESIEKAIHETQRQGIYSILDMMNVKNFEEKLREINPEL
KPNIVLLHRNVDSETSKTEKGESTANMTDWGNIKAIKEILGKGLVAVAGGITPSNMEEAL
DSEADIIIAGRYITSSRNVTRAVEDFLAHMPQDPDNMRLPLDEDESV
>A0A497SIF2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MFKIGEALVGKDNEVAHIDLIIGDKNSYVGQAFANGLTKLSAGHTPLLSVIRPNLPAKPY
TLVIPKVTIEDMEDAAKIFGPAQAAVAKAVADAVEEGIIPKEKIEEWVIIASVFVHPDAK
DYRKIYQYNYGATKLALKRALNDYPSLDKIMFDKDRAIHPIMGFRVPRLPKWNIPYLQIA
LDIPDIDRIKRVISELPRSDKIILEAGTPLIKRYGTQVIRELREVAISDFIIADLKTLDV
GQVEVDLAFDEGADGVVASGLAAVEVLDKFIYEAKRLGIYAILDTMNVDDPVKKLKALKE
LPDIVIVHRAIDVEKKENVRLDLIKKLKNEFPKMMVAVAGGITPETGPLALKEGADILIV
GRYITQSKDVERSTREFIRFMGGDIDLTRVHVE
>A0A497P5Q2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MRKPEKFTYLIGEALAGEGPEVAHVDLIIGDKNGPVGEAFANGLSTLSMGHTPLLAVIRP
NLPPKPHTLLVPKVTVKNLEQAGKIFGPAQAAVAKGVADAVEEGIIPKDKLEDWVIITSV
FVHPEAKDYRKIYQYNYGATKLALKRALAKYPPLEKIIYDKDRATHPIMGYKVPRLWRPP
YIQIALDIPSLERTKKIISALPKSDRLILEVGTPLLKKYGTRVIRDLRELAPDMFIVADL
KTLDVGKVEVDLAFDETADAVVASGLAASETLNKFIYEAKRLGIYAAVDMMNVEDPVQKL
RMLKTFPDIVILHRAIDVEKRTGKTRWDIIKELRQAFKEEKFLVAVAGGIIPETAPEALE
RGADIIIVGRYITQSKDIERSVREFLKCTKEMKVDIDLFRVHVE
>A0A7K4IRJ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTDAAKKEIEIRGLSRKKSTKPTVSGTAKHLNIHRDTLYTWLKEFNVDFDEISGEISTN
LLESVETSKKYAYLIGEALIGEGNEVAHIDLLIGDKEGPVGEAFALGLSNLSVGHTPLLA
VIRPNLPPKPHTLLVPKVTVKNLEDAGKIFGPAQAAVAKAVADAVEEGLVPKDKLDDWVI
VCSVFVHPEAGDYRKIYHYNYGATKLALKRALAKYPTLEKILYDKDRAKHPVMGFRVPRL
WRPPYVQISLDIPELERNKKIIAQIPKSDRIILEAGTPLIKRYGTKVISDLREIAKDVFV
IADLKTLDVGKVEVDLAYEETADAVVAAGLAPIETLDSFIHEAKRLGIYAVVDMLNVEDS
LAKLKPLKEFPDVVILHRGIDQETGRSIGLELIQEMRQTFKDKKFLIAVAGGIVPETAKE
ALEKGADIIIVGRYVTQSKDIERAVRDFLELTPTMREDVDLFRVHVE
>A0A550GYW8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MDTKKPETQDELLRIVSEAALKSVKIRSAQKRISTKPTISGTAKTLNIHRDTLYTWLKEF
NVDFKEILDSISTDISDDAEVLGKTYLIGESLVGEGNEVAHVDLLVGDKEGPVGKAFANG
LSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMEDTGKIFGPAQAAVAKAVADSVEE
GIIPADKVDDWVIICSVFIHPQATDYRRIYQYNYGATKMALQRALKKYPSLEKINYDKDR
AKHPIMGFKVPRLWRPPYLQISLDAPSLESAKKVIAQLPGSDRIIIEVGTPLIKRYGTRV
ISDLREVGKDAFMVADLKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLDAFVHEAKRLG
IYAVIDMLNVEDVLKKLQSLKQLPDIVILHRGIDQESGRTCGLERIQMMRQAFSGKRFLI
AVAGGIVPETAKEALKQGADILIVGRYVTQSKDIERAARDFLELTPSMREDIDLFRVHTE
>A0A6B9TBN1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. THM-1|TrEMBL
MYRIGEALIGSRNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVSCLEDADKIFGPAQTAVARAVADAVEEGIIPEEKAEDLVVIVSVFIHPDAE
DYRKIYQYNYGATKLALRRAMEGYPSIRKVITEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIIDSLPNRERILLEAGTPLVKKFGVGVVSRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVEKLKGLKYKP
DIVLLHRNVDLETLRAERGEDIGDMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALE
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A0E3LBZ6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina siciliae C2J|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNLDQAAKIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVVVASVFIHPEAQ
DYNKIYRYNYGATKLAIRRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISRIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKAMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDVREVAEQFINALNKPEIDQFRVMTDF
>A0A7K4DF69|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALVGDGAELAHIDLMIGDKGGPVGQAFANSFSQLSQGHTPLLAVVRPNLPAKPS
TLVIPKVTLKKEYQVNQVFGPVQAAVAKAVADSVEEGVFEGVDIEETVIMASVFIHPSAG
DYNKLYRFNYGAMKLALRRALDRFPGVDTLIYEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRDHMRRVLEGLPKNDHLIIEAGTPLIKKFGLSVISEIREIRPSAFIVADLKTLDTGN
LEARMAADAGADAVVVSGLAPISTIEKAITDTRKTGIYTVVDMLNVEDPVAVVERLAVKP
DVVELHRAIDVEDSDHAWGDIPAIKKAGGERLLVATAGGIRQHVVKDALHAGADILVVGR
AITASKNIRNAAEGFLQEMDAEEVDQFRIMTDF
>A0A2R6T918|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon SCG-AAA382B04|TrEMBL
MFKVGEALIGEEPEVAHIDLIIGEKNGPAGQSFLNGVTNPTRGHTPLLGVIRPNLPTKPS
TLIVPKVTVENMEDSEKVFGPAQEAISKAVADAVEEGLIDKEKAEELVVIVNVFIHPKAQ
NYQKIYRYNYGATKLALKRALNNFPDANKVLEEKERGGHPIMGSRITKLFNPPYLQVALD
IPSLDKVKNVVDQIPKSDNITIEIGTPLVKKYGVDVVGELRESKKDAFFVVDLKTLDTGN
LETRMVADAGGDGVVISGLAPEPTIENAIKEADKTGIYSIIDTLNVDNPLELIENLDQKP
DIVELHRAIDKEDEESHGWQNIEDIRELLGKQGLVAVAGGIRTHNVQEALESGADILVVG
RAITNAKDPEGAIRDFLERMEKPDTDQFRVKTDF
>A0A0E3NJY3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. WWM596|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQASKIFGPAQSAVAKAVADSVEEGVITKDQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNIEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPIFVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKVAPKALIAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDIREMAEQFINSLNKPEIDQFRVMTDF
>A0A1Y3GG62|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanonatronarchaeum thermophilum|TrEMBL
MFKVGEALIGEEPELAHIDLVIGDKSGPAGQAFLNGLTNLSQGHTPLLGVIKPNLPTKPS
TLIVPKVTIQGMEDTEKIFGPAQEAVSKAVADSLEEGIIDPETAEEKVIITSVFIHPEAT
DFQKIYRYNYGATKLAIKRALNEEPTPNEVIKEKDIGGHPIMGNRITRLSKPPYLQVALD
TTNFQHVEKLLKEIPENDNVIFEVGTPLVKKYGVDVVSRMREIREDAFIVVDLKTLDTGN
LEARMVADAGGDGVVVAGIASKPTIEGVIEEAEKTGIYSIIDTINMKNPIELIKKLDKKP
DILELHRAIDMEDQAEHAWHNIPELKKELNNGLISVAGGIKTQNVKEAVDAGADILVVGR
AITGAKDPEGAAREIIEEIKTTL
>A0A7D5I3S1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus zinderi|TrEMBL
MLLVGEALIGENPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMDQAGQIFGPAQAAVAKAVADALEEGAFGDMDVEDLVVVASVFIHPEAK
DYNRIYRYNYGATKLAVKRAVDGFPDVDTVLKEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPVIQEIVSQIPKSDHVILEAGTPLIKRYGVDVVTKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVATLNKAIEEAHKTGIYAIMDTLNCDDPVAVLKQLDVLP
DVVELHRGIDIEETEHAWGNIDEIKALSPKLLVAVAGGVRINTMPQALKAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A832YR35|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGNGDIKAIVNVIIGNGDKIDIAFTNALTRVPSPLFANLRDNLIVKPLTVVV
PRNNLYSDIQCNLLHGPIQYGVAKAVADLDIDEDLRLIVTVSVPDVPYTNLNNRKLFHYY
YGATKLAITRALKEYPSKEKIKKEKYRAIHPLVGFRDIRLERPPYLQVALDVPTIENMEY
ILESLPQSDRIIIEAGTPLIKKYGIEVIEHIREIYDGYIIADLKTLDTGRIEVRMAFEST
ANAVVLSATAPKNTILKGIHECEKCGIMSYLDTMNIGDPIKLYESLELKPDVLLLHRGID
EEIEREMKIENNIGNKSIEGIGEERPLLGIAGGVSIDNVEELKDKYDILVVGRGITKSRD
PGRIARAI
>A0A5E4K7L1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MVHIVKSMVGEALVGDGAEIAHIDLVIGAKGTAVETAFMNSLAMPREGHTPLLAVLEPNL
QPKPSTLIVNKVTIKNADQALLMFGPAQASVAKAVMDCVEEGTINKDDAEDLLIIVSVFI
HWEAKDKQKIYDYNYEATKLAIERAVKREPSVDEALARKEKAKHPFA
>A0A0E3WMT7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei LYC|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A524FFX8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKTDYFIGEALLGAEENLAHIDLLIGSKDGPVGISFANALSTPSMGHGRLLACIRPNLL
TKPISLIVPKVTLSNMEDSNKIFGPAQAAVAKAIADAVEENLIPISKIDEWVLIVSVFIH
PDAKDYRKIYQYNYGATKLAIQRALKSYPPIEKIFYDKDRAKHPVAGIKVPRLWRPPYIQ
VAMDHPDIAHHIKVLSQLPKSDRIILEVGTPFLKRYGMEAIKEIREHAQQKFIVADLKTL
DVGKLEVDFVFDATADAAVASGLASSSSIDKFLLEAHRLGMYGFVDTMEVEDPIAKLSKL
>A0A257MQ10|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. NSM2|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKEGPVATAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADSVAEGIIPKDRAEDLLVIVSVFIHPQAK
DYDAIYRYNYGATKLALERAMAGFPDVDLMLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLAALPESDHILIEVGTPLVKMLGISVVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVPDPLAVLKGLEVLP
DVVELHRAIDMEKSAHAWSNIGEIQALAKDGRRLLVAVAGGIRVDTEAAALAAGANILVV
GRAINPLQGHSRHGRAVPHGPEADRDRPVPGHDGLLRISDTL
>A0A7C1E4P5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobia archaeon|TrEMBL
MFVGEALIGEGAEVAHIDLMIGDKFGPVGIAFTNALSQMSAGHTPLFAVIRPNLPVKPST
VVVPKVTVRNLKEAQKIFGPAQSAIAKAVADSVEEGVIPEEKVEDYVVIVSVFMHPHASD
YNKIYRYNYGATKLALKRAMEGFPDIKKVLYEKDRSRHPSIGMKVTKLWDPPYLQVALDI
PKWEHMERVVRELPLNDHLIIEAGTPLIKRYGVDIVEKIKAIKPDTFVVADLKTLDTGNL
ETRMVADAGADAVVISGLAPLRTIEKAIEEARKTGIYASIDMLNVRNVLDVLNDLSVSGF
IPDIVELHRAIDVEELERHAWGNIEEIKQVDSKGKMLVAVAGGVREESVEYALRAGADIL
IVGRGITNASDVEGAARRYLRLARLSEKGETLGEIDQYRVMTDF
>A0A842PHK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobia archaeon|TrEMBL
MYVGEALIGEGPEVAHIDLMIGDKYGPVGVAFTNAMSRMSAGHTPLFAVIRPNLPVKPST
VVVPKVTVRNMKEAGKMFGPAQSAVAKAVADSVEEGVIPEDKAEELVVIVSVFLHPQAED
YNKIYRYNYGAAKLAIKRAMEGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALDI
PKWEHMERVVKELPRNDHLIIEAGTPLIKRYGVDIVGKIKEIKPETFVVADLKTLDTGNL
ETRMVSDAGADAVVISGLAPLRTIEKAIEEAKKTGIYSSIDMLNVTNPIERLSELSIGGL
MPDVVELHRAIDVEELGEKHAWGNIEEIKRIGGKMLVAVAGGIREENAPEAIKGGADILI
VGRGITNARDVEGVARRFLRLMKEEIDQYRVMTDF
>A0A1F2P4W7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Syntrophoarchaeum butanivorans|TrEMBL
MGEGAELAHVDLVIGSKSSPVGIAFANSMAQLSAGHTPLFAVIRPNLPVKPSTLIVPKVT
IKNLDQASKVFGPAQTGVAKAIADAMEEGIIQKDEAEDQVIIVSVFIHPDAKDYNKIYRY
NYGATKLALKRALSGFPDADKVLYEKDRSTHPVMGFKVTKLWDPPYLQVALDVPDWDLTS
RVLAQIPKNDHLILEAGTPLIKRYGLDVITRIREIKPDAFIVADLKTLDTGNLEARMAAD
LTADAVVISGLAPIETIDKAIEEAKKTGIYAVIDMLNVEDPVEVLKRLKTLPEVVELHRA
IDVELYGEGSNYAWGDIGAIKSLGDILVGVAGGIREDTLEIALKSGADILIVGRAITKSK
DVEAACRRFLRGLKKEEIDQYRVMTDF
>F7XNN5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)|TrEMBL
MLLIGEALIGEGSELAHIDLMAGDKAGPVGQAFANGMTQLSAGHTPLLSVIRPNLLTKPT
TLIVPKVTVKNMEQASQIFGPAQAAVAKAVADSVEEGVIPKDQAEDIVIVASVFIHPDAS
DYNRIYRYNYGATKLALKRAFDAFPDVDTVLHEKDRAAHAVMGFKVSRLWDPPYLQVALD
NPNIDAILGVIRQLPKSDHLILEAGTPLIKRYGVDVISRIREVKPDSFIVADLKTLDTGN
LEARMVADSTADAIVVSALAPVPTLNKAINEAHKTGIYAVMDTLNHPDPLSVLKQLDELP
DVVELHRAIDVEDTEHAWGSIEEIKKLSPRILVAVAGGIRAHTIPAALKAGADILVVGRA
ITNAKDVRQAAENFIEGLNKPEIDQFRVMTDF
>A0A7W8P359|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia youngii|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGEPSAAEVVSKKGTVAHPFAPN
>A0A366MG41|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum sp. MCE|TrEMBL
MKSLYPPGANTTAEIIPMFLIGEALVGDGAELAHIDLMIGDKNGPVGMSFANGLTQLSAG
HTPLLGVIRPNLLPKPAVLIVPKVTLKHTEQVTQIFGPAQAAVSKAIADALEDGVFEGMD
VEENVIVASVFIDPSAKDFNKLYRFNYGATRLALSRALDKFPDTATVLKEKDRAAHGVMG
FKVQRLWNPPYLQVAMDLVDMKQVERVLTGVPQNDHVIFEAGTPLIKQFGLSVINEIRKI
RPNCFIVADLKTLDTGNLEARMVSNAGGDAAVVSGLAPVETIAAFIKEAKKCGIYAIIDM
LNVDEPAKLIESLGQMGGAALLPQYVEMHRAIDKEATGDYSWGDIKKIKEVAKKYNAKIL
VATAGGIRQLVVKKALAAGADIVVVGRAITASKDIKNAAESFLEELDSEEIDQFRIMTDF
>A0A839EM55|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Phyllobacterium myrsinacearum|TrEMBL
MQIINRVMVGESLVGEGNEVAHIDLLMGPRGSAVETAFCNALTNNKDGFTSVLAVIEPNL
PCKPNTVMYNKVTIRGAGQAMQLFGPAQSGIAKAVRDSVAEGVIPQNEADNLFICVGVFI
HWQASDDTKIHDYNYQATKEAILRAVTGRPTAAETLTGRQ
>A0A0H1QY71|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sediminis|TrEMBL
MYLIGEALVGDGAELAHIDLLIGNKEGAVGQAFANSISQLSKGHTPLLAVVRPNLPAKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGIDIEDTVVMASVFVHPTAE
DYNKIYRFNYGAMKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMNRVLDELPQNDHLIIEAGTPLIKKFGLSIISEIRERRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVIDMLNVKDPVAVVKQLKVKP
DVVELHRGIDVEDTAYAWGDIPAIKKAGGERLLVATAGGIRQGVVKDARKAGADILVVGR
AITASKNIQHAAEEFLQELSTEEIDQFRIMTDF
>A0A842KPD5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
MYRIGEALIGKGNEVAHVDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMESYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDTLPPRERILLEAGTPLVKKFGVGIVDKIRKLRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGVYSVLDMMNVENIPEKLEELRYKP
DIVLLHKNIDVGAAEVSEWGDIPKIKEIIGERGLVAVAGGITPSKTKKALESGADIIVVG
RYITGSKDPRRAAEDFLEQLPPDPDTMRLPHEEDEPI
>A0A7J4III2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon|TrEMBL
MYLIGEALVGDGPELAHVDLMIGDKAGPIGQAFANGLSQLSAGHTPLLAVVRPNLMTKPA
TLVIPKVTLKKGEQVREMFGPVQAAVAKAVADALEEGVFGDLDVDDLVILASIYLAPEAK
DYNRIFRFNYGATKLALGRALESFPPTKTLLYEKDRGAHAVMGFKVQRLWDPPYLQVALD
LVDLNRVRAVLADLPESDHLVIEAGTPTIKQFGLSVIAEIRKVRPNAFIIADLKTLDTGN
LEARMAANATADAVVISGLAPLPTIETALAEAKKTGIYSIIDMLNVADPVAVIRNLKVKP
DIVELHRGIDCEKEGTCHVWGDIQAMREAAGGKLLVATAGGIRVENVRDALAAGSQILVV
GRAITASKDVRHAAEEFLEQLGREEIDQFRIMTDF
>A0A7W8RYU3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. CI2|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGDPSAAEVLAKKGSVAHPFAPN
>A0A0E3RCW0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei S-6|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A2Z4LA67|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. BMS|TrEMBL
MYEIGEALIGNGPELAHIDLIIGDKDGPVGHAFANNMASMSVGHTPLLSVIRPNLPAKPA
TLIIPKVTVQNLEDASKIFGPAQTAVGRAVADAVEEDIIPKEKVNDIVIMVNVFIDPSAK
DYRKIYQYNYGATKLAIRRAFEGYPNVEKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEEKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVDSIDKAIHECTKQGIYSILDMMNVDDILGKLDQLQFKP
NIVLLHRNIDTETMKQNDDDQASEWGNIKDIKAKLGDKGLAAVAGGVTPEKVDKAITNGA
DIIIAGRYIIGSSDVRRAADDFLRYLPQDSDTMRVALDEDEDISPKK
>F6D7C3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)|TrEMBL
MYQIGEALIGNGDEVAHVDLVIGDKKGPVGDAFVNNMTNLSIGHTPLLSVIRPNLMTKPA
TLIIPKVTVRDLEDADKIFGPAQTAVGRAVADAVAEGIIPQEEAEDIVIMVSVFISPSAK
DFRKIYQYNYGATKLAIKRAMEGYPSVKKVLAEKDRGTHPIMGFKVTKLWNSPYLQVALD
LDNLTEMERIIKTLPDRERVLIEAGTPLVKKFGVGVVGKIRELRRDAFIIADLKTLDVGR
VEVKMAADETADAIAISGLGTVESIEKAIHESSKQGIYSILDMMNVENFVEKLRGLKLKP
DIVLLHRNVDMETSKAERGEKQGERTEWGNINEIKSILGEGKLVAVAGGITPDKVNTALD
SGADIIVVGRYIIGSRDVRRSAQDFLDHMPQDPDTMRLALDEDESV
>A0A7J3EH62|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MIICTCGRLERGFYIGEALIGLGYEVAHVDIVIGEKNGPAGLAFTNALSNPSAGHTAMLA
VLRPNLPVKPSTLIVPKVTVKSMEDSEKVFGPTQAAVAKAIADAVEEGIIPRDKCEDWVV
IVSAFVHPKAKDYRKIYQFNYAATKLAIRRALKGYPSVEKILREKNKAVHPIMGFRVKRL
WSPPYLQVALDLSNLEKALEIVKQLPKSERVILEAGTPLIKAYGVGVVGKIREIWKDAFI
VADLKTMDVGRVEVKEAADATADAVCILAAASKTTIDKAILEAQKQGVYSILDMMEVSNP
IAKIEALEYKPDIVLLHVSADVERRAVESGKPVEFKWNEISEVKSSFKVLVAVAGGITPS
SAIEALKSGADVIVVGRYIVGSGDPRRASEQFLNLMPPEPDVMRLTLDEDESIGEI
>A0A842ZII4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MVADDADDDSGKNVYLIGEALVGEGNEVAHIDLLVGNKDGPVGMAFAHGMTSLSAGHTPV
LAVIRPNLPPKPHTLIVPKVTVKNMEDTEKIFGPAQAAVAKAIADSAEEGVIPASKLDDW
VIICSVFIHPKATDFRKIYQYNYGATKMALQRALKKYPSFEKINYDKDRAKHPIMGFKVP
RLWRPPYLQISLDAPSVENAKKIIAQLPGSDRIIIEVGTPLIKRYGTRVISELRKDAKDT
FMVADLKTLDVGKVEADIAYEDTADAVVAAGLAPPETLDAFTHEAKRLGIYAVIDMLNVE
DVLGKLQSLKEFPDVIILHRGIDQETGRSSGLERIQIIRQAFPNKKYLIAVAGGIVPETA
KEALEKGADILIVGRYVTQSKDVERAVRDFLELTPSMREDIDLFRVHTE
>A0A7C4DD31|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MEFYIGEALVGKGAEVAHVDLIIGDKLGPVGLAFAQGLTHMSQGHTPLLGVIRPNLPPKP
HVLIIPKVTVKNMEQANKIFGPAQSAVAKAVADAVEEGIIPADKVDDWVIVASVFVHPDA
KDYRKIYHYNYSATKLALRRALQAYPPLEKVMYDKDRAVHPIMGFKVPRLWRPPYLQIAL
DNPSLEQALRVVSELPKSDMIILEAGTPLIKRHGVSAVSKLREVAPDTFIVADLKTLDTA
QVEVDLAYEETADGVVASGLASKESIDKFIYEAKRLGIYAFLDMMDVPDPIEKLKSLKEL
PDVLIIHRAIDTESSGRRSRWELINEINNAFKGKKMLFAVAGGIVPETADEALDSGAHIL
IVGRYITQSKDVKRSVREFLEILKKRIPGEPGDVDLLRIHVE
>A0A842NK24|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSEDKGLVRAPGRITQEQYKFLEELVEQGRYASISEALRGAINRFNVSASSPGGTFLIGE
ALVGEGDEIAHIDLMIGDKSGPVGTAFAQSLSQLSMGHTPLLAVIRPNLPPKPHTVIVPK
VTIKNMEDAGKIFGPAQSAVAKAVADAVEDGIIPREVVDDWVVVVSVFIHPKAEDERRIY
QYNYSATKLSISRALESYPSLDKIMYEKDRARHPLMGFRPPRLWRPPYLQIALDNPNIDS
ILGVVKSVPKNDNVLLEAGTPLLKRYGVEVIKRIREARKDSFIIADLKTMDVGKVEVDMA
FEQTADAVCCAGAASSATIDDFIYECRRMGIYSFVDMMQVEDPVAKLKVLQRPPDGVILH
RAIDVEKSGVEISWGDIPKIKEAFPERRVLVAVAGGIRPNTAQIALDAGADVLIVGRYIT
QSKDIERSVRNFLSLLQGDIDLFRVHTE
>A0A371NBQ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter defluvii|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKIFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A7K4BFF9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
RALDRFPGVDTLIYEKDRTAHAVMGFKVQRLWDPPYLQVAMDLVDRNHMRRVLESLPDND
HLIIEAGTPLIKKFGLSIISEIRETRPSAFIVADLKTLDTGNLEARMTADAGADAVVVSG
LAPISTIEKAITDTRKTGIYTVVDMLNVEDPVAVVERLAVKPDVVELHRGIDVEDSDHAW
GDIPAIKKAGGERLLVATAGGIRQHVVKDALHAGADILVVGRAITASKNIRDAAEGFLRE
MNAEEVDQFRIMTDF
>A0A0Q0VVI7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp. SDB|TrEMBL
MYLIGEALVGEGAELAHIDLLIGDKTGPVGTAFANSASHLSAGHTPLLAVVRPNLLAKPA
TLIIPKVTLKKEAQVTEMFGPVQAAVAKAVADSLEEGIFGDTGIEEIVILASIYLNPEAR
DFNRIYRYNYGAMKLAIKRAFEKFPGTDTLLYEKDRAPHAVMGFKVQRLWDPPYLQVALD
LVEMGKVRQVLEELPKNDHLIIEAGTPLIKQFGLAIIGEIRNIRPDAFIIADLKTLDTGN
LEARMAANASADAVVVSGLAPISTLEKAILEAKKTGIYSVIDMLNVAAPAKVIAELAKRG
ASPDVVEMHRPIDAEGTDYNWGDIPAIRKAAKGKILIATAGGIRQPVVKEALKAGADIIV
VGRAITASKNIANAAEGFLEELNSEEIDQFRVMTDF
>A0A5Q4Z310|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia dioscoreae|TrEMBL
MAKINRVLIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVIAPNL
LTKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPKDEADDLFLCVGVFI
HWQADDDKKIQEFNYKATREAIQRAVAGEPSAAEVVAKKGSVAHPFAPN
>A0A4U8YXY6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylocella tundrae|TrEMBL
MAGLTIDRVLVAEALVGEGNELAHIDLIMGPRGSAAEIAFCNTLTNQKRGDNALLALVAS
NLMAKPMTLMFNKVEIKNATQATQMFGPAQRGVAKAVVDSVKAGIIPEAEAENVFICVGV
FIHWEAKDNTKIQDWNYEATKIAIARAVKGEPKIAEVIAQEDVMHHPLAAHV
>A0A662VN24|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobales archaeon|TrEMBL
MDMRIGEALIGEGYEVAHIDLMIGTKDSPVGIAFANALSNLSQGHTPLLAVLRPNLITKP
PAVIIPKVTVKDMRQAELIFGAAQAAVAKAIADAVEEGIIPMDIAEDFVVVVSVFIHPKA
KNKHKVYYYNYGATKLALKRAMQSFPDVETVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLDEVLNVLKQIPDSDHIVYEVGTPLAKRYGSEVILKLREIKPDSFFVLDLKTLDVG
NLEARMAADATANAIVISGLAPIQTIVKGVREAEKTGILSVVDMLNVEDPVERLKKIKEY
VTPDVVELHRAIDAEGVAEMPWKHASKIKEFGVLVAVAGGIKPENVQDAISAGADVLVVG
RAITKARDVEGAVRRFLAHMKPDTDQFRIMTDF
>A0A2H6AWQ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|bacterium HR39|TrEMBL
MPKIDRMLVGEALVGEGNEVAHIDLIMGPRGTPAEEAFARTLCDQKEGVNALLAVLEPNL
MVKPATVMFNKVTIKNARQATQMFGPAQRAVAMAVADCVAEGVIPVDEADDIFICVGVFI
HWEAQDDAKIQQYNYEATKLAIERAVNGYPPAAKVVALKDRTRHPFQAG
>A0A5E4HJ27|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MFLIGEALIGEAPELAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGVIPEDQVEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIIEARKTGIYAVIDMLNVDKPLSVIKALSVKP
HVVELHRAIDTEGKAEHAWGDISAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>A0A7W7KJL5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas nitritireducens|TrEMBL
MKKLDLYIGEGFEGPGVNAAHINILLGPRSGPAGQAFSNSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAEINGDLHANATWGASQAGIAKAVTEALLDGTLPPEAEDEWAIVTANWVN
PSCDDLDAVYRNNYNACRTAIRAALSCKPERAQLADVVNAIANPFYTPKA
>A0A842VSJ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MANKVDFFIGEALLGDGENIAHVDLMIGSKNGPVGNAFATALTQLSQGHTPLLACIRPNL
TTKPQTIIIPKVTLQTLDDTDKIFGPAQTAVAKAVADALEEGIVPIDKVDEWVICASVFI
HPKASDYRKIYSFNYGATKLAIKRALKKAPSIDKLFYDKDRAKHPVAKIRVPRLWRPPYL
QIALDQPSFSHHEKLLKMIPNSDRIIIEAGTPLVKKEGIQVIKKLRELAPEAFIVADLKT
LDVGKLEVDFAFNATADAAVCSGLANNASIDKFILEAQRVGIYGIIDMMEVPDPVAKLKQ
LSETPDVVILHKGIDTEAVREDPKQRWAMIPKIKALYESKKYVSGRDRVLIAVAGGIVPE
TANHALDMGADILIVGRYITSAKDPERAVRNLINIIPGHSDIDLKRIHTDDDDVLDK
>A0A7K4GJ41|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKSDYFIGEALLGAEENLAHIDLIIGSKDGPVGISFANALSSPSIGHGGLLACIRPNLL
TKPISLVIPKVTVSKMEEANKIFGPAQAAVAKAIADAVEENMIPMNKLDEWVLIVSVFIH
PEAKDYRKIYQYNYSATKLAIQRALKNYPPIEKIFYDKDRAKHPVAGIRIPRLWRPPYIQ
VALDHPNIDHHMKVVKQLPKSDRIILEIGTPFLKKYGMEAIRKIRELAPQKFIVADLKTL
DVGKLEVDFVFDATADAAVASGLAAPSSIDKFLLEANRMGIYGFVDTMEVDDPVAKLSKL
KQVPDVVILHRAIDVEQATGSESSNAAQKVRWAAIPKIKELYKDKKLASGRDRVLIAVAG
GIDPNSANYALEMGADILIVGRFVTSSKDIENSMRRLLNIIPGYSDIDLKRIHTEDDDSS
VKRPKWD
>A0A524C5S5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKVEYYVGEALLGSEENLAHVDVVLGSKDGPVGISFANAISAPSMGHGGLLACIRPNLL
PKPYTIIIPKVTVVKMEDANKIFGPAQAAVAKAVADSVEEGIIPMNKIDDWLIIVSVFIH
PEATDYRKIFQYNYGATKLALQRALKAYPPIEKIFYDKDRAKHPIAGMRVPRLFRPPYLQ
VALDAPDLEKQVKVIQKLPKSDRIILEVGTPFLKKYGMDAIKKIREVSVDKFIVADLKTL
DVGKLEVDFSFDATADAVVCSGLASSSSIDKFLLEAHRLGIYGFVDTMEVSDPIAKMKSL
KQIPDVVILHRAIDVEQDVEAQSPDAAQKARWALVPKIKAAFADQKLASGRDRVLVAVAG
GIEPESAKYALDMGADILIVGRFIASARDVENAMRRLLNIIPGYSDINLKRVHEEDDDES
IKKATWD
>A0A0E3NDR6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina thermophila (strain ATCC 43570 / DSM 1825 / OCM 12 / VKM B-1830 / TM-1)|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIVPKVTVKNMEQASKIFGPAQTAVAKAVADSVEEGIISKDLVEDIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPSIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLESVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMP
DVIELHRGIDIENTEHAWGNIEEIKKVAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAEQFIMSLNKPEIDQFRVMTDF
>F0T6U1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium lacus (strain AL-21)|TrEMBL
MYQIGEALIGNGNEIAHVDLVIGDKNGPVGTAFVNNMASMSIGHTPLLSVIRPNLLTKPA
TLIVPKVTVRDLEDADKIFGPAQTAVGRAVADAVDEGIIPKEDVEDIVIIANVFIHPGAK
DFRKIYQYNYGATKLAIQRAMEGYPSVKKVLAEKDRGTHPIMGFKVTRLWNPPYLQVALD
LDNMEEMERIIKTLPDRERILIEAGTPLVKKFGVGIIGKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAIAISGLGTVESIEKAIHEAKKQGIYSILDMMNVENFVEKLEAVQFKP
DIVLLHRNVDLETMQAERGEELAEVTEWGNIHQIKSILGEGKLVAVAGGITPDRVDKAID
SDADIIVVGRYIIGSRDVRRSAQDFLDRMPQDPDTMRLAMDEDESI
>A0A285FXY5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus euhalobius|TrEMBL
MLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPSA
LIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQALD
YNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALDN
PNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGNL
EARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELPD
VVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRAI
TNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A7J4MUV8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter thermautotrophicus|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A8A3S4U4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis aquaemaris|TrEMBL
MYLIGEALVGTGAELAHIDLVMGDKNGPVGMAFANGMSQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKKGEQVNEIFGPAQAAVAKAVADSVEEGVFEGIDLDETVILASVFIAPDAE
DYSKIYRYNYGATKLAITRAIQKFPDTETLLYEKDRSTHAVMGFKVQRLWNPPYLQVAMD
LVDMAKVEAVLTAVPKNDHVLFEAGTPLIKQFGLNVLSEIRKIRPDAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPTATIEKAIEETKKTGIYSVIDMLNVKDPVALIRELKVKP
DIVELHRAIDAEGDEYSWGNIPAIKEAAGGKLLVATAGGVRQHVVQKALDSGADILVVGR
AITASKDIGHAADEFLERMDNPEIDQFRIMTDF
>A0A842Y7Y2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLVGEALIGEEPELAHVDIIIGDKNGPAGQAFANGFTQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVKDMDDAAKIFGPAQTAVARAIADAMDEGIIPKEQAEDLVIVASVFIHPKAD
DYSKIYRYNYGATKLAVQRAMEGFPDVETLMHEKDRTMHPIMGFKVVRLWDPPYLQVAID
IPDIEFVKKVLKQLPQSDHLILEAGTPLIKRYGLNVVEQMREARPNAFIVADLKTLDTGN
LEARMVADATADAVVISGLAPISTIEKAIKEAKKTGIYAYIDMLNVADPVKVLKELSVKP
DVIELHRAIDAEDSAHAWSSIPELKKIHPKLLIAVAGGIGKLEEGAARVTDATDAGADIM
VVGRAITKAKDVRSVAEIFLEEMHKAEIDQYRVMTDF
>A0A849QSK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGEEPELAHVDIIIGDKNGPAGQAFATGFTQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVQNMDGAAKIFGPAQSAVARAVADAMDEGIIPKEQAEDLVIVASVFIHPQAE
DYSKIYRYNYGATKLAVQRAMEGFPDVDTVMEEKDRTMHPIMGFNVTRLWDPPYLQVAID
IPDMDFVKKVLKQLPQSDHLIIEAGTPLIKRYGLDVVSKIREARPNAFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIKEAKKTGIYACIDMLNVPDPVKVLKDLSVKP
DIIELHRAIDAEDSEYAWGSIPDMKKVHPKLLVAVAGGIGKLEAGSAKVSDACSAGADII
VVGRSITKAKDVRLATEVFLEDMQKAEIDQYRVMTDF
>A0A7J4FU02|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MGFKISRLWDPPYLQVALDNPDIDQILGVIKSLPDSDHLILEAGTPLIKRYGVDVITRIR
EVAPNAFIVADLKTLDTGNLEARMVADATADAVVISALAPVSTIDKAIQEAHKTGIYAVI
DTLNLSDPLPMLRKLKTLPDVVELHRAIDAEETEYQWGSIPEIRALSEKLSRKVLIAVAG
GIRADNIGDALDAGADILVVGRAITNAKDVYQTAEMFIEGLSKEEIDQFRVMTDF
>A0A8F7WLM8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylovirgula sp. HY1|TrEMBL
MSEIWLRTGEATVLAADGQFTDAMPEVMIGDVRGPVGQAFAGMAGQVAGHPRMFVIRDLN
QMVRPATMMTTKMTVGSEAYVELLGGIVQAATGDAIVDCLAEGILPKDQADMLCMIIMIW
LDPRCAEDENLDRRDLYRTNYDATKLAIARAMKGEPTVEQLIANRQSISHYGLEGVFDAD
A
>A0A839PFB9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Mesorhizobium sp. RMAD-H1|TrEMBL
MAKITKVMVGESLVGDGNEVAHIDLLIGPRGSAVESAFCNALTNNKDGFTSLLAVIAPNL
PCKPNTVMFNKVTIKGAKQAVQMFGPAQHGVAKAVQDSVAEGIIPADEADDLFICVGVFI
HWEAEDDAKIQDFNYRATKEAIERAVTGKPTAAEATAQRDKVKHPFGA
>A0A3R7DNE3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon|TrEMBL
MMLIGEALIGEEPELAHVDLIIGNKEGPVGQAFATGMTQLSEGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMAQAARIFGPAQAAVAKAVADAAQDGIIPREEVEDLVIVASVFIHPDAK
DYNRIYRYNYGAAKLALKRAMDGFPEIDTVLDEKDRGTHAIMGFKISRLWDPPYLQVALD
NPDIDQVLRILKALPDSDHLILEAGTPLIKRYGVEVIGKMREVVPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPTQTIDKAIEEAHKTGIYAVIDTLNLPDPVPVLQKLDALP
DVVELHRAIDAEKTEYQWGSIPAIKALSDRILVAVAGGIRADTMRDAMDAGADILVVGRA
ITNAKDVRQAAEMFIEGLAKEEIDQFRVMTDF
>R9SHP7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. AbM4|TrEMBL
MYNIGEALIGDGNELAHVDLMIGDKEGPVGNAFANALANLSVGHTPLLTVIRPNLMTKPA
TAIVPKVTVGNLEDASKVFGPAQTAVGRAVADAVEEGILPKDKIDDIVLVVSVYVHPEAE
NYRKIYQYNYGATKLAIRRAMKGYPDINKVLAEKDRGTHPIMGFKVQRLWNPPYLQVALD
LDNLDAVKNIMNALPQRERILIEAGTPLVKKFGVGVVGKIRELRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVDDFEGKLKQLKPEL
KPNIVLLHRNVDLETTKAEKGEDTSNMTEWGNIKAIKEIMDGGLVAVAGGITPEKVEEAT
SKGADIIIAGRYIIGSKDPRRAADDFLAHFPVDPDNMRLALDEDETI
>A0A7J3TJM9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Geoglobus ahangari|TrEMBL
MFRIGEALVGTGNEVAHIDLLIGSKDGPVGYAFANALSQLSAGHTPLLAVIRPNLITKPP
AVIIPKVTIKDMKQAELIFGQAQMAVAKAIADAVEDGIIPKDKAEDLVVIVSVFIHPKAE
NKEKVFYYNYSATKLALKRAMEGFPDVDKVIWEKDRSFHPLVGRKLTRLWDPPYLQIAID
IPDLDEVFKIIRQIPESDHIIFEVGTPLAKRYGAEVILELRKERPDAFYVLDLKTLDTGN
LEARMAADATANAVVISGLAPLNTIKKAIEEVKKLGIYSVVDMLNVEDPVKRLDKIVETG
ILPDVVELHRAIDSETEEPPWKFAKEIKEKYNVLVAVAGGIRPENVEEVIREGADILIVG
RAITKARDIXGATRKFLKYMKPDTDQFRIMTDF
>A0A0F7IIU4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Geoglobus ahangari|TrEMBL
MEYRIGEALVGTGDEVAHIDLMIGTKDSPVGEAFANALSQLSAGHTPLLAVLRPNLITKP
PAVIIPKVTVKDMFQAELIFGPAQMAVAKAIADAVEDGIIPKEKAEDYVIVVSVFIHPKA
KNKEKVFYYNYSATKLAIKRAMQSFPDVDTVLYEKDRSFHPFAGRKLTRLWDPPYLQVAI
DIPSLEEVLRVLRYIPDSDHIIYEVGTPLAKRYGAEVILKLREEKPDAFFVLDLKTLDTG
NLEARMAVDATANAVVISGLAPINTIKKAVNEAQKLGIYCVVDMLNVEDPVSRLDKIVEA
GVKPDVVELHRAIDSEHEEPPWKFARPIKEKHDVLVAVAGGIRPENVEDAISGGADMLVV
GRAITRARDIEGAARRFLANMKPDTDQFRVMTDF
>A0A843HI26|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp|TrEMBL
MYEIGEALIGNGPELAHIDLIIGDKDGPVGHAFANNMASMSVGHTPLLSVIRPNLPAKPA
TLIIPKVTVQNLEDASKIFGPAQTAVGRAVADAVEEDIIPKNKVNDIVIMVNVFIDPSAK
DYRKIYQFNYGATKLAIRRAFEGYPNVEKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEEKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVDSIEKAIHECSKQGIYSILDMMNVDNILGKLDELKYKP
NIVLLHRNIDTETMKNNDDDQASEWGNIKDIKAKLGDKGLAAVAGGVTPEKVDKALKNGA
DIIIAGRYIIGSSDVRRAADDFLRYLPQDSDTMRVALDEDETI
>A0A328Q6R3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera stadtmanae|TrEMBL
MYEIGEALIGDGPELAHIDLIVGSKQGPVGTAFATNMASMSVGHTPLLSVIRPNLPTKPA
TLIVPKVTVQNLDDASKIFGPAQTAVGRAVADAVEEEIIPKDIVEDIVLMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRAFDKYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDRMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECSKQGIYSILDMMNVSDIPSKLEELKLKP
NIVLLHRNIDSETMRDNDGEQQSEWGNIKDIKSKLGKRGLIAVAGGVTPEKVDTALANGA
NIIIAGRYIIGSSDVRRAAEDFLRYLPQDSDTMRLALDEDEKI
>A0A679JMR0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Hyphomicrobium sp. ghe19|TrEMBL
MSSPTSRPASGRFGIRVGEALVAGGPPGTAAEPEVAIGEMDGPFGTAFATLLGDQVKGHT
RVLSLLNTDVMVRPPTICVSKVTVDNERYTSILMGTVQYATAMGVLDAVRSGDLPKDKVD
DLGIIVSVWLHPSVATIEKLDHKVLFDIHRKATSLAIHKAMNYQPSIDWLLENQDKIIHK
YFERGLKGEI
>A0A679K3D4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Hyphomicrobium sp. ghe19|TrEMBL
MAKINKVMVGESLVGDGNEVAHIDLIIGPRGSAAETAFCNALTNNKDGFTTLLAVIAPNL
ACKPNTILYNKVTIKDARQAVQMFGPAQYGVAKAVQDSVAEGVIPAAEADDLYICVGVFI
HWEAADDAKIQDYNYRAVKESIARAVAGKPTAAEATAQRNSAQHPFAAKA
>A0A257APX0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-1 cluster archaeon ex4572_4|TrEMBL
MQVGEALVGEGAEVAHIDLLVGEKNGPVGTAFTNAMSQMSAGHTPIFAVIRPNLPVKPST
LIVPKVTVRNMKEAERIFGPAQSAVAKAVADSVEEGVIPEEKAEELVVIVSVFLHPQAAD
YNKIYRFNYGAAKLAVKRAMTGFPDIKKVLYEKDRSRHPALGLKVTKLWDPPYLQVALDI
PSWKQMERVVSELPQNDHLIIEAGTPLIKRYGVEIVGRIKEIKPETFVVADLKTLDTGNL
EARMVSDAGADAVVISGLAPLQTIEKAVAEARKTGIYACLDMLNVASPLELLEKLSSGEE
GASGGSISGGSIPDVVELHRAIDVEQAERHAWGNIAELKRIGRGGSSGSSGSSGSSGGKM
LVAVAGGIREENAAEALKGGADILIVGRGITNSRDVEAVARRFLRLMKEEIDQYRVMTDF
>A0A497JMT8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MREFHVKFDDVARTFSVPTAPLEAFESLRGAAYFIGEALVGEGEEVAHVDLLIGDKTGPI
GEAFASGLSSLSMGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMEDAGKIFGPAQAAVAKA
VADAVEEGIIPRDKVDDWVIICSVFVHPKAKDYRKIYHYNYSATKLALRRALMKYPPLDK
VLYDKDRAKHPIMGFKVPRLWRPPYLQIALDIPSLERTKKIIEQVPRSDRIILEVGTPLI
KKYGTRVIEELRSVAKDVFMIADLKTLDVGKVEVDIAYEATADAVVASGLAAPQTLDKFI
YEAKRLGIYAFVDMMYVKNPLEKLRELKELPDVVIIHRAIDVETGKTIGLELISKLKAAF
KEKRLLIGVAGGIIPETAREALQKGADIIIVGRYITQAKDVERAVREFLKLTREMREDID
LYRVHVE
>A0A523X171|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MGAAQRGGAFLIGEALVGEGNEVAHVDLLIGDKQGPVGLSFAQSLSNLSAGHTPLLAVIR
PNLPPKPHTVIVPKVTVKNMEDAGKIFGPAQSAVAKAVADAVEDGIIPRAVIDDWVVIAS
VFIHPQAEDERKIWHYNYSATKLALSRALQSYPSWDKLMYDKDRARHPLMGFRAPRLWRP
PYLQIALDNPNIEMIKRVIKQIPRNDNVLLEAGTPLIKRYGVGVIRDLREARADSFIIAD
LKTMDVGKVEVDMAFDETADAVCCAGAASSATIDEFVYEARRLGVYSFLDLMQVEDPVAK
LKSLERLPDCVILHRAIDVEQRGGEARWGYIAKIREAFKDRKLLISVAGGIRPNTAQFAL
EAGADILIVGRYITQSRDVERSVREFLPLLQGDIDLFRVHVE
>A0A7J2NMW7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKRKEHTYLIGEALMGEGTEVAHIDLLIGDKEGPIGEAFANGLSNLSAGHTPLLAVIRPN
LPPKPHTLLVPKVTVKNMEQTGKIFGPAQAAVAKAVADAVEEGIIPEDKVDEWVIICSVF
IHPQAKDYRSIYHYNYGATKLALKRALENYPSLKKIMYDKDRAKHPIMGFNVPRLWRPPY
LQIALDVPRLEIVKKIISELPESDRIILEVGTPLLKKYGVNVIRELRTVAKDMFIVADLK
TLDVGKVEVDLAFEETADAVVVAGLATAETIDKFIEEAKRLGIYAVMDLMNVDDPVEKLK
SLKKLPDVAILHRAIDAEKTGKTRWDLIKEIRKTFQSQKFLVAVAGGITPETAPEALANG
ADIIIVGRYITQSKDVERATREFLKCTREMAEDVDLFRVHVE
>A0A7C4WKI3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYIRGRLERGFYVGEALVGLGYEAAHVDIVIGEKNGPVGLAFTNALSNPSAGHTAMLAVL
RPNLPVKPSTLIVSKVTVKSMEDSEKVFGPAQAAVAKAIADAVEEGIIPRDKCEDWVIVV
SVFVHPKAKDYRKIYQFNYAATKLATRRALKGYPSIDKILKEKDRAVHPVMGFRVRRLWS
PPYLQVALDLSSLEKALEVVKQLPKSERIILEAGTPLIKAYGVGVIGRIREVWRDAFIVA
DLKTMDVGRVEVKEAADATADAVCILAAASKTTIDKAILEAQKQGVYSILDMMEVSDPIA
KIETLEYKPDIVLLHISADVERKTVESGKPVEFRWNEISEVKKRFKVLVAVAGGITPSSA
IEALKSGADVIVVGRYIVGSGDPRWASEQFLNLMPPEPDVMRLTLDEDESIGEI
>A0A101F5G5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archeaon 56_1174|TrEMBL
MRLLLVGEALIGEEPELAHIDLMIGDKDGPVGEAFAAGLSTLSMGHTPLLAVIRPNLLTK
PATLIVPKVTVRSMEDAAKVFGPAQSAVALAVADSVQAGIIPRDKVEELVMVVSVFIHPE
AKDFDRLYRYNYGATKLAIARAMEGFPSIDKVLEEKDRDVHPIMGYRVLKLFDPPYLQIA
IDIPDIAHVERVLREVPHSDHVIFEAGTPLIKRYGLSIIERMRAVRRDAFIMADLKTLDT
GNLEARMAADAAADGVVVSGLAPLSTIESAISEAKKTGIYSCIDMLNVKEPAGLLGRLSI
KPDIVELHRAIDAEGAESHAWERITEVKEASPTSLIAVAGGIRMDNMQQALDAGADILVV
GRAITKSKDIRNTAEMFLSGLKVSEIDQFRIKTDF
>A0A1B8X011|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus sp. DAL1|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A7K3YB33|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANSLSQLSKGHTPLLAVIRPNLPTKPS
TLVIPKVTLGKEYQVNQMFGPVQAAVAKAVADSLEEGVFEGIDIEDTVIMASVFLHPTAE
DYNKIYRFNYGAMKLALRRALDRFPDADTLIHEKDRTAHAVMGFKVQRLWDPPYLQVAID
LVEKNRMRRVLEDLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPDAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIIDTRKTGIYTVVDMLNVSDPVAVVEHLAVKP
DVVELHRGIDVEDADHAWGDIPAIKKAGGERMLVATAGGIRQHVVKDALHAGADILVVGR
AITASKNIKNAAEEFLQKMNTEEIDQFRIMTDF
>A0A419JY10|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MYVGEALVGEGLEVAHVDLMIGDKYGPVGTAFTNALSQLSVGHTPIFAVLRPNLPVKPST
LIVPKVTVQNMKDAEKIFGPAQSAIAKAVADSVEEGVLQEDKTEEIVVIASVFLHPNAKD
YNKIYRFNYGAAKLAIKRAMEGFPDITKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALDI
PNWEHMGQVVTELPRNDHLIIEAGTPLIKRYGVDIVGKIKEIKPETFVIADLKTLDTGNL
EARMVADAGADAVVISGLAPRQTIEKAIAETKKTGIYSSLDMLNVADPIEVIKELNKSGF
MPDVVELHRAIDVEQDEPHAWGNIKEIKRIGGKVLVAVAGGIREESAPTALKGDADILIV
GRGITNAKDVEGVSRRFLRLMKEEIDQYRVMTDF
>A0A843IDS1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculaceae archaeon|TrEMBL
MFLIGEALVGDGAELAHIDLMIGDKNGPVGSAFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIVPKVTLKHGEQVTQIFGPAQAAVSKAIADALEDGVFDGIDIEENVIVASVFIDPSAK
DFNKLYRFNYGATRLALSRALDKFPDAATVLKEKDRAAHGVMGFKVHRLWNPPYLQVAMD
LVDMKQVERVLTSVPQNDHVIFEAGTPLIKQFGLSVIGEIRKIRPNCFIVADLKTLDTGN
LEARMVSNAGGDAAVVSGLAPIETIAAFIKEAKKCGIYAIIDMLNVEAPAKLIEKLGEMG
GKALLPQYVEMHRAIDKEASGEYSWGDILKIKEVGQKYGANILVATAGGIRQPVVKKAIA
AGADIVVVGRAITASKDIKNAAESFLAELDSEEIDQFRVMTDF
>A0A564Q1U4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanolliviera sp. GoM_oil|TrEMBL
MGSTDLYLIGEALIGEGDELAHVDLMIGGKEGPVGMAFANGIVNLSKGHTPLLSVIRPNL
PTKPSTLIVPKVTIQDMEDANKIFGPAQTAVAKAVADSVEEGVIPRDMVEKIVVVVSVFV
HPAAKDYEKIYRYNYGATKLAIQRAFESFPDVDTVLYEKDRSTHPIMGFRVTKLWDPPYL
QVALDLTDIDKALSVVSQLPDSDHLILEAGTPLIKRYGIDVVSRLRENKPGIFIVADLKT
LDTGNLEVRMTADASADAVVISGLAPVSTIEKSIKEAKKTGIYSAIDMLNVKDPLEVLKS
LSMNPDVVEIHRAIDNESSEKERWDLIEKIKKEFSGILVGVAGGIRPENCQEALESGADI
LIAGRAITAAKDVEGAARKFLKVFKGEIDQFRIKTDF
>A0A524F3K8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKIDFFIGEALLGEGVNVAHVDLMIGSKNGPVGTAFANALSQLSKGHTPLLACIRPNLI
TKPATVIVPKVTLKTLTDTDKIFGPAQTAVARAVADALEEGLIPVDKVDEWVILASVFIH
PEAEDYRRIYNYNYGATKLAIRRALKQSPSINKLFYDKDRAKHPIARIRVPRLWNPPYLQ
VALDQPSFAYHEKLLKHIPQSDRIILEVGTPLLKKEGIDIIKKLREIAPEAFIVADLKTL
DVGKLEVDFAFDATADAAVCSGLANASSIDKFILEAQRVGIYAFLDMMEVSNVTAKLNKL
KETPDVIILHKGIDTEATKVDPKARWEPIRQIKDYYKDKKLISGKDRVLVAVAGGITAET
AQYPLSMGADIIIVGRYITSAKDPERATRNLLNTIPGLSDIDLKRVHTEDDDDNPQ
>A0A401HQG4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofervidicoccus abyssi|TrEMBL
MGIFMLKFGEGVLGRDITAIVNVVLGKGETIDTVFTNALTRVPTPILANLRDNLIVKPLT
LVVPRNTLNSDIQCNLLHGPIQYGVAKAVVDLDLDGDLKLIVTVSVPDVPYTTLNKRKLF
QYYYGATRLAISRALNDYPSKEKIKREKYRALHPLVGFRDIRLERPPYLQVALDVPSMEN
VEYVLESLPPSDRIIVEAGTPLIKKYGIEVVERIREIYDGFIVADLKTLDTGRVEVRMAF
ESTANAVVLSGTAPRETILKGIHECERCGIMSYLDTINVRDPFGLYNSLELKPDVLLLHR
AIDEEEKVPMKEYRDVKRREKLLLGIAGGVTLENIEKLKNRYHIIVVGRGITKSRDPGRV
ARAIVNKLGDDIDQYRLYLEEDEDVPIR
>A0A7K3ZXC1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKEGPVATAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADAVAEGVIPKDKAEELLVIVSVFIHPQAR
DYDAIYRYNYGATKLAIERAMAGFPDVDLMLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLAALPESDHILIEVGTPLVKMLGINVVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVTDPLAVLKSLEVLP
DVVELHRAIDMEKSAHAWQNIPAIKALAKEGRRLLVAVAGGIRVDTEAAALAAGADILVV
GRAITRSKDIRDMAEQFLAGLQQTEIDQYRVMTDF
>A0A101DXY7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon 55_53|TrEMBL
MRLLLVGEALIGEEPELAHIDLMIGDKDGPVGEAFAAGLSTLSMGHTPLLAVIRPNLLTK
PATLIVPKVTVRSMEDAAKVFGPAQSAVALAVADSVQAGIIPRDKVEELVMVVSVFIHPE
AKDFDRLYRYNYGATKLAIARAMEGFPSIDKVLEEKDRDVHPIMGYRVLKLFDPPYLQIA
IDIPDIAHVERVLREVPHSDHVIFEAGTPLIKRYGLSIIERMRAVRRDAFIMADLKTLDT
GNLEARMAADAAADGVVVSGLAPLSTIESAISEAKKTGIYSCIDMLNVKEPAGLLGRLSI
KPDIVELHRAIDAEGAESHAWERITEVKEASPTSLIAVAGGIRMDNMQQALDAGADILVV
GRAITKSKDIRNTAEMFLSGLKVSEIDQFRIKTDF
>A0A7C0XNL1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobia archaeon|TrEMBL
MQVGEALVGEGAEVAHIDLLVGEKNGPVGTAFTNAMSQMSAGHTPIFAVIRPNLPVKPST
LIVPKVTVRNMKEAERIFGPAQSAVAKAVADSVEEGVIPEEKAEELVVIVSVFLHPQAAD
YNKIYRFNYGAAKLAVKRAMTGFPDIKKVLYEKDRSRHPALGLKVTKLWDPPYLQVALDI
PSWKQMERVVSELPQNDHLIIEAGTPLIKRYGVEIVGRIKEIKPETFVVADLKTLDTGNL
EARMVSDAGADAVVISGLAPLQTIEKAVAEARKTGIYACLDMLNVASPLELLEKLSSGEE
GASGGSISGGSIPDVVELHRAIDVEQAERHAWGNIAELKRIGRGGSSGSSGSSGGKMLVA
VAGGIREENAAEALKGGADILIVGRGITNSRDVEAVARRFLRLMKEEIDQYRVMTDF
>H8IA85|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254)|TrEMBL
MRYEVGIVYLVGEALVGEGNEVAHIDLLVGDKAGPVGMAFANGMTNLSMGHTPLLAVIRP
NLIPKPATLIIPKVTIKSLDQANKMFGPAQAAVAKAVADAVEEGIIPREQCEELVIIASV
FIHPEAKDYTRIYKYNYGATKLALTRAMEKFPGVDKVLYEKDRGVHGVMGYKIMRLWDPP
YLQVAIDTPDIAVVERVLTQAPRNDHIIFEAGTPLIKRYGLEVISKIRQIKRDAFIVADL
KTLDTGNLEARMAADATADAVVCSGLAPLETIEKFCEEARKVGIYSIIDMLNVGDPAKVV
ESLRHKPDIVELHRGIDTEARKAEHAWGNIPAIKKAAGGKKLLVAVAGGVKAENVEVALK
GGADILVVGRAITNAKDIEGATRAFLRAMHKDEIDQFRIMTDF
>A0A497RXV9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MFKIGEALVGKGNEVAHVDLIIGDKEGYVGQAFANSLSHLSAGHTPLLSVIRPNLPAKPY
TLVIPKVTVEDMDDAVKIFGPAQAAVAKAVADAVEEGIIPKEKIEDWVIIASVFIHPDAK
DFRKIYQYNYGATKLALKRALQDYPSLEKIMYDKDRAVHPIMGFRVPRLPRWNRPYLQIA
LDIPDLERTKQILREIPKSDKIILEAGTPLIKKYGTKVINELREVAKSEFMIADLKTLDV
GQVEVDVAFDEGADGVVASGLATPEVIDKFIYEAKRLGIYAIVDMMNVEDPVKKLKSLKE
LPDIVIIHRAIDSEKTQEIRWQAIKEIRKEFGDKIMVAVAGGIEPDTVPVALKQGADIII
VGRFITQSKDIERSTRLFINLLGGDIDLKRVHVE
>A0A843ADC9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter arboriphilus|TrEMBL
MYKIGEALVGDGNELAHVDLIIGDKEGPAGTAFANGMTQLSIGHTPLLSVIRPNLMTKPA
TLIIPKVTVGDLDDASKIFGPAQTAVGRAVADAVEEGLIPKDIAEDIVIMVSVFIHPDAE
DYRKIYQYNYGATKLAIRRAMSDYPGINKVLAEKDRGTHPIMGFKVTRLWSPPYVQVALD
LDNLDAMEKIISAVPDRERILLEAGTPLIKKFGVGVVSKIRKLRPDAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIEKAIHEAQKQGIYSILDMMNVDNFKEKINKLQDNL
KPNIVLLHRNVDLETSMAEKGQDTSDMTEWGNIKEIKKLIGDGLVAVAGGITPEKVDEAI
ESGADIIVVGRYIIGSRDVRRSAEDFLAHLPQDPDNMRLALDEDEQV
>A0A849PKB8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKNGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMEQAALIFGPAQAAVAKAVADAVEDGVVPTEQAEELVIVASVFIHPDAK
DYNRIYRYNYGATKLALKRAMDGFPGIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVKTLPDSDHLILEAGTPLIKRYGVDVIARLREAKPNAFIVADLKTLDTGN
LEARMVA
>A0A8F7ZIF7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylovirgula sp. HY1|TrEMBL
MAKITKLCVGESLVGDGNEIAHIDLIMGPRGSAAEGAFANALVNNKDGFTTLLAVVAPNL
LCKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVADSVAEGVIPADEADDLFICVGVFI
HWEADDDKKIHDFNYTATKEAIARAVAGEPKANEVVAKRNSAKHPFSPE
>A0A2A5P0H4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Geothermarchaeota archaeon ex4572_27|TrEMBL
MSDDAEFYVGEALIGSGYEVAHVDLIIGSKKGPVGIAFAQALANPTRGHTPMLAVIRPNL
MPKPCTLIVPKVTVNSMEDADKVYGPAQAAVAKAIADAVEEGIIPREKCEDWVVIASVFV
HPKAKDYRKIYQFNYGATKTALMRALQRYPSVEKVLREKDRAVHPVMGFKVPRLWNPPYL
QVALDLLTIEEAIKVVEQLPRRERLIIEVGTPLIKAYGVKAVEELRKVRRDTFIIADLKT
MDVGRIEVKEAAEATADAICILGVASNATIDRAIFEAKKHGIYSFLDMMEVQDVEAKLNS
LRFKPDVVILHRSVDVEREAAERGIELKTRWGDIRGLKKKYGVMVAVAGGVTPQTASEAM
RAGADIIIVGRYIVRSRDPRRAAEQFLDLMPPDADTMRLLLDEDELPGD
>A0A139CKT9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus sp. T328-1|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A1I4TK37|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus profundi|TrEMBL
MLLIGEALIGEAPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVVRPNLPTKPA
TLIVPKVTVKNMDQASQIFGPAQAAVAKAVADALEEGAFGDLDVEDIVVVASVFIHPEAT
DYNRIYRYNYGATKLAVKRAVDGFPDIDTVLKEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPVIQNIVKQIPKSDHVILEAGTPLIKRYGVDVISKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVATLNKAIEEAHKTGIYAIMDTLNCDDPVAVLKQLDVLP
DVVELHRGIDIEETEHAWGNIDDIKALSPKILVAVAGGVRIDTMPAALKAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A0E3QQS1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri MS|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFLHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKVAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A850MHP4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Helarchaeota archaeon|TrEMBL
MYAIGEALLGREPELAHVDLIIGEKKGNVGIAFANALSHLSKGHTPLLAVIRPNLPCKPW
TVIIPKVTIEGFSQITKIFGSAQYAVAKAVADAVEEGLIPKGKIEEWVIIVSVFVHPQAK
NDRKIYTYNYSATKLAIRRALSNYPPYDKILYDKDRAKHPVLGFRVPRLWRPPYLQIALD
VPSKERTLKIIKMLPKSDRIILEVGTPLLKHYGTQLIGELRESVKDAFIIADLKTLDVGK
VEVDLAFEETADAVVAAGLASIQTLDKFVYEARRLGIYSFIDMMDLESPLEKLKKLKDLP
DLVIMHRAIDTEADQKPRWDLIKEIKELGVKLVAVAGGIRPMTTVDALKSGADIIIVGRY
ITQSKDVERSTREFLKIFEEKKYWSDIDLFRVHEE
>A0A842L8V3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriales archaeon|TrEMBL
MYRIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIGEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNKIRELRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGIYSILDMMNVENVPEKLEELRYKP
EIVLLHKNIDVGAAEVSEWGNIPEIKKIIGERGLVAVAGGITPSKTRRALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDEPI
>A0A1J5S8G8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MNIHIINKVLVGEALVGEGNEVAHVDLIIGPRGSGAETAFCIALTNQKRGDNALLSVVAP
NLMTKPPTVMFNKVDIKNAKQAVQMFGPAQCGVAAAVADSVKEGIIPIDEANDLFICVGV
FIHWDAEDNTKIQDWNYEATRLALKRAILGLPLPTEVIAQEKVAHHPLAAHDYKKGGF
>A0A843DN02|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum sp|TrEMBL
MFLIGEALVGDGAELAHIDLMIGDKNGPVGSAFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIVPKVTLKHGEQVTQIFGPAQAAVSKAIADALEDGVFDGIDIEENVIVASVFIDPSAK
DFNKLYRFNYGATRLALSRALDKFPDAATVLKEKDRAAHGVMGFKVHRLWNPPYLQVAMD
LVDMKQVERVLTSVPQNDHVIFEAGTPLIKQFGLSVIGEIRKIRPNCFIVADLKTLDTGN
LEARMVSNAGGDAAVVSGLAPIETIAAFIKEAKKCGIYAIIDMLNVEAPAKLIEKLGEMG
GKALLPQYVEMHRAIDKEASGEYSWGDILKIKEVGQKYGANILVATAGGIRQPVVKKAIA
AGADIVVVGRAITASKDIKNAAESFLAELDS
>D2RDB7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)|TrEMBL
MRIGEALVGKGYEVAHIDLLIGEKNGIVGQAFANALSQLSAGHTPLLAVLRPNLITKPPA
IIVPKVTIKNLEQAELVFGPAQAAVAKAVADAVEEGIIPKEKAEDLVVIVSVFIHPKAKD
KNKIYYYNYSATKLAIKRAMSGFPDVDKVLWEKDRAFHPHIGRKLTKLWDPPYLQIAFDL
TSLEEVLNVMRQIPESDHIIYEIGTPLAKRYGADVVLKMREIKPDAFYIIDFKTLDVGKL
EARMAVDATANGVVISGLAPIKTIVEGIKEAQKVGIYAIVDMLGVEDPIKRLEKIKETGV
FPDVVELHRAIDEEEAKPPWHLAKPVKEKFNVLVAVAGGIRVENVQEVISAGADILVVGR
AITRARDVEGAVRRFLSALKKPDTDQFRIMTDF
>A0A1G5W956|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter millerae|TrEMBL
MDPMYRIGEALIGDGPELAHIDLLIGDKFGPVGQAFANGLSNLSIGHTPLTSVIRPNLMT
KPATLIIPKVTVGDLSDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDP
SAEDFRKIYQYNYGATKLAIRRAMEGYPSIEKVLAEKDRGTHPIMGFRVQKLWSPPYLQV
ALDLDSKEAMARILNDIPDKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLD
VGRVEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMMNVKDFEAKLSQLP
DDLKPDIVLLHRNVDLETYKAEKGEDISEMTEWGNIKKIKEIIGDGLIAVAGGITPENVE
EAIDKGADIIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN
>A0A842LRT5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADSVEEGIIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMEGYPSVRKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A315XJD7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter thaueri|TrEMBL
MDPMYRIGEALIGDGPELAHVDLLIGDKQGPVGQAFANGLSNLSVGHTPLTSVIRPNLMT
KPATLIIPKVTVGDLEDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDP
SAEDYRKIYQYNYGATKLAIRRAMEGYPSIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQV
ALDLDNEQAMERIIKDLPDNDRILLEAGTPLVKKFGVGIIGKIRALRPDAFIIADLKTLD
VGRVEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAEFEKKLAKLP
EDLKPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKAILGDKGLIAVAGGIKPNNV
EEAIIKGANIIIAGRYIIGSRDVRRAAQDFLEHFDPDPDNMRLAMDEDENIEVKDD
>A0A2U3LUE1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Desulfosporosinus infrequens|TrEMBL
MNKIDRVLVGEALVGEGNEVAHIDLFMGPRGSAAETAFCNTLSNNKDGFTSLLAVIAPNL
MCKPATVMFNKVTIKDAKQAVQMFGPAQRGVAMAVADCVADGTIPSAEAEDIFILVGVFI
HWEAADDTKIQDYNYEATKLSIKRAVAGEPKVAEVLEQKDKAAHPFAAHI
>A0A7J3M5R1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus|TrEMBL
MEFRVGEALIGEGYEVAHVDLLIGTKDSPVATAFANALANLSAGHTPLLAVLRPNLITKP
PAIIVPKVTVKTMEQAELVFGVAQAAVAKAIADAVEEGYIPKERAEDYLIIVSVFIHPMA
SNKHKIYYYNYGATKLAIKRAMDNFPDVGTMLYEKDRSAHPFVGRKLTKLWDPPYLQIAF
DIPDLEEVMAILSQIPESDHIIFEIGTPLVKKYGSEVVLKLRDIKPNAFFILDLKTLDVG
NLEARMASDATANAVVISGLAPVSTIVKGINEAKKTGIMAFVDMLNVENPIARLEVISKE
VLPDVVELHRAIDVESSEPPWAIAREIKEKFKILVAVAGGIRPENVSEVISAGADIVIVG
RAITKAKDVEGAVRRFMNFLKPDTDQFRIMTDF
>A0A1D2W4Q6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. A39|TrEMBL
MYHIGEALIGSGNEVAHVDLVIGDKNGPAGTAFVNNLTQLSIGHTPLLSVIRPNLLTKPA
TLIIPKVTVKDLCDAEKIFGPAQTAVSRAVADAVQEGLIPEDKAEDLVILASVFIHPEAS
DYRKIYQYNYGATKLAIRRAMEGYPSVGKVLAEKDRGAHPIMGFKVVKLWNPPYLQVALD
LDNFDDVERIINSLPNRERILLEAGTPLIKKFGVGVISKIRELRKDAFIIADLKTLDVGR
VEVKIAADETADAVAISGLGTVESIEKAIHEAMKQGIYSILDMMNVENFVEKLQSLRFKP
DIVLLHRNVDLETAAKERGEAEAEVTEWGNINQIKEILGKNGLVAVAGGITPDKVDKALT
SGASIIIVGRYIIGSRDVRRAAEDFLAHMPQDPDTMRLALDEDEAI
>A0A2H5VFH1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon HR06|TrEMBL
MFLVGEALVGKEPEVAHIDLIIGDKEGVVGQAFANALSQLSAGHTPLLAIIRPNLPSKPY
ALIVPKVTI
>A0A2J6N4L1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MPGKYTYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFASGLSNLSVGHTPLLAVIRPNL
PPKPHTLLVPKVTVKHLEDANKIFGPAQAAVAKAVADAVEEGIIPKEKVDDWVIVCSVFV
HPQASDYRRIYHYNYGATKLALKRALAKYPSLEKVFYDKDRAKHPIMGFRVPRLWRPPYL
QISLDIPDLDRTKKIIAQIPRSDRIILEAGTPLIKRYGTKVISDLREIAKDTFVIADLKT
LDVGKVEVDLAYDETADAVIAAGLAPEETLDSFIHEAKRFGIYAAVDMLNVEDPIKKLKA
LKEFPDIVIIHRGIDQETGMTVGLNRIEELRKTFSDKRFLIAVAGGIVPETAKEALEKGA
DIIVVGRYVTQSKDIERAVRDFLELTPSMREDVDLFRVHVE
>A0A7J4AWJ9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
WVIVCSVFVHPQASDYRRIYHYNYGATKLALKRALAKYPTLEKVFYDKDRAKHPIMGFRV
PRLWRPPYLQISLDVPDLDRTRKIIAQIPRSDRIILEAGTPLIKRYGTKVISDLRDIAKD
IFFIADLKTLDVGKVEVDLAYDETADAVIAAGLAPEETLNAFIHEAKRLGIYAVVDMLNV
EDPIKKLKTLKEFPDVVIIHRGIDEESGRTIGLELIQELRKTFSDKRFLIAVAGGIVPET
AKEALEKGADIIIVGRYVTQSKDIERAVREFLEITPSMREDIDLFRVHVE
>A0A842N3V2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSEAVRAAIDRFSTGSAQRGGAFLIGEALVGEGNEVAHVDLMIGDKQGPVGYSFAQSLSH
LSAGHTPLLAVIRPNLPPKPHTVIVPKVTIKNMEDAGKIFGPAQSAVAKAVADAVEDGIV
PKAIIEDWVVIVSVFIHPKAEDERRIWQYNYSATKLALSRALESYPPWEKIQYDKDRVKH
PLMGFKAPRLWRPPYLQIALDNPNIEMIKRVIKQVPMNDNVILEAGTPLLKRYGVSVIRE
LREARKDSFIIADLKTMDVGKVEVDMAFEETADAVCCAGAASSGTIDEFVYEARRLGVYS
FLDLMQVEDPVEKLKDLEKLPHGVILHRPIDMEQRGGEARWGYISKIREAFPDTKLLIAV
AGGIRPNTAQFALEAGADILIVGRYITQSKDVERSVREFLPLLQGDIDLFRVHVE
>A0A0E3Q9Z8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. Kolksee|TrEMBL
MGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPSTLIIPKVT
VKNMDQAGKIFGPAQSAVAKAVADSVEEGVISKDQVEEIVIVASVFIHPDAQDYNKIYRY
NYGATKLAIKRALKGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQVAFDNPDIQFVQ
SAISQIPKSDHVIIEAGTPLIKRYGMDVISKIRQVRPDAFIVADLKTLDTGNLEARMVAD
AAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRG
IDIEATEHAWGNIAEIKKIAPKTLVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVR
EVAEQFINSLNKPEIDQFRIMTDF
>A0A6J5G6J6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia fynbosensis|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCHALTNNKDGFTSLLAVVAPNL
LTKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPPDEADDLFLCVGVFI
HWQAEDDKKIQEFNYQATREAIKRAVNGEPNAAEVVAKKSTVAHPFAPN
>A0A4E0PY63|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus halotolerans|TrEMBL
MLLIGEALIGEEPELAHIDIMVGNKDGPVGQAFANGFTQLSVGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMAQAAQIFGPAQAAVSKAIADALEEGAFGDMDIEDIVVVASVFIHPGAK
DYNKIYRYNYGAAKLAVKRAVDGFPDVDTVLREKDRMGHAVMGFKVSRLWNPPYLQVALD
NPNLPVILDIVKQIPKSDHVILEAGTPLIKRYGVDVISKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATMNKVIEEAHKTGIYAVMDTLNCDDPVAVLKKLDVLP
DVVELHRGIDVESTAHAWGSIDDIKALSPKILVAVAGGVRIDTMPQALEAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A6J5KGK4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia phenoliruptrix|TrEMBL
MSVSADKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSEFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSAN
WVNPATDDLDAVFDNNYRACKNAILAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A832ZYF7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEAVLGRDIVAIVNLVIGRGEKIDTVFSNALTRVPTPILANLRDNLIVKPLTLVVP
RNTLTSDIQCNLLHGPIQYGVAKAVADLELEEDLKLIVTVSVPDVPYTLLNRRKLFHYYY
GATRLAIKRALDDYPSREKIRKEKYRAIHPLVGFRDIRLERPPYLQVALDIPSMENVEYV
LESLPPSDRIIVEAGTPLIKKYGIDVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVILSGTAPRETILKGIHECERCGIISYLDTINVSDPFGLYHSLKLKPDVLLLHRAIDE
EGKVPMREYSGVKGERGPLLGIAGGVTLDRIEELKEKYDIIVVGRGITRSRDPGRVARAI
INKLGEDIDQYRLEEDEDVPLR
>A0A5E4KUL0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MFLVGEALIGEEPELAHIDLIIGEKTGPVGQAFANGFTQLSMGHTPLLSVIRPNLLAKPA
TLIVPKVTVKNMPQAAQIFGPAQTAVARAVADSVQEGVIPENQLEDLTIIVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDNKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAID
MPDIDAVKSILKQIPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNAFVVADLKTLDTGN
LEARMVADATADAVVISGLAPVSTIEKAIKEAKKTGIYAVIDMLNVDKPVSVLKQLSIKP
DVVELHRAIDTENKAEHAWGDIPAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFLEELKQPEIDQYRIMTDF
>A0A3G9CU62|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina thermophila|TrEMBL
MGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPSTLIVPKVT
VKNMEQASKIFGPAQTAVAKAVADSVEEGIISKDLVEDIVIVASVFIHPDAQDYNKIYRY
NYGATKLAIKRALEGFPSIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFDNPNLESVL
SAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGNLEARMVAD
AAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMPDVIELHRG
IDIENTEHAWGNIEEIKKVAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVR
EVAEQFIMSLNKPEIDQFRVMTDF
>A0A5E7MUJ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas fluorescens|TrEMBL
MKELDLYIGEGFEGPGVNAAHINILIGPRNGPAGQAFASSLASPSQGHCPFMVIVQPNIP
VKPMTLYVNKAAIGSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGKPDTAQLKDVVNHISNPFYTPKA
>A0A0F8EUV6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 2.H.T.1A.15|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A7L4PQ04|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGDKDGPVGAAFANGLTNLSSGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMDQAAQIFGPAQTAVARAVADAVAEGVIPRDKVEELVVVVSVFIHPDAK
DYDAIYRYNYGATKLALERAMEGFPSIETVLYEKDRSTHPIMGFRVTRLWDSPYLQIALD
LVDLGEVRRVLSQIPDSDHILIEVGTPLVKMLGVQVVREVRAARPGSFVILDLKTLDTGN
LEVRLAADASADAVVISGLAPQKTIDLAIREARKTGIYSIIDMLNVKDPLEVLKGLSVLP
DVVELHRAIDMESSAHAWNNIPEIKALAKDNRKLLVAVAGGIRVDTVGQALAAGADMIVV
GRAITRSKDIRDMVEQFLSQLKQTEIDQYRVMTDF
>A0A7J2MFU8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKTGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMEQASLIFGPAQAAVAKAVADAVEDGIVPTEQAEELVIVASVFIHPDAK
DYNRIYRYNYGATKLALARAMDGFPGIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVKTLPDSDHLILEAGTPLIKRYGVDVIARLREVKPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPIPTIVNAIREAHKTGIYAIIDTLNLPDPLPLLRELGEIG
ALPDVVELHRAIDAEKTEYQWGSIPEIKALSSKILVAVAGGIRADTIRAARDAGADVLVV
GRAITNAKDVRQAAERFIEGLSKEEIDQFRVMTDF
>A0A7L4Q2Y8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLVGEALIGKGPEVAHIDLIIGEKEGPVGTAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMDQAAQIFGPAQTAVAKAVADSVAEGVIPKDRAEELLVIVSVYIDPKAT
DYDAIYRYNYGATKLAVARAMAGFPDIDKVLYEKERSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPDSDHILIEVGTPLVKMLGMNVVKEIRAIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTIELSINEARKTGIYSIIDMLNVADPLAVLKGLDVLP
DVVELHRAIDMEKSAHAWQNIPDIKALAEEGRRLLVAVAGGIRTDTEGAALAAGADILVV
GLAITRSRDIRDMTEQFLTGLKQTEIDQYRIMTDF
>A0A662R260|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MMYVGEALVGEGSEVAHIDLVIGDKNGPVGEAFVNSLSSPSIGHTPLLGVIRPNLMPKPP
TLIVPKVTIKNMEDASKIFGPAQTAVSKAIADAVEEGIIPKDEVENLVVVVSVFIHPDAK
DYARIFRYNYGATKLALKRAMEGFPDINTVIEEKDRDVHPIMGYKLMTQLFDPPYLQIAI
DIPEIGVVKKVLRDVPMSDHVIFEAGTPLIKKYGLNVITLMREVRKDAFIVADLKTLDTG
NIEARMAADATADEVVVSGLAPKSTIEKAIMEAKKTGIYSCIDMLNVDDPVSLLKSLSVK
PDVVELHRAIDEEEGSEHKWGDIEKIKKVSENALVAVAGGITIDNLREAIESGADIIIVG
RAITKAGDIRAVAEAFLDVMRKPEVDQFRVKTDF
>A0A822J4K8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGEAPELAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQVFGPAQTAVARAVADSVEEGVIPKDQIEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
IPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIKEARKTGIYAVIDMLNVDKPLSVIKALSIKP
HVVELHRAIDTEGKAEHTWGDIPAMKKLSERMLVAVAGGIRVDTVKEALESGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRVMTDF
>A0A833DVQ9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus profundus|TrEMBL
TIKDMKQAELIFGPAQAAVAKAIADAVEEGIIPKEEAENLVVIVSVFIHPKAKDKNKIYY
YNYGATKLALKRAMSGFPDVDTVLYEKDRAFHPLVGRKMTKLWDPPYLQIAFDLTSLDEV
LNVMKQIPESDHIIYEVGTPLAKKYGAEVILKLREIKPDAFYILDLKTLDVGKLEARMAA
DATANAIVISGLAPIKTIIEGIKEADKTGIYAIVDMLGVEDPIKRLEKIKEAGYLPNVVE
LHRAIDEEDAKPPWGLAKDIKEKFNVLVAVAGGIRPENVPEIIQAGADILVVGRAITRAR
DVEGAVRRFLNYMKPDIDQFRIMTDF
>A0A1F2P8Z2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Syntrophoarchaeum caldarius|TrEMBL
MGEGGELAHIDLIVGSKSGPVGMAFTNGMTQLSAGHTPLLAVIRPNLPVKPSTLIVPKVT
VENLDQASKIFGPAQTGVAKAIADAMEEGIIQKEEAEDQVIIASVFIHPEAKDYNKIYRY
NYGATKLALKRALIGFPDADTVLYEKDRSIHPVMGFKVTKLWDPPYLQIALDIPDLDLIT
HVLSQVPKNDHLIIEAGTPLIKRYGLDVLGKIREIKPDAFIVADLKTLDTGNLEARMASD
LTADAVVISGLAPIETIDKAIEEAKKTGIYAVIDMLNVDDPVEVLRQLKTLPEVVELHRA
IDVELYGEGSHEAWGAIGAIKELGQILVGVAGGITEDTVQLALDSGADILIVGRAITKSK
DVEGACRRFLKALNKEEIDQRRVMTDF
>A0A1J5R5U5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
METLKINKVLVGEALVGEGNEVAHIDLIIGPRGSGAETAFCIALTNQKRGDNALLSLVAP
NLMTKPPTVMFNKVDIKNAKQAVQMFGPAQSGVAAAVADSVKEGVIPLAEANDLFICVGV
FIHWDAEDSTKIQDWNYEATKLALKRAVAGLPLPAEVVAQEKVVHHPLAAHDYKKGGY
>A0A124FVE5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocalculus sp. 52_23|TrEMBL
MYSIGEALVGDGPELAHIDLLVGDKNGPVGSAFANALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTLKKGEQVKEMFGPVQAAVAKAVADCLEEGLFNGINIDEIVIIASVYLAPDAE
DYNRIYRYNYGAMKLSLSRAFESFPDEKTIIHEKDRAAHGVMGFKVQRLWNPPYLQVAMD
LVDMNQVGRVLTELPQNDHLIIEAGTPLIKQFGLSVIGEIRKMRPSAFIIADLKTLDTGN
LETRMCANASADAVVISGLAPISTIEKAVLEARKTGIYAVVDMLNVSSPLNLVKELAKIN
ALPHVIEMHRAIDAEGSDYAWGDIPAIKKAAGGKILVATAGGIRVNVAKKALASGADILV
VGRAITASKNIHHAAEEFLEEIDSEEIDQFRIMTDF
>L0HGC6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)|TrEMBL
MYLVGEALIGDGAELAHIDLLMGDKEGPVGNAFANAISQLSQGHTPLLAVVRPNLLTKPA
TVIIPKVTLKDMDQVNEMFGPVQAAVAKAVADCVEENAFAGLDIENTVIICSAFVHPDAK
DYNKIYRYNYGATKLAIHRALEKFPDTKTLVFEKDRAAHAIMGFKVTRLWDPPYLQVAMD
LVDMGKVAQVLKSVPDNDHVIIEAGTPLIKKFGLSVLGEIRKLRPNAFIIADMKILDTGN
LEARMAADATADAVVVSGLAPTSTIEKAISEARKVGIYSIIDMLNVTNPAKLIASLKVKP
DIVELHRAIDVEETAHAWGDIPAIKKAAGGKLLVATAGGIRVDVVKEALKSGADILVVGR
AITASKDIGHAADEFLEQLNRDEIDQFRVMTDF
>A0A1V4V9M5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaB.Bin087|TrEMBL
MFLIGEALMGDEPELAHIDLLIGDKDGPVGTAFASGLAQLSAGHTPLLSVIRPNLPPKPA
TLIVPKVTVKNMEQAAAIFGPAQNAVAKAVADSVAEGVIPKAEVENLVVIASVFIHPQAR
DYDAIYRYNYGATKLAVKRAMEGFPDIDTVLFEKDRSTHPIMGFRVIRLWDPPYLQVALD
LVDLAVVRRVLSQLPDSDHLLIEVGTPLVKKFGASVVKEIRTVRPSSFVVLDLKTLDTGN
LEVRLAADATADAVVISGLAPKKTLELAIQEARKTGIYSVIDMLNVPDPLAVLRSLSALP
DVVEMHRAIDQEAERHNWEAIAEIKRMAATSDRKILVAVAGGIRVDTVASALSSGADIVV
SGRAITGSKDVKDAAEQFLSELKQTEIDQYRVMTDF
>A0A800UET2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon Met12|TrEMBL
MTDNGFLVGEALVGEEPEIAHIDLMIGSKNGAMGQAFANSLAQPRQGHTPILAVIRPNLP
VKPATLIVPKVTIRNLEDAEKTFGPAQSAIAKAVADAVEEGIIPKEAVEEIAIIVSVFIH
PRGKDYQRIYRYNYGATKLAIRRAIEKFPDIDKVLEEKDKAMHAMIGFRINNLKNPPYLE
VAFDIPDWRRVEGIIRALPRTDAIIIEAGTPLIKRYGVEVVQKIHQLRPESVVVADLKTL
DTGNLEARMAGDATADVIGFSGLAPLKTMEKFIAECKKVGALSLMDTLNVSDPVAVLKKL
KEKPDIVELHRAIDVERVEEAQWGNIKEIKKACNNKVLVAVAGGIRADKVEDALKSGADI
LVVGRAITSAKDVTGAARAFLQKMGIEEVDQFRVMTDF
>A0A1V4Z756|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. PtaU1.Bin242|TrEMBL
MYKIGEALIGSGNEIAHIDLVIGDKEGPVGAAFVENMTGLSIGHTPLLTVIRPNLLTKPA
TLIVPKVTVSGLKDADKIFGPAQTAVGRAVSDAVAEGIINKDDAENMVILVNVFIHPDAE
DYRKIYQYNYGATKLAIRRAMDKYPSINKVLAEKDRGLHPIMGFKVVRLWNPPYLQVALD
LDNMEDMERIIDSLPNRERILIEAGTPLVKKFGVGIISKIRELRKDAFIIADLKTLDVGR
IEVKIAADETADAVAISGLGTLESIQKAVHEASKQGIYSILDMMNVENFVEKLKALKYKP
DIVLLHRNVDLETHKAEKGEIIGDVTEWGNIKEIKEIIGKGKLVAVAGGITPDKVDQALG
SGADIIVVGRYIIGSRDARRATDDFLKYMPQDPDTMRLALDEDESIDIDPSKG
>A0A7W5DX94|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Rhodopirellula rubra|TrEMBL
MHFHIGEALVGDGNEVAHIDLMIGSKNGPVGTAFANALANQSEGHTNLLAVLEPNVAVKP
STVMITKVTIKGMKQAVQMFGPAQAAVAQAVADAVSQGIIPRDAAEELVCVCGVFIHPAA
EDDEKIYKYNYEATLESLKSALANKPSVDDMLAKKDSAAHPFKGF
>A0A532T5Y1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon Loki_b32|TrEMBL
MAKSEYFIGEALIGEPPNLAHVDLIMGSKDGPVGISFANAISTPSRGHGGLLSCIRPNLL
TRPYTIIVPKVSVAKMADANKIFGPAQAAVAKGIADAVEEGLIPMNKLDDWLIIVSVFIH
PEATDYRKIYQYNYGATKLAIQRALKNYPPIEKIFYDKDRAKHPVAGIRVPRLWRPPYIQ
VALDAPNLEKQIKVVKQLPKSDRIILEVGTPFLKKYGVESIKQIREAAKEKFIVADLKTL
DVGKLEVDFAFDATADGVVASGLAATASLDKFILEAQRLGIHAFVDTMEVTNPIEKLSSL
RQTPDVVILHRAIDVEQSTAGDKSPDASQKARWALIPKIKELYAGQKKASGRDRVLVAVA
GGIEPSTATYALEQGADILIVGRFIASAKDVEFAMRRILSVLPGYQDIDLKRIHSEDDDN
TVEKSGGPKWD
>A0A832HWU8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSERDVRKPKSRDELIQILKDAVKKEVKTRSLLAGRPTKPTVSGTAKVLNIHRDTLYSWL
KEFSVDFDAFVQEETANLLPETVEFSKKYTYLIGEALVGEGNEVAHIDLLIGDKEGPVGE
AFATGLTSLSQGHTPLLAVIRPNLPPKPHTLLVPKVTVKNLEDANKIFGPVQFAVAKAVA
DAVEEGLIPKDKIDDWVIVCSAFVHPQASDYRKLYHYNYGATKLALKRALAKYPTLEKIF
YDKDRAKHPIMGFQVPRLWRPPYVQISLDVPDLDRTKRILTQIPRSDRIILEAGTPLIKR
YGTKVISDLREIAKDVFIIADLKTLDVGKVEVDLAYDETADAVIAAGLAPVETLDAFIHE
AKRLGIYAFVDMLNVEDPLKKLKQLKEFPDVIILHRGIDQESGRTIGLELIQELRQTFSD
RRFLIAVAGGIVPETAREALEKGADIVVVGRYVTQSKDVKRAVRDFLELTPAMREDVDLF
RVHVE
>A0A832GPQ6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MFLIGEALVGSGPEVAHIDLIIGDKEGVVGQAFATGLASLSAGHTPLLAVIRPNLPPKPF
TLLVPKVTIKNMEQAAKVFGPAQAAVAKAVADAVEEGIIPKDKIDEWVIICSVFIHPEAK
DPRRIYHYNYSATKLALKRALMNYPSLEKIMYDKDRATHPIMGFRVPRLWMPPYLQIALD
IPDLEKTKSIIAELPKSDRIILEAGTPLIKRYGARVIQELREIAKDVFIIADLKTLDVGQ
VEVDLAYEETADAVVASGLASVETLNKFIYEAKRLGIYAAIDMMDVSNPLKLLEQLSDLP
DIVIIHRGIDEEKIKKTRWELIKELKEKYKDRKLLIAVAGGIEPSNAPLALESGADIIVV
GRYITQSKDVKKATREFLVHLGLDMDVFRVHVE
>A0A7J2TPY0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTEAAKKEAKTRSLLRGKPTKPTISGTAQFLNIHRDTLYTWLKEFNVDFDEVTESLSAD
LLSEAIETPQKHTYLIGEALIGEGNEVSHIDLLIGDKDGPVGEAFAAGLSNLSAGHTPLL
AVIRPNLPPKPHTLLVPKVTVKNLADAGKIFGPAQAAVAKAVADAVEEGIIPKDKVDDWV
IVCSVFVHPQASDYRKIYHYNYGATKLALKRALSKYPTLEKVFYDKDRAKHPIMGFRVPR
LWRPPYVQISLDIPEFEKTKKIIMEIPRSDRIILEAGTPLIKRYGTKVISDLREIAKDIF
FIADLKTLDVGKVEVDLAYEETADAVIAAGLAPAETLDAFIHEAKRLGIYSMVDMLNVED
PIKKLKTLKQFPDVVILHRGIDEETGRTLGLELIQEMRQTFSDKRFLIAVAGGIVPETAK
EALEKGADIIVVGRYVTQSKDIERAVRDFLELTPAMREDVDLFRVHVE
>A0A7K4AII1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix soehngenii|TrEMBL
MFLVGEALIGKGPEVAHIDLIIGEKEGPVGTAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMDQAAQIFGPAQTAVAKAVADSVAEGVIPKDRAEELLVIVSVYIDPKAT
DYDAIYRYNYGATKLAVARAMAGFPDIDKVLYEKERSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPDSDHILIEVGTPLVKMLGMSVVKEIRAIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTIELSINEARKTGIYSIIDMLNVTDPLAVLKGLDVLP
DVVELHRAIDMEKSAHAWQNIPDIKALAEEGRRLLVAVAGGIRTDTEGAALAAGADILVV
GRAITRSRDIRDMAEQFLTGLKQTEIDQYRVMTDF
>A0A1D3L4S2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium congolense|TrEMBL
MYINGEALVGDGNEVAHIDLLIGDKEGPIGQAFANALVNQVERHTPLFAVVAPNLMCKPV
TMLLPKVSIKDLDDATRIFGPAQKAVAMAVSDCVEDGTIMKEMVEDICILCGVFIHPQAE
DPDKIYQYNYEATKLAIKRAFVDEPPIDEILAKKDSLKHPFYK
>A0A7J4EWS3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobaceae archaeon|TrEMBL
AQPIMGHTPILGVIRPNLPAKPSTLIVPKVTIRNLEDAEKIFGPAQSAVAKAVADAVEED
IIPEDKAEKLVVIVSVFIHPRGKDYQRIYRYNYAATKLALRRAMSGFPCVDKVLEEKDKS
MHAMIGFRINNLKKPPYLEVALDIPDWRRVEGVIRALPRSDAIIIEAGTPLIKKYGVEVV
QKIHQLRPESVVVADLKTLDTGNLEARMAGDATADVIGFSGLAPVKTMEKFIEECKKVGS
LSLMDTLNVPDPVEVLKKLDVKPDIVELHRAIDVEQTQESAWGNIKEIREVCDNKVLIAV
AGGIRVDKVEVALNAGADILVVGRAITAAKDVTGAARAFLQKMGVEEVDQFRVMTDF
>H1Z3H1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoplanus limicola DSM 2279|TrEMBL
MIDLLVGDKTGPVGMAFANAMSQLSPGHTPLLAVIRPNLLTKPATLIIPKVTLKTGEQVN
AMFGAVQAAVAKAVADSVEEGAFGDNNIEDLVLLVSAFLHPDAKDYNRIYRYNYGSTKLA
ITRALAGFPDKETVLKEKDRAGHAVMGFKVHRLWDPPYLQVAMDLVDMKSVERVLTSVPK
NDHVLIEAGTPLIKQFGLSVISEIRKIRPDAFIIADLKTLDTGNLEARMAANASADAVVV
SGLAPVPTIVKFIQEAKKTGIYSVIDMLNVDKPAELIEKLAKEGAVPSIVEMHRAIDAEG
DDYNWGDIPAIKEAAGGKLLVATAGGVRQHVVKDALKSGADILVVGRAITASRNIQNSAE
QFLEEMNKEEIDQFRIMTDF
>A0A498H872|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus sp. WG1-DM|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A524E5X7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKTDYFIGECLIGEAPNLAHVDLIIGSKDGPIGVSFANALSSPSMGHGGLLGCIRPNLL
SKPISLIVPKVTVSKMEDANKIFGPAQAAVAKGIADAVEEGLIPMNKLDDWVIIASVFIH
PEASDYRKIYQYNYGATKLAIKRALQQYPPIEKIFYDKDRAKHPVAGIRVPRLWRPPYLQ
IALDHPSVEHQIKVVKQLPKSDRIILEVGTPFLKKYGVESIKKIREVAPEKFIVADLKTL
DVGKLEVDFAFDASSDAVVASGLASPSSLDKFVMEAQRLGIYAFIDTMEVPDPIEKLSQL
KQTPDVVILHRAIDVEQDIETKSPDAQQKQRWSSVQKIKELFKNQKLASGRDRVLVAVAG
GIEPSTAKYALEMGADILIVGRFITSSKDIKNSTRRFLNMLPGYSDINLKRIHSEDDDSS
IKKATWD
>A0A7K4D0V7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MSEFLIGEALLGKDSEVAHIDLMLGDKTGPVGQAFATALINMSKGHTPLLAVVRPNLMPK
PAVVIVPKVTIQNLEDAGKIFGPAQAAVAKAVADCVEEGLIPQDKLDDWVIVACVFIHPE
SKDERKIYKYNYSATRLAIKRALDKYPSAKKLMEEKDRARHPFSSVKMPRLWRPPYLQIA
LDNPSLSSALSIIKQAPRSDRIIWEAGTPLVKKYGVEVVKELRKETKDGFIVADLKTLDV
GKVEVDMAFDADADAAVVSGLAAVDSIDKFLLEADRMGIYGIIDMMNVADPLALLKQLKR
APRVVIIHRGIDMEGSVKKNKWEVIAEIKAMYRDIKPPVLCAVAGGITPENMGEAAKNKV
DIIIVGRYITQSQDVERSIRNFINAMPGDADVDLKRIHSDDDDKGENLS
>A0A151F546|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Theionarchaea archaeon (strain DG-70-1)|TrEMBL
MRIGEALIGDGLEVAHIDLIIGEKDSPVGYAFANSLAQPSYGHTPILGVIRPNLPPKPST
LIVPKVTVRNFKDAGKIFGPAQAGVAKAVADAVDEGLIPREHCDDWVVIVSVFVHKDAQD
YRKIYQFNYGATKLAIKRAMENYPSVDKVMKEKDRATHPIMGFRVYRLWSPPYLQVALDL
TSEEDVRKIIEQLPVRERLLLEAGTPLIKNCGIEIVEKIRKMREQSFIIADLKTLDVGRL
EVKMAADATADAVCISGLAPNASVEKSIQEAQRQGIYSVVDFMNVTDIEGKLKSLKYKPD
IALLHRNVDVETAARERGEELETKWGNISAIKKLVKLVSVAGGITPKTSEEALKKGADII
VVGRYIIRSHDPYQAVRDFLEKMPPDPDTMRLILDEDEVVGT
>A0A432Q4E0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus sp|TrEMBL
MRVGEALIGIGNEVAHVDLLVGSKNGPVGQAFANALSQLSAGHTPLLAVLRPNLITKPPV
VLVPKVTVKDLHQAELIFGPAQAAVAKAIADSVEEGILPKDMAEELVIIASVFIHPKAKN
VHKIYYYNYGATKLALKRAMKGFPDVEKVLYEKDRSVHPFVGRKMTKLWDPPYLQVAMDL
TSLSEVKKVLELVPESDHVIFEIGTPLAKKYGVDVILELRDVRPDAFFVLDIKTLDTGNL
EARMAADATANAVVVSGLAPRSTIEKFIREADKTGIYSVIDMLNVDKPTALLEKLSVKPN
VVELHRAIDTEGTAPPPWNGVREIKEKFDLLVGVAGGIRPENVGEAISAGADILVVGRAI
TRARDIEGAARRFLISMASAKELSDTDQFRVMTDF
>A0A6J5EK31|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia solisilvae|TrEMBL
MAKINRVLVGESLIGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
MTKPNTVMFNKVTIKGAKQAVQMFGPAQHAVALAVADCVEDGTIPKDEADDLFICVGVFI
HWQAEDDKKIQEFNYKATREALQRAVAGEPSAAEVVSKKSSAAHPFAPN
>A0A1L3Q0Q8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus halophilus|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEEIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAVDTVLDEKDKGSHAIMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLNELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADVLVVGRA
ITNSKDIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A520JWX6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGSAPELAHIDLIIGDKNGPAGSAFAAGMTQLSAGHTPVLSVIRPNLLTKPA
TLIVPKVTMKKTEQVNQIFGPAQNAVALAIADSVEEELIPQDKAEEWVVIASVFIHPDAK
DYSKIYRYNYGATKLAIQRAMEQFPSINTVLDEKNRAEHPVMGFKVTRLWDPPYLQVAID
VPDIDYVQQILKEMPQSDHLIIEAGTPLIKRYGVDVIEKIREARNNPFIVADLKTLDTGN
LEVRMAADATADAVVISGLAPTSTIEKAIKEAKKTGIYSVIDMLNVKDAAGLIDNLSVKP
NIVELHRAIDLENTVTTGWDSIQKIKKISGKILVAVAGGIRIDKLKPSDHTVDEALAAGA
DIIVVGRDITKAKDVRLKTEQFLEHMKKPEIDQYRIMTDF
>A0A1M4MP85|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus chikugoensis|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANAISQLSKGHTPLLAVVRPNLPTKPS
TLIIPKVTMKKGYQVNQMFGPVQAAVAKAVADSVEEGVFEGVDIEDTVIMASVYLDTAAE
DYNKIYRFNYGAVKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMRKVLESLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVVDMLNVENPVAVIEQLKVKP
DVVELHRGIDIEDTDYAWGDIPAIKKAGGERLLVATAGGIRQPVVKDALKAGADILVVGR
AITASKNIQHAAEEFLQELSTEEIDQFRIMTDF
>A0A3A5HH26|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp|TrEMBL
MYKIGEALIGSGNEIAHIDLIIGDKEGPAGTAFANGLSQLSLGHTPVLSVIRPNLMTKPA
TLIVPKVTVGDLKDAEKIFGPAQAAVGRAVADAVEEGLIPEEKVEDLVLVVSVFIHPEAE
DYRKIYQYNYGATRLAIRRAVGEYPEVGKVLAEKDRGSHPIMGFGVVRLWSPPYLQVALD
LDNMDEMERIINSLPDRERILLEAGTPLVKKFGVGIVSKIRELRPDSFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTTESIEKAIHEAQKQGIYSILDMMNVENFVEKLNNLDYKP
DIVLLHRNVDLETLKAERGEAQSEMTEWGNIKEIKELIGKNGLVAVAGGITPSKVGEALD
SSADIIVVGRYIIGSRDVRRAAEDFLDHMPQDPDTMRLALDEDESL
>A0A7J4TIB8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium subterraneum|TrEMBL
NLSLGHTPLLSVVRPNLMTKPATLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGI
LPAEEAENMVLIISVFIHPEASDYRKIYQYNYGATKLALRRAMEEYPSVNKVLAEKDRGA
HPIMGFKVTRLWKPPYLQVALDLDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVS
KIRELKKDAFIIADLKTLDVGRIEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIY
SILDMMNVDNFTGKLETLNYKPDIVLLHRNVDLETMKAERGEEQADMTEWGNINQIKDLL
GKNGLVAVAGGIVPKKMDQALDSGADIIVVGRYIIGSRDVRHAAEDFLEKMPQDPDTMRL
ALDEDESI
>A0A099T4S1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcoides methylutens|TrEMBL
MMFIGEALIGEAPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVAKAIADAVEEGIVPKDQAEDLVIIASVFIHPQAV
DYNRIFRYNYGATKLALKRALDNFPSIDTVLEEKDKSSHAIMGFKVSRLWDAPYLQVALD
NPNIDAIRNVVKQLPKSDHLILEAGTPLIKRYGVDVITKLREIKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATLNKAIAEAHKTGISAVMDTLNQPDPVAVLEQLDELP
DVVELHRAIDIEETAHAWGSIEGIKAIGEKRNKKILVAVAGGVRVDTISAALGAGADILV
VGRAITNSKDIKQAADQFIEGLNKPEIDQFRVMTDF
>A0A7L4NY42|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon|TrEMBL
MYNIGEALIGSGNELAHIDLVIGEKNGPVGSAFVENMTSLSIGHTPLLAVIRPNLPTKPS
TLIIPKVTVGCLDDANKIFGPAQTAVGRAVADAVSEGIIDKKKAEDLVIMVTVFIHPEAK
DFRKIYQYNYGATKLALKRAMDSYPSTEKVTAEKDRGTHPVMGFKVIRLWNPPYLQVALD
LDNMEDMERIIDSLPNRERILIEAGTPLVKKFGVGIISKIRELRTDAFIIADLKTLDVGR
IEVKIAADETADAVAISGLGTPESIQKAVQEASKQGIYSILDMMNVDNFVEKLKGLKYKP
DILLLHRNVDLETYKAEKGENLGDMTEWGNIKEIKEILGGNRLVAVAGGITPDKVDQALE
SGADIIVVGRYIIGSRDVRRATDDFLKYLPQDPDTMRLALEEDEPLELNDDKK
>A0A7V9A6H6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Bremerella alba|TrEMBL
MSMYIGEALAGDGNEVAHIDLMIGSKDGPVGHAFASALVNQTAGHSNLLAVLTPNLAVKP
ATVTITKVTIKNSKQAVQMFGPAQAAVAKAVADAVEQGVIPKDQCEDLVIVCGVFIHWEA
QDDKKIYEYNYEATLESIKSAMAGKPTIDEVIAGKEQAAHPFRGF
>A0A847PW10|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp|TrEMBL
MFQIGEALMGQGAELAHIDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQASKIFGPAQSAVAKAVADSVEEGVISKDQVEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALDNFPDINTVLEESNKSTHAIMGFKVTRLWNPPYLQIAFD
NPNLEFVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRADAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTINKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DIIELHRGIDIESTEHAWGNIEEIKKVAPKALVAVAGGVRLDKVPVALNQGADILVVGRA
ITNAKDVREAAEQFINSLNKPEIDQFRIMTDF
>A0A832TY61|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAGKIFGPAQSAVAKAVADSVEEGVISKDQVEELVIVVSVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQRDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGDIAEIKKVAPKTLVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A1D2WFF0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. A6|TrEMBL
MYEIGEALIGDGPELAHIDLIVGSKQGPVGTAFATNMASMSVGHTPLLSVIRPNLPTKPA
TLIVPKVTVQNLDDASKIFGPAQTAVGRAVADAVEEEIIPKDIVEDIVLMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRAFDKYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDRMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECSKQGIYSILDMMNVSDIPSKLEELKLKP
NIVLLHRNIDSETMRDNDGEQQSEWGNIKDIKSKLGKRGLIAVAGGVTPEKVDTALANGA
NIIIAGRYIIGSSDVRRAAEDFLRYLPQDSDTMRLALDEDEKI
>A0A347AM87|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. BAmetb5|TrEMBL
MYQIGEALIGNGNELAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVSVRDLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAENMVLIISVFIHPEAS
DFRKIYQYNYGATKLALRRAMEGYPSVNKVLAEKDRGAHPVMGFKVNRLWSPPYLQVALD
LDNMQDMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTEKLENLNFKP
DIVLLHRNVDLETLKAERGEEQADMTEWGNINQIKEIIGKNGRVAVAGGIVPKKMDQALD
SGADVIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDESI
>A0A832X9J6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregula sp|TrEMBL
MYLVGEALIGDGAELAHIDLLMGDKEGPIGSAFANSISQLSMGHTPLLAVVRPNLLTKPA
TLVIPKVTLRDMTQVNEMFGPVQAAVAKAVADCVEEDLFRDIDIESIVIMVSAFVHPDAK
DYNKIYRYNYGATKLALHRAIDKFPDTRTLVFEKDRAAHGIMGFKVTRLWDAPYLQVAMD
LVDMGKVAEVLKCVPQNDHVIIEAGTPLIKKFGLGVIGEIRKLRPNAFIIADMKILDTGN
LEARMAADATADAVVVSGLAPMSTIEKAISEARKVGIYSIVDMLNVTSPVKLIQSLKVKP
DIVELHRAIDVEESAHAWGDIPALKKAAGGKLLVATAGGIRVDVVRDALKAGADI
>A0A399FAH6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Meiothermus granaticius NBRC 107808|TrEMBL
MYIGEAFVGSGPNAAHLNVVLGPRNGPVGTAWATALSSPSAGHVPFMVVLQPGVPVKPAT
VFINKAALSGETHETMTWGPAQAGVARGIQECLLEGVLPVEAENEWCVLAAVWVNPSANQ
ADEVFANNYKAAKDAVINALGLLPLLSDVREAASRVHNPFYTPKD
>A0A1V4UIB8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon PtaB.Bin152|TrEMBL
MYLIGEALVGDGPELAHVDLILGEKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLAKPA
TLIVPKVTLRKGVQIKEMFGPVQAAVAKAVADCVEEGLFGKSDLESLVIMASIYLDPAAA
DYNKIYRYNYGATKLALSRAMEKFPDQKTLLYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVDMNKVHSVLAELPQNDHLIIEAGTPLIKRFGLSIISEIRKVRPNAFIIADMKILDTGN
LEARMAADSSADAVVISGLAPLPTLEKAIAEAKKTGIYSVVDMLNVPEPLKVLKALRVKP
DVVELHRAIDAESSEHAWGDIPALKKAAGGKLLVATAGGIRVDGVKKALASGADIIVVGR
AITASKDVHTAADLFLEQMNKEEIDQFRVMTDF
>A0A7C3VF65|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus fulgidus|TrEMBL
MEFRIGEALVGEGFEVAHVDLIIGTKDGPAGIAFANALANLSAGHTPLLAVLRPNLITKP
PAVIIPKVTVKNMEQAELIFGPAQAAVAKAVADAVEEGIIPKEKADEYVVIASIFIHPNA
ANRHKIYYYNYGATKLAIRRAMQNFPDVDTVMYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLNEVLRVLEQIPESDHIIFEIGTPLVKKYGSEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPISTIVKGIREAEKTGILSYVDMMNVEDPLKRLEEIKKA
GVLPN
>A0A1Z5HAL2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Bathymodiolus platifrons methanotrophic gill symbiont|TrEMBL
MAKINNLRVGESLNGDGNEVAHIDLMIGPRGSAAESAFANCLTNNKDGFSSLLAVVAPNL
MVKPATVMFNKVTIKGSKQAVQMFGPAQRGVAMAVADCVEDGTIPADEADDLFISVGVFI
HWLAEDDTAIEKNNYDAVKASIKHAVAGTPTAAEVVAQKATSEHPFAANKV
>A0A2H5VG51|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon HR06|TrEMBL
MIIPKVTMKNLKQAELMFGPAQEAVARGVLESVKEGVIPKGKVEDLCIVCSVFIHPLASD
KKKIYEYNLLAVKEAIKRAFSKQPTIDEILSKMDTVKHPFRGF
>A0A524NN96|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MPTTADDFEDDSGPTYLIGESLLGEGNEVAHIDLMIGDKNGPIGQAFANGMTQLSAGHTP
VLAVIRPNLPPKPYTLIVPKVTVKNMEDTSKIFGPAQAAVAKAIADSAEEGVIPANKLDS
WVIICSVFIHPKAIDFRKIYQYNYGATKMALKRALKKYPTMEKIIYEKDRAKHPIMGFKV
PRLWRPPYLQIALDAPSLEGAKKVIEALPGSDRIILEVGTPFIKRYGTRGINELRQIAKD
KFIIADLKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLNATVSESRRLGIYAVIDMLNV
EDVLGKLKSIKEFPDIVILHRGIDQETGRSSGLERIKIIRQAFPNKKFLIAVAGGIVPET
AKEALELGADILIVGRYVTQSKDIERSVRDFLELTPSMREDVDLYRVHTE
>A0A7J9RJU1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MYTGEALIGKGSEVAHIDLLIGDKYGPVGVAFANALSQMSAGHTPLLAVIRPNLPVKPPT
LIVPKVTVRNMKDAERIFGPAQSAIAKAVADSVEEEVIPEDKAENYMVIVSVFIHPAARD
YNKIYRYNYGSAKLAIKRAMDGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALDI
PNWEHIKRVISKLPRSDHLIIEAGTPLIKQYGLDIIGKIKEIKPDTFVVADLKTLDTGDL
EARMVVDSGADAVVISGLAPLRTIEKAISEAVKTGIYSVIDMLNVKNPVDLLKELSGAGA
TMPDVVELHRAIDVEELGEKYAWGNITEIKRLQSGKGSNSRILVAVGGGIREENAPDALK
AGADILVVGRGITNAGDVEAASRRLLRLMKEEIDQYRVMTDF
>A0A532TWU7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon Loki_b31|TrEMBL
MAKTDYFIGEALLGSGSSVAHIDLIIGSKDGPVGISFANALSNPSIGHGGLLACIRPNLL
TKPVSLVIPKVTVSKMEEANKIFGPAQAAVAKAIADAVEENLIPMNKIDEWLLIVSVFIH
PEAKDYRKIYQYNYGATKLAIQRALKNYPPIEKIFYDKDRAKHPVAGLRVPRLWRPPYIQ
VALDAPSLEHQLKVVKQLPKSDRIILEIGTPFLKKYGVEAIEKIREIAPEKFIVADLKTL
DVGKLEVDFAFDATADAVVASGLASPKSIDKFLLEARRLGIYGFVDTMEVVDPIEKLKQL
KQIPDVVILHRAIDVESAIEGSDDAQKQKWQFVPKIKELYADKKLASGKDRVLVAVAGGI
EPSTAEYALKMKADILIVGRYITSSKDIKNSMRQFINILPGYSDIDLKRIHVDDDDINSL
KSK
>A0A3B1DJI3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|hydrothermal vent metagenome|TrEMBL
MSMYVGESLVGEGNEIAHIDLLIGDKAGPVGVAFANALSNQSAGHSNLLAVLEPNLAVKP
ATVMITKVTIKGAKQAVQMFGPAQFAVAKAVADSVEAGIIPKDQVEDLVIVCGVFIHWDA
EDDKKIYEYNYNATKESIARAMNNEPSVDEMLSKKDAASHPFSGLE
>A0A0P8A4V5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedens sp. BLZ1|TrEMBL
MFLIGEALIGEAPELAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGVIPEDQVEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIIEARKTGIYAVIDMLNVDKPLSVIKGLSVKP
HVVELHRAIDTEGKAEHAWGDISAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>A0A7K4HGZ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKSDYFIGEALLGAEENMAHIDLIIGSKDGPVGISFANALSSPSIGHGGLLACIRPNLL
TKPISLVIPKVTVSKMEEANKIFGPAQAAVAKAIADAVEENIIPMNKLDEWVLIVSVFIH
PDAKDYRKIYQYNYSAAKLAIKRALMNYPPIDKIFYDKDRAKHPVAGMKVPRLWRPPYIQ
VALDHPNIEHHMKVVKQLPKSDRIILEIGTPFLKKYGMEAIKKIRELAPQKFIVADLKTL
DVGKLEVDFVFDATADAAVASGLAAASSIDKFLLETNRMGIYGFVDTMEVDDPVAKLSKL
KQIPDVVILHRAIDVEQAAGSESSNAAQKARWAAIPKIKELYKDQKLASGRDRVLVAVAG
GIDPTTANSALEMGADILIVGRFVTSSKDIENSMRRLLNLIPGYSDIDLKRIHTEDDDNS
VKKPKWD
>A0A524D271|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MADYLIGEALIGEAPDLAHIDLVVGSKTGPIGTAFANAIASPSMGHGGLLACIRPNLVPK
PYTLIVPKVTVSKMEEANKIFGPAQAAVAKGVADAVEEGIIPLNKLDDWIILASVFIHPE
ARDYRKIYQYNYGATKLALKRAIEGYPPIEKVFYDKDRAKHPVAGMRVPRLWRPPYVQVA
LDAPSIEHQMKVVKALPKSDRIILEIGTPFLKKYGVESIRKIREIASDKFVVADLKTLDV
GKLEVDFAFDATADGVVASGLAAPASIDKFLLEAKRMGIYGIVDTMELDDPVVKLKKLKQ
IPDVVILHRAIDVEEVAEGTDEAQRKKWNNIAKIKELYKDQKLASGRDRVLVAVAGGIDD
KTAKFALEMGADILIVGRFITSSKDIKNAMRCILNELPGYSDIDLKRIHTDDDDVNNLRK
>A0A853BZX4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Nocardioides thalensis|TrEMBL
MADPAFQVGESFVGSGPNAAHLNTVLGARSGPAGAAWATALATPSAGHVPFVTVVKPGVP
AKPATLFVSKSAPQGDVHGRLIWGPAQAGVAAGVTDAVADGLLDGIDLDEVVLIAAVWVD
PAAHDADEVFRNNREATRTSLANGARLLPTVEEVLAAREDLHNPFYTPPTVATGTA
>A0A117KR12|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriaceae archaeon 41_258|TrEMBL
MYRIGEALIGKGNEVAHVDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMESYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDTLPPRERILLEAGTPLVKKFGVGIVDKIRKLRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGVYSVLDMMNVENIPEKLEELRYKP
DIVLLHKNIDVGAAEVSEWGDIPKIKEIIGERGLVAVAGGITPSKTKKALESGADIIVVG
RYITGSKDPRRAAEDFLEQLPPDPDTMRLPHEEDEPI
>B9AFJ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter smithii DSM 2375|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPSAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A7W9WU47|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia bannensis|TrEMBL
MKALEVYIGEGFAGPGVNAAHINIMIGPRNGPVGQAFTNSLSSPSQGHVPFMVVAQPNVP
VKPATLYVNKADIRGDLHGNATWGASQAAIAKAVTEAMLDGTLPPEAENEWCVVTANWVN
WSCDDLDAVYENNYAACKTAIHAAMNGLPKLDDIAKIKDQISNPFYTPKAKAA
>A0A5E7D8K7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas fluorescens|TrEMBL
MKELDLYIGEGFEGPGVNAAHINILIGPRNGAAGQAFASSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAAISSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGKPETAQLADVVDHISNPFYTPKA
>D3S424|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus sp. (strain FS406-22)|TrEMBL
MIKFGEAVLGNEIKAIVNVALGKDKGIDEVFTNALTRGNCVFANLRPNLIVKPLTLVVPR
HNIESDIQDELFQGVIQYAVAKAVADLDLDEDLKVVVSVNVPEVPITNLNKRKLFQYFYA
STRLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
QTIPKSDHIILEAGTPLIKKFGLEVIEVMREYFDGFIVADLKTLDTGRVEVRLAFETTAN
AVAISGVAPKSTIIKAIHECQKCGLISYLDMMNVSEPQKLYDSLKLKPDVVILHRGIDEE
TFGVKKEWKFKGNCLLAIAGGVGVENVEELLKEYQILIVGRAITKSRDPGRVIRMFINKM
GYDIDTYRLYFDEDEDIDI
>A0A1Q6DW15|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanohalarchaeum thermophilum|TrEMBL
MFKVGEALVGEEPNVAHIDLVIGKKNGPAGKSFLNGMTNPTQGHTPLLGVIRPNLPTKPS
TLIVPKVTVQDMEDSEKVFGPAQMAISRAIADSMEEGIIDEEKAEEYVVIVSVFIHPQAE
DYQKIYRYNYGATKLALKRAIQEFPESDTVLEEKDKGGHPVMGSRLTKLFDPPYLQVALD
IPDLDHVKNVISSIPKNDHIIYEVGTPLVKKYGVGVVEELRKVKEDAFIVVDLKTLDTGN
LEARMVSDAGGDGVVISGLAPNSTIEKSIEEAEKTGIYSIVDTLNVDKPLELIEDLDQKP
KVVELHRAIDVEGEEEHGWQNIESIKKQLDPDGLVAVAGGIRSHNIRNALKSGADLLVVG
RAITNAKDPQGAVREFIEQMEKPDVDQFRVKTDF
>A0A2P0QMN0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured bacterium|TrEMBL
FANALTNNKDGFSTLLAVVAPNLMVKPATILFNKVTIKGSKQAVQMFGPAQRAVAMAVAD
CVEDGTIPADEADDLFISVGVFIHWQAENDALIEKFNYQATKEALKRAIAGSPTAAEVVA
AKSTA
>A0A7W5PRN8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Rhizobium sp. BK275|TrEMBL
MLYIGEGFEGSGPNAAHINLYLGPKNGPISGALAGAAASPGPGHLPFQAVLKPNLPAKPV
TLFIAKAVMESGSSHELMTWGPAQAGVAAGITAALLDASLPAEAEDDWLAIAAVWVNPSA
NDAEEVYHNNKAATHLAAKRALMKGWPSRAELAEGVATVGNPFFTPKVA
>A0A843IWP6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MYRIGEALIGDGPELAHVDLLIGDKQGPVGQAFANGLSNLSVGHTPLTSVIRPNLMTKPA
TLIIPKVTVGDLEDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDPSAE
DYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFKVKKLWSPPYLQVALD
LDNEAAMERIINDLPDNDRILLEAGTPLVKKFGVGIIGKIRALRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAEFEKKLAKLPEDL
KPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKSALGPKGLVAVAGGIKPNNVEEA
ITKGANIIIAGRYIIGSRDVRRAAQDFLEHFDPDPDNMRLAMDEDENIEVKDD
>A0A2H4VS61|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium subterraneum|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAEDMVLIISVFIHPEAS
DYRKIYQYNYGATKLALRRAMGGYPSVNKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNMQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRALKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTGKLETLNYKP
DIVLLHRNVDLETMKAERGEEQADMTEWGNINQIKDLLGKNGLVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDEAI
>A0A6J4K3E2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured Gemmatimonadaceae bacterium|TrEMBL
ATRPTTTWCSSACSSTGTRRTTRRSTTTTTRRRRSRSSAPWRTRRRPPTWCRRRSPPSTR
SRATPSRSTARRPAARAASRCRARAS
>A0A2R5FCA1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Novimethylophilus kurashikiensis|TrEMBL
MAVIDRVLVGEALVIDMRVDSNELDLLNVAHIDLILGPRGSAAEEAFCRTLTDQKQGVNG
LLAVVAPNLMTKPATVMFNKVTIKNGKQAVQMFGPAQRGVSMAVMDCVEEGIIPAAEADD
IFICVGVFIDHNADNDERIQDWNYQATKQAIKNAIARFPSAEHVLEERKKAAHPFAAK
>A0A6J5D4S5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia humisilvae|TrEMBL
MAKINRVLVGESLVGDGNEVAHIDLIIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
MAKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADCVEDGTIPKDEADDLFICVGVFI
HWQAEDDKKIQEFNYKATREALQRAVAGEPSAAEVVSKKSSAAHPFAPN
>A0A564G5L2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium dankookense|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAESAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPADEADDLYILVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKAATVTEQRNSAQHPFAANA
>A0A1J5RTT2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MSKIIFKAGEATVYTEGKDVTAAMPEILIGSVDGPVGQSFANLMAQSKGHTSMFAVRDIN
QLVRPVCMTVPKVTLKGSTDVALFGGVVQAATADAILDCVIEGIIPKEQANDLCIISLVW
IDPGCIALEKEGKLDKADMYKNNYEATKLAIKRALNDEPTIDELIANRHKIKHCMWEDSW
DQK
>A0A2H6AGG1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|bacterium HR36|TrEMBL
MSMYIGEALVGEGAEVAHIDLLLGSKDGPVGYAFAQALADQKQGHSNLLAVLTPNLICKP
ATVIITKVTLKSGEQAELIFGPAQKAVAKAVADAVAEGIIPKGVVDDLVCVCGVFIHWEA
KDKDKIYRYNYEATKLALQRAMHGEPKIDEILAKKDTVAHPFYK
>A0A2G1NYJ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon ex4572_44|TrEMBL
MNYTKSISAGHTPLLSVIRPNLLTKPATLIVPKVTVKNMEQVAQIFGPAQNAVALAVADS
VENGVIPVERVEDLVVVASVFIHPDARDYSKIYRYNYGATRLALERAMEEFPDIKTVIDE
KDRAAHPIMGFKVTRLWDPPYLQVAIDIPEIGYVQRILKEMPESDHLIIEAGTPLIKRYG
VNVVEQIREARPNAFIVADLKTLDTGNLEARMVADATADAVVISGLAPTSTIEKAIREAK
KTGIYSVIDMLNVKDPMKLLKSLAVKPEVVELHRAIDLENTGALGLDVISEIKELSDKIL
VAVAGGVRVDKLSPTDQTIDEALQAGADIIVVGRDITKAKDVRLKTEQFLERMKKPEIDQ
YRVMTDF
>A0A7C6YJY7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp|TrEMBL
MYLIGEALIGNGNEIAHIDLVIGDKNGPAGTAFVNNMANLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAENAEELVLIISVFIHPEAS
DFRKIYQYNYGATKLAIRRAMKGYPSVEKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNLQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTKESIEKAVHEAQKQGIYSILDMMNVDNFTEKLEMLNYKP
DIVLLHRNVDLETMKAERGEEQEALTEWGNISQIKEILGNKGLVAVAGGIVPNKMDQALN
SNADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDEAL
>A0A109UVT0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. YE315|TrEMBL
MYKIGEALIGDGPELAHIDLLIGDKFGPVGQAFANGLSNLSVGHTPLTSVIRPNLMTKPA
TLIIPKVTVGDLDDASKIFGPAQTAVARAVADAVEDGYIPKEIVEDIVINVSVFIDPSAK
DYRKIYQYNYGATKLAIRRAMEGYPSIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQVALD
LDNEAAMERIINDLPDNDRILLEAGTPLVKKFGVGIIGKIRSLRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAGFEKKLAKLPDDL
KPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKKLLGEKGLVAVAGGIKPNNVEEA
IEKGANIIIAGRYIIGSRDVRRAAQDFLEHFDPDPDNMRLAMDEDENIEVKDD
>A0A843CVF6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinaceae archaeon|TrEMBL
MVKEIPFFNIGEALMGTGSELAHVDLMIGDKKGPVGQAFATGMTQLSAGHTPLLSVIRPN
LPTKPSTLIVPKVTLKKGADTAKIFGPAQSAVAKAIADAVEEGIIPKDIAEDIVVVASVF
IAPDAEDYSKIYRYNYGATKLAVKRALTGFPSIDKVLEESNKSTHAIMGFKVSRLWNPPY
LQVAFDTTSLDFVLRAVRELPQNDHLLIEAGTPLIKSYGVNVISKIREARPDAFIVADLK
TLDTGNLEARMVADAAGDAAVVSALAPISTIAKFIDEAHKTGIYAVMDTLNCQDPVAVMK
DLKKLGSLPDVVELHRAIDLEHTKPRWDCIDDIKKISPKTLVAVAGGVKLETVPDALKAK
ADILVVGRAITGSKDIRNTAEQIIAKIGNPEIDQFRVMTDF
>A0A7K4A9P1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinaceae archaeon|TrEMBL
MSKDIKLPYFEIGEALIGTGNELAHIDLMIGVKNGPVGQAFATGMTQLSAGHTPLLSVIR
PNLPTKPATLIVPKVTLKSGEDTSKIFGPAQSAVAKAVIDAVDENIIPKEMAEEIVIVAS
VFIAPNATDYNKIYRYNYGATKLAIKRALKGFPSVDKVLEENNKSTHAVMGFKVSRLWDP
PYLQVAFDTTNLDFVINAVKELPQNDHLLIEAGTPLIKRFGTDVISKIREIRPDAFIVAD
LKTLDTGNLEARMIADAAGDAVVVSALAPISTIIKAINEAHKTGIYAILDTLNVPDPVPL
FKELVENDAVPDVVEIHRAIDLEHTEPRWDSIDEIKKISPKTLVAVAGGLRLETIPIALK
QNADILVVGRAITGSKDIKAAAEQFIAKIGKPEIDQFRIMTDF
>A0A7C1BWQ2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MFKIGEALVGKGNEVAHIDLILGDKNGIVGQAFALGLTILSKGHTPLISVMRPNLPAKPF
TLVVPKVSIESMEDAEKIFGPAQAAVAKAVADAVEEGIIPKDKIDEWVIIASVFIHPNAK
DYRKIYHYNYSATKLALKRALQDYPSYDKIMFEKDRAVHPIMGFRVPRLPRWNAPYLQVA
LDIPDLERTKFIIQQLPKSDKLILEAGTPLIKKYGTKVLNDIKAIVKDAFVIADLKTLDV
GQVEVDIAYEEGADGVVASGLAATDVLDKFIYEAKRLGIYAIVDMMNVQDPIEKLSSLTE
LPDIVVLHRAIDIEKKEEIRWEFIGKIKKKFPKLMVAVAGGITPETAPIALREGADIIIV
GRHITQAKDIERTAREFLRLLGTDIDQNRVHVE
>A0A523WFX2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MNIHRDTLYTWLKEFNVDFKEIGDVISTAQTIETVGTPRKHTYLIGEALMGQGNEVAHID
LLIGDKEGPVGEAFATGISNLSKGHTPLLAVIRPNLPPKPHTLLVPKVTIKNTEDTNKIF
GPAQAAVAKAVADAVEEGLIPKDKVDDWVIVCSVFIHPKAKDYRKIYHYNYGATKLALKR
ALTNYPPLEKILYDKDRAKHPIMGFKVPRLWRPPYLQIALDIPDLRRNKKIIASLPKSDR
IILEMGTPFIKRYGTKVISEIREDARDLFFVADLKTLDVGKVEVDLAYEETADAVVAAGL
APVETLNAFIHEAKRLGIYAVVDMLNMQDPIRKLRMLKEFPDIVILHRGIDQETGRTLGL
ELIEELRQAFKNRKFLIAIAGGIVPETAKEALQKGADILIVGRFVTQSKDVERAVRELLE
LTPEMQKDIDLFRVHVE
>A0A7C2R1U0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYLIGEALMGEGTEIAHVDLMIGDKSGPVGTAFANGLSNLSAGHTPLLAVIRPNLPPKPH
TLLVPKVTVKNMADAGKIFGPAQAAVAKAVADSVEEGVIPEDKVDDWVIVCSVFIHPQAK
DYRSIYHYNYSSTKLAIQRAMDNYPSLEKVMYEKDRAKHPIMGFNVPRLWRPPYLQIALD
VASTETAIKIVKELPESDRIILEVGTPLLKKEGIGVVRKLREVAKDMFIVADLKTLDVGQ
VEVDMSFEETADAVVVAGLATTETIDKFIAEAKRLGIYAVMDLMNVTDPIEKLKSLKRLP
DVAILHRAIDAEATGKTRWDIIKEMRETFKGKKFLVAVAGGITPQTAPEALANGADIIIV
GRYITQSKDVERATREFLKSTSEMTHDIDLFRVHVE
>A0A7J4L1P2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocellales archaeon|TrEMBL
LIKRYGLDIIQKMREIRRDAFIVADLKTLDVGNLEARMAADATADALVVSGLAPPATIEK
VITEARKTGICSVIDMLNVGDPKGLLERLTVMPDVVELHRAIDVESKDIKHAWSDIKGIK
LLSDKMLVAVAGGIMADNAKEAIKAGADILIVGRAITKAKDIEGMTRRFLELMKEEIDQF
RVMTDF
>A0A7K4BNM7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANAISQLSKGHTPLLAVVRPNLPTKPS
TLIIPKVTMKKGYQVNQMFGPVQAAVAKAVADSVEEGVFEGVDIEDTVIMASVYLDTAAE
DYNKIYRFNYGAVKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMRKVLESLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVVDMLNVENPVAVIEQLKVKP
DVVELHRGIDIEDTDYAWGDIPAIKKAGGERLLVATAGGIRQPVVKDALKAGADILVVGR
AITASKNIQHAAEEFLQELSTEEIDQFRIMTDF
>A0A7K3Z0D9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLVGEALVGDGAELAHIDLLMGEKEGPIGSAFANAVSQLSIGHTPLLAVVRPNLLTKPV
TLVIPKVTLKDMQQVNEMFGPVQAAVAKAVADSVEEGVFGDLDIENLAILCSTFVHPEAK
DFNKLYRFNYGATKLALARALESFPDKKTILHEKDRAAHAVMGFKVQRLWDPPYLQVALD
IVDLNKLHAVLAALPENDHLIIEAGTPLVKKFGLNVISEIRKVKPNAFIIADMKILDTGN
LEARMAGDATADAVVVSGLAPTSTIEKAIIEAKKVGIYSVIDMLNVANPVKVLQGLKVKP
NIVELHRAIDVEETSHAWGDIPALKKACGGKLLVATAGGIRVNVVKDALKAGADILVVGR
AITASKDVG
>A0A0F8UM86|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 1.H.T.1A.1|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A847V275|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum sp|TrEMBL
MYLIGEALVGDGPELAHVDLVVGEKGGPVGQAFVNGLTQLSKGHTPLLAVVRPNLMTKPA
TLVIPKVTLKRGEQVREMFGPVQAAVAKAVADALEEGVFGDHDVEDLVILASVYLDPNAA
DYNRIYRFNYGATKLALVRALDRFPPAETLLHEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVDMNRIRHVLAELPDSDHLIIEAGTPTVKQFGLSVISEIRKVRPNAFVIADLKTLDTGN
LEARMAADATADAVVVSGLAPRETIEKALAEAKKTGIYSIIDMLNVSDPVAVLGGLAVKP
DIVELHRAIDCEQDGTCHVWGNIDAMREAAGGRLLVATAGGIRVENVREALAAGSQVIVV
GRAITASKDVHHAAEEFLEQLGQPEIDQFRVRTDF
>A0A133VCD8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|candidate division MSBL1 archaeon SCGC-AAA261G05|TrEMBL
MIKDEFSVGEALVGEEPELAHIDLAIGRKNSKIGQAFMDSLAQPRQGHTPILAVIRPNLP
VKPSTLILPKVTIRSLEDADKIFGPAQSAVAKAVADVVEEGVIPKEEAESLVIVASVFVH
PRGKDYSRIYRYNYGATKLAIKRAMEKFPSIDKVLEEKDKATHGVIGFRMNNLKNPPYLE
VALDIPDWRRVEGIIRSLPRSDSLIIEAGTPLIKRYGVEVVQKIRQLRPESVILADLKTL
DTGNIEARMAGDATANVVACSGLAPVNTMEKFIEECEKVGALSLIDTLNLSDPKTVLGKL
TVKPNIVELHRAIDVEEEEEARWGNIEEIRKVCGDDTLIAVAGGIRTKNAKKALDAGADI
IVVGRAITGAKDVAGAARAFLQQMGVEEVDQFRVMTDF
>A0A7W6DF64|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Rhizobium azooxidifex|TrEMBL
MAKISKVMVGESLVGEGNEVAHIDLLIGPRGSAVETAFCNALTNNKDGFTSLLAVIAPNM
ACKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVQDSVAEGIIPVEEADDIFICVGVFI
HWEADDDAKIQEYNYKATKEAIERAVTGKPTAAEATAQRDKVKHPFSA
>A0A832ZKV2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGRDIVALVNLVLGKGEKIDSVFTNALTRVPTPVVANLRDNLIVKPLTLVVP
RNTLTSDIQCNFLHGPIQYGVAKAVADLDLPEDLKLIVTVAVPDVPYTNLNKRKLFQYYY
GATRLAINRALNDYPSKEKIKEEKYRAIHPLVGFRDIRLERPPYLQLALDVPSMENVEYV
LESLPPSDKIVVEAGTPLIKRYGVEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGMISYLDTINVKDPFGLYNSLELKPDVLLLHRAIDE
EGKVPMREYRGVKGEKGPLLGIAGGVTLEKIEELKNRYHIIVVGRGITKAKDPGWVVRAI
LNKLGEDIDYRLPLEEDEDVSLK
>A0A524D9L1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MPKTDFYIGEALIGKEPELAHVDVMIGSKGGPVGYAFSQSLSQPSRGHGSLLGVIRPNLT
TKPQTLIIPKVTIANLEQANRIFGPAQSAVAKAVADVVEEGVIPIGKVDEWVIIVNVFIH
PEAEEYRRIYQYNYGATKLAIKRALKDYPPIEKIFYDKDRAKHPVAGIKAPKLWRPPYLQ
IALDHPSLNHHKKVVDTIPESDRIILEIGTPFLKKYGMEAIEDIREVRSKKYIVADLKTL
DVGKLEVDDAFKAGADGVVCSGLASTASIDKFLLEAERMGIDGFVDMMEVPDPVAKLKKL
KQVPRVVILHRGIDAEQSTVEGGSDDAQKQKWGFVPKIKELYANNKLASGRDRVLVAVAG
GIVPETANDALSMGADILIVGRFITSSKDIRNSVRRIVNLLPGYSDVDLKRIHTEDDDDE
ALKKQIEEKQ
>A0A5C9EUG8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MPKTEFYIGEALIGDAPNLAHVDVMVGSKDGPVGYAFSQSLSQPSVGHGSLLAVIRPNLV
PKPQTLIIPKVTIKKMEEANKIFGPAQSAVAKAVADAVEESIIPMDKLDDWVIIVNVFIH
PEGDDYRKIYQYNYGAVKLALRRALKNYPPIEKIFYDKDRAKHPVAGIKAPKLWRPPYLQ
VALDHPSIEHQTKVIQRLPKSDRIILEAGTPFLKKYGMDAITTIRELEPNKYIVADLKTL
DVGKLEVDDAFNAGADGVVCSGLASSASIDKFLLEAERLGIDGIIDMMEVPDPVQKLKSL
KQIPRVVILHRGIDAEQSTATSGSDEAQKKKWGFVPKIKELYAGNKLASGRDRVLVAVAG
GITPETADDALSMGADILIVGRFITSSKDIKNSTRRIINKLPGYSDVDLKRIHSEDDDEE
ALQKQLKENETTKP
>A0A524F9U5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MKNEYYVGEALVGTGADLAHIDLLIGSKNGPIGISLANALSEPSKGHGGLLAAIRPNLLA
KPITLIVPKVTVSKMEEANKIFGPAQAAVAKGVVDAVEEGLIPMNKLDEWVIIASVFIHP
GATDYRKIFQYNYGATKLAIQRALKAYPPIEKIFYDKDRAKHPVAGIRIPRLWRPPYIQV
ALDAPNLERQIKVVKELPKSDRIILEVGTPFLKKYGMEAIKEIREVAKEAFIVADLKTLD
VGKLEVDFAFDATADGVVASGLASTASLDKFILEAQRLGIHAFVDTMEVQDPVAKLSSLK
QIPDVVILHRAIDVEQSVEGDQSPDAAQKARWALVPKIKELYKEQKKASGRDRVLVAVAG
GIEPNSAIFALKQGADILIVGRFIASAKDVKFAMRRILQTLPGYQDIDLKRIHEEDDDES
VKKATWD
>A0A7R9R973|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedenaceae archaeon GB37|TrEMBL
MFLVGEALIGEAPELAHVDLIIGEKDGAAGTAFATGMAQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVKSMDQASQIFGPAQNAVALAVADSVESGVIPRERVEELVVVVSVFIHPDAR
DYSKIYRYNYGATRLALERAMEGFPDIKTVIDEKDRAAHPIMGFKVTRLWDPPYLQVAID
IPDIGYVQRILREIPESDHLIIEAGTPLIKRYGVNVVERIREVRPNAFIVADLKTLDTGN
LEARMVADATADAVVISGLAPTSTIEKAIREAKKTGIYSVIDMLNVKDPVELLKELAIKP
EVVELHRAIDLENTGALGLDVISEIKELSKGILVAVAGGVRVDKLSPTDQTIDEALKAGA
DIIVVGRDITKSKDVRLKTEQFLERMKKPEIDQYRVMTDF
>A0A2P0QMN4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured bacterium|TrEMBL
SITDYIYNFFFTGEYTTRAKINKLCVGESLVGEGNEIAHIDLIIGPRGSVAEYAFANALT
NNTHGFSTLLAVIAPNLMVKPATILFNKVTIKGSKQAIQMFGPAQRGVAMAVADCVEDGT
IPVDEADDLFISVGVFI
>A0A0F8EKW6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 2.H.A.1B.4|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLAESNKSTHAIMGFKVIRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGIDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAVVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKVMP
DIIELHRGIDIEGTEHAWGNIAEIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
IAGAKDIREMAEQFINSLNKPEIDQFRVMTDF
>A0A063ZCI2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp. MH98A|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANSISQLSKGHTPLLAVVRPNLPTKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGVDIEDTVIMASVFVHPTAQ
DYNKIYRFNYGAMKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMNRVLDELPLNDHLIIEAGTPLIKKFGLSIISEIRERRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVIDMLNVKDPVAVVKQLKVKP
DVVELHRGIDVEDTAYAWGDIPAIKKAGGERLLVATAGGIRQGVVKDARKAGADILVVGR
AITASKNIQHAAEEFLEELSTEEIDQFRIMTDF
>A0A1V6N1K6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter arboriphilus JCM 13429 = DSM 1125|TrEMBL
MYKIGEALVGDGNELAHVDLIIGDKEGPAGTAFANGMTQLSIGHTPLLSVIRPNLMTKPS
TLIIPKVTVGDLDDASKIFGPAQTAVGRAVADAVEEGLIPKDIVEDIVIMVSVFIHPDAE
DYRKIYQYNYGATKLAIRRAMSDYPGINKVLAEKDRGTHPIMGFKVTRLWSPPYVQVALD
LDNLDAMEKIISAVPDRERILLEAGTPLIKKFGVGVVSKIRKLRPDAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIEKAIHEAQKQGIYSILDMMNVDNFKEKINKLQDNL
KPNIVLLHRNVDLETSMAEKGQDTSDMTEWGNIKEIKKLIGDGLVAVAGGITPEKVDEAI
ESGADIIVVGRYIIGSRDVRRSAEDFLAHLPQDPDNMRLALDEDEQV
>A0A832URF7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp|TrEMBL
MYEIGEALIGNGPELAHIDLIIGDKNGPVGTAFATNMGSMSVGHTPLLSVVRPNLPTKPA
TLIIPKVTVQNLGDASKIFGPAQTAVARAVADAVEEEIIPRDIVEDIVLMVNVFIDPSAE
DYRKIYQYNYGATKLAIKRAFDKYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECTKQGVYSILDMMNVKDIPAKLEELKLKP
SIVLLHRNIDSETMSDNDNEQQSEWGNIGDIKSKLGPRGLIAVAGGVTPEKVNTALDNGA
DIIIAGRYIIGSSDVRRAADDFLRYMPQDSDTMRVALDEDEKI
>A0A0E3SNR6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri 3|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAGKIFGPAQSAVAKAVADSVEEGVISKDQVEELVIVVSVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQRDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGDIAEIKKVAPKTLVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDIREVAEQFINSLNKPEIDQFRVMTDF
>A0A7Y9W0A9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Pseudomonas moraviensis|TrEMBL
MKELDLYIGEGFEGPGVNAAHINILIGPRNGPAGQAFANSLASPSQGHCPFMVIAQPNIP
VKPMTLYVNKAAISSDLHGNATWGASQAGIAKAVLEALLDGTLPPEAEDEWAIVTANWVN
PACDDLDAVYLNNYNACRTAIRAALTGKPETAQLKDVVNHISNPFYTPKA
>A0A832LIM9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp|TrEMBL
MYKIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISLGHTPLISVIRPNLMTKPA
TLMIPKVTIGNLEDANKVFGPAQTAVARAVADAVEEGVIPKEKVEDLVIIVSVFIHPEAK
DYQKIYHYNYGAMKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNKIRELREDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLATKATIEKAVHESQKQGVYSILDMMNVENVTEKLEELRYKP
DIVLLHKNIDVGTAEVSEWGNIPEIKEILGKRRLVAVAGGITPSKTRKALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDEPI
>A0A3R7VYM1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosalsum natronophilum|TrEMBL
MLLIGEALIGEGPELAHIDLLAGDKNGPVGQAFANGMTQLSAGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMDQASQVFGPAQAAVAKAVSDSVEEGVIKKEDAEDLVLVVSVFIDPSAS
DYNRIYRYNYGATKLAVKRAFDGFPDVDTVLHEKDRASHAIMGFKVSRLWDPPYLQVALD
NPNIDAILNVIQQIPKSDHVILEAGTPLIKRYGVDVVSRIREVKPDAFIVADLKTLDTGN
LEARMVADSTADAIVVSALAPIPTLNKAIDEAHKTGIYAVMDTLNHPDPVSILKKLDKLP
DVVELHRAIDVEDTEHAWGSIEEIKQLSPKILVAVAGGIRVHTIPDALKAGADILVVGRA
ITNAKDVRQVAETFIENLNKPEIDQFRVMTDF
>A0A497RPV7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MYKIGEALVGKGNEVAHVDLLIGDKEGFVGQAFANGISHLSSGHTPLLSVIRPNLPCKPY
TLVVPKVTMKDMEDVTKVFGPAQAAVAKAIADAVEEGIIQRDRIDDWVIICSVFIHPEAK
DFRRIYQYNYGATKLALKRALQDYPSLDKIMFDKDRATHPIMGFKVPRLPKWNRPYLQIA
LDIPDVERTKKIISEIPHSDKIILEAGTPLIKKYGTKVISELREVAKDSFIIADLKTLDV
GQVEVDVAFDETADAVIASGLASVEVIDKFIYEAKRLGIYAIIDTMNVPDPINLLKSLKE
LPDIVILHRGIDVEKKERPRFELIRKIKREFPDIYVAVAGGIEPDTAPLALKEGADIIIV
GRFITQSKDIERSTRLFVNILGGDIDLKRVHVE
>A0A497NQS0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLNIHRDTLYAWLKEFNVDFKQFSEALSAKFPSIADVEGSTYLIGEALIGEGNEVAHVDL
LIGDKDGPVGEAFAAGLSHLSMGHTPLLAVVRPNLPPKPHTLLVPKVTVKNLEDANKIFG
PAQAAVAKAVADAVEEEIIPKNKVDDWVIICSVFVHPKAKDYRKIYHYNYSATKLALKRA
LAKYPSLEKLFYDKDRAKHPIMGFRVPRLWRPPYLQISLDIPDLERTKKIITQIPRSDRV
ILEVGTPLIKRYGTKVINQLREVAKDKFFVADLKTLDVGKVEVDLAYEETADAVVAAGLA
PPETLNAFIYEAKRLGIYAVVDMLNVENPVKKLKTLKEFPEVIVLHRGIDQETGRTIGLE
LIQELRRSFKDKRFLIAVAGGIVPGTAREALEKGADIIIVGRYITQSKDVERAVRDFLEL
TPEMREDIDLFRVHVE
>A0A843C818|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKEFNVDFKEILNDIKATFSDQNVGNISKTYLIGEALLGNGNELAHIDLLIGDKDGPVGK
AFANGFSNLSAGHTPLLAVIRPNLPSKPYTLLVPKVTVKNMKDAGKIFGPAQAAVAKAIA
DSVEEGIIPEDKLDEWVIVCSVFIHPQASDYHRIYQYNYSATKLALKRALKKYPSLEKML
YDKDRAQHPIMGFKVPRLWRPPYLQISLDAPNLEKAKQVISQIPGSDRIIIEVGTPLIKR
YGTRIISELRKTAKDAFMIADLKTLDVGKVEVDIAYEETADAVVAAGLAPPETLDAFVHE
AKRLGIYGAVDMLNVEDPLGKLKKMKKFPDIIILHRGIDQETGRTHGLEIIKELRQTFDN
KKFLIAVAGGILPETAKEALHKGADIIIVGRYVTQSKDTERAIRNFLELTPLMREDIDHF
RVHVE
>A0A7C5IGB4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MFLIGEALVGSGPEVAHIDLIIGDKEGVVGQAFATGLASLSAGHTPLLAVIRPNLPPKPF
TLLVPKVTIKNMEQAAKVFGPAQAAVAKAVADAVEEGIIPKDKIDEWVIICSVFIHPEAK
DPRRIYHYNYSATKLALKRALMNYPSLEKIMYDKDRATHPIMGFRVPRLWMPPYLQIALD
IPDLEKTKSIIAELPKSDRIILEAGTPLIKRYGARVIQELREIAKDVFIIADLKTLDVGQ
VEVDLAYEETADAVVASGLASVETLNKFIYEAKRLGIYAAIDMMNVPNPLKLLEQLSDLP
DIVIIHRGIDEEKIKKTRWELIKELKEKYKDKKMLIAVAGGIEPSTTPLALEAGADIIVV
GRYITQSRDVKKATREFLVHLGLDMDVFRIHVE
>A0A3R7DGV1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLNIHRDTLYAWLKEFNVDFKQFSEALSAKFPSIGDVEGSTYLIGEALIGEGNEVAHVDL
LIGDKDGPVGEAFAAGLSHLSMGHTPLLAVVRPNLPPKPHTLLVPKVTVKNLEDANKIFG
PAQAAVAKAVADAVEEEIIPKNKVDDWVIICSVFVHPKAKDYRKIYHYNYSATKLALKRA
LAKYPSLEKLFYDKDRAKHPIMGFRVPRLWRPPYLQISLDIPDLERTKKIIAQIPRSDRV
ILEVGTPLIKRYGTKVINQLREVAKDKFFVADLKTLDVGKVEVDLAYEETADAVVAAGLA
PPETLNAFIYEAKRLGIYAVVDMLNVENPVKKLKTLKEFPEVIVLHRGIDQETGRTIGLE
LIQELRRAFKDKRFLIAVAGGIVPGTAREALEKGADIIIVGRYITQSKDVERAVRDFLEL
TPEMREDIDLFRVHVE
>A0A1V5AAF6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaU1.Bin016|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGEKEGPVGTAFACGLAQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKSMDQAAQIFGPAQMAVAKAVADSVAEGIIPKERAEELVVVVSVFIHPQAK
DYDAIYRYNYGATKLALQRAMEGFPDVDKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDLDEVRRVLAALPESDHILIEVGTPLVKMLGINIVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIDEARKTGIYSVIDMLNVPDPLAVLKSLDVLP
DVVELHRAIDMEKSAHAWQNIREMQALAKPGRRLLVAVAGGIRVDTEAQALAAGADILVV
GRAITRSKDIRDMAEQFLAGLKQTEIDQYRIMTDF
>A0A3R7BFF4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MIDEGFLIGEALVGEEPEIAHIDLIIGSKKEAVGTAFACSIAQPRQGHTPILGVIRPNLP
TKPTTLIVPKVSIRNLADAEKMFGPAQSAVAKAIADAVEEGVIPKAEVEELAVIVSVFIH
PRGRDYQRIYRYNYAATKLALSRAIQKFPEIDKVLEEKDKSIHAMIGFKMNNLKKPPYLE
VALDIPDWRRVEGIIRALPRSDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVFADLKTL
DTGNLEARMAGDATADVAGFSGLAPIGTMEKFIEECKKVGTLSLMDTLNVPDPVEVLRKL
KVKPDIVELHRAIDVELYQNRGQEQESEWGNIGEVREVCGNDVLVAVAGGIRLKKVKKAL
KAGADIIVVGRAITAAKDVTGAARGFLQQMSVEDVDQFRVMTDF
>A0A0A0BG00|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylophaga thiooxydans|TrEMBL
MSDKIIMRTGEALVGGGPAFTAAEPEVVIGELDGPFGTAFANLMGDQVQGHSRVLALMNT
DMQVRPATLMVSKVTVKKTAYTNILMGTVQGAIANGVLDAVRNGTIPKEKVNDLGIIVSV
WLNPSITTVEDLDHEALFNIHREATRRALEKAMNNEPSIDYLLENQEKLVHKYYQKELDA
KA
>H1Z3F3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoplanus limicola DSM 2279|TrEMBL
MYLVGEALEGEGAELAHIDLLVGDKTGPVGMAFANAMSQLSPGHTPLLAVIRPNLLTKPA
TLIIPKVTLKTGEQVNAMFGAVQAAVAKAVADSVEEGAFGDADLEEIVLLVSAFLHPDAK
DYNRIYRYNYGSTKLAITRALAGFPDKETVLKEKDRAGHAVMGFKVHRLWDPPYLQVAMD
LVDMKSVERVLTSVPKNDHVLIEAGTPLIKQFGLSVIGEIRKIRPDAFIIADLKTLDTGN
LEARMAANASADAVVVSGLAPVPTIVKFIQEAKKTGIYSVIDMLNVDKPAELIEKLAKEG
AVPSIVEMHRAIDAEGDDYNWGDIPAIKEAAGGKLLVATAGGVRQHVVKDALKAGADILV
VGRAITASKNIQNSAEQFLEEMNKEEIDQFRIMTDF
>A0A347AFH7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. BRmetb2|TrEMBL
MYNIGEALIGNGNEIAHVDLIIGSKDGHAGAAFANNLTQLSIGHTPLLSVIRPNLMTKPS
TLIVPKVTVRDLKDADKIFGPAQTAVGRAVADAVSEGIIPKDKVEDLVIIASVFIHPEAE
DFRKIYQYNYGATKLALKRALENYPSIDKVLGEKDRGTHPIMGFRVVRLWNPPYLQVALD
LDNMEEMERIINSLPDRERILLEAGTPLVKKFGVSIVSKIRELRKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTIESIEKAVHEASKQGIYAILDMMNVDNFVEKLGKLRFKP
DIVLLHRNVDLETLKAERGEEQAEITEWGNINQIKDILGEGKQVAVAGGITPQKVEEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLALDEDESI
>A0A1V4U2G8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon PtaB.Bin009|TrEMBL
MYLIGEALVGDGPELAHVDLILGDKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLAKPA
TLIVPKVTLRKGVQIKEMFGPVQAAVAKAVADCVEEGLFGKSDLESLVIMASIYLDPSAA
DYNKIYRYNYGATKLALSRAIEKFPDQKTLIYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVDMNKVHSVLAELPQNDHLIIEAGTPLIKRFGLSIIPEIRKVRPNAFIIADMKILDTGN
LEARMAADASADAVVISGLAPLPTLEKAIAEAKKTGIYSVVDMLNVSEPLKVIKALKVKP
DIVELHRAIDAESSEHAWGDIPALKKAAGGKLLVATAGGIRVDGVKKAFAAGADIIVVGR
AITASKDVHTAADLFLEQMNKEEIDQFRVMTDF
>A0A484F207|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanimicrococcus blatticola|TrEMBL
MPKDTQLPYFEIGEALIGTGAELAHVDLMIGSKDGPVGQAFATGMTQLSAGHTPLLSVIR
PNLPTKPSTLIVPKVTLKKGVDTTKIFGPAQSAVAKAVADAVEEGIIPKEIANDIVIVAS
VFIAPDAEDFSKIYRFNYGATKLAIKRALEGFPSMDKVLEESNKSTHAIMGFKVSRLFNP
PYLQVAFDTTSLDFVLKAVKELPQNDHLLIEAGTPLIKRFGTDVISKIREARPDAFIVAD
LKTLDTGNLEARMVADAAGDAVVVSALAPVPTIVKAIEEAHKTGIYAIVDTLNLPDPVPL
IKELVEKGAVPDVVELHRAIDIENTEPRWDSIEAIKKVSPKTFIAVAGGVKLDTIPLALK
SGADILVVGRAITGSKDIRGTAEQFIAKIGNPEVDQFRIMTDF
>A0A7C1LR82|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon|TrEMBL
MAKTDYFIGEALIGEGNNLAHIDLIIGSKDGPVGISFANALSNPSKGHGGLLAAIRPNLL
SKPIALIIPKVTVSKMEDANKIFGPAQAAVAKGIADAVEEGIIPMNKIDEWIIIASVFIH
PEATDYRKIYQYNYGAIKLAIQRAIKGYPSIEKIFYDKDRARHPVAGIRIPRLWRPPYIQ
VALDHPALEKQIKVVKQLPKSDRIILEVGTPFLKKYGVESIKKIREVAREKFIVADLKTL
DVSKLEVDFAFDATADGVVASGLAATVSLDKFILEAQRLGIHAFIDTMEVQNPIEKLKSL
KQIPDVVIIHRGIDVEQSSAGNTSPDAQQKQRWALVPKIKELYADKKKASGKDRVLVAVA
GGIEPSTASYALTQGADILIVGRFIAAAKDVEFAMRRILGVLPGYQDIDLKRIHTEDDDN
SVERGGGPKWD
>A0A3Q9J9N7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Microbacterium oxydans|TrEMBL
MTASLQIGESFVGEGVNAAHINTVLGHREGPAGTAWATALASPSAGHVPFVAVLRPSLPV
KPMTLFVTKAAPVGDEHGLLIWGPAQAGVAAGVADAVAEGAIPSESAETHALIAAVWVNP
AADDAEAVYRNNREATRTALVNGAGGLPLLDEVLAARHEPRNPFFTPSTPISKDTHDR
>A0A832ZCH9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGRDIVALVNLVLGKGEKIDSVFTNALTRVPTPVVANLRDNLIVKPLTLVVP
RNTLTSDIQCNFLHGPIQYGVAKAVADLDLPEDLKLIVTVAVPDVPYTNLNKRKLFQYYY
GATRLAINRALNDYPSKEKIKEEKYRAIHPLVGFRDIRLERPPYLQLALDVPSMENVEYV
LESLPPSDKIVVEAGTPLIKRYGVEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGMISYLDTINVKDPFGLYNSLELKPDVLLLHRAIDE
EGKVPMREYRGVKGDKGPLLGIAGGVTLEKIEELKNRYHIIVVGRGITKAKDPGWVVRAI
LNKLGEDIDYRLPLEEDEDVPLK
>A0A843CYT1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculaceae archaeon|TrEMBL
MFLIGEALVGDGAELAHIDLMIGDKNGPVGSAFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIVPKVTLKHGEQVTQIFGPAQAAVSKAIADALEDGVFDGIDIEENVIVASVFIDPSAK
DFNKLYRFNYGATRLALSRALDKFPDAATVLKEKDRAAHGVMGFKVHRLWNPPYLQVAMD
LVDMKQVERVLTSVPQNDHVIFEAGTPLIKQFGLSVIGEIRKIRPNCFIVADLKTLDTGN
LEARMVSNAGGDAAVVSGLAPIETIAAFIKEAKKCGIYAIIDMLNVEAPAKLIEKLGEMG
GKALLPQYVEMHRAIDKEASGEYSWGDILKIKEVGQKYGAKILVATAGGIRQPVVKKAIA
AGADIVVVGRAITASKDIKNAAESFLAELDSEEIDQFRVMTDF
>A0A523REF0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKSDYFIGEALLGTEENLAHIDLIIGSKDGPVGVSFANALSSPSIGHGGLLACIRPNLL
TKPVSLVIPKVTVSKMSEANKIFGPAQAAVAKAIADAVEENIIPMNKLDEWLLIISVFIH
PDAKDYRKIYQYNYSATKLAIKRALMNYPPIEKIFYDKDRAKHPVAGIRVPRLWRPPYVQ
VAMDHPNIEHHMKVVKQLPKSDRIILEIGTPFLKKYGMEAISRVRELAPQKFIVADLKTL
DVGKLEVDFAFDATADGVVVSGLAAPSSIDKFLLEANRLAIYGFVDTMEVDDPIAKLSKL
KQVPDVVILHRAIDVEQASGSESSDAAQKARWALIPKIKELYKDQKLASGRDRVLVAVAG
GIDPNTAKYAIDMGADILIVGRFITSSKDIENSMRRLLNIIPGYSDIDLKRIHTEDDDSS
VKRPTWD
>U6EBH9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. MB1|TrEMBL
MYQIGEALIGNGNEIAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVSVRDLDDANKIFGPAQTAVGRAVADAVEEGIIPAEEAEDMVLIISVFIHPEAS
DFRKIYQYNYGAAKLALKRAMEGYPSVNKVLAEKDRGTHPIMGFKVNRLWNPPYLQVALD
LDNMQDMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVENFTEKLENLNFKP
DIVLLHRNVDLETLKAERGEEQADMTEWGNINKIKEIIGKNGRVAVAGGIVPKKMDQALD
SGADIIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDESI
>A0A843CSV1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobium sp|TrEMBL
MYLIGEALEGEGAELAHIDLIIGDKMGPVGMAFANAASQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKHEAQVNAMFGAVQAAVAKAVADSYEEGVFDKRECDPEDMVILVSAFLHPD
AKDYNRIYRYNYGSTKLAIQRAFDKFPDKATLIKEKDRAGHAVMGFKVAKLWDPPYLQVA
LDLVDMGTVERVLKAVPKSDHVLIEAGTPLIKQFGLSVLSKIREIRPDSFIIADLKTLDT
GNLEARMAANASADAVVVSGLAPIETIEKFILEARKTGIYAVIDMLNVSDPVKLVAELAK
RGAAPGIVEMHRAIDTEGSKPNWGKIKDIKKAAGGKLIVATAGGIRQNVVKTALESGADI
IVVGRAITASKNIQNAAEQFLDEMNKEEIDQFRVMTDF
>A0A7J3KKC5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFANGLAHLSMGHTPLLAVIRPNLPPKPH
TLLVPKVTVRSMEDANKVFGPAQAAVAKAVADAVEEGIIPKDKVDDWVIVCSVFVHPKAS
DYRKIYHYNYSATKLALKRAMAKYPPLEKVFYDKDRAKHPLLGYRVPRLWRPPYLQISLD
IPDLERTKKIITQIPRSDRIILEAGTPLIKRYGTRVISELREVAKDIFIIADLKTLDVGK
VEVDIAYEETADGVIASGLAPIETLEAFIYEAKRLGIYAAIDMLNVEDPAKKLKALKDFP
DIVIIHRGIDEETGRTVGLELIQELRQTFKDKKFLIAVAGGIIPETAKEALEKGADIIIV
GRYITQSKDIERSVREFLELTPEMREDIDVYRVHVE
>A0A843M7S8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPSAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A842S5W9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MPTKTDFYIGEALIGDAPNLAHLDVMIGSKDGPVGYAFSQSLSQPSIGHGSLLAVIRPNL
VPKPQTLIIPKVTIKKMEEANKIFGPAQSAVAKGVADAVEEGIIPMDKLDDWVIIVNVFI
HPEGDNYRKIYQYNYGAVKLAIKRALKNYPPIEKIFYDKDRAKHPVAGIKAPKLWRPPYL
QVALDHPSIEHHAKVVQRLPKSDRIILEIGTPFLKKYGMEVITKIREIEPNKYLVADLKT
LDVGKLEVDDAFNAGADGVVCSGLASAASIDKFLLEAERMGIDGIVDMMEVSDPVSKLKT
LKQIPRVVILHRGIDTEQSTSASGTDNAQMKKWGFVPKIKELYSNRKLASGRDRVLVAVA
GGITPDSAPNALSMGADILIVGRFITSSKDIKNSTRQLINILPGYSDIDLKRIHSEDDDD
EALEKQIEKNDSVKP
>A0A090I8W8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium formicicum|TrEMBL
MYQIGEALIGNGNELAHIDLVIGDKNGPVGTAFVNNMSNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVSVRDLDDANKIFGPAQTAVGRAVADAVEEGILPAEEAENMVLIVSVFIHPEAS
DFRKIYQYNYGATKLALRRAMEGYPSVNKVLAEKDRGAHPVMGFKVNRLWSPPYLQVALD
LDNMQDMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAIHEAQKQGIYSILDMMNVDNFTEKLENLNFKP
DIVLLHRNVDLETLKAERGEEQADMTEWGNINQIKEIIGKNGRVAVAGGIVPKKMDQALD
SGADVIVVGRYIIGSRDVRRAAEDFLEKMPQDPDTMRLALDEDESI
>A0A126R1T3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter olleyae|TrEMBL
MFIGEALIGDGDELAHVDLLIGEKDGPVGNAFANGLSQLSVGHTPLLSVIRPNLMTKPAT
IIIPKVTVSDMDDASKIFGPAQTAVGRAVADCVEEGIIPKEKAEDWVINASVFISPDAKD
YRKIYQYNYAATKLAIKRALDGYPDMDKVLYEKDRGTHAIMGFKAIKLYEPPYLQVALDL
DNLELMERIINQLPNRERILLEAGTPLVKKFGVGVVSKIRELAPSAFIIADLKTLDVGRV
EVKMAADETADAVAISGLGTIESIEKAIHETKKQGIYSILDMMNVDNFTDKLAKINKDLL
PDIVLLHRNVDLESKLRAEGKNLDDVSAWGNIKEIKEISGAKVAVAGGVTPEKAEEAFEK
GADIIIAGRYIIGSGNPRRAAEDFLAHMPVDPNHMRVVMEDDEQI
>A0A1V5SMS6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon ADurb.Bin294|TrEMBL
MYLIGEALIGEGSELAHVDLIVGDKNGPVGMAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKNEGQVNQMFGPVQAAVAKAVADAVEEGLFGDININDICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEEFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDLGKLRSVLSSLPENDHLIIEAGTPLIKKFGLNVISEIRAVKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A7W8PJY3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. HC6.4b|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGDPSAAEVMAKKGSVAHPFAPN
>A0A0M0BLP6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|miscellaneous Crenarchaeota group-15 archaeon DG-45|TrEMBL
MDRFRERSASPGGAFFIGEALVGEGDEVAHIDLLVGDKAGPVGAAFAHSLSSLSAGHTPL
LAVIRPNLPPKPFTVIVPKVTVRNMEEAARIFGPAQSAVAKAVADAVEDGIIPREIVDDW
VVVVSVFIHPKAEDERRIYHYNYGATKLALSRALQGYPSLDKVMYDKDRARHPLVGFRAP
RLWRPPYLQIALDLPNVDAVKRVIAAIPSSDSILLEAGTPLIKRYGVRVIRDLREAARDS
FIIADLKTMDVGKVEVDIAFDETADAVCAAGAASTATLDDFIYEARRLGIYSFVDLMEVD
DPVAKLRRLEQLPDGVILHRAIDVEERGGEPRWSYIGEIREAFAGRKLLIAVAGGVHPGT
ARLALDAGADILIVGRYITQSRDVERAVREFLPYLGGDTDLFRVHVE
>J1ARM7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis liminatans DSM 4140|TrEMBL
MYLIGEALVGTGAELAHIDLVMGDKEGPVGMAFANSISQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKGEQVKEMFGPVQAAVAKAVADSVEEGVFEGIDIENTVILASVYLAPEAQ
NYNMIYRYNYGATKLAIRRALQQFPDVDTLVYEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDLKRVEQVLTAVPENDHVLFEAGTPLIKQFGLNVLSEIRRIRPNAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPKATIEKAIEETKKTGIYSVIDMLNVDDPAALVAALKVKP
DIVELHRAIDAEGDEYAWGNIPAIKKAAGGKLLVATAGGIRQDVVAKAVASGADILVVGR
AITASKDIRHAAEEFIEKLDSEEIDQFRVMTDF
>A0A564G1F5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium dankookense|TrEMBL
MSEIWFRTGEATVLAAEGQYTDAMPEVLIGSTRGPVGQAFASMMGQVQGHTRMFVVRDLN
QLVRPATMMTTKATIHTAEYVELLGGVVQAATGDAIVDCIIEGILPKDGLDELCMIIMIW
LDPRCADHDDLDQKDLYRTNYEATKLAIARALKGEPTVEELIANRKTVKHYALEDVIEY
>N0BDL4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus sulfaticallidus PM70-1|TrEMBL
MRVGEALIGEGFEVAHIDLIIGERDGPAGIAFANSISQLSMGHTPLLAVIRPNLMTKPPA
VIVPKVTVKEMDQAELIFGPAQYAVAKAIADAVEEGIIPKEKAEDYVIIVSVFIHPKAKN
KDKIFYYNYGATKLALKRAMQNFPDVDTMLYEKDRSAHPFDGRRLTKLWDPPYLQIAIDI
PDLEEVRHVLRNIPDSDHIIFEVGTPLVKRYGTEIILELRKEKPKAFFVLDLKTLDTGNL
EARMAVNATANAVVISGLAPIPTIAKAIKEARKTGILSVVDMLNVSRPAEVLQKLKEEGM
LPDVVELHRAIDVENKEQPPWKFVKEIKDSFDVLVAVAGGLRPENVGEAIGEGADILVVG
RSITRARDIEGAVRRFLNFMKPDTDQFRVMTDF
>A0A1J5RL09|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MSERIVMRTGEALIAGGPPGTAAEPEVIIGELDGPVGTAIATLTGDQVAGHTRVFALLNT
DIQVRPVTLMVSKVTVKDSKYTNILMGTVQAAIANGVLDAVRAGDIPKERANDLGIIVSV
WLNPMVSKDEKLDHKILFDIHRKATALAIHKAMTNKPDIDWLLDNQDKITHKYYQMGLDG
KL
>A0A843M1K4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum sp|TrEMBL
MFLIGEALVGDGPELAHIDLMIGEKNGPVGMAFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIIPKVTLKHGEQVTQIFGPAQAAVSKAVADCLEDGAFADMDVEDIVVVASVFIDPSSK
DFNKIYRFNYGATRLAITRALDKFPDVATVLKEKDRAAHGVMGFKVQRLWNPPYLQVAMD
LIDMKQVQRVLTGVPQNDHVIFEAGTPLIKQFGLSVIGEIRKIRPNCFIVADIKTLDTGN
LEARMVSNAGGDAAVVSGLAPIETIAAFIKEAKKCGIYAIIDMLNVESPAKLIESLGKLG
GAAVLPQYVEMHRAIDKEAAAGEYSWGDILKVKEIGKKYGAKILVATAGGIRQPVVKKAV
AAGADIVVVGRAITASKDIKNAAESFLAELNSEEIDQFRVMTDF
>A0A1U7CWQ0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paludisphaera borealis|TrEMBL
MATNILMNVGEALVGEGNEIAHIDLLIGKKDGPVGLAFANALANQSAGHTNLLAVLTPNL
VAKPATVMVTKVTIKGMKQAVQMFGPAQAAVAKAVADSVAEGVIPADAAEDLVIVCGVFI
HPAAEDNAKILKYNYEATKLSIQRAMKNEPPISEITAKKDSVEHPFAK
>A0A2H5W4D9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|bacterium HR11|TrEMBL
MASKLMVGEALVGDGNEVAHIDLIIGPKDGPVGQAFANAFVSQRAGHTALLAVVAPNLPA
KPDVVIVNKVTIKGEKQAVQMFGPAQEAVARAVVDSVKEGVIPKDQVDDLCLVVGVFIHW
EAQDNKKIYDFNYQATKLAIARALKGEPKADYVIQQAATTTHPFRGF
>A0A1V4TIP9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. PtaB.Bin024|TrEMBL
MYLIGEALIGNGNEIAHIDLVIGDKNGPAGTAFVNNMSNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPKENAEDMVLIISVFIHPEAT
DYRKIYQYNYGATKLALRRAMEGYPSVDKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNLQEMERIIESLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAVHEAQKQGIYSILDMMNVDNFTEKLESITYKP
DIVLLHRNVDLETLKAERGEVQEEMTEWGNITKIKDILGKKGLVAVAGGIVPKKMDQALD
SEADIIVVGRYIIGSRDVRYAAEEFLEKMPQDPDTMRLALDEDESI
>A0A2H4U8G5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter smithii|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPAAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A0P0RLS6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia caribensis MBA4|TrEMBL
MAKINRVMVGESLIGEGNEVAHIDLIIGPRGSAAESAFCHALTNNKDGFTSLLAVVAPNL
LTKPNTVMFNKVTIKGAKQAVQMFGPAQHAVALAVADCVEDGTIPKDEADDLFVCVGVFI
HWEADDDKKIQEFNYKATREALQRAVAGEPSAADVVSKKATAAHPFAPN
>A0A7C2XTM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolinea sp|TrEMBL
MYLIGEALVGDGPELAHVDLIIGEKEGPVGTAFANALSQLSAGHTPLLAVIRPNLLAKPA
TLVIPKVTLKKDSQVREIFGPVQAAVAKAVSDCVEEGVFGNADLESMVILASAYLDPDAA
DYNRIYRYNYGATKLAISRAFEGFPDKNTLLYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVEMAKVVRVLSELPENDHLIIEAGTPLIKKFGLNIIGEIRKVRPNAFIIADLKVLDTGN
LEARMAADASADAVVISGLAPVPTLEKAIAEAKKTGIYSIVDMLNVPDPVKVIKSLSMKP
DVVELHRAIDAEDTAHAWGDIPALKKAAGKKLLVATAGGIRANVVKDAMAAGADILVVGR
AITASKDIRNAAEIFLERMNKEEIDQFRIMTDF
>A0A419KVR3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MDTEESGLLRAPGRITREQYRFLEEQVKAGRFASVSEALRAAINSYRESSGGRSLFLIGE
ALVGEGNEVAHIDLLIGDKDGPIGQAFAVGLSNLSYGHTPLLAVIRPNLPPKPFTLIVPK
VTVRNMEEAGKIFGPAQAAVAKAVADAVEEGILPEDKVEDWVVIASVFIHPKAEDERKIY
HYNYSATKLALRRAMEGYPPLEKIMYDKDRARHPFMGFRAPRLWRPPYLQISLDIPDIER
VKRVVSQIPGSDRVILEAGTPLIKRYGTRVVREIREVAKDYFIFADLKTLDVGKVEVDIA
FNETADGVIAAGLAPKETLDDFIYEAQRLGIYAFIDLLGVEKPLEKLKALRRPPDGVIIH
RAIDVERTGVKPHLELIKEIREVFKERKVLIAVAGGIRPSTALTALREGADIIVVGRYIT
QSRDVERAVREFLPYLGGDIDLFRVHVE
>A0A497M735|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLNIHRDTLYAWLKEFNVDFKQFSEALSAKFPSIGDVEGSTYLIGEALIGEGNEVAHVDL
LIGDKDGPVGEAFAAGLSHLSMGHTPLLAVVRPNLPPKPHTLLVPKVTVKNLEDANKIFG
PAQAAVAKAVADAVEEEIIPKNKVDDWVIICSVFVHPKAKDYRKIYHYNYSATKLALKRA
LAKYPSLEKLFYDKDRAKHPIMGFRVPRLWRPPYLQISLDIPDLERTKKIIAQIPRSDRV
ILEVGTPLIKRYGTKVINQLREVAKDKFFVADLKTLDVGKVEVDLAYEETADAVVAAGLA
PPETLNAFIYEAKRLGIYAVVDMLNVENPVKKLKALKEFPEVIVLHRGIDQETGRTIGLE
LIQELRRAFKDKRFLIAVAGGIVPRTAREALEKGADIIIVGRYITQSKDVERAVRDFLEL
TPEMREDIDLFRVHVE
>A0A7J3QWM3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTEAARKEVEARSLLSGKPAKPTVSGTAKVLGVHRDTLYSWLKEFNVDFEKATEGVSAV
EVSEVRQPTTRYTYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFANGLTHLSMGHTPLL
AVIRPNLPPKPHTLLVPKVTIKNLEDANKVFGPAQAAVAKAIADAVEEGIIPRDKVDDWV
VVCSVFVHPKASDYRKIYHYNYSATKLALKRALAKYPSLEKVFYDKDRAKHPMLGYRVPR
LWRPPYLQISLDIPDFERTKKIITQIPRSDRIILEAGTPLIKRYGAKVISDLREVAKDIF
IIADLKTLDVGKVEVDIAYEETADGVIAAGLASTETLDAFIYEAKRLGIYAAIDMLNVED
PVKKLKALRDFPDIVIIHRGIDEETGKTVGLELIQELRQAFRDKKFLIAVAGGIIPETAK
>A0A497LRJ6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKILSETAETRGKYTYLIGEALVGEGNEVAHIDLLIGDKAGPVGEAFAAGLSNLSMGHTP
LLAVIRPNLPPKPHTLLVPKVTVKTLDDANKIFGPAQAAVAKAVADAVEEGILPKDKVDD
WVIVCSVFVHPQASDYRKIYHYNYGATKLALKRALAKYPSLEKVFYDKDRAKHPIMGFKV
PRLWRPPYVQISLDIPHFERTKKIISQIPKSDRIILEAGTPLIKRYGTKVISDLREVARD
VFFIADLKTLDVGKVEVDLAYEETADGVIAAGLAPIQTLNAFIHEAKRLGIYAMVDMLNV
EKPVEKLKMLKEFPDVIVLHRGIDEETGKTIGLELIPELRQAFKDKRFLIAVAGGIVPET
AREALEKGANIIVVGRYVTQSKDIERAVRDFLELTPIMREDIDLFRVHVE
>A0A842SK71|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MNKDEALQRGKAFLIGEALVGEGNEVAHIDLMMGDKQGPVGSAFAQSLSQLSAGHTPLLA
VIRPNLPPKPHTVIVPKVTIKNMEDAQKIFGPAQVAVAKAVADSVEDGIIPDTVVDDWVV
VVSVFIHPQAEDKRRIYQYNYSATKLALSRAINNYPPLDKVFYEKDRAKHPLMDFRAPRL
WRPPYLQIALDAPDINVIERIVSSIPRSDNVILEAGTPLIKRYGVEVIKKMRDIAKDSFI
IADLKTMDVGKVEVDIAFDQTADGVCCAGAASVATIDSFIYETNRLGIYSFIDMMAVEDP
IKKLKSLEKLPDGVILHRGIDTEQLGSESKWESIQKIKEIFDEKLLISVAGGIKPNTAKD
ALDSGADILIVGRYITQSRDVTRAVEEFLEYLPGAVNQFRVHIE
>A0A7Z9WJ30|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Syntrophaceae bacterium|TrEMBL
MIDETEGYLVGEALVGEEPEIAHIDLVIGSKRGAAGAAFASSIAQPKQGHTPILGVIRPN
LPTKPMTLIVPKVSIRNLADAEKIFGPAQSAIAKAVADAVEEGVIQKSRAEEFVVIVSVF
IHPRGKDYQRIYRYNYAATKLALSRAVERFPNMDKVIEEKDKSIHAMIGFRINNLKKPPY
LEVALDIPDWRRVEGIVRALPKSDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVFADLK
TLDTGNLEARMAGDATADVAGFSGLAPVSTQEKFIEECKKVGALSLMDTLNVADPVKVLE
KLKVKPDIVELHRPIDVELTQSRDREQETEWGNIAEVRKVCGNKVLVAVAGGVRVNKVEK
ALKAGADIIVVGRAITAAKDVTGAARAFLQRMGVEDVDQFRVMTDY
>A0A328PHK7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter tenebrarum|TrEMBL
MYRIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIGEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNKIRELRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGVYSILDMMNVENVPEKLEELRYKP
EIVLLHKNIDVGAAEVSEWGNIPEIKKIIGERGLVAVAGGITPSKTRRALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDEPI
>A0A840NPR7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Saccharopolyspora gloriosae|TrEMBL
MNTTRRLDGRIAQGWGGGKPHGCHVNVVLADRGSPTAAAMMTTYTAPAEGFTPILVSVGP
DQPSYETVHPPTLMMNKARADPGLIAGACQVGIAQGVLDVVAAGTLVADQETLVFVSIWL
DPDAADETAAKRSSREATRNAVGEATTGRDPAAVERLVGERDGLTHPFYGGDPG
>A0A366MAI0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. NOE|TrEMBL
MYKIGEALVGDGNELAHVDLIIGDKEGAAGTAVANGMTQLSIGHTPLLSVIRPNLMTKPA
TLIVPKVTVGDLDDASKIFGPAQTAVGRAVADAVEECLIPRDIAEDIVVMVSVFIHPAAE
DYRKIYQYNYGATKLAIRRAMSDYPGINKVLAEKDRGTHPIMGFKVTRLWSPPYIQVALD
LDNLDTMKKIISAVPDRERILLEAGTPLIKKFGVGVVSKIRALRSDAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIEKAIHEAQKQGIYSILDMMNVDNIKEKLTEIKYDL
KPNIVLLHRNVDFETSMAEKGQDTSNMTAWSNIKEIKKLIGDNGLVAVAGGITPKKVDEA
ISSGADIIVVGRYIIGSRDVRRSSEDFLAHLPEDPDNMRLALDEDEQV
>A0A0X3BL18|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus bourgensis|TrEMBL
MYLIGEALVGDGAELAHIDLILGNKEGAVGQAFANSLSQLSKGHTPLLAVIRPNLPTKPS
TLVIPKVTLKKEYQVNQIFGPVQAAVAKAVADSVEEGVFEGIDIEDTVIMASVFVHPTAE
DYNKIYRFNYGAMKLALRRALDRFPDIDTLMHEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDRNHMRRVLEELPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVVSGLAPISTIEKAITDTRKTGIYTVVDMLNVEDPAAVVEQLAVKP
DVVELHRGIDVEDTDYAWGDIPAIKKAGGERLLVATAGGVRLPVVKDALHAGADILVVGR
AITASKNIKNAAEEFLLELNTEEIDQFRIMTDF
>A0A7J4PT61|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanotrichaceae archaeon|TrEMBL
MFLIGEALIGDEPELAHIDLLIGDKDGPVGIAFANGLAQLSAGHTPLLSVIRPNLPSKPA
TLIVPKVTVKNMDQAAQIFGPAQTAVAKAVADSVAEGVIPRGEVENLVLIVSVFIHPQAR
DYDAIYRYNYGATKLAVKRAMESFPDIDTVLYEKDRSTHPIMGFRVIRLWDPPYLQVALD
LVDLGVVRNVLSRLPDSDHLLIEVGTPLVKKFGAQVVKEIRNIRPSSFVVLDLKTLDTGN
LEVRIAADATADAVVISGLAPRNTIELAIKESRKTGIYSVIDMLNVSDPLAVLQSLSSLP
DVVEMHRAIDQEAEKHNWEVIADIKKMAVDSDRKILVAVAG
>A0A848K2H1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Xanthobacter sp. SG618|TrEMBL
MAKISKVLVGEALVGDGNEVAHIDLIIGPRGSAAETAFVTSLTNNKDGFTSLLAVLAPNL
PCKPNTVMFNKVTIKDARQAVQMFGPAQYGVAKAVQDSVAEGVIPVEEADDLFICVGVFI
HWEAADDAKIQQYNYEATKLSIARAVAGTPTAKEATDKRNEAKHPFAA
>A0A0Q0ZWP5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolinea sp. SDB|TrEMBL
MYLIGEALVGDGPELAHVDLIIGEKEGPVGTAFANALSQLSAGHTPLLAVVRPNLLAKPA
TLVIPKVTLKKESQVREIFGPVQAAVAKAVSDCVEEGVFGNTDLESMVILASAYLDPDAA
DYNRIYRYNYGATKLAISRAFEGFPDKKTLLYEKDRAAHAVMGFKVQRLWDPPYLQVALD
LVEMAKVVQVLSELPENDHLIIEAGTPLIKKFGLNIIGEIRKIRPNAFIIADLKVLDTGN
LEARMAADASADAVVISGLAPVPTLEKAIAEAKKTGIYSIIDMLNVPDPVKVIKSLSMKP
DIVELHRAIDAEDTAHAWGNISALKKAAGKKLLVATAGGIRANVVKDAMAAGADILVVGR
AITASKDIRNAAEIFLERMNKEEIDQFRIMTDF
>A0A842R6G6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Heimdallarchaeota archaeon|TrEMBL
MADFFIGEALLGKGNELAHVDLMIGDKDGPVGHAFAQGMTQLSKGHTPLLALIKPNLCPH
PRTLIVPKVTVQNLKQAEKIFGAAQMAVAKAIADAVEEKDIPKEKIFEYMIIVSVYIDPK
AEDESKIYYYNYGATRLAVKRALKDYPPLEKLMKEKDRARHPVMKFRPQTLWDPPYLQIA
LDVGSLSSAVQIIDQLPRSERIIIEIGTPYIKKYGVTETVGEMRKLRPGGYIIADMKTLD
VGRAEVKDAANATANAVVVSGIAPVATVKEFIKECNKRGVHAWVDSLNTTQTEFIAMLEE
LDEKPKVVILHRGIDQEYAQKEGEKKKTGTSASRSVWGDIKKIKKITGGLVAVAGGIKPG
KPLKEAQKAGADIIIVGRYIYRSRDPNRAAMRFLDEMEIEQDTMRLFDKLDY
>A0A843JDQ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobium sp|TrEMBL
LWVPQYLHVAMDLVDMGTVERVLKAVPKSDHVLIEAGTPLIKQFGLSVLSKIREIRPDSF
IIADLKTLDTGNLEARMAANASADAVVVSGLAPIETIEKFILEARKTGIYAVIDMLNVSD
PVKLVAELAKRGAAPGIVEMHRAIDTEGSKPNWGKIKDIKKAAGGKLLVATAGGIRQNVV
KTALESGADIIVVGRAITASKNIQNAAEQFLDEMNKEEIDQFRVMTDF
>A0A0E3R5L3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina barkeri 227|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAGKIFGPAQAAVAKAVADSVEEGVISKDQVEEIVIVASVFLHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIREVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKVAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNSKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A7R9N9A7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedenaceae archaeon GB50|TrEMBL
MFLVGEALIGEAPELAHVDLIIGEKDGAAGTAFATGMAQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVKSMDQASQIFGPAQNAVALAVADSVESGVIPRERVEELVVVVSVFIHPDAR
DYSKIYRYNYGATRLALERAMEGFPDIKTVIDEKDRAAHPIMGFKVTRLWDPPYLQVAID
IPDIGYVQRILREIPESDHLIIEAGTPLIKRYGVNVVERIREVRPNAFIVADLKTLDTGN
LEARMVADATADAVVISGLAPTSTIEKAIREAKKTGIYSVIDMLNVKDPVELLKELAIKP
EVVELHRAIDLENTGALGLDVISEIKELSKGILVAVAGGVRVDKLSPTDQTIDEALKAGA
DIIVVGRDITKSKDVRLKTEQFLERMKKPEIDQYRVMTDF
>B1FV74|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MSVSADKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSEFHGNATWGASQAGIAKAVAESLENGTLPAEAENDWVVVSAN
WVNPATDDLDAVFENNYRACRNAIVAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A843ER18|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MFIGEALIGDGDELAHVDLLIGEKDGPVGNAFANGLSQLSVGHTPLLSVIRPNLITKPAT
IIIPKVTVGDLDDASKIFGPAQTAVGRAVADCVEEGIIPKDKAEDWVINASVFISPAAQD
YRKIYQYNYAATKLAIKRALKGYPDIDKVLYEKDRGTHAIMGFKAIKLYEPPYLQVALDL
DNEEAMARIIKQLPNRERILLEAGTPLVKKFGVGIVGKIRELAPSAFIIADLKTLDVGRV
EVKMAADETADAVAISGLGTIESIEKAIHETQKQGIYSILDMMNVDNFTDKIKQLNPEFM
PDIVLLHRNVDLESKLRAEGKNLDDVSAWGNIKEIKELTGGLAAVAGGITPEKAEEAFEK
GADIIIAGRYIIGSGDPRRAAEDFLAHMPVDPNHMRVVMEDDEQI
>A0A2N7WMF3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia rhynchosiae|TrEMBL
MAKINRVLIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
LTKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQDEADDLFLCVGVFI
HWQAEDDKKIQEYNYKATREAIQRAVRGEPTAAEVVSKKSTVAHPFAPN
>M1Q348|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei Tuc01|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>A0A3R7YDD3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocalculus sp. MSAO_Arc2|TrEMBL
MYSIGEALVGDGAELAHIDLLVGDKNGPVGSAFAHALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTLKRTEQVNEMFGPVQAAVAKAVADSLEEGLFTGIHIEDIVIIASVYLAPDAK
DYNKIYRYNYGAMKLSLSRAFEQFPDEATILHEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDMDHIRRILTELPTNDHLIIEAGTPLIKQFGLTVISEIRKIRPNAFIIADLKTLDTGN
LETRMCANASADAVVISGLAPVSTIEKAVKEARKTGIYAIIDMLNVESPVNLIKTLAKTN
SIPHIVEMHRAIDAEGSEYAWGDIPAIKKAAQGKVLVATAGGIRLNVVKTALAAGADIIV
VGRAITASKNIQHAAEEFLGELNQEEIDQFRIMTDF
>I7J8C5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2)|TrEMBL
MYLIGEALVGDGAELAHIDLILGNKEGAVGQAFANSLSQLSKGHTPLLAVIRPNLPTKPS
TLVIPKVTLKKEYQVNQIFGPVQAAVAKAVADSVEEGVFEGIDIEDTVIMASVFVHPTAE
DYNKIYRFNYGAMKLALRRALDRFPDIDTLMHEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDRNHMRRVLEELPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVVSGLAPISTIEKAITDTRKTGIYTVVDMLNVEDPAAVVEQLAVKP
DVVELHRGIDVEDTDYAWGDIPAIKKAGGERLLVATAGGVRLPVVKDALHAGADILVVGR
AITGSKNIKNAAEEFLLELNTEEIDQFRIMTDF
>A0A7C6G016|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp|TrEMBL
MYLIGEALIGNGNEIAHIDLVIGDKNGPAGTAFVNNMANLSLGHTPLLSVVRPNLMTKPA
TLIVPKVSVRCLDDANKIFGPAQTAVGRAVADAVEEGILPAENAEELVIIISVFIHPEAS
DFRKIYQYNYGATKLAIRRAMEGYPSVEKVLAEKDRGAHPIMGFKVTRLWKPPYLQVALD
LDNLQEMERIIDSLPDRERILIEAGTPLVKKFGVGIVSKIRELKKDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTQESIEKAVHEAQKQGIYSILDMMNVENFTEKLEMLSYKP
DIVLLHRNVDLETMKAERGEEQEDLTEWGNINQIKEIIGNNGLVAVAGGIVPNKMEQALN
SNADIIVVGRYIIGSRDVRRAADDFLEKMPQDPDTMRLALDEDESL
>A0A7J2HB60|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus veneficus|TrEMBL
MEMRIGEALIGEGYEVAHIDLMIGTKDSPVGIAFANALSNLSQGHTPLLAVLRPNLITKP
PAVIIPKVTVKDLKQAELIFGAAQAAVAKAIADAVEEGVIPMDVAEDYVVIVSVFIHPKA
KNKHKVYYYNYGATKLALKRAMQNFPDVETVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
DIPDLNEVLNILRQIPDSDHIVYEIGTPLAKRYGSEVILKLREIKPDSFFVLDLKTLDVG
NLEARMAADATANAIVISGLAPIQTIVKGIREAEKTGILSIIDMLNVENPVERLKKIKKH
AIPNIVELHRAIDTEGVAEVPWKYASKVKELGVLVAVAGGIRPENVQEAISAGADILIVG
RAITKSRDVEGAVRRFLTYMKPDTDQFRIMTDF
>A0A2I0P963|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon HGW-Methanomicrobiales-2|TrEMBL
MYLIGEALVGDGAELAHIDLLIGNKEGAVGQAFANSMSQLSKGHTPLLAVIRPNLPTKPS
TLIIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGMDIEDIVIMASVYLGTTAE
DYNKIYRFNYGAMKLALRRALDRFPDVDTLLHEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDKNHMRRVLESLPANDHLIIEAGTPLIKKFGLSIIAEIRELRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPLSTIEKAIEDTRKTGIYTVVDMLNVEDPRAVIEQLKVKP
DVVELHRGIDVEETAYAWGDIAAIKKAGGKRLLVATAGGVRQHVVKDALKAGADILVVGR
AITASKNIQNAAEEFLKELSTEEIDQFRIMTDF
>A0A843DBM7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MYRIGEALIGDGPELAHIDLLIGDKFGPVGQAFATGLSNLSVGHTPLTSVIRPNLMTKPA
TLIIPKVTVGDLDDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDPSAK
DFRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDSKEAMAKILNDLPDKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLDVGR
VEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMMNVADFEDKLSQLPDDL
KPDIVLLHRNVDLETYKAEKGEDVSEMTEWGNIKKIKEILGGGLIAVAGGITPDNVEEAI
DKGADVIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN
>A0A843F0K6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MYKIGEALIGDGPELAHIDLLIGDKFGPVGQAFANGLSNLSVGHTPLTSVIRPNLLTKPA
TLIIPKVTVGNLEDASKIFGPAQTAVARAVADAVEEGYIPKDIVEDIVINVSVFIDPSAE
DYRKIYQYNYGATKLAIRRAMTGYPDIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQVALD
LDNEAAMERIINDLPDNDRILLEAGTPLVKKFGVGIISKIRALRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTIESIAKAIHETQKQGIYSILDMMNVKGFEEKLAQLPDDL
KPDIVLLHRNVDMESYRAEHGEDTSDMTEWGNIKDIKATLGEKGLIAVAGGIKPNNVEEA
ITKGANIIIAGRYIIGSRDVRRAAQDFLEHFDPDPDNMRLAMDEDENIDVKE
>A0A3N5MN21|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon|TrEMBL
MYLVGEALVGDGAELAHIDLLMGEKEGPIGSAFANAISQLSVGHTPLLAVVRPNLLTKPV
TLVIPKVTLKNIAQVNEMFGPVQAAVAKAVADSLEEGAFGSADTESLVILCSAFVHPEAK
DYNKLYRFNYGATKLAITRAMEKFPDNKTLIKEKDRAAHAVMGFKVQRLWDPPYLQVACD
IVDLGKLQAVLSALPENDHLIIEAGTPLVKKFGLNVLSEIRKVKPSAFIIADLKILDTGN
LEARMAADATADAVVISGLAPASTIEKAIIEAKKVGIYSVIDMLNVQNPVKVVQNLKVKP
DIVELHRAIDVEETAHAWGDIPALKKAAGGKLLVATAGGIRVNVVKDALKAGADILVVGR
AITASKDVSHAADEFLEQLDREEIDQFRIMTDF
>A0A843L6C6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp|TrEMBL
MYLIGEALVGDGAELAHIDLVMGNKEGAVGQAFANSISQLSRGHTPLLAVIRPNLPTKPS
TLVIPKVTLKKEYQVNQMFGPVQAAVAKAVADSVEEGVFEGIDIEDTVIMASVFVHPTAQ
DYNKIYRFNYGAMKLALRRALDRFPDVGTLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDKNHMRRVLESLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPLSTIEKAIEDTRKTGIYTVVDMLNVEDPRAVVEQLKVKP
DVVELHRGIDVEDTAHAWGDIPAIKKAGGERLLVATAGGIRQHVVKDAIKAGADILVVGR
AITASKNIQHAAEEFLEELSTEEIDQFRIMTDF
>A0A843KMD8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus sp|TrEMBL
MYLIGEALVGDGAELAHVDLIMGNKEGPVGQAFANALSQLSKGHTPLLAVVRPNLPAKPS
TIIIPKVTLKKEYQVNQIFGPVQSAVAKAVADLVEEGAFEGIDIEDIVIMASVFVHPTAE
DYNKLYRFNYGATKLAIRRALDRFPDVDTLLHEKDRATHAVMGFKVQRLWNPPYLQVAMD
LVDRNHMRKVLEELPESDHLIIEAGTPLIKKFGLSIISEIHEIRPGSFIVADLKTLDTGN
LEARMAADAGADAVVISGLAPLSTIEKAIQEARKTGIYSVLDTLNVSDPVAVIGQLKVKP
DVVELHRAIDIEDTDYAWGDIPAIRKAGGERMLIATAGGIRQHVVKEALRAGADILVVGR
AITASKNIKHAAEEFLEELNTEEVDQFRIMTDF
>A0A3G9D2W4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. MT-2|TrEMBL
MYKIGEALIGKGNEVAHIDLIIGDKEGIVGSAFATGLTNISLGHTPLISVIRPNLMTKPA
TLMIPKVTIGNLEDANKVFGPAQTAVARAVADAVEEGVIPKEKVEDLVIIVSVFIHPEAK
DYQKIYHYNYGAMKLAIRRAMEGYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDVLPPRERILLEAGTPLVKKFGVGIVNKIRELREDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLATKATIEKAVHESQKQGVYSILDMMNVENVTEKLEELRYKP
DIVLLHKNIDVGTAEVSEWGNIPEIKEILGKRRLVAVAGGITPSKTRKALESGADIIVVG
RYITGSKDPRRAAEDFLKELPPDPDTMRLPHEEDEPI
>A0A6G8NUV0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Caballeronia sp. SBC1|TrEMBL
MPTPQTGRTLHIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIAQ
PGVPTKPLTLYVNKAPIAGEFHGNATWGASQAGIAKAVAESLEDGTLPPEAENDWVVVTA
NWVNPSTDDLDAVFRNNYRATKNAIKAAMLGLPSKEDVFAAAREVSNPFYTPRSPQAAL
>A0A7J2ICE7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon|TrEMBL
MYKIGEALVGKDNEAAHIDLIIGDKEGNVGEAFANGLAKLSAGHTPVLSVIRPNLPSKPY
TLVIPKVTIKDMEDANKIFGPAQAAVAKAVADAVEEGIIPRDKIEDWVIICSVFVHPEAK
DFRKIYQYNYGATKLALKRALQDYPSLDKIMFDKDRATHPIMGFRVPRLPKWNRPYLQIA
LDIPDLERTKKIIREIPKSDKIILEAGTPLIKRYGTKVINELREVAKSDFIIADLKTLDV
GQVEVDLAFDDGADAVVASGLATVEVIDKFIYEAKRLGIYAILDMMNVKDPVKRLKSLKE
LPHIVILHRAIDSEKREKHRFGLIRDIKKEFPDLYVAVAGGIEPETVPLALKEGVDIIIV
GRFITQSKDIERSTRLFINQLGGDIDLKRVHVE
>A0A7Z8P4I2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus vulcani|TrEMBL
MLLIGEALIGEEPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVIRPNLPTKPA
TLIVPKVTVKNMDQAAQIFGPAQAAVAKAVADALEEGAFGDLDPEDLVVVASVFIHPEAT
DYNRIYRYNYGATKLAVKRAVDGFPDIDTVLNEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPLIQNIVKQIPKSDHVILEAGTPLIKRYGVDVISKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATMNKAIEEAHKTGIYAIMDTLNCDDPVAVLKKLDVLP
DVVELHRGIDIEETEHAWGNIDAIKALSPKILVAVAGGVRIDTMPAALKAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A7C4GSL7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKAAKKEVEARSLLSGKPAKPTVSGTAKVLGVHRDTLYSWLKEFDVDFEKATEGISAAEV
SEIRQVSRGYTYLIGEALVGEGSEVAHIDLLIGDKDGPVGEAFANGLAHLSMGHTPLLAV
IRPNLPPKPHTLLVPKVTIRNLEDANKVFGPAQAAVAKAIADAVEEGIIPKDKVDDWVVV
CSVFVHPKASDYRKIYHYNYSATKLALKRALAKYPPLEKVFYDKDRAKHPMLGYRVPRLW
RPPYLQISLDIPDLERTKKIIMQIPRSDRIILEAGTPLIKRYGTKVISDLREVAKDIFII
ADLKTLDVGKVEVDIAYEETADGVIAAGLAPTETLNAFIYEAKRLGIYAAIDMLNVEDPI
RKLKALKDFPDLVIIHRGIDEETGKTIGLELIQELRQTFRDKRFLIAVAGGIIPETAKEA
LEKGADIIIVGRYVTQSKDIERAVREFLELTPEMREDIDLYRVHVE
>A0A3R7EJ04|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MRAALEHFRRAYASPRGLYLIGEALVGEGDEVAHVDLIIGDKSSPVGEAFARALSNPTVG
HTPLLAVIRPNLPPKPFTLIVPKVTIRNMEDASKIFGPAQMAVAKAVADAVEEGIIPREV
VDDWVIVASVFIHPKARDMRRIYHYNYSATKLALRRAMMGYPPLEKIMYEKDRAKHPLVG
FRAPRLWRPPYLQIALDIPDIEAVKRVLRAMPRSDSIIFEAGTPLIKRYGVRVIREIREV
VGDSFIVADLKTLDVGKVEVDLAFNETADGVCASGLASKETLDGFIYEARRLGIYSYIDM
MEVKNPVEKLRSLERPDVVILHRAIDVERRGGEPRWSYIKEIREAFEGERLLIAVAGGIT
PQTAPRALEMGADILIVGRYITQSRDVERAVREFMPYLRGDIDLFRVHVE
>A0A7J3V1F5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTEAARKEVEARSLLSGKPAKPTVSGTAKVLGVHRDTLYSWLKEFNVDFEKATEGVSAV
EVSEARQPTKRYTYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFANGLTHLSMGHTPLL
AVIRPNLPPKPHTLLVPKVTIKNLEDANKVFGPAQAAVAKAIADAVEEGIIPRDKVDDWV
VVCSVFVHPKASDYRKIYHYNYSATKLALKRALAKYPSLEKVFYDKDRAKHPMLGYRVPR
LWRPPYLQISLDIPDFERTKKIITQIPRSDRIILEAGTPLIKRYGAKVISDLREVAKDIF
IIADLKTLDVGKVEVDIAYEETADGVIAAGLASTETLDAFIYEAKRLGIYAAIDMLNVED
PVKKLKALRDFPDIVIIHRGIDEETGKTVGLELIQELRQAFRDKKFLIAVAGGIIPETAK
EALEKGADIIVVGRYVTQSRDIERAVREFLELTPEMREDIDVYRVHVE
>A0A7J2I045|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKILSETAETRGKYTYLIGEALVGEGNEVAHIDLLIGDKVGPVGEAFAAGLSNLSMGHTP
LLAVIRPNLPPKPHTLLVPKVTVKTLDDANKIFGPAQAAVAKAVADAVEEGILPKDKVDD
WVIVCSVFVHPQASDYRKIYHYNYGATKLALKRALAKYPSLEKVFYDKDRAKHPIMGFKV
PRLWRPPYVQISLDIPHFERTKKIISQIPKSDRIILEAGTPLIKRYGTKVISDLREVARD
VFFIADLKTLDVGKVEVDLAYEETADGVIAAGLAPIQTLNAFIHEAKRLGIYAMVDMLNV
EKPVEKLKMLKEFPDVIVLHRGIDEETGKTIGLELIPELRQAFKDKRFLIAVAGGIVPET
AREALEKGANIIVVGRYITQSKDIERAVRDFLELTPIMREDIDLFRVHVE
>A0A2U0S5G9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MREFDVDFSDVDERQLFSETSQPKASTYLIGEALMGEGTEVAHVDLLIGDKDGPVGTAFA
NGLSNLSAGHTPLLAVIRPNLPPKPHTLIVPKVTVKNMDQTGKIFGPAQAAVAKAVADSV
EEGVIPEDKVDDWVIICSVFIHPQAKDYRSIYHYNYGATKLALSRALDNYPSLKKIMYDK
DRAKHPIMGFKVPRLWRPPYLQVALDVPNLERVKKIISELPESDRIILEVGTPLLKKYGV
NVIREMRKVAKDMFIVADLKTLDVGKVEVDLAFEETADAVVVAGLATPETIDKFIKEAKR
LGIYAIMDLMNVDDPIAKLRSLKRLPDVAILHRAIDAEKTGKTRWDIIKEMKQTFQGQKC
LVAVAGGITPETAPEALANGADIIIVGRYITQSKDVERATREFLKSTKDMAKDIDLFRVH
VE
>A0A7C2LPP3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon|TrEMBL
MFIGEALIGEGYEVAHIDLIMGDKNGAVGQAFAIGLSNLSSGHTPLLSVIRPNLPPKPYT
LVVPKVTVKAMGDVEKIFGPAQAAVAKAVADSVEEGIIPLKKLDEWVIVVSVFIHPEATD
YRRIYHYNYSGTKLAIKRAMTNYPSWDKIKFDKDRATHPIMGFKVPRLWRPPYLQIALDV
PNIDNARDVIKNIPKNDRIILEAGTPLLKRYGTKVISELREVAKDSLFVADLKTLDVGKI
EVDLAYDETADAVVVSGLATS
>A0A7K3YJM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALVGDGAELAHIDLIMGKKEGPVGQAFANSFSQLSQGHTPLLAVVRPNLPAKPS
TLIIPKVTLKKEYQVNQIFGPVQAAVAKAVADSVEEGVFEGIEIEETVIMASVYLNPSAQ
DYNKIYRFNYGAMKLAIRRALDRFPDTETLLHEKDRAAHAVMGFKVQRLWNPPYLQVAMD
LVDRGHMRKVLESLPQNDHLIIEAGTPLIKKFGLSIISEIRELRPNAFIVADLKTLDTGN
LEARMPADAGAAAVVISGLAPISTLEKAIEDSRKTGSYTVVDMLNVENPVAVVEQLKVKP
DVVELHRGIDVEDTDYAWGDIPAIKKAGGERLLVATAGGIRQHVVKDALHAGADILVVGR
AITASKNIQNAAEEFLLELNTEEIDQFRIMTDF
>A0A7L4R1S0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLVGEALVGDGPELAHIDLIIGEKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKEVQIREMFGPVQAAVAKAVADCIEEGVFGNQDLESLVVLASVYLDAGAA
DFNRIYRFNYGATKLALRRAMEGFPDKATILYEKDRSAHAVMGFKVQRLWDPPYLQVALD
LVEMRKVESVLAELPENDHLLIEAGTPLIKKFGLQIIPEIRKIRPNAFIIADMKVLDTGN
LEARMAADSSADAVVISGLAPLPTLEKAIAEAKKTGIYSIVDMLNVPDPVKVIKSLKMKP
DVVELHRAIDAEDTAHAWGDIPALKKAAGGKLLVATAGGIRVDVVKDAVRAGADIIVVGR
AITASKDPHTQADLFLEQLNREEIDQFRVMTDF
>A0A840ZIY3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylorubrum rhodinum|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAMAVQDAVAEGIIPADEADDLYVLVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKASAVTEQRKSATHPFAANA
>A0A2H6JZW6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon BMS3Bbin16|TrEMBL
MTSQSFSIGEALIGEAPEIAHIDLIVGSKNGPVGQAYATSLAQPRMGHTPIMAVIRPNLP
VKPATLIVPKVTLRDLEAAERIFGPAQSAVAKAVADAVDEGTIPREQAEELAIIVSVFIH
PRGKDYQRIYRYNYSATKLALKRAMAGFPDINVVLEEKPKATHAMIGFRINNLEEPPYLG
VELVHDDWRRIEGILRDLPRKDGIVIKAGAPLIKKYGIEVCQKIHEMRPESVVIADMKSL
DTGNLEARMAGDSTADVVVFSALAPLKTQERFIKECRTIGVLSYMDTINAADPLEIINRL
EVKPDIVELRGKPTADLIAKVKEACGKRALVAVAAEVDPAGAKEAVESGAAIIMVGETIT
ESAEINRTASSYLEELGIYEVDQFRVMTDF
>A0A1E7GFI1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. Ant1|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKNGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMEQAAKIFGPAQAAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLAESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNIEFVMSAISQIPNSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKIMP
DVIELHRGIDIEGTEHAWGNIADIKKVAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIREVAEQFINSLNKPEIDQFRVMTDF
>A0A5E4J385|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGEKEGPVGTAFASGLAQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADSVAEGIIPKDKAEELLVIVSVFIHPQAK
DYDAIYRYNYGATKLALKRAMEGFPDIDKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPESDHILIEVGTPLVKMLGMSVVKEIRSIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTIELSINEARKTGIYSIIDMLNVPDPLAVLKGLDVLP
DVVELHRAIDMEKSAHAWQNIREIQALAKDGRRLLVAVAGGIRTDTEGAALAAGANILVV
GRAITRSRDIRDMAEQFLTGLKQTEIDQYRIMTDF
>A0A5E4K9Q9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MCISAMGDLMVHIVKSIIGEALVGEGNEIAHIDLVIGTKGGAVETAFMNSLAMPREGHTP
LLAVLEPNLQPKPSTLIINKVTIRNADQAVLMFGPAQAAIAKAVMDSVEDGVIDKNDAED
LLLIVSVFIHWDAKDKQKIYDYNYEATKLAIKRAIEREPSVQEALARKDSAKHPFA
>A0A7J4EW17|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanococcaceae archaeon|TrEMBL
MLKFGEGVLGRDIVALVNLVLGKGEKIDSVFTNALTRVPTPVVANLRDNLIVKPLTLVVP
RNTLTSDIQCNFLHGPIQYGVAKAVADLDLPEDLKLIVTVAVPDVPYTNLNKRKLFQYYY
GATRLAINRALNDYPSKEKIKEEKYRAIHPLVGFRDIRLERPPYLQLALDVPSMENVEYV
LESLPPSDKIVVEAGTPLIKRYGVEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGMISYLDTINVKDPFGLYNSLELKPDVLLLHRAIDE
EGKVPMREYRGVKGEKGPLLGIAGGVTLEKIEELKNRYHIIVVGRGITKAKDPGWVVRAI
LNKLGEDIDYRLPLEEDEDVSLK
>A0A1D2WTG9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. A54|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPAAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A679K5J6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium bullatum|TrEMBL
MAKINKVLVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQYGVAKAVQDAVAEGIIPADEADDLFILVGVFI
HWEAADDAKIQKYNYDAVKLSIQRAVKGEPTAAYATEQRNSASHPFASNA
>A0A8J7XXE1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Theionarchaea archaeon|TrEMBL
MRIGEALIGDGLEVAHIDLIIGEKDSPVGYAFANSLAQPSYGHTPILGVIRPNLPPKPST
LIVPKVTVRNFKDAGKIFGPAQAGVAKAVADAVDEGLIPKEHCDDWVVIVSVFVHKDATD
YRKIYQFNYGATKLAIKRAMENYPSLDKVMKEKDRATHPIMGFRVYRLWNPPYLQVALDL
TSEEDVRKIIEQLPVRERLLLEAGTPLIKNCGIEIVEKIRKMREQSFIIADLKTLDVGRL
EVKMAADATADAVCISGLAPNASVEKSIQETQRQGIYSIVDFMNVTDIEGKLKSLKHKPD
TALLHRNVDVETAARERGEELETKWGNLSAIKKLVKLVSVAGGITPKTSEEALKKGADII
VVGRYIIRSHDPYQAVRDFLEKMPPDPDTMRLILDEDEVVGT
>A0A3M9LRK7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus sp. RSK|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEEADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAVDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNIEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAIAEAHKTGIYAVMDTLNHPDPMAVLKELNELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADVLVVGRA
ITNSKDIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A076LIT1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus bathoardescens|TrEMBL
MIKFGEAVLGNEIKAIVNVALGKDKYIESIFTNALTRGNCVFANLRPNLIVKPLTLVVPR
HNIESNIQDELFQGVIQYAVAKAVADLDLDEDLKVVVSVNVPELPITNLTKRKLFQYFYA
STKLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
QTIPKSDHIILEAGTPLIKKFGLEVIEIMREYFDGFIVADLKTLDTGRVEVRLAFESTAN
AVAISGVAPKSTIIKAIHECQKCGLISYLDMMNVSEPQKLYDSLKLKPDVVILHRGIDEE
TFGIKKEWKFKGNCLLAIAGGVGVENVEELLKEYQILIVGRAITKSRDPGRVIRMFINKM
GYDIDTYRLYFDEDEDIDI
>A0A5S9NFM6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Starkeya sp. HF14-78462|TrEMBL
MSDIWFRTGEATVLAADGQFTDAMPEVLIGSVRGPAGHAFASMMGQVQGHTRMFVVRDLN
QMVRPATMMTTKATIHTLEYVDLLGGVVQGAIGDAIVDALAEGILPKDQADELCMIVMVW
LDPRCAEDPNLDKADLYRTNYEAMKIALERAMTGKPTVDELIANRKTIKHYALDGVVEY
>A0A7W8T6A2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. MM5384-R2|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGDPSAAEVLAKKGSVAHPFAPN
>A0A133U990|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|candidate division MSBL1 archaeon SCGC-AAA259A05|TrEMBL
MYKVGEALVGDEPNLAHIDLVIGEKDGPVGQAFLNGISQPSKGHTPLLSVIRPDLQTKPS
TLIVPKVTVQGMEDADKAFGPVQEGVARAVADSVEEGIIPKDRTEELVIIVSVFIHPEAS
DFQKLNRFNYGATRLAIRRAMEEFPSIDKVFEEKDKAGHPLMGTRTVKLRNPPYLQVAMD
KPSLEQQLNVIQELPENDHLIVEAGTPLIKKYGISVVEKLREKNDSTFIIADLKTLDTGH
LEARMAADAGADGVVVSGLADKNTIEKATREADKCGIYCIVDTLNVSNPVVLLKELEEKP
HIVELHRGIDQEYAGEEHSAWGDIPTIKELTRENLVAVAGGITKDTIREALESGADIIVV
GRAIANSKDPESKTRDFLEAMGKAYSKLEEEKFGDIEQFRWRTDF
>A0A0U3CH67|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter millerae|TrEMBL
MDPMYRIGEALIGDGPELAHIDLLIGDKFGPVGQAFANGLSNLSVGHTPLTSVIRPNLMT
KPATLIIPKVTVGDLDAASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDP
SAEDYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQV
ALDLDSKEAMAKILNDLPDKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLD
VGRVEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMMNVADFEEKLSQLP
DDLKPDIVLLHRNVDLETYKAEKGEDVSEMTEWGNIKKIKEILGGGLIAVAGGITPDNVE
EAIDKGADVIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN
>A0A139CRT2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus sp. T82-4|TrEMBL
MLLVGEALIGENPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMDQAGQIFGPAQAAVAKAVADALEEGAFGDLDIEDLVVVASVFIHPEAK
DYNRIYRYNYGATKLAVKRAVDGFPDVDTVLKEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPVIKEIVSQIPKSDHVILEAGTPLIKRYGVDVVSRLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVATLNKAIEEAHKTGIYAIMDTLNCDDPVAVLKQLDVLP
DVVELHRGIDIEETEHAWGNIDEIKALSPKLLVAVAGGVRINTMPAALKAGADVLVVGRT
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>L0KWT4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)|TrEMBL
MLLVGEALIGEEPELAHVDLIIGDKNGPVGLAFANGLTQLSVGHTPLLSVIRPNLPAKPS
TLIVPKVTVKNMGQAAQIFGPAQAAVAKAVADSVEEGVIDKKDVEDLVVIASVFIHPEAK
DYNRIYRYNYGATKLALKRAMEGFPSVETVMKEKDRAAHGIMGFKVTRLWDAPYLQVALD
NPNIAAIRSIVAQIPKSDHVILEAGTPLIKRYGVDVISQLREVRPDAFIVADLKTLDTGN
LEARMVADATADAIVISALAPVSTLQKAIEEAHKTGIYAVMDTLNCSDPVAVLNELKKIG
SLPDVVELHRGIDIEETEHAWGNIADIKAFSTESHKVLVAVAGGIRIDTMPVALEAGADI
LVVGRAITNAKDVRQVAEKFIEGINKSEIDQFRVMTDF
>A0A8F5ZFG9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum hungatei|TrEMBL
MYLIGEALIGEGSELAHVDLIVGDKNGPVGIAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKHEGQVNQMFGPVQAAVAKAVADAVEEGLFGDVNINDICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEEFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDMGKLRSVLSSLPENDHLIIEAGTPLIKKFGLQVISEIRAIKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A679IUS7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium bullatum|TrEMBL
MSEIWFRTGEATVLAADGQYTDAMPEVLIGSTRGPVGQAFAGMMGQVQGHTRMFVVRDLN
QLVRPSTMMTTKATIHTVEYVNLLGGVVQAATGDAIVDCVIEGILPKDGLDDLCMIIMIW
LDPRCAEDANLDQKDLYRTNYEATKLAIARAIKGEPTIDELIANRKTVKHYALEDIVEY
>A0A7J3AAH5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Nitrososphaerales archaeon|TrEMBL
MTDFFVGEALVGEEPEVAHIDLIIGKKSGPAGIAFANALAQPRMGHTPILAVIRPNLPAK
PSTLIVPKVTIRDLEDAEKVFGPAQSAVAKAVADAVEEGIIPKEGVEDYVVLVSVFIHPK
GRDYQRIYRYNYAATKLALQRALSSFPSIDKVLEEKDKAIHGMVGFRINNLKKPPYLEVA
LDIPDWRRVEAIIKALPRSDAILLEAGTPLIKRYGVEVIQKIHSLRPESVVIADMKTLDV
GNVEARMAGDATADVIGFSGLAPIKTIEKFIEECKKIGALSLMDTINVQNPVDVLRKLKV
KPDIVEIHRAIDVEDEAYAWGNIKEIREVCGKVLIAVAGGIRLNNVEAALKAGADIIVVG
RAITAAKDVTGAARAFLQKMGVEEVDQFRVMTDF
>A0A7W8RU90|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. Cpub6|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGDPSAAEVLAKKGSVAHPFAPN
>A0A6M5YN88|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Frigoriglobus tundricola|TrEMBL
MSMFIGEGLVGEGNEIAHIDLLIGDKTGPVGIAFANALANQSAGHSSLLAVITPNLICKP
ATVMITKVTIKGAKQAVQMFGPAQAAVARAVADSVAEGVIPASKAEDYVIVCGVFIHWDA
ADDAKIYQYNYEATKLAIKCAMTGEPKVADITAKKDTVKHPFSPK
>A0A497F6C6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Verstraetearchaeota archaeon|TrEMBL
MEEFYVGEALIGSGDEVAHVDLIIGSKKGPAGIAFANALSQLSAGHTPLLAVIRPNLAVK
PSTIVIPKVTIRNLEDANKIFGPAQTAVARAVADAVAEGIIPKEKCEDWVIIASVFVHPN
AKNYRKIYQFNYGATKLAIRRALKGYPSVDKVLREKDRGVHPIMGFRVQRLWNPPYLQVA
LDLDKLDYVLKIVEQLPNRERLILEAGTPLIKAHGTKVIEKIREVRPEAFIIADLKTMDV
GRIEVKEAADSTADAVCILGVSSKATIEKAILEAQKHGIYSILDMMEVYDPVARLEDLYY
KPDIVLLHRNVDAERAAAEAGKPWETEWGNITEIKEKFKCLVGVAGGITPQTAKKALEKG
ADIIVVGRYIIRSRDPRRAAEQFLDLMPPDPDTMRLILDEDEAIGEI
>A0A7J3NQB6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MEFYIGEALVGKGAEVAHVDLIVGDKLGPVGLAFAQGLTHMSQGHTPLLGVIRPNLPPKP
HVLIIPKVTIKNMEQANKIFGPAQSAVAKAVADAVEEGIIPADKVDEWVIVASIFVHPDA
KDYRKIYHYNYSATKLALRRALQAYPPLDKVMYDKDRAVHPIMGFKVPRLWRPPYLQIAL
DNPSLEQALHVVSELPKSDMIIIEAGTPLIKRHGVSAVSKLRDIAPDMFIVADLKTLDTA
QVEVDLAYEETADGVVASGLASKESIDKFIYETRRLGIYAFLDMMDVPNPLEKLKSLKEL
PDVVIIHRAIDTESSGRRSRWELINEIKNAFKDKKILFAVAGGIVPETANEALDAGAHIL
IVGRYITQSKDIRRSAREFLEILKRRIPGEPGDVDLLRVHVE
>A0A7C5IWW9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
PAQAAVAKAIADAVEEGIIPKDKVDDWVVVCSVFVHPKASDYRKIYHYNYSATKLALKRA
MARYPTLEKVFYDKDRAKHPMLGYRVPRLWRPPYLQISLDIPDLERTKKIIMQIPRSDRI
IFEAGTPLIKRYGTKAISELREVAKDIFFIADLKTLDVGKVEVDVAYEETADGVIAAGLA
PTETLDAFIYEAKRLGIYAAIDMLNVEDPIKKLKALRDFPDIVIIHRGIDEETGKTIGLE
LIQELRQAFRDKKFLIAVAGGIIPETAKEALEKGADIVVVGRYVTQSKDIERSVREFLEL
TPEMREDIDVYRVHVE
>A0A7J3TW83|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MERGFYVGEALVGSGYEVAHVDIVIGEKNGPVGLAFTNALSNPSAGHTGMLAVLRPNLPV
KPSTLIIPKVTVKSMEDSEKVFGPAQAAVAKAIADAVEEGIIPRDKCEDWVVVVSVFVHP
KAKDYRKIYQFNYAATKLATRRALKGYPSIDKILKEKDRAVHPIMGFRVRRLWSPPYLQV
ALDLSSLEKALEVVKQLPRSERIILEAGTPLIKAYGVGVIGKIREVWKDAFIVADLKTMD
VGRVEVKEAADATADAVCILGVASKTTIDKAILEAQKQGIYSVLDMMEVSNPIAKIEALE
YKPDIVLLHVSADVERKTVESGKQVEFRWNEISEVKNRFKVLVAVAGGITPSSAIEALKS
GADVIVVGRYIVGSGDPRRTSEQFLNLMPPEPDVMRLTLDEDESIGEI
>A0A564QA14|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanolliviera sp. GoM_asphalt|TrEMBL
MGSTDLYLIGEALIGEGDELAHVDLMIGGKEGPVGMAFANGLVNLSKGHTPLLSVIRPNL
PTKPSTLIVPKVTIQDMEDANKIFGPAQTAVAKAVADSVEEGVIPRDMVEKIVVVVSVFV
HPAAKDYEKIYRYNYGATKLAIQRAFESFPDVDTVLYEKDRSTHPIMGFRVTKLWDPPYL
QVALDLTDIDKVLSVVSQLPDSDHLILEAGTPLIKRYGIDVVGRLRENKPGIFIVADLKT
LDTGNLEVRMTADASADAVVISGLAPVSTIEKSIKEAKKTGIYSAIDMLNVKDPIFVLKS
LSMNPDVVEIHRAIDNESSEKERWDLIEKIKKEFSGILVGVAGGIRPENCQEALESGADI
LIAGRAITAAKDVEGAARKFLKVFKGEIDQFRIKTDF
>A0A0E3RUV6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei C16|TrEMBL
MGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPSTLIIPKVT
VKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQDYNKIYRY
NYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFDNPNLEFVL
SAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGNLEARMVAD
AAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRG
IDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVR
EMAEQFINSLNKPEIDQFRVMTDF
>A0A3R8C6U9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocalculus sp. MSAO_Arc1|TrEMBL
MYAIGEALVGDGAELAHIDLLVGDKNGPVGTAFANALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTLKRTEQVNEMFGPVQAAVAKAVADSLEEGLFAGMNIDDIVIIASVYLAPDAK
DYNKIYRFNYGAMKLSLSRAFEQFPDEKTILHEKDRAAHAVMGFKVQRLWNPPYLQVALD
LVDMKQVERVLTELPANDHLIIEAGTPLIKQFGLQVISEIRKIRPNSFIIADLKTLDTGN
LETRMCANASADAVVISGLAPVSTIEKAVKEARKTGIYAIIDMLNVKSPVDLVKSLAQAN
ALPHIVEMHRAIDAEGSDYSWGDIPAIRKAAGGKVLVATAGGIRVNVVKKALESGADIIV
VGRAITASKNIQNAAEEFLAEINQEEIDQFRIMTDF
>A0A839FKU7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Phyllobacterium sp. P30BS-XVII|TrEMBL
MDKPLGNGLGRYLAVAKINKVMVGESLVGDGNEVAHIDLLIGPRGSAVETAFCNALTNNK
DGFTSLLAVIAPNLACKPNTILFNKVTIKGAKQAVQMFGPAQHAVAKAVQDSVADGTIPA
DEADDLFICVGVFIHWEAEDDAKIQDFNYRATKEALERAVSGKPTAAEATAQRDAVKHPF
SA
>A0A7J4ECS5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MMYVGEALIGEGDEIAHIDLMIGDKFGPVGVAFTNALSQMSAGHTPLFAVIRPNLPVKPS
TVVVPKVTVRNMKEAEKIFGPAQSAIAKAVADSVEEGVIEEDKAEELVVIVSVFMHPQAK
DYNKIYRYNYGATKLALKRAMEGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALD
IPKWEHMERVVKELPRNDHLIIEAGTPLIKRYGVDIVEKIKEIKPDTFVIADLKTLDTGN
LEVRMVADSGADAVVISGLAPLRTMEKAIEEAKKTGIYSSLDMLNVDNPIEVLSELTVGG
LMPDVVELHRAIDVELEEKHAWGDIAEIKRIGGKILVAVAGGIREDNAPEAIKGGADIII
VGRGITNSRDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A497RL32|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobales archaeon|TrEMBL
MRIGEALVGEGYEVAHIDLMIGERDGVVGQAFANALSQLSAGHTPLLAVLRPNLITKPPA
IVVPKVTVKSMEQAEIVFGPAQAAVAKAIADAVEEGIIPREMAEEFVIIVSVFIHPKAKD
RNKIYYYNYSATKLAIKRAMSGFPDVDKVLWEKDRAFHPLVGRKLTRLWDPPYLQIAFDL
TSLEEVLEVMKQIPESDHIIYEVGTPLAKRYGAEIVLKMREVKPDAFYVIDFKTLDVGKL
EARMAVDATANGVVISGLAPIRTIVEGIKEAQKVGIYAVVDMLGVEDPIGRLEKIVDAGV
LPEVVELHRAIDEEEAKPPWSLARDVKEKFKVLVGVAGGVRVENVQEVVLAGADILVVGR
AITRARDVKGAVRMFLNALKKPDTDQFRIMTDF
>A0A524FP15|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKAEYFVGEVLIGEPPNLAHLDLVIGSKDGPIGVAFANAISSPSIGHGGLLACIRPNLV
PKPYTLIIPKVTVSKMEDANKIFGPAQAAVAKGIADAVEEGIIPMNKLEDWLIIVSVFIH
PEATDYRKIYQYNYGAVKLALQRALKSYPPIEKIFYDKDRAKHPVAGMRVPRLWRPPYIQ
IALDDPDLPRQIKVVKDLPKSDRIIIEIGTPLLKKYGVEAIKQIREFSNESFMVADLKTL
DVGKLEVDFAFDATADAVVASGLASISSIDKFILEAQRLGIYAFIDTMEVENPIAKLSQL
KQIPDVVILHRAIDAEAAASGTNEAQKAAWQNIPKIKELYKDKKLASGKDRVLVAVAGGI
DQRSASYAIDMGADILIIGRFITSAKDVKNAMRQVLNILPGYSDIDLKRIHSEDDDNSVK
KPKWD
>A0A5C9EG83|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MVDYFIGEALIGDGPELAHIDLLIGSKDGPIGISFANAISNPSVGHGGLLACIRPNLLSK
PKSLIVPKVTVGKLQEANKIFGPAQSAVAKAIADTVEEGVIPIKKLDDWLIIASVFIHPE
AEDYRKIYQYNYGAMKLAIKRALNDYPPIQKIFYDKDRAKHPVAGIKAPKLWRPPYLQVA
LDHPSVKHHLKVVDELPSSDRIILEIGTPFLKKYGMEVIEKIRENAPNKYIVADLKTLDV
GKLEVDDAFEASADAVVASGLASPASIDKFLLEAERMGIDGFVDMMEVADPVAKLKRLEQ
IPRVVILHRGIDAEQSTASTGSDAAQKKKWGFVPKIKELYKDKRLESGRDRVLVAVAGGI
SPETAQNALSMGADILIVGRFITSSKDIKNSTRRIINMFPGYSDIDLKRIHTEDDDDSAL
EKQLEENDSVKKDAE
>A0A843KDX7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKAGPVATAFASGLAQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVAKAVADAVAEGLIPKEKAEELLIIVSVFIHPQAR
DYDAIYRYNYGATKLAIERAMAGFPSVDLMLFEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLAALPESDHILIEVGTPLVKMLGINVVKEIRAIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVPDPLAVLKSLEVLP
DVVELHRAIDMEKSAHAWQNIPAIKDLAKEGRRLLVAVAGGIRVDTEAAALAAGADILVV
GRAITRSKDIRDMAEQFLAGLKQTEIDQYRIMTDF
>W9DPR6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus tindarius DSM 2278|TrEMBL
MLLIGEALIGEEPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVVRPNLPTKPA
TLIVPKVTVKNMGQAAQIFGPAQAAVAKAVADALEEGTFGDLDIEDLVVVASVFIHPEAK
DYNRIYRYNYGATKLAVKRAVDGFPDIDTVLKEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPVIQNIVKQIPKSDHVILEAGTPLIKRYGVDVITKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATMNKAIEEAHKTGIYAIMDTLNCDDPVAVLKQLDVLP
DVVELHRGIDIEETEHAWGNIDAIKALSPKILVAVAGGVRINTMPQALKAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A497QRL2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Heimdallarchaeota archaeon|TrEMBL
MTPVVLKKLADFFIGEALQGKGNELAHVDLMIGDKDGPVGHAFANGMTQLSQGHTPLLAL
IKPNLQPHPRTLIVPKVTIENLDQAGKIFGPAQMAVAKAVADAAAEGDIPQEKLFKYVII
VSVYIHPKAEDESKIYYYNYGATRLAIKRALSDYPPLKKLIAEKDRAKHPVMKFKPQTLW
NPPYLQIALDVGSLSQAVKIVEQLPKSERIIIEIGTPYIKKYGIEETVGRMRQIKPGAYI
IADMKTLDVGRAEVNAAADATANAVVVSGIAPESTIAEFIRACNKRGVHAWIDSLNTTQT
EFLAMLGRLKEKPKVVILHRGIDQEDAQKTGAAKKEGTSASRSVWGDIKQIKKITGGLAA
VAGGLKPGKPLNDALKAGADIIIVGRYIYRSSDPNRAAMRFLDEMEIEPDTMRLFDKLDY
>A0A151ESH0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Theionarchaea archaeon DG-70|TrEMBL
MKIGEALIGDGLEVAHIDLLIGEKDGVVGQAFANSLAQPSRGHTPMLGVIRPNLPPKPST
LIVPKVTVKTFKDAGKIFGPAQAGVAKAVADAVEEGLIPPEHCDDWVVIVSVFVHKDAKD
YRKIYQYNYGATKLAIKRAMKDYPSVDKVMKEKDRATHPIMGFRVYRLWSPPYLQVALDL
TSAEQVKGIIEKLPVRERLLLEAGTPLIKNCGIEIVEEIRKMREESFIIADLKTLDVGRL
EVKMAADATADAVCISGLAPNESVEKSIQEAQRQGIYSIVDFMNVTDIEGKLQSLKYKPD
IALLHRNVDVETAARERGEELETKWGNLSEIKKLVKLVSVAGGITPKTCQEALDKGADII
VVGRYIIRSHDPYHASRDFLEKMPPDPDTMRLILDEDEIVGT
>A0A7C4TQL1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus sp|TrEMBL
MEFRVGEALIGEGYEVAHVDLLIGTKDSPVAAAFANALATLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVRNMEQAELIFGPAQAAVAKAVADAVEEGYIPKERAEDYLIVVSVFIHPMA
KNKHKIYYYNYGATKLAIKRAMQNFPDVGTMLYEKDRSHHPFVGRKLTKLWDPPYLQIAL
DIPDLEEVISVLSQIPESDHIIFEVGTPLVKKYGCEVILKLRDVKPDAFFILDLKTLDVG
NLEARMAADATANAVVISGLAPISTIAKGVSEAKKTGMLAVVDMLNVEDPVKRMDQIVKE
AQPDVVELHRAIDSEQSVPPWSLAKEIRKYRVLVAVAGGIKPENVSEVIAAGADIVVVGR
AITKARDVEGAVRRFMAHLKPDTDQFRIMTDF
>A0A523APY7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobi archaeon|TrEMBL
MEFRVGEALIGEGYEVAHVDLLIGTKDSPVATAFANALATLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVRNMEQAELIFGPAQAAVAKAVADAVDEGYIPREKAEDYLIVVSVFIHPLA
KNKHKIYYYNYGATKLAIKRAMQNFPDVGTMLYEKDRSYHPFVGRKLTKLWDPPYLQIAL
DIPELEEVISVLSQIPESDHIIFEVGTPLVKKYGCEVVLKLRDVKPDAFFILDLKTLDVG
NLEARMAADATANAVVISGLAPISTIAKGVSEAKKTGMLAVVDMLNVEDPVKRMDQIAKE
TLPDVVELHRAIDSEQSVPPWSLAKEIKKYRVLVAVAGGIKPENITEVISAGADIVVVGR
AITKARDVEGAVRRFMTHLKPDTDQFRIMTDF
>A0A7C4CX81|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSSDEYYVGEALIGSGNEVAHVDLIIGSRKGPAGIAFANALTNVSAGHTPLLAVIRPNLP
PKPNTVLVPKVTVKSMEDANKVFGPAQAAVAKAVADAVEEGLIPRDKCEEWVIIASVFVH
PEAKDYRKIYQYNYGATKLAIRRALQGYPSVEKVLKEKDRAIHPIMGFKVPRLWNPPYLQ
VALDLDSFEAVERLLNLLPNRERLILEAGTPLIKACGVGVIGRMRAIRKDAFIIADLKTM
DVGRMEVKEAADATADAVCILGIASKATIERSIHEARRQGIYSILDTMEVEDVIGRVSSL
SVKPDVILLHRSVDVERQAVETGRPLEAYWGDIKGVKERFKCLIAVAGGLTPETAKIALR
EGADIIVVGRYIIRSRDPRRAAEHFLDLMPPDPETMRLILDEDEVVGD
>A0A846QD29|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Nitrososphaeria archaeon|TrEMBL
MADEIFVGEALIGSGDEVAHVDLIVGDKGGPAGIAFTNAFSKLSTGHTPLLSVIRPNLPV
KPSTLLIPKVTVRGMKDANKIFGPAQTAVARAVADAVEEGIIPQEKCEDWVVIASVFIHP
KAENYRKIYQYNYGATKTALRRALQHYPSIDKVLREKDRSTHPIMGFKVQRLWNPPYLQV
ALDLDSTEAAGRVITDLPYRERILLEAGTPLIKKNGVGVIERIREIRKDAFIVADLKTMD
VGRIEVKEAADATADAVCILGAASNESIEKSIQEAQKQGIYSILDMMNVLDPVARLKALK
VKPDITLLHRSVDVETAAREKDRPLETKWGDISEIKKITKMVSVAGGITPKTSNEALSKG
ADIIVVGRYIIRSREPRRAAEDFLQHMPPDADTMRLILDEDEIPGE
>D5WEW0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia atlantica|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVSGEPTASEVVAKKGSVAHPFAPN
>A0A2A2HFX0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera cuniculi|TrEMBL
MYEIGEALIGDGPELAHIDLLIGDKKGPVGTAFATNMASMSVGHTPLLAVIRPNLATKPA
TLIIPKVTVQNLDDASKIFGPAQTAVGRAVADAVEEEIIPKDIVDDIVLMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRALENYPSVDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIQALPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECQKQGIYSILDMMNVSDIPAKLEQLKLKP
NIVLLHRNIDSETMRDNDNEQQSEWGNIKEIKSLLGERGLIAVAGGVTPEKVTTALENGA
DIIIAGRYIIGSSDVRRAAEDFLYYMPQDSDTMRLALDEDEKI
>A0A497IVF1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFKVGEALMGEGGELAHIDLIVGSKSGPVGMAFTNGMTQLSAGHTPLLAVIRPNLPVKPS
TLIVPKVTVENLDQASKIFGPAQTGVAKAIADAMEEGIIQKEEAEDQVIIASVFIHPEAK
DYNKIYRYNYGATKLALKRALIGFPDADTVLYEKDRSIHPVMGFKVTKLWDPPYLQIALD
IPDLDLITHVLSQVPKNDHLIIEAGTPLIKRYGLDVLGKIREIKPDAFIVADLKTLDTGN
LEARMASDLTADAVVISGLAPIETIDKAIEEAKKTGIYAVIDMLNVDDPVEVLRQLKTLP
EVVELHRAIDVELYGEGSHEAWGAIGAIKELGQILVGVAGGITEDTVQLALDSGADILIV
GRAITKSKDVEGACRRFLKALNKEEIDQRRVMTDF
>A0A0E3PU03|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina mazei WWM610|TrEMBL
MGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPSTLIIPKVT
VKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQDYNKIYRY
NYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFDNPNLEFVL
SAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGNLEARMVAD
AAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRG
IDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVR
EMAEQFINSLNKPEIDQFRVMTDF
>A0A2R5F858|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Novimethylophilus kurashikiensis|TrEMBL
MAVIDRVLVGESLVIENRPDGSGLDLLNVAHIDLIIGPRGSAAEEAFCRTLTDQKEGVNG
LLAVVAPNLMTKPATVMFNKVTIKNGRQAVQMFGPAQRGVAMAVMDCVADGTIPQEEADD
VFICVGVFIDHKADIDERIQEWNYRATKEAIKRAINREPKVADVVKSYKDSAHPFAAK
>A0A843ICD1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp|TrEMBL
MYRIGEALIGDGPELAHIDLLIGDKFGPVGQAFATGLSNLSVGHTPLTSVIRPNLMTKPA
TLIIPKVTVGDLDDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDPSAE
DYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDSKEAMAKILNDLPDKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLDVGR
VEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMMNVSDFEDKLSQLPDDL
KPDIVLLHRNVDLETYKAEKGEDVSEMTEWGNIKKIKEILGGGLIAVAGGITPDNVEEAI
DKGADVIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN
>A0A2S6RV63|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Alphaproteobacteria bacterium MarineAlpha6_Bin3|TrEMBL
MFFKRLFNLGGIMAKINKVLVGESLVGDGNEVAHIDLLIGPRGSAAEAAFCNTLTNNKDG
FTSLLAVVAPNLPCKPNTVMFNKVTIKGAKQAVQMFGPAQAAVARAVADSVEDGTIPSGE
ADDVFVSVGVFIHWDAKSDQKIYDYNYQAVKESIERAIKGEPKAKDVVSQKASAEHPFGN
VKV
>A0A1D2UZM0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus sp. 2-GBenrich|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
ALIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A7W8WG81|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sp. WSM4180|TrEMBL
MAKINRVMIGESLVGDGNEVAHIDLLIGPRGSAAETAFCHALTNNKDGFTSLLAVVAPNL
ITKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPQEEADDLFLCVGVFI
HWQAEDDKKIQQFNYQATREAIKRAVTGDPSAAEVVAKKGSVAHPFAPN
>A0A679JY55|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Hyphomicrobium sp. ghe19|TrEMBL
MKNLVFLTGEATVLASEGQYTDAMPEVVIGTVDGPVGHAFAGMMGQSMGHTRFFVIRDLN
QQVRPAALMTSKVTIPNSAYIELFGGVVQGAIGDAIVDCLKDGILPKDKANEICMIITVW
LDPRVADHEELDKKDLYRCQYEATKLAISRAMKGEPTVDELIANRDKIKHYALADVFPG
>A0A0E3Q217|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina vacuolata Z-761|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAGKIFGPAQSAVAKAVADSVEEGVISKDQVEEIVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALKGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQVAFD
NPDIQFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGNIAEIKKIAPKTLVAVAGGVRLDKVPVALSQGADILVVGRA
ITNAKDVREVAEQFINSLNKPEIDQFRIMTDF
>A0A7J4LAS4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Halobacteria archaeon|TrEMBL
MESRDDDFLYLVGEALVGEGDEVAHIDLIVGDKRGAVGEAFANGLVNLSKGHTPLLSVIR
PNLPSKPSTLIVPKVTIRDMNDANKIFGPAQSAVAKAVADCVEEGVIPKKDVERIVIIAS
VFIHPNARDYEKIYRYNYGAAKLAINRAFSSFPDLDTVLYEKDRSINPIMGFYVQRLWNP
PYLQVALDLTDLSRVQEVIEQLPDSDHIIIELGTPLIKRYGIDVISKIREKKPGIFIVAD
LKTLDTGNLEARIVANASGDAIVISGLAPIKTIEKAISEAKKTGIYSVIDMLNVKDPIDV
LSRLTIKPNVVEIHRAIDNESVEKEDWVVVKEIKNKFKNILVGVAGGLKPENVQKALDSG
ADILIVGRGITASKDVEGETRKFLKSLKAEEIDQYRVKTDF
>A0A7C4FAY1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
FGPAQTAVAKAVADAVEEGIIPIDKCEDWVIIASVFVHPKAKDYRKIYQYNYGATKLAIR
RALQGYPNALKVLKEKDRAIHPVMGFKISKLWNPPYLQVALDIDSLEQVEKIVKELPVRE
RLIYEAGTPLIKAYGVYNVIDKIREHRRDAFIIADLKTMDVGRMEVKEAADATANAVCIL
GVASKATIERAIQEAKKQGIYAVLDMMEVKDVKARLETLSVKPDIVVLHRSVDVEREIAE
RGLKPETEWGDIRGVKEEFKCKVAVAGGITPETAVKALEGGADIIVVGRYIVRSRDPRRA
AEQFLDQMPPDADTMRLILDEDEVIGE
>A0A7C5JZL6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTEAARKEVEARSLLSGKPAKPTVSGTAKVLGVHRDTLYSWLKEFNVDFEKATEGVSAV
EVSEVRQPTTRYTYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFANGLTHLSMGHTPLL
AVIRPNLPPKPHTLLVPKVTIKNLEDANKVFGPAQAAVAKAIADAVEEGIIPRDKVDDWV
VVCSVFVHPKASDYRKIYHYNYSATKLALKRALAKYPSLEKVFYDKDRAKHPMLGYRVPR
LWRPPYLQISLDIPDFERTKKIITQIPRSDRIILEAGTPLIKRYGAKVISDLREVAKDIF
IIADLKTLDVGKVEVDIAYEETADGVIAAGLASTETLDAFIYEAKRLGIYAAIDMLNVED
PVKKLKALRDFPDIVIIHRGIDEETGKTVGLELIQELRQAFRDKKFLIAVAGGIIPETAK
EALEKGADIIVVGRYVTQSRDIERAVREFLELTPEMREDIDVYRVHVE
>A0A550GIP0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSDEKGLVRAPGRITQEQYKFLEGLVEQGRYASISEALRGAINRFNLTASSPGGSFLIGE
ALVGEGNEIAHIDLMIGDKSGPVGTAFAQSLSQLSMGHTPLLAVIRPNLPPKPHTVIVPK
VTVKNMEDAGKIFGPAQSAVAKAVADAVEDGIIPREVVDDWVVVVSVFIHPKASDERRIY
QYNYSATKLSISRALESYPSLDKIMYDKDRARHPLMGFRPPRLWRPPYLQIALDNPNIDS
ILSVVKSVPKNDNVLFEAGTPLLKRYGVEVIKRIREAQKDSFIIADLKTMDVGKVEVDMA
FEQTADAVCCAGAASSATIDDFIYECSRMGIYSFVDMMEVGDPVAKLKKLQRPPDGVILH
RAIDVESSGVEISWGNISKIKEAFPERRVLVAVAGGIRPNTAQIALDAGADILIVGRYIT
QSRDVERSVRNFLSLLQGDIDLFRVHTE
>A0A523SRX0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKEFGVNFEDVEERKPTFIEAVERREKPTYLIGEALMGEGSEVAHVDLMIGDKDGPVGAA
FANGLSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNFEQTEKIFGPAQAAIAKAVAD
SVEEGIIPEDKVDDWVIVCSVFVHPKAEDYRRIYQYNYGATRLSLKRALAQYPPLKKIMY
DKDRAKHPIMGFKVPRLWRPPYLQIALDIPSLERTKKIISQLPKSDRIILEVGTPLLKKY
GVKVIRDLRETARDVFIVADLKTLDVGKVEVDLAFEETADAVVASGLAAAGTLNKFIYEA
KKLGIYAVVDMMNVEEPVKKFQSLTEFPDIVILHRAIDVEKTGKPRWYLIKEFRRVFRDK
KFLVAVAGGITPETAPEAFAEGADIIIVGRYITQSRDVEHSVREFLECTREMKRDIDLFR
VHVE
>A0A539CT45|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Beijerinckiaceae bacterium|TrEMBL
MGILSMAKISKLCVGESLVGDGNEVAHIDLIIGPRGSAAETAFATALTNNKDGFTTLLAV
VAPNLLVKPATILFNKVTIKNATQAVQMFGPAQHGVAKAVADSVAAGVIPVGEADNLFIC
VGVFIHWDAKDNQKIQDFNYQATKESIARAINGEPTPAYVVAQRNIAKHPFAPN
>A0A2V3JIJ5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MQVGEALVGEGAEVAHIDLLVGEKNGPVGTAFTNAMSQMSAGHTPIFAVIRPNLPVKPST
LIVPKVTVRNMKEAERIFGPAQSAVAKAVADSVEEGVIPKEKAEELVVIVSVFLHPQAAD
YNKIYRFNYGAAKLAVKRAMTGFPDIKKVLYEKDRSRHPALGLKVTKLWDPPYLQVALDI
PSWKQMERVVSELPQNDHLIIEAGTPLIKRYGVEIVGRIKEIKPETFVVADLKTLDTGNL
EARMVSDAGADAVVISGLAPLQTIEKAVAEARKTGIYACLDMLNVASPLELLEKLSSGEE
GASGGSISGGSIPDVVELHRAIDVEQAERHAWGNIAELKRIGRGSSSGSSGGKMLVAVAG
GIREENAAEALKGGADILIVGRGITNSRDVEAVARRFLRLMKEEIDQYRVMTDF
>A0A8D6SVK6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus sp. SG7|TrEMBL
MIKFGEAVLGNEIKAIVNVSIGKGKDIDNIFTNALTRGNCVFANLRPNLIVKPLTLVVPR
HNIESNIQDELFQGVIQYAVAKAVADLDLDEDLKIVVSINVPELPITNLTKRKLFQYFYA
STKLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
HNIPKSDHIILEAGTPLIKKFGLEVIEIMREYFDGFIVADLKTLDTGRVEVRLAFEATAN
AVAISGLAPKSTIIKAIHECQKCGLISYLDMLNVSNPQKLYDSLKLKPDVVILHRGIDEE
TFGIKKEWKFEGNCLLAIAGGVGIENIEELLKEYQILIVGRAITKSGDPGRVIRMFINKM
GYDIDTYRLYFDEDEDIEY
>A0A6J5A8P1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia phenoliruptrix|TrEMBL
MSVSADKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSEFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSAN
WVNTATDDLDAVFDNNYRACKNAILAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A832YR83|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermococcus okinawensis|TrEMBL
MLKFGEGVLGRDITAIVNVVLGKGETIDTVFTNALTRVPTPILANLRDNLIVKPLTLVVP
RNTLNSDIQCNLLHGPIQYGVAKAVVDLDLDGDLKLIVTVSVPDVPYTTLNKRKLFQYYY
GATRLAISRALNDYPSKEKIKREKYRALHPLVGFRDIRLERPPYLQVALDVPSMENVEYV
LESLPPSDRIIVEAGTPLIKKYGIEVVERIREIYDGFIVADLKTLDTGRVEVRMAFESTA
NAVVLSGTAPRETILKGIHECERCGIMSYLDTINVRDPFGLYNSLELKPDVLLLHRAIDE
EEKVPMKEYRDVKRREKLLLGIAGGVTLENIEKLKNRYHIIVVGRGITKSRDPGRVARAI
VNKLGDDIDQYRLYLEEDEDVPIR
>A0A3Q9JC84|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Microbacterium oxydans|TrEMBL
MTSTIQLGESFVGDGVNAAHINTVLGHREGPAGTAWATALASPSQGHVPFVAVLRPSLPV
KPLTLFVTKAAPAGDEHGLLIWGPAQAGVAAGVADAVADGVIPREAADTHALIAAVWVNP
AADDADTVYRNNREATRTALANGAAGLPKLDAVLEARHAPTNPFYTPSTASA
>C9RHI2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)|TrEMBL
MIKFGEAVLGNEIKAIINVALGNDKEINEIFTNALTRGNCVFANLRPNLIVKPLTLVVPR
HNIESDIQDELFQGVIQYAVAKAVADLDLDENLKVVISVNVPEVPITNLNKRKLFQYFYA
SAKLAINRALNEYPSKEKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
QTIPKSDHIILEAGTPLIKKFGLEVIEIMREYFDGFIVADLKTLDTGRVEVRLAFEATAN
AVAISGVAPKSTIIKAIHECQKCGLISYLDMMNVSEPQKLYDSLKLKPDVVILHRGIDEE
TFGVKKEWKFKGNCLLAIAGGVGVENVEELLKEYQILIVGRAITKSRDPGRVIRMFINKM
GYDIDTYRLYFDEDEDIGEEL
>A0A524ESX7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKVEYYVGEALLGSEENLAHVDVILGSKDGPVGISFANAISAPSMGHGGLLACIRPNLL
PKPYTIIIPKVTVVKMEDANKIFGPAQAAVAKAVADSVEEGIIPMNKIEDWLIIVSVFIH
PEATDYRKIFQYNYGATKLAIQRALKAYPPIEKIFYDKDRAKHPIAGMRVPRLFRPPYLQ
VALDAPDLEKQLKVIQKLPKSDRIILEVGTPFLKKYGMDAIKRIREVAIDKFIVADLKTL
DVGKLEVDFSFDATADAVVCSGLASSSSIDKFLLEAHRLGIYGFVDTMEVSDPIAKMKSL
KQVPDVVILHRAIDVEQDIEAQSPDAAQKARWALVPKIKSAFADQKLASGRDRVLVAVAG
GIEPESAKYALDMGADILIVGRFIASAKDVENAMRRLLNIIPGYSDINLKRVHEEDDDES
IKKSTWD
>A0A839NUD6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylobacterium sp. R2-1|TrEMBL
MAKITKVQVGEALVGDGNEVAHIDLIIGPRGSPAETAFCNGLVNNKHGFTSLLAVIAPNL
PCKPNTLMFNKVTINDARQAVQMFGPAQHGVAKAVQDAVAEGIIPADEADDLYILVGVFI
HWEAADDAKIQKYNYEATKLSIQRAVNGEPKASVVTEQRNSAQHPFAANA
>A0A1H7F4Z6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter gottschalkii|TrEMBL
MDPMYKIGEALIGDGPELAHIDLLIGDKFGPIGQAFANGLSNLSVGHTPLTSVIRPNLMT
KPATLIIPKVTVGDLDDAGKIFGPAQTAVARAVADAVEDGYIPKEIVEDIVINVSVFIDP
SAKDYRKIYQYNYGATKLAIRRAMEDYPSIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQV
ALDLDNEDAMERIINDLPDNDRILLEAGTPLVKKFGVGIIGKIRALRPDAFIIADLKTLD
VGRVEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAGFEEKLAKLP
KDLKPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKSMLGDKGLVAVAGGIRPNNA
EEAIEKGANIIIAGRYIIGSKDVRRAAQDFLEHFEPDPDNMRLAMDEDENIEVKDD
>F4BSV0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)|TrEMBL
MFLVGEALIGKGPEVAHIDLIIGEKEGPVGTAFASGLTQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMDQAAQIFGPAQTAVAKAVADSVAEGVIPKDRAEELLVIVSVYIDPKAT
DYDAIYRYNYGATKLAVARAMAGFPDIDKVLYEKERSTHPIMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPDSDHILIEVGTPLVKMLGMSVVKEIRAIRPGAFIILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTIELSINEARKTGIYSIIDMLNVTDPLAVLKGLDVLP
DVVELHRAIDMEKSAHAWQNIPDIKALAEEGRRLLVAVAGGIRTDTEGAALAAGADILVV
GRAITRSRDIRDMAEQFLTGLKQTEIDQYRVMTDF
>A0A8G1A1B3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanofollis formosanus|TrEMBL
MYLIGEALVGTGAELAHIDLVMGDKNGPVGMAFANGMSQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKTGEQVNEIFGPAQAAVAKAVADSVEEGVFEGIDLDETVILASVFIAPDAE
DYSKIYRYNYGATKLAIRRAIQKFPDTETLLYEKDRSTHAVMGFKVQRLWNPPYLQVAMD
LVDMAKVEAVLTAVPKNDHVLFEAGTPLIKQFGLNVLSEIRKIRPDAFIIADLKTLDTGN
LEARMASDAGADAVVISGLAPTATIEKAIEETKKTGIYSVIDMLNVADPVALIKELKVKP
DIVELHRAIDTEGDEYSWGNIPAIKEAAGGKLLVATAGGVRQHVVRKALDSGADILVVGR
AITASKDIGHAADEFIERMDNPEIDQFRIMTDF
>A0A842LAN7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacteriales archaeon|TrEMBL
MYRIGEALIGKGNEVAHVDLIIGDKEGIVGSAFATGLTNISIGHTPLLSVIRPNLMTKPA
TLMIPKVTIGCLEDANKVFGPAQTAVARAVADAVEEGIIPKEKVEDLVIIVSVFIHPEAE
DYQKIYHYNYGATKLAIRRAMESYPSIEKILSEKDRGVHPVMGFKPIRLWNPPYLQVALD
LESIEEMERVVDTLPPRERILLEAGTPLVKKFGVGIVDKIRKLRKDAFIIADLKTLDVGR
MEVKMAADETADAVAISGLATKATIEKAVHEARKQGVYSVLDMMNVENIPEKLEELRYKP
DIVLLHKNIDVGAAEVSEWGDIPKIKEIIGERGLVAVAGGITPSKTKKALESGADIIVVG
RYITGSKDPRRAAEDFLEQLPPDPDTMRLPHEEDEPI
>A0A1L9C5H5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus portucalensis FDF-1|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
TLIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEEADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAVDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLNELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGANILVVGRA
ITNSKDIRQSAEQFVEGLNKPEIDQFRVMTDF
>A0A4U8Z2L2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylocella tundrae|TrEMBL
MGGFFNVTKINKLLVGESLVGEGNEVAHIDLLIGPRGSAAEAAFANALTNNKDGFTTLLA
VVAPNLLVKPATVLFNKVTIKNATQAVQMFGPAQRGVAKAVADSVADGVIPIKEANDIFI
SVGVFIHWEAKDDQKIQDYNYQATKEAIARAINGDPTPETVVAERNTAKHPFAPN
>A0A822J1H1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MFLIGEALIGEAPEVAHIDLMIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGVIPKDQVEDLSIVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIEAVKNILKQVPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNSFIVADLKTLDTGN
LEARMVADATADAIVISGLAPISTIEKAIIEARKTGIYAVIDMLNVDKPLSVLKALSVKP
HVVELHRAIDTEGKSEHAWGDISAMKKLSERLLVAVAGGIRVDTVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>A0A822JBA8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MNSLAMPREGHTPLLAVLEPNLQPKPCTLMVNKVTIKNADQAVLMFGAGQAAVAKAVIDS
VEEGVIAKSDA
>A0A062V384|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedens nitroreducens|TrEMBL
MFLVGEALIGEEPELAHIDLIIGEKTGPVGQAFANGFTQLSMGHTPLLSVIRPNLIAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSIQEGVIPEDQVEDLAIVVSVFIHPEAK
DYNKIYRYNYGATKLAIDRAMRGFPDTKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAID
IPDIDAIKNIIKQIPQSDHLIIEAGTPLIKRYGVNVVQSIREVRPNAFVVADLKTLDTGN
LEARMVADATADAVVISGLAPVTTIEKAIKEAKKTGIYAIIDMLNVGDPLALLKKLSIKP
DVVELHRAIDTENRVEHAWGDIPAMKELSERMLVAVAGGIRVDTVKEALRSGADIIVVGR
AITKAKDVRFMTEQFLEELKQPEIDQYRIMTDF
>A0A0P9E712|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon BA2|TrEMBL
MSDIQRNHFAIPTCFYISSVSLLIESDVVSEFDGKKPESREEFIRLLRAAKEKETEMRVA
RKMRSTKPTVSGTAKIMKVHRDTLYEWMKEFNVIFEDVAVGELAPAEVVKKREEFTYLIG
EALTGEGSEVAHVDLIIGDKAGPVGEAFANSLSNLSVGHTPLLAVIRPNLPPKPHTLLVP
KVTVKNMEQAGKIFGPAQAAVAKAVADAVEEGVIPEDKLEDWLIICSVFVHPNAKDYRRI
YQYNYGATKLALRRALAKYPPLKKIMYDKDRAKHPIMGFKVPRLWRPPYLQIALDIPSVE
RTKKIVSELPESDRIILEVGTPLLKKYGVKVIRDLREVARDVFIVADLKTLDVGKVEVDL
AFEETADAVVASGLAATETLDKFIYEAKRLGIYAVVDMMNVEDPVRKLQPLESFPDIVIL
HRAIDIEEKTGKTSWDLIKEMRQTFKHEKFLVAVAGGITPETAPEALANGADIIIVGRYI
TQSRDVERVARDFLKCTREMALDIDLFRVHVE
>A0A2I0QE19|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon HGW-Altiarchaeales-3|TrEMBL
MYKIGEALIGKDNEIAHIDLMVGTKDGPVGQSFANGMVSLSQGHTPLLGVIRPNLPPKPH
VLIVPKVTIKDMTDAGKIFGPAQAAVAKGVADAVAEGVLKDYNLDDIVIIASVFIHPDAK
DYRKIYQYNYSATKLALRRAISDYPSLEKIMFEKDRATHAIMGFKVPRLPKWNAPYLQIA
LDVGSFAAAERVIKELPMSDKLLIEIGTPLVKAEGVKVINEIRKHCPNSFIIADLKALDV
GDVEVDLAFDATADAVVVSGLGSKVMIEEFICEAEKLGIYSMVDTMNVKNSAGELNPMEM
LKTLNKLPDIVLLHRGIAGEKALPRDALWGFVREIKEYGNTQGKELIVGVAGGIEAHNVR
DAVEKGADIVVIGRAITQARDIRRSTEDVLRQLGGDIDLKRVHKMTD
>A0A368PEG5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon|TrEMBL
MMLIGEALIGEAPELAHVDLIIGEKNGPVGQAFATGMTQLSGGHTPLLSVIRPNLLTKPA
CLIVPKVTVKNMEQAALIFGPAQAAVAKAVADAVEDGVVPTDQAEELVIVASVFIHPDAK
DYNRIYRYNYGATKLALKRAMEGFPGIETVLDEKDRGAHAIMGFKVSRLWDPPYLQVALD
NPDIDQILHVVETLPDSDHLILEAGTPLIKRYGVDVIARLREAKPNAFIVADLKTLDTGN
LEARMVADATADAVVISALAPIPTIVNAIKEAHKTGIYAIIDTLNLPDPMPKLRELGELG
ALPDVVELHRAIDAEKTEHQWGSIPAIKALSDKILVAVAGGIRADTIQDAKDAGADILVV
GRAITNAKDVRQAAEMFIEGLSKEEIDQFRVMTDF
>A0A6B9TH61|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter sp. THM-2|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFANGLTSLSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVSCLEDADKVFGPAQTAVARAVADAVEEGIIPEEKVEDLVVIVSVFIHPEAE
DYRKIYQYNYGATKLALRRAMENYPSARKVLSEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMDEMERIIDALPNRERILLEAGTPLVKKFGVGVVSRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLRYKP
DIVLLHRNVDLETLRAERGEDVGEMSEWGNIREIKDILGPRGLVAVAGGITPSKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDESI
>A0A832P7Q4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp|TrEMBL
MFQIGEALMGQGAELAHIDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQASKIFGPAQSAVAKAVADSVEEGIISKDQVEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALRRALDNFPDINTVLEESNKSTHAIMGFKVTRLWNPPYLQIAFD
NPNLEFVLSAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
DVIELHRGIDIETTEHAWGNIGEIKKVAPKTLIAVAGGVRLDKVPVALNQGADILVVGRA
ITNAKDVREAAEQFINSLNKPEIDQFRIMTDF
>A0A0E3WSI2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina horonobensis HB-1 = JCM 15518|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISDIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPVSVLKQLKIMP
DVIELHRGIDIEGTEHAWGNIAEIKKIAPKALVAVAGGVRLDKVPVAIAQGADILVVGRA
ITNAKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A843D592|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum sp|TrEMBL
MFLIGEALVGDGAELAHIDLMIGDKNGPVGSAFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIVPKVTLKHGEQVTQIFGPAQAAVSKAIADALEDGVFDGIDIEENVIVASVFIDPSAK
DFNKLYRFNYGATRLALSRALDKFPDAATVLKEKDRAAHGVMGFKVHRLWNPPYLQVAMD
LVDMKQVERVLTSVPQNDHVIFEAGTPLIKQFGLSVIGEIRKIRPNCFIVADLKTLDTGN
LEARMVSNAGGDAAVVSGLAPIETIAAFIKEAKKCGIYAIIDMLNVEAPAKLIEKLGEMG
GKALLPQYVEMHRAIDKEASGEYSWGDILKIKEVGQKYGAKILVATAGGIRQPVVKKAIA
AGADIVVVGRAITASKDIKNAAESFLAELDSEEIDQFRVMTDF
>D2ZP19|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter smithii DSM 2374|TrEMBL
MYNIGEALIGDGNELAHIDLIIGEKEGPVGQAFANGLSNLSVGHTPLTTVIRPNLMTKPA
TLIIPKVTVGDLDDAAKVFGPAQTAVGRAVADAVEEGYIPKDIVEDIVINVSVFIDPSAK
NYRKIYQYNYGATKLAIRRAMEGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALD
LDNLDAMERIINDLPDKERVLIEAGTPLVKKFGVGVVGKIRELRPSAFIIADLKTLDVGR
VEIKMAADETADAVAISGLGTIESIKKAIHETQKQGIYSILDMMNVADFEEKLSALPDDL
KPDIVLLHRNVDLETYKAEKGEDTSEMTEWGNIKSIKKLIGDGLVAVAGGITPNKVEEAT
SKGADIIIAGRYIIGSRDVRRAAEDFLAHFPQDPDSMRLALDEDEQVN
>A0A8D6PV05|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocaldococcus sp. SG1|TrEMBL
MIKFGEAVLGNEIKAIVNVSIGKGKDIDNIFTNALTRGNCIFANLRPNLIVKPLTLVVPR
HNIESNIQDELFQGVIQYAVAKAVADLDLDENLKVVVSVNVPELPITNLTKRKIFQYFYA
STKLAINRALNEYPSREKVKKEKYRALHPLVGFRDVRLEYPPYLQIALDVPTMENLEFLL
QNIPKSDHIILEAGTPLIKKFGLEVIEIMREYFDGFIVADLKTLDTGRVEVRLAFEATAN
AVAISGVAPKSTIIKAINECQKCGLISYLDMMNVSEPQKLYESLKLKPDVVILHRGIDEE
TFGIKKEWRFKGNCLLAIAGGVGIENVEELLKEYQILIVGRAITKSRDPGRVIRMFINKM
GYDIDTYRLYFDEDEDVGEEL
>A0A257M7X1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. ASP1-1|TrEMBL
MIVSVFIHPQAKDYDAIYRYNYGATKLALERAMAGFPDVDLMLYEKDRSTHPIMGFRVTR
LWDPPYLQVAFDLVDVAEVRRVLAALPESDHILIEVGTPLVKMLGISVVKEIRAIRPGAF
VILDLKTLDTGNLEVRLAADSTADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVPD
PLAVLKGLEVLPDVVELHRAIDMEKSAHAWSNIGEIQALAKDGRRLLVAVAGGIRVDTEA
AALAAGANILVVGRAITRSKDIRDMAEQFLTGLKQTEIDQYRVMTDF
>A0A2A2HIF3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocorpusculum parvum|TrEMBL
MFLIGEALVGDGAELAHIDLMIGDKNGPVGMSFANGLTQLSAGHTPLLGVIRPNLLPKPA
VLIVPKVTLKHTEQVTQIFGPAQAAVSKAIADALEDGVFEGMDVEENVIVASVFIDPSAK
DFNKLYRFNYGATRLALSRALDKFPDVATVLKEKDRAAHGVMGFKVQRLWNPPYLQVAMD
LVDMKQVERVLTGVPQNDHVIFEAGTPLIKQFGLSVINEIRKIRPNCFIVADLKTLDTGN
LEARMVSNAGGDAAVVSGLAPVETIAAFIKEAKKCGIYAIIDMLNVEEPAKLIASLGKMG
GAALLPQYVEMHRAIDKESCGDYSWGDIMKIKEVAKTYNAKILVATAGGIRQPVVKKALA
AGADIVVVGRAITASKDIKNAAESFLEELDSEEIDQFRIMTDF
>A0A7Z7FE43|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolobus vulcani|TrEMBL
MLLIGEALIGEEPELAHVDLMIGNKDGPVGQAFANGLTQLSAGHTPLLSVIRPNLPTKPA
TLIVPKVTVKNMDQAAQIFGPAQAAVAKAVADALEEGAFGDLDPEDLVVIASVFIHPEAT
DYNRIYRYNYGATKLAVKRAVDGFPDIDTVLKEKDRMGHAIMGFKVSRLWNPPYLQVALD
NPNLPAILNIVNQIPKSDHVILEAGTPLIKRYGVDVVSKLREIRPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPIATMNKAIEEAHKTGIYAIMDTLNCDDPVAVLKQLDVLP
DVVELHRGIDIEETEHAWGNIDAIKALSPKILVAVAGGVRIDTMPAALKAGADVLVVGRA
ITNAKDVRQVAEKFIEGLNNPEIDQFRVMTDF
>A0A523VW12|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MKTKVAIEKPTYLISEALVGKGDEVAHIDLLIGDKEGPVGEAFASGMSHLSAGHTPLLAV
IRPNLPPKPHTLIIPKVTVKNLDEVGKIFGPAQAAVAKAVADSVEDGVIPKDKVEDWVIV
CSVFIHPNAKDYRKIYHYNYGATKLALKRALTGYPSLDKIMYDKDRARHPIMGFKVPRLW
RPPYLQIALDIPHLEKIKRIIQELPESDRIILEVGTPLLKKYGVRVIRDLRAITRDVFII
ADLKTLDVGKVEVDLAFEETADAVVAAGVAAKETLNHFIYEAKKLGIYAIVDMMNVDDPV
KKLRTLKELPAVIILHRGIDAETGRVHGLEHIQELKQAFAGHKFLVAVAGGIRPDTAKEA
LEKGADILIVGRYVTQSKDVKRSAREFLELTRAMGEDVDLYRVHVE
>A0A550GJP4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MPTTASNDAEISEKTYLIGEALVGDGNEVAHIDLLVGDKNGPVGKAFATGLSNLSAGHTP
LLAVIRPNLPPKPHTLLVPKVTVKNMEDTGKIFGPAQAAVAKAVADSVEEGIIPADKIDE
WVIICSVFIHPQASDYRRIYQYNYGAAKMALQRALKKYPSLEKINYDKDRAKHPIMGFKV
PRLWRPPYLQISLDAPSLEGAKRVISQLPGSDRLIIEVGTPLIKRYGTRVIGDLREIAKD
TFMVADLKTLDVGKVEADIAYEDTADAVVAAGLAPSETLNAFVHEAKRLGIYAVIDMLNV
EDVLEKLQSLKQLPDIVILHRGIDQESGRTCGLERIQMMRKAFPDKRFLIAVAGGIVPET
AKEALEQGADILIVGRYITQSKDIERATRDFLELTPSMREDIDLFRVHTE
>A0A497MD27|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYCRGACLEEGFYVGEALVGSGYEVAHVDLVIGSKRGAAGIAFVNALSQLSAGHTPMLAV
IRPNLPAKPNTVIVPKVTVKTMEDADKIFGPAQAAVAKAVADAVEEGLIPRDKCEDWVVI
ASVFIHPKAKDYRKIYQYNYGATKLAIRRALKGYPSAEKVLKEKDRAVHPIMGFKVRRLW
NPPYLQVALDLRSVDRALEVVKLLPKRERLILEAGTPLIKAQGVGVVEKIRSVWRDAFIV
ADLKTMDVGRVEVKEAADATADAVCILAVASDTTVDKAILEAQKQGIYSVLDMMEVSDPI
ARLERLTYKPDIVLLHVSADVERAAAEAGKPLETRWGNISEIKRRFKVLVAVAGGVTPIT
AGEALRSGADIIVVGRYIVRSGDPRRAAEQFLDLMPPDPDTMRLILDEDERVGEI
>A0A497KY78|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSEAVRAALEHFRRAYASPRGVYLIGEALVGEGDEVAHVDLIIGDKSSPVGEAFARALSN
PTMGHTPLLAVIRPNLPSKPFTLIVPKVTIRNMEDAGKIFGPAQMAVAKAVADAVEEGII
PREVVDDWVIVASVFIHPKARDMRRIYHYNYSATKLALRRAMMGYPPLEKIMYEKDRAKH
PLVGFRAPRLWRPPYLQIALDIPDIEAVKRVLRAMPRSDSIILEAGTPLIKRYGVRVIRE
IREVVGDSFIVADLKTLDVGKVEVDLAFNETADGVCASGLASKETLDGFIYEARRLGIYS
YIDMMEVENPVEKLRSLEKLPDVVILHRAIDVEGRGEGPRWSYIKEIREAFKDERLLIAV
AGGITPQTAPRALEMGADILIVGRYITQSRDVERAVREFMPYLRGDIDLFRVHVE
>A0A2E8ED87|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSEAVRAAIDRFSVSSSYKGGALLIGEALVGKGDEIAHIDLMIGDKQGPVGYSFAQSLSH
LSAGHTPLLAVIRPNLTPKPHTVIVPKVTIKNMEDAAKIFGPAQSAVAKAVADAVEDGII
PMAILDDWVVIVSVFIHPKAKDERRIWQYNYSATKLALSRALQAYPPWEKIQYDKDRVKH
PLMGFRPPRLWRPPYLQIALDNPNIEMIKQVIKNVPRNDNVILEAGTPLIKRYGVQVIRE
LRKIRKDSFIIADLKTMDVGKVEVDMAFEETADAVCCAGAASSATIDEFIYEARRLGIYS
FLDLMQVDDPVEKLKGLKKIPDGIIFHRPIDTEHRGAEVRWGYISKIREAFRDSKLLIAV
AGGIRPDTAQFALEAGADILIVGRYITQSKDVERSVKEFLPLLQGDIDLFRVHIE
>A0A7C5TD76|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MYLIGEALVGEGNEVAHIDLLIGDKDGPVGEAFASGLAHLSMGHTPLLAVIRPNLPPKPH
TLLVPKVTIRNMEEANKIFGPAQAAVAKAVADAVEEGIIPKEKVDDWVIVCSIFVHPKAS
DYRKIYHYNYSATKLALKRAMAKYPPLEKVFYDKDRAKHPILGYRVPRLWRPPYLQISLD
IPDLERTKKVITQIPRSDRVILEAGTPLIKRYGTRVISELREVAKDVFIIADLKTLDVGK
VEVDIAYDETADGVIAAGLAPTETLDAFIYEAKRLGIYAAVDMLNVENAIEKLKTLKEFP
DIVIIHRGIDEETGRTVSLELIQELRQTFKDKKFLIAVAGGIIPETAKEALEKGADIIIV
GRYITQSRDIERAVREFLELTPEMREDIDVYRVHVE
>A0A550G994|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MSGTDTKKPETQEELVRIVAEAAKKSVKSRIAQKHVSTKPTISGTAKALNIHRDTLYTWL
KEFDVDFKEISDCIPTNISNNAATLGETYLIGESLVGEGNEVAHVDLLVGDKNGPVGKAF
ANGLSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVTVKNMEDTGKIFGPAQAAVAKAVADS
VEEGVIPADKVDDWVIICSVFIHPQASDYRRIYQYNYGATKMALKRALKKYPSLEKINYD
KDRAKHPIMGFKVPRLWRPPYLQISLDAPSLEGAKKVIAQLPGSDRLIIEVGTPLIKRYG
TRVITDLRQVTKDAFMVADLKTLDVGKVEADIAYEDTADAVVAAGLAPPETLDSFVHEAK
RLGIYAVIDMLNVEDVLEKLKGLKNFPDIVILHRGIDQESGRTCGLERIQMMRKAFPDKK
FLIAVAGGIVPETAKEALAQGADILIVGRYITQSKDIERATRDFLELTPSMREDIDLFRV
HTE
>A0A7J2TF52|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MPFTDECVEESGPTYLIGEALLGEGSEVAHIDLLIGDKNGPVGQAFATSLSNLSAGHTPL
LSVIRPNLPPKPHTLLVPKVTVKNMEDAGKIFGPAQAAVAKAVADAVEEGIIPREKVDDW
VIICSVFIHPQASDYRKIYQYNYGATKLALRRALNKYPSLDKMLYEKDRAKHPIMGFKVP
RLWRPPYLQISLDPPELDKAKKVLSQMPGSDRIIIEVGTPLIKRYGTRVINELRQVAKDA
FMIADLKTLDVGKVEVDIAYEDTADAVVAAGLAPPETLDAFVHEARRLGIYGVVDMLNVE
DPIGKLKQLKEFPDMIVIHRGIDQETGKTLGLDLIPKLRQTFPDKRFLIAVAGGIVPETA
KEALEKGADVIIVGRYVTQAKDVERAVREFLELTPAMREDIDLFRVHTE
>A0A3R7EIJ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Syntrophoarchaeum sp. WYZ-LMO15|TrEMBL
MFKVGEALVGEGAELAHVDLVIGSKSSPVGIAFANSMAQLSAGHTPLFAVIRPNLPVKPS
TLIVPKVTIKNLDQASKVFGPAQTGVAKAIADAMEEGIIQKDEAEDQVIIVSVFIHPDAK
DYNKIYRYNYGATKLALKRALSGFPDADKVLYEKDRSTHPVMGFKVTKLWDPPYLQVALD
VPDWDLTSRVLAQIPKNDHLILEAGTPLIKRYGLDVITRIREIKPDAFIVADLKTLDTGN
LEARMAADLTADAVVISGLAPIETIDKAIEEAKKTGIYAVIDMLNVEDPVEVLKRLKTLP
EVVELHRAIDVELYGEGSNYAWGDIGAIKSLGDILVGVAGGIREDTLEIALKSGADILIV
GRAITKSKDVEAACRRFLRGLKKEEIDQYRVMTDF
>A0A0E3P0E8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina siciliae T4/M|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNLDQAAKIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVVVASVFIHPEAQ
DYNKIYRYNYGATKLAIRRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQVAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGVDVISRIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKAMP
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDVREVAEQFINALNKPEIDQFRVMTDF
>A0A3N5X4X0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon|TrEMBL
MYLVGEALIGEGAEIAHIDLVIGEKEGPIGAAFANAVSQLSMGHTPLLAVVRPNLLTKPV
TLVIPKVSLKNVTQVNQMFGPAQAAVAKAVADLVEEGVFDAMDIESIVILASVFIHPEAK
DYNRIYRYNYGATKLAVSRAIEGFPDKKTLVYEKDRAAHAIMGFKVQRLWDQPYLQVAMD
LVDMNRVAAVLKALPENDHLIIEAGTPLIKRFGLSVISEIRKMRPNAFIIADMKILDTGN
LEARMAADASADAVVCSGLAPISTLEKAIKEAKKTGIYSVIDMLNVPDPVKLIKQLSIKP
DIVELHRAIDTEGQAHGWGDIPALRKAGGPRMLIATAGGIRVNVVRTAIESGANIIVVGR
AITASKDVHHAAEEFLEQMSKEEIDQFRVMTDF
>A0A3M1REJ0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon|TrEMBL
MIDGGFAIGEALVGEEPEIAHIDLVVGRKDGPIGSAFASSLAQPRMGHTPILAVVRPNLP
VKPATLIVPKVTIRDLEGAERIFGPAQSAVSKAVADAVDEGILPRESVEELAIIVSVFIH
PRGKDYQRIYRYNYAATKLALKRAVEGFPGIDVVLEEKPKAAHEMIGFRINNLEQPPYLG
VELVHDDWRRVEGILRALPRKDGIILKAGAPLIKRYGVEVCQKIHQIRPETVVIADMKSL
DTGNLEARMAGDATADVAVFSGRAPLKTMERFIEEAHKVGALAYMDTINVEDPLEVINQL
QMKPDIVELHATGEKSRIARIKEACGPRSLVAVAGEFEVDEAKRLRDAGADIIVLGETIT
EAGDINKTATDYLQGLGIYEVDQFRIMTDF
>A0A7C0ULP0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Euryarchaeota archaeon|TrEMBL
MTSQSFSIGEALIGEAPEIAHIDLIVGSKNGPVGQAYATSLAQPRMGHTPIMAVIRPNLP
VKPATLIVPKVTLRDLEAAERIFGPAQSAVAKAVADAVDEGTIPREQAEELAIIVSVFIH
PRGKDYQRIYRYNYSATKLALKRAMAGFPDINVVLEEKPKATHAMIGFRINNLEEPPYLG
VELVHDDWRRIEGILRDLPRKDGIVIKAGAPLIKKYGIEVCQKIHEMRPESVVIADMKSL
DTGNLEARMAGDSTADVVVFSALAPLKTQERFIKECRTIGVLSYMDTINAADPLEIINRL
EVKPDIVELRGKPTADLIAKVKEACGKRALVAVAAEVDPAGAKEAVESGAAIIMVGETIT
ESAEINRTASSYLEELGIYEVDQFRVMTDF
>A0A0N8PWI9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon BA1|TrEMBL
MSELYGKKPKNREDFIKLLRAAVEKEVEMRKARKAVLIKPTISGTAKMMKIHRDTLYEWM
REFGVQFEDVSGVEPTIEVMEKRGKFMYLIGEALMGEGDEVAHIDLIIGDKEGPVGEAFA
NSLSNLSAGHTPLLAVIRPNLPTKPHTLLVPKVTVRNLEQAGRVFGPAQAAVAKAVADAV
EEGVIPKDKVDDWLILCSVFVHPEAKDYRKIYHYNYGATKLALKRALVNYPSLEKIIYDK
DRAKHPIMGFRVPRLWRPPYLQIALDIPSLDRTKSIISELPESDRIVLEVGTPLLKKYGV
RVIRDLREVAKDIFMVADLKTLDVGRVEVDLAFEETADAVVASGLAATATLNSFIYEARR
LGIYAVVDMMEVEDPIQKLQSLKEFPDVVIMHRPIDVEETGETLRWEFIKEIRDAFKDKK
FLVAVAGGITPEIARQALTNGADIIIAGRYVTQSRDIERSVREFLELTREMREDIDLYRV
HVE
>A0A7K4C8Y4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLVGEALVGDGAELAHIDLLMGDKNGPIGTAFANAISQLSIGHTPLLAVVRPNLLTKPV
TLVIPKVTLKDMSQVNEMFGPVQAAVAKAVADSVEEGVFGDADIEDLVILCSAFVHPDAK
DYNKIYRYNYGATKLSIARAMDKFPDKKTLIHEKDRAAHAIMGFKVQRLWDPPYLQVACD
IVDLGKLKAVLSALPENDHLIIEAGTPLVKKFGLSVLSEIRKVKPNAFIIADMKILDTGN
LEARMAGDATADAVVVSGLAPVSTIEKAIIEAKKVGIYSVIDMLNVSSPVKLLQSLKVKP
DIVELHRAIDVEETAHAWGDIPALKKACGGKLLVATAGGIRTNVVKDALKAGADILVVGR
AITASKDVGHAADEFLEQLNREEIDQFRIMTDF
>A0A7K4A2X7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLIGEALVGDGPELAHIDLLIGDKDGPVGTAFANALSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKDVQIREMFGPVQAAVAKAVADSVEEGVFPDSDIDSLVILASIYLGPGAA
DYNRIYRYNYGAMKLALRRAMEGFPDRKTLLYEKDRSTHAVMGFKVQRLWDPPYLQVALD
LVDMNKVSSVLSELPENDHLIIEAGTPLIKKFGLEIIPEIRKFRPNAFIIADMKILDTGN
LEARMAADASADAVVISGLAPTSTLEKAIAEAKKTGIYSVIDMLNVPDPVKVIKILKVKP
DIVELHRAIDAEDTAHAWGNIPALKKAAGGRLLVATAGGIRVDVVKDAVKAGADIIVVGR
AITASKDIHTAADLFLEQLNREEIDQFRVMTDF
>A0A7L4Q0T5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobiales archaeon|TrEMBL
MYLVGEALVGDGPELAHIDLIIGEKEGPVGAAFANALSQLSAGHTPLLAVVRPNLLTKPA
TLVIPKVTLKKEVQIREMFGPVQAAVAKAVADCIEEGVFGNQDLESLVVLASVYLDAGAA
DFNRIYRFNYGATKLALRRAMEGFPDKATILYEKDRSAHAVMGFKVQRLWDPPYLQVALD
LVEMRKVESVLAELPENDHLLIEAGTPLIKKFGLQIIPEIRKIRPNAFIIADMKVLDTGN
LEARMAADSSADAVVISGLAPLPTLEKAIAEAKKTGIYSIVDMLNVADPVKVIKSLKVKP
DVVELHRAIDAEDTAHAWGDIPALKKAAGGKLLVATAGGIRVDVVKDAVRAGADIIVVGR
AITASKDPHTQADLFLEQLNREEIDQFRV
>A0A368TEK6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanophagales archaeon|TrEMBL
MLNVGEALIGDGKEIAHIDLMIGDKNGPVGVAFTNALSQMSAGHTPLFAVIRPNLPVKPS
TVVVPKVTVRNMNEAEKVFGPAQSAIAKAVADSVEEGVIPEDKAEELVVIVSVFMHPHAD
DYNKIYRYNYGATKLALKRAMDGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALD
IPNWGHMERVVKELPSNDHLIIEAGTPLIKRYGVDIVAKIKEIKPDTFVIADFKTLDTGN
LEVRMVADAGADAVVISGLAPLQTMEKAITEARKTGIYSSLDMLNVEKPLAVLKELSVLE
MMPDVVELHRAIDVEQEKQHAWGDIAEIKRIGGKMLVAVAGGIKEDTAPEAINGGADIII
VGRGITNTKDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A1D3KZ95|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium congolense|TrEMBL
MYQIGEALIGNGNELAHVDLVIGNKNSPVGAAFVNNMADMSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVRGLGDADKIFGPAQTAVGRAVADSVAEGVIPEEDAEDLVIIANVFIHPEAE
DYRKIYQYNYGATKLAIKRAMENYPSIKKVLAEKDRGTHPVMGFKVNRLWNPPYLQVALD
LDNMNEMERIINTLPDRERILIEAGTPLVKKFGVGIIGKIRELKRDAFIIADLKTLDVGR
IEVKMAADETADAIAISGLGTVESIEKAIHEAQKQGIYSILDMMNVEKFVEKLESLSYKP
DIVLLHRNVDLETMKAERGEKLGEVTEWGNINQIKEILGKGKLVAVAGGITPERVDKALE
NKADIIVVGRYIIGSRDVRRAAQDFLDRMPQDPDTMRLAMDEDESI
>A0A3M9LAY2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanohalophilus euhalobius|TrEMBL
MMLIGEALIGEEPELAHIDLMIGDKEGPVGQAFATGMTQLSAGHTPLLSVIRPNLPTKPS
ALIVPKVTVKNMDQASQIFGPAQAAVSKAVADAVEEGIVPKEKADDLVIVASVFIHPQAL
DYNRIYRYNYGATKLALKRAMENFPAIDTVLDEKDKGSHAVMGFKVSRLWDPPYLQVALD
NPNLEAVLNVVRQLPKSDHLILEAGTPLIKRYGVDVITKLREVKPDAFIVADLKTLDTGN
LEARMVADATADAIVVSALAPVPTLEKAISEAHKTGIYAVMDTLNHPDPMDVLEKLDELP
DVVELHRAIDVEDTAYAWGSIEAIKELSPKILVAVAGGVRVHTIPDALKAGADILVVGRA
ITNSREIRQSAEQFVEGLNKPEIDQFRVMTDF
>G7WJX1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta harundinacea (strain 6Ac)|TrEMBL
MFLIGEALIGDEPELAHVDLLIGDKDGPVGTAFASGLAQLSAGHTPLLSVIRPNLPPKPA
TLIVPKVTVKNMEQAAAIFGPAQNAVAKAVADSVAEGVIPKAEVENLVVIASVFIHPQAR
DYDAIYRYNYGATKLAVKRAMEGFPDIDTVLYEKDRSTHPIMGFRVIRLWDPPYLQVALD
LVDLTVVRRVLSQLPDSDHLLIEVGTPLVKKFGASVVKEIRNVRPSSFVVLDLKTLDTGN
LEVRLAADATADAVVISGLAPQKTLELAIREARKTGIYSVIDMLNVPDPLEVLRSLAVLP
DVVEMHRAIDQEAERHNWEAIAEIKRMAASSDRKVLVAVAGGIRVDTVASALSSGADIVV
TGRAITGSKDVRDAAEQFLAELKQTEIDQYRVMTDF
>E1RIY7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)|TrEMBL
MYLIGEALEGEGAELAHIDLLIGDKMGPVGMAFANAASQLAPGHTPLLAVIRPNLLTKPA
TLIIPKVTLKTEGQVNAMFGAVQAAIAKAVADSYEEGVFEGCGYDPEDIVILASAFLHPE
ARDYNRIYRYNYGSTKLAIKRALDMFPDKATLMNEKDRAGHAVMGFKVQRLWNPPYLQVA
LDLVDMNAVRKVLEEVPKNDHVLIEAGTPTIKQFGLAVIDEIRKIRPDAFIIADLKTLDT
GNLEARMAANASADAVVVSGLAPISTIEKFILEARKTGIYSIIDMLNVAKPADLIKELAK
KGAVPDIVEMHRAIDTEGDEYNWGDIPAIKKAAGGKLIVATAGGIRQHVVQTALKSGADI
VVVGRAITASKNIKNAAEQFIEEINNPEIDQFRIMTDF
>A0A497RIA4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobales archaeon|TrEMBL
MDMRIGEALIGEGYEVAHIDLMVGTKDSPVGIAFANALSNLSQGHTPLLAVLRPNLITKP
PAVIVPKVTVKDMEQAELIFGAAQAAVAKAIADAVEEGIVPIDIAEDFVVVVSVFIHPKA
KNKHKVYYYNYGATKLALKRAMQNFPDVETVLYEKDRSFHPFVGRKLTRLWDPPYLQIAI
DIPDLNEVLSVLKQIPDSDHIIYEVGTPLAKRYGSDVILKLREIKPDSFFVLDLKTLDVG
NLEARMAADSTANAIVISGLAPIQTIVKGVREAEKTGILSVVDMLNVEDPVERLKKIKEY
VTPDVVELHRAIDTEGVAEMPWKYASKIKEFGVLVAVAGGIKPENVQEAISAGADILVVG
RAITKARDVEGAVRRFLIHMKPDTDQFRIMTDF
>A0A2A2H683|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium bryantii|TrEMBL
MYHIGEALIGSGNEVAHVDLVIGDKNGPAGTAFVNNLTQLSIGHTPLLSVIRPNLLTKPA
TLIIPKVTVKDLCDAEKIFGPAQTAVSRAVADAVQEGLIPEDKAEDLVILASVFIHPEAS
DYRKIYQYNYGATKLAIRRAMEGYPSVGKVLAEKDRGAHPIMGFKVVKLWNPPYLQVALD
LDNFDDVERIINSLPNRERILLEAGTPLIKKFGVGVISKIRELRKDAFIIADLKTLDVGR
VEVKIAADETADAVAISGLGTVESIEKAIHEAMKQGIYSILDMMNVENFVEKLQSLRFKP
DIVLLHRNVDLETAAKERGEAEAEVTEWGNINQIKEILGKNGLVAVAGGITPDKVDKALT
SGASIIIVGRYIIGSRDVRRAAEDFLAHMPQDPDTMRLALDEDEAI
>A0A7K4H0X2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MAKNEYFIGEALIGEAPNLAHIDLIVGSKDGPVGISFANALSTPSKGHGGLLAAIRPNLL
SKPISLIVPKVTISDMEDANKIFGPAQAAVAKGIADAVEEGLIPMNKLDEWVIIASVFIH
PEATDYRKIYQFNYGATKLAIQRALKNYPPIEKIFYDKDRAKHPVAGIRVPRLWRPPYIQ
VALDHPALEKQIKVVKDLPKSDRIILEVGTPFLKKYGVESIKQIRDVAKEKFIVADLKTL
DVGKLEVDFAFDATADGVVASGLAATASLDKFIMEAQRLGIHAFIDTMEVQSPIEKLSSL
KQIPDVVIIHRGIDVEQSAGDKSPDAQQRQRWTLVPKIKELYASKKKASGKDRVLVAVAG
GIEPSTAAYALEQGADILIVGRFIASAKDVKFAMRRILSVLPGYQDIDLKRIHTEDDDNE
VKKATWD
>A0A5C9EKM5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MVKTDFYIGEALIGDAPNLAHLDVMIGSKGGPVGYAFSQSLSQPSVGHGSLLAVIRPNLV
PKPQTLIIPKVTISKMEEANKIFGPAQSAVAKAVADAVEEGIIPLNKVDEWVIIVNVFIH
PEAEDYRKIYQYNYGATKLALKRALENYPPIEKIFYDKDRAKHPVAGIKAPKLWRPPYLQ
VALDHPSLDHHKKVVAILPNSDRIILEVGTPFLKKYGMDAIREIRTIKPNKYIVADLKTL
DVGKLEVDDAFNAGADGVVCSGLASPASIDKFLLEAERMGIDGIVDMMEVPDPVAKLQKL
KQIPRVVILHRGIDAEQSTKAEGSIEAQKKKWGFVPKIKDLYKDNQLASGRDRVLVAVAG
GIVPETASDALALGADILIVGRFITSSKDIKNSTRRMINILPGYSDVDLKRIHSEDDDKE
ALEKQLKEKE
>A0A7K4CGU8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGEKEGPVGTAFACGLAQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKSMDQAAQIFGPAQMAVAKAVADSVAEGIIPKERAEELVVVVSVFIHPQAK
DYDAIYRYNYGATKLALQRAMEGFPDVDKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDLDEVRRVLAALPESDHILIEVGTPLVKMLGINIVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIDEARKTGIYSVIDMLNVPDPLAVLKSLDVLP
DVVELHRAIDMEKSAHAWQNIREMQALAKPGRRLLVAVAGGIRVDTEAQALAAGADILVV
GRAITRSKDIRDMAEQFLAGLKQTEIDQYRIMTDF
>A0A848K1N1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Xanthobacter sp. SG618|TrEMBL
MPRIDRLLVGEALVGDGNEVAHIDLIMGPRGSSAEIAFVNALTNNKDGFTGLLAVVEPNL
MVKPATVLFNKVTIKDARQAVQMFGPAQYAVAKAVADCVADGTIPVEEADDIFICVGVFI
HWDASDDARIQTFNHEATRLAISRAIGGTPSPVEAMTRRETARHPLAVD
>A0A0F8FWE3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 2.H.T.1A.8|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A346BBL9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia caffeinilytica|TrEMBL
MSVSTDKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSDFHGNATWGASQAGIARAVAESLENGTLPPEAENDWVVVSAN
WVNPATDDLDAVFENNYRACRNAILAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A7J9T3C7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon|TrEMBL
MFLIGEALIGEEPELAHVDIIIGDKNGPAGQAFATGFTQLSAGHTPLLSVIRPNLLTKPA
TLIVPKVTVQNMDGAAKIFGPAQSAVARAVADAMDEGIIPKEQAEDIVIVASVFIHPQAE
DYNKIYRYNYGATKLAVQRAMEGFPDVDTVMDEKDRTMHPIMGFNVTRLWDPPYLQVAID
IPDMDFVKKVLNQLPQSDHLIIEAGTPLIKRYGLDVVSNIREARPNAFIVADLKTLDTGN
LEARMVADATADAIVISGLAPLSTIEKAIKEAKKTGIYACIDMLNVPDPVKVLKDLSVKP
DIIELHRAIDAEDSAYAWGSIPDMKKVHPKLLVAVAGGIGKLEAGSAKVSDACDAGADII
VVGRSITKAKDVRLATEVFLEDMQKAEIDQYRVMTDF
>A0A822IM75|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MVHIVRSMIGEALVGDGNEIAHIDLVIGPRGGPVETAFMNSLAMPREGHMPLLAVLEPNL
QTKPCTLMVNKVTIKNANQALLMFGAGQAAVAKAVIDSVEEGVIAKSDAEDLLVIVSVFI
HWEAKDKQKIYDYNYEATKLAIKRAMASEPSLEEALARKDKANHPFA
>A0A2P5K4R4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|ANME-2 cluster archaeon HR1|TrEMBL
MSQRGVKILLLIGEALIGEEPELAHVDIIIGDKNGPVGQAFATGFTQLSAGHTPLLSVIR
PNLLTKPATLIVPKVTVQNMEDAAQIFGPAQTAVARAVADAMDEGIIPKEQAEDLVVVAS
VFIHPEAVDYDRIYRYNYGATKLAVQRAMGSFPDVDTVLKEKDRNMHPVMGFNVTRLWDP
PYLQVAIDIPDLEFVRKVLDQVPISDHIIIEAGTPLIKRYGLDVIQQMRKARPNAFIVAD
LKTLDTGNLEARMVADATADAVVISGLAPISTMEKAIEEAKKTGIYAYIDMLNVPDPVKV
LKELSIKPDIVELHRAIDEENLAHAWGSISEMKKVIPKLLVAVAGGIAKLETDAATVSDA
CSAGADIVVVGRAITKAKDVRLAAEVCLEDLQKAEIDQYRVMTDF
>A0A1V4UTI7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaB.Bin018|TrEMBL
MFLVGEALIGKEPEIAHIDLLIGEKEGPVGTAFACGLAQLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKSMDQAAQIFGPAQMAVAKAVADSVAEGIIPKERAEELVVVVSVFIHPQAK
DYDAIYRYNYGATKLALQRAMEGFPDVDKVLYEKDRSTHPIMGFRVTRLWDPPYLQVAFD
LVDLDEVRRVLAALPESDHILIEVGTPLVKMLGINIVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADSTADAVVISGLAPKKTLELAIDEARKTGIYSVIDMLNVPDPLAVLKSLDVLP
DVVELHRAIDMEKSAHAWQNIREMQALAKPGRRLLVAVAGGIRVDTEAQALAAGADILVV
GRAITRSKDIRDMAEQFLAGLKQTEIDQYRIMTDF
>A0A1J5QHJ8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|mine drainage metagenome|TrEMBL
MSSKIIFKAGEATVYTEGKDVTAAMPEIVIGAVDGPVGQAFANMMAQNKGHTAMFAVRDI
NQMVRPVTMMVPKVTLKDSANVALFGGVVQAATADAVLDCVIEGIIPRDQANDLCIISLV
WIDPGCAKEANLDKADMYKNNYEATKLAIKRALSDEPSIEELIKNRHTIKHCMWEDSWDQ
K
>A0A832TQX5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp|TrEMBL
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDIVIVASVFIHPEAQ
DYNKIYRYNYGATKLAIKRALKGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRGVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQPDPISVLKQLKAMP
DVIELHRGIDIENTEHAWGNIAEIKKIAPKTLV
>A0A1V5AGV9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosaeta sp. PtaU1.Bin028|TrEMBL
MFLIGEALIGKEPEIAHIDLIIGDKEGPVGAAFANGLTQLSAGHTPLLSVIRPNLPAKPA
TLIVPKVTVKNMDQAAQIFGPAQTAVARAVADCVAEGIIPRDQVEKLVVVVSVFIHPEAK
DYDALYRYNYGATKLALRRAMEGFPEIEKVLYEKDRSTHPIMGFRVTRLWDPPYLQVALD
LVDLSEVRRVLSSIPDSDHVLIEVGTPLVKMLGVSVVREVRAARPGSFVILDLKTLDTGN
LEVRLAADASADAVVISGLAPVKTIELAVREAKKTGIYSIIDMLNVKDPLAVLSGLEVLP
DVVELHRAIDMESSGHAWQDIPQIKALQKDGGRVLVAVAGGIRADTVKDALSAGADIVVA
GRAITRSKDIRDMAEQFLTQLKQSEIDQYRIMTDF
>A0A2A2HNX8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina spelaei|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKGGPVGQAFANGLTQLSVGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDQAGKIFGPAQSAVAKAVADSVEEGVISKDQVEELVIVASVFIHPDAQ
DYNKIYRYNYGATKLAIKRALEGFPDINTVLEESNKSTHAIMGFKVIRLWDPPYLQVAFD
NPDIEFVQSAISQIPKSDHVIIEAGTPLIKRYGMDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTIDKLIEEAHKTGIYAVMDTLNQRDPISVLKQLKVMP
DVIELHRGIDIEATEHAWGDIAEIKKVAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
IANAKDVREVAEQFINSLNKPEIDQFRVMTDF
>A0A8E7AZ70|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanospirillum sp. J.3.6.1-F.2.7.3|TrEMBL
MYLIGEALIGEGSELAHVDLIVGDKNGPVGMAFANALSQLSAGHTPLLAVVRPNLLTKPA
TVVIPKVTLKHEGQVNQMFGPVQAAVAKAVADAVEEGLFGDVNINDICILASAFLHPSAK
DYNRIYRYNYGATKLAISRAFEEFPDEKTLIHEKDRAAHAVMGFKVPRLWDPPYLQVALD
IVDMGKLRSVLSSLPENDHLIIEAGTPLIKKFGLQVISEIRAIKPNAFIVADMKILDTGN
LEARMAADSSADAVVMSGLAPASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKP
DIVELHRAIDAEHTSHAWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGR
AITASKDVRHAAEEFLEQLNKEEIDQFRIMTDF
>A0A7W6HE46|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Aurantimonas endophytica|TrEMBL
MATINKVMVGESLVGEGNEVAHIDLIIGPRGSAAESAFCNSLTNNKDGFTTLLAVVAPNL
PCKPNTVMFNKVTIKGAKQAVQMFGPAQTAVARAVADSVEKGIIPAAEADDLFICVGVFI
HWEAEDDAKIRDYNYQATMESIERAIKGTPTAAEVVAKKGTASHPFAGA
>A0A7K4IKU3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Nitrososphaerales archaeon|TrEMBL
MTDFFVGEALIGEEPEIAHIDLIVGKKNGSVGIDFANSIAQPRMGHTPILGVIRPNIPAK
PSTLIVPKVTIRSLEDAEKIFGPAQSAVAKAVADAVEEGIIPKEQAEEFVVIVSVFIHPR
GKEYQRIYRYNYAATKLALRRAMENFPTIDKVLEEKDKAIHGMIGFRINNLKKPPYLEVA
LDIPDWRRVEGIIRTLPRSDAIIIEAGTPLIKRYGVEVVQKIHQLRPESVVIADLKTLDT
GNLEARIAGDATADVVGFSGLAPIKTMEKFIEECKKIGALSLMDTLNVLDPVEILTKLKI
KPDILELHRAIDVEHEEYAWGNIPEIRKLCGNALIAVAGGIRVKNVDAALKAGADIIVVG
RAITAAKDIAGAARAFLQKMGVEEVDQFRVMTDF
>A0A0M0C282|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|miscellaneous Crenarchaeota group-6 archaeon AD8-1|TrEMBL
MKSVAENGRAYLIGEALLGVGNELAHVDLLIGDKDGPVGKAFANGFSNLSAGHTPLLAVI
RPNLPPKPHTLLVPKVTVKNMKDAGKIFGPAQAAVAKAVADSVEEGIIPKDKVDEWVIVC
SVFIHPQANDYHRIFQNNYSATKLALTRAMKKYPSLEKMLYDKDRAKHPIMGFKVPRLWR
PPYLQISLDAPSVENAQKIISQIPGSDRIILEVGTPLIKRYGTKVINELRKTAKDAFMIA
DLKTLDVGKVEVDIAYEETADAVVAAGLAPPETLDAFVYEAKRLGIYGAVDMLNVEDPLG
KLKGMNIFPDIVILHRGIDQETGRTLGLELIKNLRQVFSDKKFLIAVAGGILPETAKEAL
LEGADIIIVGRYVTQSKDPERAIREFLELTPLMRKDIDHFRVHVE
>A0A315XDP6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Methanoperedenaceae archaeon|TrEMBL
MFLVGEALIGEAPELAHIDLIIGEKSGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVEEGIIPKDQIEDLSIVVSVFIHLEAK
DYNKIYRYNYGATKLAIDRAMQGFPDVKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAFD
MPDIDAVKNILKQIPQSDHLIIEAGTPLIKRYGVNVVHPIREARPNSFVVADLKTLDTGN
LEARMVADATADAIVISGLAPISTVEKAIKEARKTGIYSVIDMLNVDKPMSVLKALTVKP
NVVELHRAIDTEGKSEHAWGDIHAMKKLSERMLVAVAGGIRVDSVKEALKSGADIIVVGR
AITKAKDVRSMTEQFIEEMKQPEIDQYRIMTDF
>F6BCK3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)|TrEMBL
MIKFGEAVFGNEVKAVINLVIGKGKEMDEAFTNALTRTPCPLFANLRPNLIVKPLTLVVP
RHPISSEIQDELLNGVIQYGVAKAIADLDLEEDLKIIATVSVPDVPLTTLTKRKLFQYYY
GATKLAINRALNEYPSKEKIKKEKYRALHPLVGFRDVRLERPPYLQVALDVPTIENLEFI
LNALPKSDRIILEAGTPLIKKFGIEVIEHIREYFDGFIVADLKTLDTGRIEVRMAFESTA
NAVCISGVAPKSTILKGIHECQKCGIMSYLDMMNVENPINLYNSLKLKPDVVILHRGIDE
ETFGVKKEFSITKEDVDAILAIAGGVSPENIDELIKNYDILIVGRAITKSRDPGRVARMF
VNRLGDDIEQYRLYLDEDEEIDIYSRVR
>A0A7C5IX22|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MVVSEARQPTKGYTYLIGEAFVGEGNEVAHIDLLIGDKDGPVGEAFANGLAHLSMGHTPL
LAVIRPNLPPKPHTLLVPKVTVKNLEDANKVFGPAQAAVAKAIADAVEEGIIPKDKVDDW
VVVCSVFVHPKASDFRKIYHYNYSATKLALKRAMARYPSLEKVFYDKDRAKHPMLGYRVP
RLWRPPYLQISLDIPDLERTKRIIMQIPRSDRIILEAGTPLIKRYGTKAISELREVARDI
FFIADLKTLDVGKVEVDVAYEETADGVIAAGLAPTETLDAFIYEAKRLGIYAAIDMLNVE
DPIKKLKALRDFPDIVIIHRGIDEETGRTIGLELIQELRQAFRDKKFLIAVAGGIIPETA
KEALEKGADIIVVGRYVTQSRDIERSVREFLELTP
>A0A842SKG0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
SVEEGVIPRSKLDEWVVVASVFIHPEAKDERSIYTYNYSATKMAIRRALDNYPPWEKIEY
EKDRAKHPLMGFRPRRLWRPPYLQIALDLPSIDAVKRVVSQVPDNDSIILEAGTPLIKKE
GIGIIREMREFAPDSFIVADLKTMDVGKVEVDMAFDETADAVCCAGAASINTIDEFVYEA
RRLGIYSFLDMMQVDDPVKKLKDLDELPDGVILHRAIDTELTAEPRWSYIPEIRDAFKEE
KLLISVAGGIRPDTAKLALENGADVLIVGRYITQSKNVRKSVENFLPFLQGDIDLFRVHI
E
>A0A7L4PIW1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocellales archaeon|TrEMBL
MYLLGEALVGEEPEIAHIDLIIGDKKGPVGMAFANAISHMSAGHTPLLAVIRPNLPTKPS
TLVVPKVTVQNLEQAAQVFGPAQTAVAKAVADTVEEGLIPKGKAEDLVIMVSVFVHPEAE
DYSKIYRYNYGATKLAIQRAMEGFPSVDKVIYEKDRSTHPVMGFKISKLWDPPYLQVALD
VPDLEVTKKVLENLPESDHLILEAGTPLIKRYGLDIVKKMREIRRDAFIVADLKTLDVGN
LEARMAADATADALVVSGLAPTETIEKVITEARKTGICSVIDMLNVGDPKVLLGQLTIMP
DVVELHRAIDVESKEMKHAWRDIKDIKALSDKILVAVAGGIIAENAKEAIKSGADILIVG
RAITKAKDIEGISRRFLKLMKEEIDQFRVMTDF
>A0A6J5GR09|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia caffeinitolerans|TrEMBL
MDKQLYIGEGFEGPGVNLAHINVLVGPRSGPAGQAFSTALATPSAGHAPFVVIAQPGIPA
KPLTLYVNKAQIESDFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSANWVNP
KTDNLDAVFENNYRACKNAILAAMKGLPRKEDVFAAARDVSNPFYTPKKV
>Q64CL3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon GZfos21B5|TrEMBL
MMNVGEALIGDGEEIAHIDLMIGDKNGPVGMAFTNALSQMSAGHTPLFAVLRPNLPVKPS
TVVVPKVTVRNMKEAEKVFGPAQSAIAKAVADSVEEGVIPEDKAEELVVIVSVFLHPHAD
DYNKIYRYNYGATKLALKRAMDGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALD
IPNWGHMERVVKDLPSNDHLIIEAGTPLIKRYGVDIVAKIKEIKPDTFVIADLKTLDTGN
LEVRMVSDAGADAVVISGLAPLRTMEKAIEEARKTGIYSSLDMLNVEKPLAVLKELSVGG
MMPDVVELHRAIDVEQEERHAWGDIAEIKRIGGKMLVAVAGGIKEDTAPEAINGGADIII
VGRGITNSKDVEGVSRRFLRLLKEEIDQYRVMTDF
>A0A842YLX4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothermobacter thermautotrophicus|TrEMBL
MYRIGEALIGSGNEVAHIDLIIGDKEGNAGAAFASGLTNLSLGHTPLLSVIRPNLMTKPA
TLIVPKVTVGCLEDANKVFGPAQTAVARAVADAVEEGVIPEEKAEDLVVIVSVFIHPEAE
DYRKIYQYNYGATRLALRRAMEGYPSVSKVLAEKDRGSHPIMGFRAVRLWNPPYLQVALD
LDSMEEMERIINTLPDRERILLEAGTPLVKKFGVGVVRRIRELRRDAFIIADLKTLDVGR
IEVKMAADETADAVAISGLGTVESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKP
DIVLLHRNVDLETLRAERGEEIGEMSEWGNIREIKEILGPRGLVAVAGGITPAKMQEALD
SGADIIVVGRYIIGSRDVRRAAEDFLEHMPQDPDTMRLPLDEDEAI
>A0A662VXT7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobales archaeon|TrEMBL
MRIGEALIGEGYEVAHIDLLIGEKNGPVGMAFANSLSQLSAGHTPLLAVIRPNLITKPAA
LIIPKVTVKEMEQAELIFGPAQSAVAKAIADAVEEGIVPVEEAENLVVIVSVFIHPLAKN
KDKIYYYNYGATKLALKRAMEGFPDVDTMLYEKDRSVHPFVGRKLTKLWDPPYLQIAIDL
PDLEEVKSVLEKIPLSDHIIFEVGTPLVKRYGAEVILELRKERPDGFFVLDLKTLDTGNL
EARMAADATANAVVVSGLAPIPTIVKAIKEARKTGILSVVDMLNVSDPVDVLKKLEKEGV
MPDVVELHRAIDVENKEKPPWEQISEVKSSFKVLVAVAGGLRPENVNQAINEGADVLVVG
RSITKARDVEGAVRRFLQYMKPDTDQFRIMTDF
>Q64E70|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon GZfos13E1|TrEMBL
MTDERDEFLIGEALVGEEPEIAHIDLIIGSKRGAAGAAFASSIAQPKQGHTPILGVIRPN
LPTKPMTLIVPKVSIRNLADAEKIFGPAQSAIAKAVADAVEEGVIRKSQAEEFVVIVSVF
IHPRGKDYQRIYRYNYAATKLALSRAVEKFPNIDKVLEEKDKSIHAMIGFRINNLKKPPY
LEVALDIPDWRRVEGIVRALPKSDAIIIEAGTPLIKRYGVEVVQKIHQLRPETVVFADLK
TLDTGNLEARMAGDATADVVGFSGLAPVSTMEKFIEECKKVGALSLMDTLNVPNPVKVLK
KLKVTPDIVELHRAIDVEQAQGSEWRNIGAVRKVCGNNVLVAVAGGIRVDKVEKALKAGA
DILVVGRAITAAKDVTGAARAFLQRMGVEEVDQFRVMTDF
>A0A5E4KKL6|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MFLVGEALIGEEPELAHIDLIIGEKTGPVGQAFANGFTQLSMGHTPLLSVVRPNLLAKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVQEGVIPEDQVEDLAIVVSVFIHPEAK
DYNKIYRYNYGATKLAVERAMQGFPDTKTLMYEKDRTMHPIMGFKVIRLWDPPYLQVAID
IPDVDAVKSIIKQIPQSDHLIIEAGTPLIKRYGVNIVQAIREVRPNAFVVADLKTLDTGN
LEARMVADATADAVVISGLAPVSTIEKAIKEAKKTGIYAVIDMLNVEKPLSVLKALSIKP
DVVELHRAIDTETKAEHAWGDIPAMKKLSERLLVAVAGGIRVDTVREALKSGADIIVVGR
AITKAKDVRSMTEQFLEELRQPEIDQYRVMTDF
>A0A524DPN8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Lokiarchaeota archaeon|TrEMBL
MVKNEYYVGEALVGTGADLAHIDLLIGSKNGPIGISLANALSEPSKGHGGLLAAIRPNLL
AKPITLIVPKVTVSKMEEANKIFGPAQAAVAKGVADAVEEGLIPMNKLDEWVIIASVFIH
PGATDYRKIFQYNYGATKLAIQRALKAYPPIEKIFYDKDRAKHPVAGIRIPRLWRPPYIQ
VALDAPNLQRQIKVVKELPKSDRIIIEVGTPFLKKYGMEAIKEIREVAKEAFIVADLKTL
DVGKLEVDFAFDATADGVVASGLASTASLDKFILEAQRLGIHAFVDTMEVQDPIAKLSSL
KQIPDVVILHRAIDVEQSVEGDQSPDAAQKARWALVPKIKELYKEHKKASGRDRVLVAVA
GGIEPNSAIFALKQHADILIVGRFIASAKDIKFAMRRILQTLPGYQDIDLKRIHEEDDDS
SVTKATWD
>A0A147JYN2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Hadesarchaea archaeon DG-33-1|TrEMBL
MGEGSEVAHVDLLIGDKNGTVGEAFANSLSNLSAGHTPLLAVIRPNLPPKPHTLLVPKVT
VKNLEQAERIFGPAQAAVAKAVADAVEEGIVPEDKVDDWVVICSVFVHPEAKDYGRIYQY
NYGATKLALKRALTSYPPLEKIMYDKDRAKHPMMGFRVPRLWRPPYLQIALDVPSLERTK
EIICELPKSDRIILEVGTPLLKKYGVKIVRDLREIAKDTFIVVDLKTLDVGKVEVDLAFE
ERTDAVVASGLAAKEVLDGFIYEAKRLGIYAVVDMMGVEDPARKLRSLKQFPDVVILHRA
IDVEKAGVGRRMELIKGLRNAFPKEKFLIAIAGGITPETAKVALDSGADIIIAGRHITQS
KDVKRSVREFLECTAEMGEDVDLYRVHVE
>A0A832D206|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus sp|TrEMBL
MEFRVGEALIGEGYEVAHVDLLIGTKDSPVATAFANALANLSAGHTPLLAVLRPNLITKP
PAIIVPKVTVKTMEQAELVFGVAQAAVAKAIADAVEEGYIPKERAEDYLIIVSVFIHPMA
SNKHKIYYYNYGATKLAIKRAMDNFPDVGTMLYEKDRSAHPFVGRKLTKLWDPPYLQIAF
DIPDLEEVMAILSQIPESDHIIFEIGTPLVKKYGSEVVLKLRDIKPNAFFILDLKTLDVG
NLEARMASDATANAVVISGLAPVSTIVKGINEAKKTGIMAFVDMLNVENPIARLEVISKE
VLPDVVELHRAIDVESSEPPWAIAREIKEKFKILVAVAGGIRPENVSEVISAGADIVIVG
RAITKAKDVEGAVRRFMNFLKPDTDQFRIMTDF
>A0A328S3S5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. rholeuAM6|TrEMBL
MYEIGEALIGNGPELAHIDLIIGDKNGPVGTAFATNMANMSVGHTPLLSVVRPNLPTKPA
TLIIPKVTVQNLDDASKIFGPAQTAVARAVADAVEDEIIPKDIVEDIVLLVNVFIDPSAK
DYRKIYQYNYGATKLAIRRAFEGYPNVEKVLEEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIRDLPQRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECTKQGVYSILDMMNVKDIPTKLEQLKLKP
NIVLLHRNIDSETMTDNDNEQQSEWGNIMDIKSKLGKRGLIAVAGGVTPEKVNTALGNGA
DIIIAGRYIIGSSDVRRAANDFLMYMPQDSDTMRVALDEDESI
>A0A162FQY4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter oralis|TrEMBL
MDPMYRIGEALIGDGAELAHVDLLIGDKLGPVGQAFANGLSNLSVGHTPLTSVIRPNLMT
KPATLIIPKVSVGDLEDASKIFGPAQTAVARAVADSVEDGYIPKEIVEDIVLNVSVFIDP
SAKDFRKIYQYNYGATKLAIRRAMSGYPSIDKVLAEKDRGTHPIMGFRVQKLWSPPYLQV
ALDLDNLDAMAKIIADLPDKERVLIEAGTPLVKKFGVGVVAKIRELRPDAFIIADLKTLD
VGRVEVKMAADETADAIAISGLGTIESIKKAIHETQKQGIYSILDMMNVSNFEEKLSQLP
DDLKPDVVLLHRNVDLETYKSEKGEDTSEMTEWGNIKEIKKLIANGLVAVAGGITPDKVE
EATSKGADIIIAGRYIIGSRDVRRSAQDFLAHFPQDPDSMRLALDEDEQVN
>A0A843IMJ9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanomicrobium sp|TrEMBL
MYLIGEALEGEGAELAHIDLIIGDKMGPVGMAFANAASQLSAGHTPLLAVVRPNLLTKPA
TLIIPKVTLKHEAQVNAMFGAVQAAVAKAVADSYEEGVFDKRECDPEDMVLLVSAFLHPD
AKDYNRIYRYNYGSTKLAIQRAFDKFPDKATLIKEKDRASHAVMGFKVAKLWDPPYLQVA
LDLVDMGTVERVLKAVPKSDHVLIEAGTPLIKQFGLSVLSKIREIRPDSFIIADLKTLDT
GNLEARMAANASADAVVVSGLAPIETIEKFILEARKTGIYAVIDMLNVSDPVKLVAELAK
RGAAPGIVEMHRAIDTEGSKPNWGKIKDIKKAAGGKLIVATAGGIRQNVVKTALESGADI
IVVGRAITASKNIQNAAEQFLDEMNKEEIDQFRVMTDF
>B1FSE1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MAKINRVLIGESLVGDGNEVAHIDLLMGPRGSAAETAFCNALTNNKDGFTSLLAVVAPNL
LAKPNTILFNKVTIKGAKQAVQMFGPAQHAVALAVADSVEDGTIPADEADDLFLCVGVFI
HWQAEDDKKIQEYNYKATREAIQRAVRGEPTAAEVVQKKSSVAHPFAPN
>A0A0D5VN08|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia fungorum|TrEMBL
MSVSTDKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSDFHGNATWGASQAGIAKAVAESLENGTLPPEAENDWVVVSAN
WVNPATDNLDAVFDNNYRACKNAILAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A1D2R0E1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Altiarchaeales archaeon WOR_SM1_SCG|TrEMBL
MYKIGEALLGKDNEIAHIDLIIGTKEGYVGQAFANGMVNLSQGHTPLLGVIRPNLPPKPH
VLIVPKVTVKDMADAGKIFGPAQSAVSKGIADAVEEGILKEYNLDDIVIIASVFIHPGAK
DYRKIYQYNYGATKLALQRAISDYPNLDKIMYEKDRATHAIMGFKVPRLPKWNAPYLQIA
LDVASSKNAERIVKELPPSDKIIIEIGTPLIKAEGVKAVSKLREAAPNAFIIADLKTLDV
GQVEVDIAFDETADAVVASGLACPEMLREFIYEAHRLGIYAMVDTMNVPDPVKLLKDISE
DGKEKCNASMPKSPKPPQMPDIVLLHRGISGETTKEVGAEWNKIKEIKDFAKKKGKDLLV
AVAGGIEAHNAEEALRKGADIIVVGRYITQSKDIERAVRAFLYAMGAKAADIDLKREHVE
>A0A8D4VIA9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoculleus chikugoensis|TrEMBL
MYLIGEALVGDGAELAHIDLIMGNKEGAVGQAFANSISQLSKGHTPLLAVVRPNLPAKPS
TLIIPKVTMKKGYQVNQMFGPVQAAVAKAVADSVEEGVFEGIDIEDTVIMASVYLDPAAE
DYNKIYRFNYGAVKLALRRALDRFPDVETLLHEKDRAAHAVMGFKVQRLWDPPYLQVAMD
LVDRNHMRKVLESLPQNDHLIIEAGTPLIKKFGLSIISEIREIRPNAFIVADLKTLDTGN
LEARMTADAGADAVVISGLAPISTIEKAIEDTRKTGIYTVVDMLNVENPVAVIEQLKVKP
DVVELHRGIDIEDTDYAWGDIPAIKKAGGERLLVATAGGIRQPVVKDALKAGADILVVGR
AITASKNIQHAAEEFLQELSTEEIDQFRIMTDF
>A0A843C4P9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcinales archaeon|TrEMBL
MYVGEALIGEGSEVAHIDLIIGDKYGPVGMAFTNALSQMSAGHTPLFAVLRPNLPVKPST
LVVPKVTVRNMKDAEKIFGPAQSAIAKAVADSVEEGVIPEDKAEDYVIIVSVFMHPHAED
YNKIYRYNYGSAKLAIKRAMEGFPDIKKVLYEKDRSRHPSLGMKVTKLWDPPYLQVALDI
PKWELMERVVKELPRNDHLIIEAGTPLIK
>A0A8B3S6H9|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Argoarchaeum ethanivorans|TrEMBL
MFLIGEALIGSAPELAHIDLMIGDKNGPVGSAFAAGMTQLSAGHTPVLSVIRPNLLTKPA
TLIVPKVTMKKTEQVNQIFGPAQNAVALAIADAVEEELIPQDKAEEWVVIASVFIHPDAK
DYSKIYRYNYGATKLAIQRAMEQFPSINTVLDEKNRAAHPVMGFKVTRLWDPPYLQVAID
VPDIDYVQQILKEMPQSDHLIIEAGTPLIKRYGVDVIEKIREARNNPFIVADLKTLDTGN
LEVRMAADATADAVVISGLAPTSTIEKAIKEAKKTGVYSVIDMLNVKDAAGLIDNLSVKP
NIVELHRAIDLENTVATGWDSIQKIKKISGKILVAVAGGIRIDKLKPSDHTVDEALAAGA
DIIVVGRDITKAKDVRLKTEQFLEHMKKPEIDQYRIMTDF
>A0A0F8EI33|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 2.H.T.1A.3|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A166AW19|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter curvatus|TrEMBL
MFKIGEALIGDGNELAHIDLLIGSKDGPVGTAFANGLSQLSIGHTPLLSVIRPNLPTKPA
TLIVPKVTVGSLEDASKIFGPAQTAVARAVADAVAEGIIDRNDAEDLVLVVSVFIHPEAT
DYRKIYQYNYGATKLAIKRALKEYPNVDKVLDEKDRGTHPIMGFKVSRLWKPPYLQVALD
LDNADTMEQIIAQIPDKERILLEAGTPLVKRFGVDIISKIRELRPNAFIIADLKTLDVGR
IEVKMAADQTADAIAISGLGTIESIEKAIQEAQKQGIYSILDLMNVDNFIEKIVALKDDL
KPDIVLLHRNVDLETLKAERGEDLDDISEWGNIKEIKKLIGNGLAAVAGGITPDKVEEAI
SKGADIIVVGRYITGSRDVRRATDDFLQYLPQDPDNMRLPLDEDESID
>A0A0G3V3V3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Actinobacteria bacterium IMCC26256|TrEMBL
MQIGEAFVGEGAEAAHVNTILGDRSGPVGAAWATGLATPSSGHAAFVAVLQPGVPVQPMT
LFVNKAEIAHGDHGTLTWGPAQAGVAAGVADAVADGLIEATSVALQCLIAAVWVNPEASD
ADLVFANNRKATHDAIANGRRNEPDLRTVLDARDDVFNPYYRAPSK
>A0A1V4ZQM8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanoregulaceae archaeon PtaU1.Bin059|TrEMBL
MVRPNLLAKPATLIIPKVTLRKGVQIKEMFGPVQAAVAKAVADCVEEGLFGKSDLESLVI
MASIYLDPSAADYNKIYRYNYGATKLALSRAMEKFPDQKTLLYEKDRAAHAVMGFKVQRL
WDPPYLQVALDLVDMHKVHSVLAELPQNDHLIIEAGTPLIKRFGLSIIPEIRKVRPNAFI
IADMKILDTGNLEARMAADASADAVVISGLAPLPTLEKAIAEAKKTGIYSVIDMLNVPEP
LKVIKALKVKPDIVELHRAIDAESSEHAWGDIPALKKAAGGKLLVATAGGIRVDGVKKAL
ASGADIIVVGRAITASKDVHTAADLFLEQMNKEEIDQFRVMTDF
>A0A0E3NW39|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. MTP4|TrEMBL
MFQIGEALIGQGSELAHVDLMIGDKTGPVGQAFATGLTQLSAGHTPLLSVIRPNLPPKPS
TLIIPKVTVKNMDEAAKIFGPAQAAVAKAVADAVEEGIIPKDQTEDIVVVASVFIHPDAT
DYNKIYRYNYGATKLAIQRAMTGFPDIDTVLEEANKSTHAIMGFKVTRLWNPPYLQVAFD
NPNLEFVLAAISQIPKSDHVIIEAGTPLIKRYGVDVISKIRDVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPINTINKLIEEAHKTGIYAVMDTLNQPDPISVLKQLEVMP
DVIELHRGIDIEGTEHAWGNIADIKKVAPKALVAVAGGVRLDKVPVALNQGADILVVGRA
IAGARDIREAAEQFINALNKPEIDQFRVMTDF
>A0A839Z926|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Angulomicrobium tetraedrale|TrEMBL
MAKINKVLIGESLVGDGNEVAHIDLIIGPRGSAAESAFVNALTNNKDGFTSLLAVVTPNL
LAKPNTILFNKVTIKDARQAVQMFGPAQYAVAKAVVDSVAEGVIPEEEADDLFISVGVFI
HWEAADDAKIQQFNYEATKEALKRAVNGEPKIGEVLAKAGAAKHPFAA
>A0A7K3Z8B5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Crenarchaeota archaeon|TrEMBL
MKELNVDFKEILDQTPINSAEYLEESVNTYLIGESLVGEGNEVAHIDLMIGNKDGPVGQA
FATGMTQLSAGHTPLLAVIRPNLPPKPFTLLVPKVTIKNMEDTSKIFGPAQAAVAKAVAD
SVEEGIIPIEKVDEWVIVCSVFIHPQATDARRIYQYNYGATKMAIQRALNKYPSIDKINY
DKDRAKHPIMGFKVPRLWRPPYLQISLDAPDLEAAKRVLSQLPGSDRLIIEVGTPLIKRY
GTRVIKELRQSIKDVFIVADLKTLDVGKIEVDIAYEDTADAVVAAGLAPPETLDSVVQEA
RRMGIYGVIDMLNVEDVLEKLKSLKEFPDIVILHRGIDQETGRSSGLERIPLIRKAFPNK
KFLIAVAGGIVPETAKEALEKGADILIVGRYITQSRDLERAVRDFLELTPNMREDVDLFR
VHTE
>A0A2H9N8E5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon CG_4_8_14_3_um_filter_42_8|TrEMBL
MIGEALVGEGNEVAHIDLLIGDKNGPVGEAFASGMSNLSVGHTPLLAVIRPNLPPKPHTL
LVPKVTIKNTEDIGKIFGPAQAAVAKAVADAMEEGIIPKEKADEWVIIASVFVHPQATDF
RKIYHYNYSATKLALKRALAKYPTLEKIFYDKDRAKHPIMGFKVPRLWRPPYLQISLDVP
ELERTKKIISQLPGSDRIILEVGTPLIKRYGTRIINDLRQVAKDIFFVADLKTLDVGKVE
VDLAYEETADAVVAAGLAPAETLDSFINEAKRLAIYAAVDMLNVEDPIKKLKSIKEFPDI
VILHRGIDQETGRSLGLELIQQIRQTFSDKRFLIAVAGGIVPETAKEALSKGANIIIVGR
YVTQSKDIERAVRDFLESTPEMREDIDLFRVHVE
>A0A1V4YCJ1|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobacterium sp. PtaU1.Bin097|TrEMBL
MYNIGEALIGSGNELAHIDLVIGEKNGPVGSAFVENMTSLSIGHTPLLAVIRPNLPTKPS
TLIIPKVTVGCLDDANKIFGPAQTAVGRAVADAVSEGIIDKKKAEDLVIMVTVFIHPEAK
DFRKIYQYNYGATKLALKRAMDSYPSTEKVTAEKDRGTHPVMGFKVIRLWNPPYLQVALD
LDNMEDMERIIDSLPNRERILIEAGTPLVKKFGVGIISKIRELRTDAFIIADLKTLDVGR
IEVKIAADETADAVAISGLGTPESIQKAVQEASKQGIYSILDMMNVDNFVEKLKGLKYKP
DILLLHRNVDLETYKVEKGENLGDMTEWGNIKEIKEILGGNRLVAVAGGITPDKVDQALE
SGADIIVVGRYIIGSRDVRRATDDFLKYLPQDPDTMRLALEEDEPLELNDDKK
>A0A328RRC8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosphaera sp. SHI1033|TrEMBL
MYEIGEALIGDGPELAHIDLIVGDKKGPVGTAYATNMASMSVGHTPLLAVIRPNLPVKPA
TLIVPKVTIQNLEDANKIFGPAQTAVGRAVADAVEEEIIPKNMVEDIVIMVNVFIDPSAK
DYRKIYQYNYGATKLAIKRAFDKYPSIDKVLAEKDRGTHPIMGFKAMKLWNPPYLQVALD
LDNEDKMRSIIRDLPKRERILIEAGTPLVKKFGVEIISKIREERPGAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTNESIEKAIHECSKQGIYSILDMMNVQDIPAKLEQLELKP
NIVLLHRNIDSETMNDNDNEQQSEWGNIKEIKAKLGKRGLIAVAGGVTPEKVNTALDNGA
NIIIAGRYIIGSSDVRRAAEDFLRYMPQDSDTMRVALDEDEEI
>A0A7J3JDE3|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Bathyarchaeota archaeon|TrEMBL
MGIHRDTLYSWLKEFNVDFKEIIDRVPTVSDDTDEYSGITYLIGEALVGEGNEVAHVDLM
IGDKTGPVGQAFANGLTTLSAGHTPLLAVIRPNLPPKPHTLIVPKVTVKDMEDTGKIFGP
AQAAVAKAIADSAEEGVIPTSKLDDWVIVCSVFIHPQATDYRKIYQYNYGATKMALRRAL
TKYPSLDKINYDKDRAKHPIMGFKVPRLWRPPYLQIALDAPSLEGAKKVIEALPGSDRII
LEVGTPLIKRYGTRVIGELRAVAKDKFIIADLKTLDVGKVEADIAYEDTADAVVAAGLAP
PETVDATVQEAKRLGIYAVVDMLNVDDVLAKLKSLKEFPDIVILHRGIDQETGRSCGLER
IQIIRKAFPNKKFLIAVAGGIVPETAKEALELGADILIVGRYVTQSRDVERAVREFLELT
PAMREDIDLYRVHTE
>A0A6J5ABX4|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Paraburkholderia sediminicola|TrEMBL
MSVSTDKQLFIGEGFEGPGVNLAHINVLVGPRNGPAGQAFATALATPSAGHAPFVVIARP
GVPTKPLTLYVNKAQIGSDFHGNATWGASQAGIARAVAESLENGTLPPEAENDWVVVSAN
WVNPATDDLDAVFENNYRACKNAILAAMKGLPHRDEVFAAARDVSNPFYTPKQR
>A0A8J7W6K0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanocalculus chunghsingensis|TrEMBL
MYSIGEALVGDGPELAHIDLLVGDKNGPVGAAFANALSQLSAGHTPLLAVIRPNLLTKPA
TVIIPKVTMKKGEQVKEMFGPVQAAVAKAVADSLEEGLFNGINIDDIVIIASVYLAPDAV
DYNKIYRFNYGAMKLSLSRAFEQFPDEATILHEKDRAAHGVMGFKVHRLWNPPYLQVAMD
LVDMNHMERVLRELPKNDHLIIEAGTPLIKQFGLSIIGEIRKLRPDAFIIADLKTLDTGN
LETRMCANASADAVVISGLAPISTIEKAVLEARKTGIYAVVDMLNVESPVALVEALAKKN
ALPHVVEMHRAIDAEGSEYSWGDIPKIKEAAGGKILVATAGGIRVNVAKKALAAGADILV
VGRAITASKNIQHAAEEFLEEIDSEEIDQFRIMTDF
>A0A0A0BI50|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methylophaga thiooxydans|TrEMBL
MPVIDRVLVGESLVIEDGDLDNVAHIDLIMGPRGSAAEDAFCRTLTDQKQGVNGLLAVVA
PNLMVKPATVMFNKVTIKNMKQAVQMFGPAQRGVSLAVAECVEDGTVPAGEADDCFICVG
VFISPTADSDEKIQDWNYRATKEAIKRAVAREPKAADVVAQYKTSEHPFGAK
>A0A7R6WA31|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methyloprofundus sp|TrEMBL
MSDRIVMRTGEALVAGGPAGTAAEPEIVIGELDGPVGTALATLTGDQAKGHSKVFAILNT
DIQVRPVTLMVSKVTVTNSRYTNILMGTVQAAIANGVLDAVRAGDIPKEKANDLGIICSV
WLNPSVATDDNLDHQILFDIHRKATALAIHKAMTNTPDIDWLLENQDKITHKYFQMGLDG
KI
>A0A0F8NFD0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanosarcina sp. 1.H.A.2.2|TrEMBL
MFQIGEALMGQGAELAHVDLMIGDKEGPVGQAFANGLTQLSAGHTPLLSVIRPNLPAKPS
TLIIPKVTVKNMEQASRIFGPAQSAVAKAVADSVEEGVISKAQAEDLVIVASVFIHPDAQ
DYNKIYRYNYGATKLALKRALEGFPDIDTVLEESNKSTHAIMGFKVIRLWDPPYLQIAFD
NPNLEFVLSAISQIPNSDHVIIEAGTPLIKRYGMDVISKIRDVKPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQLKVMP
DVIELHRGIDIEGTEHAWGNIADIKKIAPKTLVAVAGGVRLDKVPVALGQGADILVVGRA
ITNAKDIRDMAEQFINSLNKPEIDQFRIMTDF
>A0A4Y3FWV0|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|archaeon|TrEMBL
MFIGEALIGEGYEVAHIDLIMGDKNGAVGQAFAIGLSNLSSGHTPLLSVIRPNLPPKPYT
LVVPKVTVKAMGDVEKIFGPAQAAVAKAVADSVEEGIIPLKKLDEWVIVVSVFIHPEATD
YRRIYHYNYSGTKLAIKRAMTNYPSWDKIKFDKDRATHPIMGFKVPRLWRPPYLQIALDV
PNIDNARDVIKNIPKNDRIILEAGTPLLKRYGTKVISELREVAKDYLFIADLKTLDVGKI
EVDLAYDETADAVVVSGLATSQTIDKFIYEARRLGIYAVVDMLNVESPLERLKSIKELPD
VVILHRAIDAESEEDQRWKWIRMIKEEFKGEKILIAVAGGVTPQTASKALQNGADILIVG
RYITQSKDVRKSTIDFLDVLSRELPKEPGDIDLFRVHVE
>A0A256Y0U2|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Candidatus Aenigmarchaeota archaeon ex4484_52|TrEMBL
MYKIGEALLGSGNEVAHIDLLIGEKEGKVGMAFANGLVNLSKGHTSILSLIRPNLPPKPH
TLIVPKVTIEDMDDADKIFGPAQSGVAKAVADCVEEEIIPKNKLDEWVIIASVFIHPKAN
DYRKIFRFNYSATKLAIKRALNDYPKIEKLLYDKDRAMQGIDGYKIPKLWMPPYLQIAFD
ITNIDYVKKIIQQIPGSDRIIIEAGTPLIKEYGVKVINELRKTTKNSFIVADLKTLDVGN
VEVDLAFEQTADAVVASGLAPVECIDKFIYEAKRTGIYSVVDTLNVKDPIGLLKLLKQIP
DVLIIHRAIDVERCNKNGIETQKTQTKDSNSWKIIQEIKKQFNIIVAVAGGITPQTAPQA
LSQGADIIIVGRYITQARDIERTIREFTGILGLDKDHLRAHIE
>A0A5E4KZZ7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|uncultured archaeon|TrEMBL
MFLVGEALIGEEPELAHIDLIIGEKTGPVGQAFANGFTQLSKGHTPLLSVIRPNLLTKPA
TLIVPKVTVKNMAQAAQIFGPAQTAVARAVADSVQEGVIPEDQLEELAVVVSVFIHPEAK
DYNKIYRYNYGATKLAIERAMQGFPDSKTLMYEKDRTMHPIMGFKVVRLWNPPYLQVAID
IPDIDAVKSIIKQIPQSDHLIIEAGTPLIKRYGVNVVQSIREARPNAFVVADLKTLDTGN
LEARMVADATADAIVISGLAPVSTIEKAIKEAKKTGIYAVIDMLNVDKPLSVLKALTIKP
DVVELHRAIDTEGKAEHAWGDIPAMKKLSERLLVAVAGGIRVETVKEALKSGADIIVVGR
AITKAKDVRSMTEQFLEELKQPEIDQYRVMTDF
>A0A843LHS5|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanothrix sp|TrEMBL
MFLVGEALIGKEPEIAHIDLIIGDKEGPVAAAFASGMASLSAGHTPLLGVIRPNLPPKPS
TLIVPKVTVKNMEQAAQIFGPAQMAVSKAVADAVAEGIIPRDRAEELLVIVSVYIHPKAR
DYDAIYRYNYGATKLAIQRAMTGFPDVDIMLYEKDRSTHPVMGFRVTRLWDPPYLQVAFD
LVDVAEVRRVLSALPDSDHILIEVGTPLVKMLGVSVVKEIRAIRPGAFVILDLKTLDTGN
LEVRLAADATADAVVISGLAPKKTLELSIREARKTGIYSIIDMLNVADPLALLKGLEMLP
DVVELHRAIDMETSAHAWNNIRDIQALARDGRRLLVAVAGGIRVDTEGEALDAGADILVV
GRAITRSKDIRDMAEQFLAGLKQSEIDQYRIMTDF
>A0A832AFH8|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Archaeoglobus sp|TrEMBL
MEFRVGEALIGEGYEVAHVDLLIGTKDSPVATAFANALATLSAGHTPLLAVLRPNLITKP
PAVIVPKVTVRNMEQAELIFGPAQAAVAKAVADAVDEGYIPREKAEDYLIVVSVFIHPLA
KNKHKIYYYNYGATKLAIKRAMQNFPDVGTMLYEKDRSYHPFVGRKLTKLWDPPYLQIAL
DIPELEEVISVLSQIPESDHIIFEVGTPLVKKYGCEVVLKLRDVKPDAFFILDLKTLDVG
NLEARMAADATANAVVISGLAPISTIAKGVSEAKKTGMLAVVDMLNVEDPVKRMDQIAKE
TLPDVVELHRAIDSEQSVPPWSLAKEIKKYRVLVAVAGGIKPENITEVISAGADIVVVGR
AITKARDVEGAVRRFMTHLKPDTDQFRIMTDF
>H1KW53|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanotorris formicicus Mc-S-70|TrEMBL
MIKFGEAVFGNEVKAVVNLIIGKGKEIDEAFTNALTRTPCPLFANLRPNLIVRPLTLVVP
RHPIENEIHDELLNGVIQYGIAKAIADLDLEEDLKIIATVSVPDVPLTTLTKRKLFQYYY
GATKLAINRALNEYPSKEKIKKEKYRALHPLVGFRDVRLERPPYLQVALDVPTIENLEFI
LNALPKSDRIILEAGTPLIKKFGIEVIEIIRENFDGFIVADLKTLDTGRVEVRMAFESTA
NAVAISGVAPKSTIIKGIHECQKCGIMSYLDMMNVENPINLYKSLKLKPDVVILHRGIDE
ETFGIKKEFGISREDMNAILAIAGGVSPENVDELIKNYDILIVGRAITKSRDPGRVARIF
INKLGDDIEQYRLYLDEDEDINI
>A0A1D2WMD7|5,6,7,8-tetrahydromethanopterin hydro-lyase|EC 4.2.1.147|Methanobrevibacter sp. A27|TrEMBL
MYKIGEALIGDGPELAHIDLLIGDKFGPIGQAFANGLSNLSVGHTPLTSVIRPNLMTKPA
TLIIPKVTVGDLDDAGKIFGPAQTAVARAVADAVEDGYIPKEIVEDIVINVSVFIDPSAK
DYRKIYQYNYGATKLAIRRAMEDYPSIEKVLAEKDRGTHPIMGFKVKKLWSPPYLQVALD
LDNEDAMERIINDLPDNDRILLEAGTPLVKKFGVGIIGKIRALRPDAFIIADLKTLDVGR
VEVKMAADETADAVAISGLGTVESIAKAIHETQKQGIYSILDMMNVAGFEEKLAKLPKDL
KPDIVLLHRNVDMETYRAEHGEDTSDMTEWGNIKDIKSMLGDKGLVAVAGGIRPNNAEEA
IEKGANIIIAGRYIIGSKDVRRAAQDFLEHFEPDPDNMRLAMDEDENIEVKDD