>P55792|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium aminobutyricum|Swiss-Prot
MLMTAEQYIESLRKLNTRVYMFGEKIENWVDHPMIRPSINCVAMTYELAQDPQYADLMTT
KSNLIGKTINRFANLHQSTDDLRKKVKMQRLLGQKTASCFQRCVGMDAFNAVFSTTYEID
QKYGTNYHKNFTEYLKYIQENDLIVDGAMTDPKGDRGLAPSAQKDPDLFLRIVEKREDGI
VVRGAKAHQTGSINSHEHIIMPTIAMTEADKDYAVSFACPSDADGLFMIYGRQSCDTRKM
EEGADIDLGNKQFGGQEALVVFDNVFIPNDRIFLCQEYDFAGMMVERFAGYHRQSYGGCK
VGVGDVVIGAAALAADYNGAQKASHVKDKLIEMTHLNETLYCCGIACSAEGYPTAAGNYQ
IDLLLANVCKQNITRFPYEIVRLAEDIAGGLMVTMPSEADFKSETVVGRDGETIGDFCNK
FFAAAPTCTTEERMRVLRFLENICLGASAVGYRTESMHGAGSPQAQRIMIARQGNINAKK
ELAKAIAGIK
>A4FJG9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)|TrEMBL
MPSEHPATPGEPSIVSLDSMKNDMQPVDIGTFRAIMGSLPTGVCVVSAIDKEDEPRGLTC
NAVCSVSQEPPLVLVCVDLLKESLHALRDSGGFVVNVLREDRSRVSQLFASPSASKFDGV
FWEASEVLKLPMLTTDALAYAECRIVADLQVGDHAMLVGMIVGGEPPLGGRPLMYWRRGY
SNWPEAAIPNGMGRPTNSA
>A0A835X7V7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MGIKTGQEYIQSLRGRKMKVYLFGELVEEPVDHPLIRPSINAVAETYDIAVREEELATAQ
SSITGQRVNRFLHIAESVQDVVLQNKMQRKLGQNTGTCFQRCVGMDALNSLHSVTFEMDE
KHGTNYHKRLLDFIKMLQTENFVIGGAMTDPKGDRSKGPAEQVDPDMFVHVVKKDDKGIY
LTGAKAHQTGCINSHWIIIMPTMRLTEDDKEYAIVGAIPADAEGITYIYGRQSCDTRSME
EGDLDAGNSQYSGQEAMIVLENVFIPWDKVFMNGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAATIADYNGIPNVTHIKDKLIEMTHLNESIFAAGIASSYQSHKMKSGVWMNEE
MLANVCKHNVTRFPYEIARLAQDIAGGLMVTMPSEKDFKNPETGPMLRKYLAGRKGVDVE
SRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKMNLAKHLAKVKD
DFLEPTEPSDYFKRVFKIPNKEE
>A0A1V4X765|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaB.Bin184|TrEMBL
MGIKTKNEYIESLRSLKPTAYMFGEKLTNIVDNPRLRAGIEATGATYEMAELDPDLMITT
SPLINEPVSRFTLPPGNTEDLVARVKVNRKIANHVGTCHQRCTGLDCLSTLAIVTYDVDK
KYGTEYYPRFMEFLKYMQKNDLTANAGVTDVKGDRSLLPYQQADKDMFVHVVEKKADGIV
VRGAKAHQTGSLSSHEIIVLPSRAMTKDDQDYALAFAVPADVKGLIHVVGRSSLDMRELD
GCDMGNAYYSKYCPTLIFDDVFVPWDRVFLCGETEFALDMVVKFSSFHRQSHGGCKAGKI
DCMVGCALTLMDYNGTSKVTHLKQKVIDMIHRAETLYGCCLASSYEGLKQPSGAYFIDTV
LANASKIHEGKEMAEATRLMIDCCGGFVADLPSDRDIANPEIGGFLKKYLKGVDSVPVEK
RVKMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETNINDKKKAAKRLAGVQD
>A0A1E3AQ56|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eisenbergiella tayi|TrEMBL
MGLMTGQEYIESLRRLHTKVYLFGKRVENFVDHPIIRPSINSVAMTYDLALDPQYQDIML
AVSNLTGKTINRFCHLHQNEQDLINKVRMQRLLGQKTGACFQRCVGMDAFNAVYSTTFEV
DQKYHTNYHQNFIAFMKEVQEKDLTVDGAMTDPKGDRSLSPGKQKDPDMYLHVVEKNTKG
IYVTGAKAHQTGAVNSHEHLIMPTVAMGENDKEYAVSFAIPSDAEGIKMIYGRQSCDTRK
LEKSGGMDCGNCRFGGQEALVVFEHVFVPWERVFLCEEYEFAGVLVERFAGYHRQSYGGC
KTGVGDVLIGAAAVAAEYNGVQKASHIKDKLIEMIQLNETMYSCGIACSVLGTQTAAGNY
QIDNLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEEDFNSPETAEICRKYFKGSAD
ADTVERMKILRLIENMTLGSAAVGYRTESMHGAGSPQAQRIMINRQGKLEEKKKLAKVIA
GISSEPDK
>A0A485LV71|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|anaerobic digester metagenome|TrEMBL
MPMMNAKQYEESLRKLKLKVYMFGKRVENVVDDPIIRPSMNAVAATYEFAHMPEYEDLMT
ATSHLTGKKINRFTHIHQSIDDLVKKSKMGRLLGSLTGCCFQRCVGMDAMNALSMTTYDI
DQKYGTEYNKRFLKFVEYVQENDLTCDGAMTDPKGDRSKAPHQQVDPDLFMHVVEERPDG
IVVRGAKCHQTGAVNSHEIIIMPTISMREEDRDYAISFALPSDAEGIIYIMGRQSCDTRK
LEKGTIDRGNQIYGGHEALVVFDNVFVPWERVFMYKEWDFAGHLVERFASYHRQSYACKA
GVGDVLIGATQCIAEYNGAHKASHIKDKIIEMNHLNETLFCGSIACAAEGHREPSGTYYV
NTLLANVCKQNVTRFPYEIARLAQDIAGGLMVTLPSEDDLRSPEVGKWIEKYYRGNPDVS
TEARMRMLRLIENITMGTAAVGYLTESMHGAGSPQAQRIMIAREVNMDMKKKVAKRLCGI
EGE
>A0A259UV14|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporomusa acidovorans DSM 3132|TrEMBL
MGIGTYEAYKERLLKMKPNVYLNGKKVDRSGSWIDGGCYVMKQCYDLANDPEYEDVCTAT
SHLTGKKINRFTHIHQSKEDLLNKQLMTRLLCQHVGGCTQRCMGSDALNAIAVVSFDCDA
ACGTKYHERFNKYLLYCQENDLICNCAQTDVKGSRNPKYKRAHMQPDPDQFVHIIKTDVD
GIGIDGKPCKGIIVRGAKICNSNAPYVDEIIVNPTKFMGKGDEGYAISFALPADWDGIKL
MALPGQHHKRKHIQAPFNQVGDVESLTIFDDVFVPEDRVFLNGFDHPDAVQYAGYLALMF
AHFHRHSYTGCKTAVSEVIASQAALVADVNDIAKEPHVREKICEIISTAELVFAAGQASA
IRAVKFPNGSWVPDEILTNAGRKLAGQKIYHEYETLADLTGGICASLPTEESFYDPETAD
LCNKYIMRNPDYTAEQTHRVMRMMEDKLCDPFEAAQAVAGVHGGGSPLMETITMMSRYDL
ESLKDIAKYLAGFEGVKCPRYERKTVTPRAMLDKFKKTQIEK
>A0A0S3PQB8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variibacter gotjawalensis|TrEMBL
MLMSAADYRDSLRRFKPRVFVNGERIDSVADAPQLSPGINAIGVSYDFALKSEHLPLMTA
RQRTSGKTVNRMLHINDTSTDLLYKLEAVRLMCRESGCAQRYLAHDALNAIFQATTRIDA
NHGTDYHARFLNYLHRVQEEDLTLGIAMTDAKGDRSRKPGAQDNPDVYVHIKERRKDGIV
IRGTKAIVTSAPYVHEFLVMPCRTMTPDDKDFAVCCAVPVDAEGVTIAARPAGRPGESAA
KFSARYGQSTGVVMFDDVFVPWDNVFLASECEEGGYLTTSYATHHRHSCIGARAGFGDLL
IGTGALMIEANGLDTDRHAHVRDAMVELIKIVEGFFACGVAASVYGIKDESATMMPDAVF
SNIGKLLLATQIYDMHRLAHYVSGGLIVALPGPDEDHNPETAASLSAVLAGRPDIPSSQR
MEVARLMEDLTASHQGSWYSLISLHGGGSPEAMKREIWRNYPVGEKRELVEQLLDRGVLA
DGQRVSKQPGRCCVTGCEVPELPGAKEAAE
>A0A075G819|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_12_C10|TrEMBL
MQKTVKPIRTGEEYIESLKGRDLKVYLFGELVKEPVSHPMIRPSINAVAKTYDLAVEEED
LAFPKSSISGERVNRFLHIAESAEDLVLQNKMQRKLGQLTGTCFQRCVGMDAMNSLHSTT
YEIDEKHGTKYHQRLLEFIKMVQHENLVIGGAMTDVKGDRSLAPSEQEDPDLFLHIVDRD
DKGVYVTGAKAHQTGTINSHWMIVMPTMRLLENDKDYAIVGALPVDAPGITYIYGRQSCD
TRSMEPGDIDVGNSEFGGQETMVIFDRVFIPNEMIFMDGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAAAIAEYNGVPKVSHIKDKIIEMTHLNESIYAAGIAASYQGHKMKSGV
FLNDDMLANVCKHNVTRLPYELARLAQDVAGGILVTLPSEAEFRSAETGPLLEKYLKGKS
GIEVENRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKQLAKNL
AKVKEEPEEMKENSEYFKRVFKIPEK
>A0A644W4U6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MALTFALYHRHSYTGCKPGIGDVIMGTTALMADYNNIRKESHVKEKLVDLISVAELVYAA
GIAAAVKSKKAASGTQVPDVTYANVGRRHAGHNIYHEYNILCDIAGGLPATLPQPKDYNN
PEVSDYIKKYITRREGVSSEDMYKAYLFCSDILTGELFQVLLVAGVHGGGSPIMEDIAIM
GTYDLKSKKKLAEHLAGIKSE
>A0A0J1FNJ0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfosporosinus acididurans|TrEMBL
MKTATEYLESMKAYNPRIFLGGKQVNLHENSTTVTVLRANARVYELAEDPKYADIMNVFS
PYLGDKVSRNLHIASSVADLERRSEMATLTSQMLGTCNYRCVGADVLNALAGITWEMDRE
LGTEYHSRLLNHLKYLQENDLAVSGGVTDAKGDRTKRPVEQDDPDVYVHIVEKREDGIVV
RGAKVSQSGAIGSHETLVIPTMGMRQGEEDFAVAFAVPNGAEGLTYICQYTPFTAERELS
PDVKYLGNPLYGQRETCIMVFDNVFIPWEHVFMCGEAKYSGRLVARFAKTHRMNCGGACK
VGFADLIIGATQLAAEFSGIQKAPHIVEKMTDMIRINETARACTVAAALKGHEEPAGSGF
FQPDDIFGNAAKLTIADGFWDILKWAGDIGGGMAVTMPSELELENPETAHYVRKFMKASA
PAEQRLRIAKFIQNWCAGLHGAGTWHGAGSPMAQKMALYNLTNFEEKKSYARSLAGLKEE
>A0A1C6AAW1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Roseburia sp|TrEMBL
MALMTGEQYVESIRKMNMQIYMFGEKIENPVDHPILRPSLNSVKMTYDLASMPEYEDLMT
AKSHITGEKINRFTHIHQNTEDLRKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTSYEC
DEKHGTHYHDNFLKFLEYTQRNDLTVDGAMTDPKGDRSKAPHAQADPDLYLRVVETRADG
IVVRGAKAHQTGIINSHEVIVMPTIAMGEDDKDYAVSFSVPVDTEGIYMIIGRQSCDTRK
MEGGSIDVGNSEFGGVEALVVFDDVFVPNDRIFLNGEYEFAGILVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAAEYNGAQRASHVKDKLIEMTHLNETLYCCGIACSAEGTKTASGNYI
IDLLLANVCKQNITRFPYEIARLAEDIAGGLMVTAPSEKDLSDPKLGPVIDKYFKGVAEV
STENRMRILRLIENLTLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLAMKKKLAKAIAK
IEE
>A0A1C6F1W1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Butyricicoccus sp|TrEMBL
MMTKDQYIESLRKLHLNLYSFGEKVENPVDNAIIRPSLNSFAATYELAEDPQYEDLMTAT
SNLTGKKINRFTHLHQSTDDLIKKVKMQRLLGQKTAACFQRCVGMDASNAVYSTTYETDE
ACGTHYFDNFVKFWTDVQENDWAVDGAMTDVKGDRSLSPSKQADPDLFLHVVERTADGVY
VTGAKAHQTGYINSHYVLVMPTISMREGDEDYAISFACPTDAEGITLILGRQSCDTRKTE
EYNDIDVGNKVYGGHEVLVIFDHVFIPNEMIFLNGEVQFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGATALAGDMAGSAKASHVKDKLIEMTHLNETLYCCGIACSSQGTKTKSGNYLI
DLLLANVCKQNVTRFPYEIARLAQDLAGGLMVTQPSEADYRNPATHDYIEKYLKGVASVP
TEDRMRVLRLIENMTMGTAAVGYLPESMHGAGSPQAQRIMIARQSNLEMKKELAKKIARI
K
>A0A011PCK9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. SK-11|TrEMBL
MVARPAGRPGEKLEHGAALFSRRYGQSTAVLIFDRVFVPWDKVFLAGEWEHSASLTYNYA
THHRHSCIAARAGFGDLLIGAGALMCEANGFDPGRKSSLREPMVELIKITEGFFACGVAA
SVYGTPDPYSGSFMPEPVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPAT
AATLAEVLRASPDVPYDKRIEVARFIEDLTASYQSGWYSVISLHGGGSPAAMKQEIWRNY
PLGSKVELVERLLERGVLHDESRPITRNRQPGRCCDAGCSPPGQAIMVPLPAPAENQPTP
AGSEPPAG
>A0A174KDL9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Flavonifractor plautii|TrEMBL
MDNPILRPALNSVRMTYDLAQKPEYQDLMAAVSPYTGERVNRFTHIHQSASDLVKKVKMQ
RLLGQQTASCFQRCVGMDAMNAVFSTTYEIDQKYGTSYHQSFLTFLKMVESQDLTVDGAM
TDPKGDRSKAPHQQEDPDLFLRVVERRPDGIVVRGTKMHQTGILNSHEVIVMPTISMGPE
DKDYAVCFAVPMNTKGIYMIVGRQSCDTRKLEGSELDMGNAEFGGVESVTVFDDVFVPND
RIFLNGETEFAGMVVERFAGYHRQSYGGCKVGVGDVLIGAAALAADYNGCAKASHIKDKL
IEMIHLNETLYCCGIACSAEGYPTASGGYIIDLLLANVCKQNVTRFPYEIVRLAEDIAGV
LVVTAPSEADFRDSELGPVIEKYLKAAPGVTVENRLRVLRLIENLCLGTAAVGYRTESMH
GVGSPQAQRIMIARQGGLEHKKELAKAIAHIKG
>A0A379DAE5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Peptoniphilus indolicus|TrEMBL
MLMTGKEYIESLRKLDIKVYMFGERVENPVDNPIIRPSINSVAMTYDLAHDPEYEDLMTA
TSHLTGEKINRFCHIHQSREDLVKKIKMQRLLGQKTASCFQRCVGMDAFNSIYSTTYEID
RENGTNYHERFKKYLLECQKNDWTVDGAMTDPKGDRGLAPSKQKDPDMYVHIKEVREDGI
IVRGAKAHQTGSINSHEHLIMPTIAMGEDDKDYAVSFAIPTDAKGVFMIYGRQSCDTRKL
EEAADIDLGNNTYGGQEALVIFDDVFVPNERVFMCGEWKYAGMLVERFAGYHRQSYACKT
GVGDVLIGAAALAADYNGVPKASHIKDKIIEMQHLNETMWACSLACSAEGSKTDSGAYLI
DLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEKDLKGEFTGPWVEKFLNGKVGTS
TENRMRVLRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEAKKEMARRIAHV
DVSKDK
>A0A259U5G6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporomusa silvacetica DSM 10669|TrEMBL
MRAVKFPNGSWVPDEILTNAGRKLAGQKIYHEYETLADLTGGICASLPTEESFYAPETAD
LCNKYIMRNPDYTAEETHRVMRMMEDKLCDPFEAAQAVAGVHGGGSPLMETITMMSRYDL
EPLKEIAKYLAGFEGVKCPRYERKTVTPRAMLDKFKNTQIEKK
>A0A1C6CVS2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Clostridium sp|TrEMBL
MALMTGEQYVESMRKLNLQVYMFGEKIENPVDDPILRPSLNSVKATYDLAQDPEYADLMT
AKSILTGETINRFTHIHQSTDDLIKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTTYET
DEKYGTHYHENFKKFLQYVQEHDYTVDGAMTDPKGDRSLPPHLQADPDLYLRVVERRPDG
IVVRGAKAHQTGFVNSHEVIVMPTQAMGEDDKDYAVAFAVPTDAKGIFMIVGRQSCDTRK
LEGSEIDVGNSQFGGTEALVIFDDVFVPNDRIFLNGENEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAADFNGAQKASHIKDKLIEMTHLNETLYCCGIACSAEGRPTKSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLKDPFLGKYVDKYFRGVNAV
STENRLRIMRLIENLTLGAAAVGYRTESMHGAGSPQAQRIMISRQGNLAMKKKLAKDIAK
ITE
>A0A1V6IWF3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MRTKEQYIKGLRKMKRNLYFNGSKIDRDDEEQLPALNVMGFTFDAPHIPEFKDLCTAKSH
LTGETINRFCHVHQNSDDLHRKQDMTRALCRTGRMCIQRCMGVDAINGVNAASYEADKQN
NGSTEYHKNFLKWLENFQRNDLVGCCAQTDMKGERLKRPAEQTDPDMYLRVVGKKKDGIV
VRGCKLHISEASIADEIIVVPTRILGPDEQQFAVSFAVPADYDGVKQVVHIHKIRKRTHF
KTGNPDIGYTDSYVIFDDVFVPWERVFLCGEYVHGGALAMLFALFHRHSYSGCKPAIGDM
LLGTASLAAKMNGISKAHHVREILSRIIMVTELGYAAGFTASAKSKPEIYVPGIGQMPYG
PGSYIPHSIYANVGRCLTGEAVFDEQEMLCNIAGGLPSTFPYEADLANPELKPLLEKYLK
RNPKIPIADQIKFWLLFAEATCSSSTGFMCYGSYHGGGSPIMEQIAITLQYDTKLREHLV
NAAAGIEKLDYGRVTKI
>A0A645DLE7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MYLRIIESREDGIVVRGAKSCNSAAPYVDEIIVTPTRFMGPKDSAYAVSFAIPADWPGVK
LAALPGIRHKRKHIEAPISQVGDLESLTIFDDVFIPRDRVFMDGLGNPGCTPYAGFLAIM
FAHFHRHSYTGCKPATSEVIASQAALVAEYNGIEKTSHAQDKICHIIGIAELVFAAGIAS
AYRAEKSPSGTMIPDEILTNAGRKLAGEEIYNEARILADLAGGLIATLPLEAGYYNEDIG
GLLHKYIMRNPLVPAESVHRCFRMIEDQLISEFGGAMVVAGLHGGGSPQMEAVAMMGGYD
LEELKGIAKYLAGIEKDIPIYRRKTVTPRRVLEKFKKQTGK
>A0A6N2YGA7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eubacterium limosum|TrEMBL
MKTARDYIDSLRDRDIKVYIKGELIDSDKVIDHPFIKGHVNAASMTYALAGSPQYEDLMT
TTSHLTGKKINRFTHIHQSVSDLVKKVKMLRMISQKTGTCYQRCVGFDAMNATYSVTYDM
DKAMGTEYHERFKKFLLYVQENDLMIAGAMTDPKGDRSLRPSQQADPDLFVHVVDKNEEG
IVIRGAKAHMTGMVNSHEMLIMPTMGMKEDDADYAVCCALPVDAPGVIHIFGRQTNDDRK
MEGEIDQGNAKFGIVGGECLTVLNDVFVPWERVFMCGETPYSGLLVERFACYHRQNYGGC
KGGVSDVVVGAAALMADYSGYGKAGHVKEKINEMIHLTETLYACSLACSCEGKPTESGAY
FVDPLLANVGKHNVTQLIYDIDRLAQDIGGGIIATMPSESDLRNPEIGKYVDKYLKGVAD
VPTEDRMRIGRLIENMTGGTALVESMHGAGSPQAQKVMYSKLSNLEKKKEFAAHLAGIHS
DKSEEE
>A0A6P2FN01|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. PBL-E5|TrEMBL
MPLKTPEQYVESLRDGRVTYWDGERIDDITTHPRFRMPIDSVKADYRYDDPKYGALRQYQ
TEDGAVAHRIFQIPRDEADLNTRVEMMNHTSIGTLVTGVYMALMSVKDAVEKVNPMYGAN
IERMYRYCRDNDLRAAEVITDPKGDRKRSAAQQDDPDLYLRIVERRKDGIVVRGAKLHIT
AASLVHELVVMPTKGMKAEETDYAVSFSIPVNAPGVKIINRSVAGPDLNPFDYPASSHHG
MPEGFVVFDDVFVPWDRVFLAGEVELAGKLAQSLGLWERTGGMVEAVRLSELFVGLAQLV
NEMQGKDSDPVTQNSVAELIAYAEMLRMSLDFACRHYEKTPSGMVFPNTLAINAAKYYYA
ANYHQTVRYLHDLGGGLVLTLPLEADLRNEESGKYIRKYLYTKAGVNVETRMRVYNLIRD
LTADAYGGWQFVVALQAGGGLPAQRVMMRRSYNMDQAKKRALSAAGADVPE
>A0A1C6BMW9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Butyricicoccus sp|TrEMBL
MMTKDQYIESLRKLHLNLYSFGKKVENVVDNPIVRPSLNSFAATYELAEDPQYEDLMTAT
SNLTGKKVNRFTHLHQSTDDLIKKVKMQRLLGQKTAACFQRCVGMDAANAVYSTTFETDE
ACGTKYHENFVKFWTDVQNNDWGVDGAMTDVKGDRGLSPSKQADPDLFLHVVERTADGVY
VTGAKAHQTGYLNSHYVLVMPTISMREGDEDYAISFACPTDAEGITLILGRQSCDTRKTE
EYNDIDVGNKVYGGHEVLVIFDRVFIPNDMIFLNGETQFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGATALAGEMAGSAKASHVKDKLIEMTHLNETLYCCGIACSSQGTKTKSGNYLI
DLLLANVCKQNVTRFPYEIARLAQDLAGGIMVTQPSEADYRNPATHDYIEKYLKGVASVP
TEDRMRLLRLIENMTMGTAAVGYLPESMHGAGSPQAQRIMIARQSNMEMKKELAKKIARI
G
>A0A6N2RN65|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Anaerostipes caccae|TrEMBL
MALMTGNEYVESMSKLNLQVYMFGEKIEHPVDNPILRPSLNSVKATYDLAQMPEYEDLMT
AVSSETGEKINRFTHIHQSAGDLIKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTTYEV
DEKYGTSYHENFKNFLKYAQEKDLTTDGAMTDPKGDRSLAPHAQADPDLFLHVVERRPDG
IVVRGAKAHQTGIINSHEVLVMPTIAMGEDDKDYAVSFTVPTDSDGIFMIVGRQSCDTRK
LEGSQMDVGNSEYGGMEALVVFDNVFVPNDRIFLNGEYDFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGASAAAAEYNGAGRASHVKDKLIEMTHLNETLYCCGIACSAEGAATRSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLKDPKLGAYVEKYLHGVSGV
STENRLRIMRLIENLTLGSAAVGYRTESMHGAGSPQAQRIMIARQSNLTMKKKMAKEIAK
IKEE
>A0A2H1FHK6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosotalea okcheonensis|TrEMBL
MPIKTAAEYIQSLRGRDMKVYLFGELVKEPVDHPMIRPSINAVAETYDLAEKEAEMATAK
SSITGLQVNRFLHIAESANDLVNQNKMQRKLGQLTGTCFQRCVGMDALNSLYSVTFEIDE
KHKTNYHKRLVDFIKMIQQENFVIGGAMTDPKGDRSKAPHQQEDPDVFLHVVEKNDKGIF
VTGAKAHQTGCINSHWIIVMPTMRLLEGDKDYAVVGAMPADSPGITYIYGRQSCDTRSME
EGDIDSGNAKFAGQEALMVFDRVFIPWDKVFMFGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAASIADYNGVPDVSHIRDKLVEMTHLNETIYATGIASSSQAHRTKSGVWLNDD
MLANVTKHNVTRFPYEIGRMAQDIAGGLVVTLPSEKDLKNPTTGPILKKYLRGRKGVDVE
NRIRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNLASIKE
NSESEPEQSDYFERVFKIRK
>A0A1V6AS81|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MRTREQYIEGLRKMKRNLYFNGSKIDRDDEEQLPSLNVMGFTFDAPHIPELRDLCTAKSH
LTGETINRFCHIHQNPQDLHHKQDMTRTLCRTGRMCIQRCMGTDAINAVNAASFEADKQN
NGSTEYHKNFLRWLENFQNNDLAGCCAQTDMKGERLKRPAEQTDPDMYLRVVEKKKDGIV
VRGCKLHISEASIADEIIVVPTRILGPDEQQYAVSFAVPADYDGVKQVVHIHKIRKRTHF
KTGNPDIGYTDSYVIFDDVFVPWERVFLCGEHIHGGALAMLFALFHRHSYSGCKPAIGDM
LLGLASLAARHNGISKAPHVREMLSRIIMITELGYAAGFTASAKSKPEIYVPGIGQMPYG
PGSYIPHSIYANVGRCLSGEAVFHEQEMLCNIAGGLPSTFPYEADLANPELRPLLEKYLK
RNPKIPIADQLKFWLLFSEVTCSSNTGFMCYGSYHGGGSPIMEQIAITMQYDIKLREHLV
NSAAGLEKLDMGRITKF
>A0A143B284|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfuromonas sp. DDH964|TrEMBL
MKTGNQYRKSLKQLAPNLYKWGKPIKDVTRHAATRLHVKAIADCYDAGFDPEHAAIFTGE
SHLTGKRAHRWNTLMRSADDVVANARIKRAQFQRTGACHGATCAGWTALNALWATTWELD
QAEGTDYHRRLENYFRYLEENALATAGALTDAKGDRSLGPAAQSEADQYLHIKEVRDDGI
VVRGVKAQICGVAAAHEIVCVPGGGLKEGEEAFAVAFAVPRDVAGLTAVETRRPSDTRDE
EEGWDAPRAGGVGQAFLLFDDVFVPNERVFIQGQTRYAGVFINHFTALYRAPIGACVAGQ
GDVMIGAVLALAEAGGLSQKVFQEKLTRMAINNETTFGLGLGAILQGQAHPSGVWIPDPL
LAHINKVQVAMLPYETKRLAQEIGGGITETGCFPSWQDLTSPLYGDKLLTALAAVSDGET
RARLARLVEWLTVGGGIPGCLNGGGSPDGARLVVRALEPWKKFATNARRIAGLDQN
>A0A1V5E4P1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MRSKEEYIQALSKMKRNVYFNGEKIDRADERQMDCINNIGTTYDEAARPENQELMTAISH
LTGERINRFTHIHQNKEDLHRKQDMTRMLCQKVGGCIQRCMGIDATNAIYNVSYEADKQN
NGATQYHENFKKWLKRFQSEDLIGCCAQTDVKGDRLLRPADQPNPGSYVYIKERLKDGIV
VEGCKLHISEASVSDEVLVVPTRALREKDKDYAVAFAVPGDWDGLKQVVTIHSFRPREHY
KRGHMPGSTDSYMIFENCFVPWERVFLAGEWQQGGINALLFALFHRHSYSGCKPAIGDIV
LGAAALAAEVNNIHKESHVREKLAEIIMVIELGYAAGYTASDLGGPQVFMPGKGFIPYGP
GSYIPHSIYCNVGRCLSGENVFREAEILCDIAGGVVATFPHERDFLSPETGELLKKYTKR
NPTMPVEDQAQFWRYLGDVLCSAKGGIHNVGGYHGGGSPIMEQIAITTQYDIESRKKLVK
YIAGMGGGDREVFAKQIKSS
>A0A852TWS4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Spinactinospora alkalitolerans|TrEMBL
MVMMTKAEYLASLNDGRRIFADGEEIKDLTTHPQFATSLELVGDGYDRHHRPGRGACGPY
FSIPHSREELKELLETLLGWDMVTVTTSQGLLALLTAAARMRSAHPEYAKRIEDYFDHCK
DNDLRCVQAITDAKGDRTVAPGKQEDPDVYTRIVERRSDGIVVRGAKLHISSASISHELV
VMPTKKMKPGEEDWAVACAIPVNAPGVRIVNTNYAPRDRHEDFPHSSRHNMPEGFVLLDD
VFVPNERVFLAGETDHSATFAHSLGLWERLGGTAHLVEIGDTLVGLAQLIAESNGTQRIS
HIREKIAEMVIYATLVRAGLEAAIANAEPSPEGWYFPSELFTNAAKHFGAAEFSHMVRHL
HDIGGGSIVTAPSIADLENEEVGEQIKKYMHTVDGVDGEYRTRLFHAIRDYTADAFGGWQ
LVTMIQSGGGLYAQRLVSRKHYDMDKAKALALEVVNGPKG
>A0A1C6AT21|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Flavonifractor sp|TrEMBL
MPLMTAKEYIESLRRLKTRVYMFGEKIDNWVDHPIIRPSINCVAMTYALVQDPRYEDLMT
ATSSLTGRKVNRFTHLHQSADDLVKKVKMQRLLGQKTASCFQRCVGMDAFNAVYSTTFEI
DEKHGTHYHENFKKFLIYVQDHDLTVDGAMTDPKGDRSKAPHQQTDPDLFVHVVERRPDG
IVVCGAKAHQTGSINSHWHIFMPTIAMGEADRDWAVSFACPTDADGLYMIYGRQSCDTRK
LETGGCIDQGNAKFGGQEALVVLDHVFIPNEYIFLNGEYEFAGMMVERFAGYHRQSYGGC
KVGVGDVVIGAAALASEYNGVEKASHIRDKLIEMTHLNETLYSCGIACSCEGCPTKAGNY
QIDLLLANVCKQNITRFPYEIVRLAEDIAGGLMVTMPSEQDFTSETVVGRNGETIGDICN
KFFAGREGVSTQDRQKIMRFLENICLGAAAVGYRTESLHGAGSPQAQRIMIARQGNIQGK
KELAKLIAGITRDSE
>A0A644UBB7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MGVGTYEAYRERLLKMKPNVYLNGQKVDRSGSWIDGGCYVMKQNYDLANDPEYADVCTAT
SHLTGEKINRFTHIHQSREDLLNKQMMTRLLCHHVGGCTQRCMGSDALNALAVVTYDCDE
ACGTKYQERFNKYLLYCQENDLICNCAQTDVKGSRNPKYKRAHMQPDPDQFVHVIKTDVD
GIGVDGKPCKGIIVRGAKICNSNAPYVDEIIVNPTKFMGKGDEGYALAFALPADWDGIKL
MALPGQHHKRKHLEAPFNKVGDVESLTIFDDVFVPEDRVFMNGFDHPDVVQYAGYLALMF
AHFHRHSYTGCKTAVSEVIGAQAALVADVNDIAKEHHVREKVCEIISTAELVFAAGQASA
LRAVKFPNGSWVPDEILTNAGRKLAGQKIYHEYETLADLTGGICASLPTEESFFAPETAE
LCNKYIMRNPDYTAEETHRVMRMMEDKLCDAFESAQAVAGVHGGGSPLMETITMMSRYDL
EPLKDIAKYLAGFEGVKCPRYERPTVTPRAMLDKFKKTQVNTSK
>A0A212LVN6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Sporomusa sp|TrEMBL
MRTGKEYIESLKQRNIKVYIKGQLLKSEEVVDHPFIRGHVNSAALTFDLAHDPAYEDLMT
TTSHLTGKKINRFTHIHQSVDDLLKKVKMLRMISQKTGTCYQRCVGFDAINALYTVTYEM
DKKLGTEYHERLKKYLINWQENDLMVAGAMTDPKGDRSLRPGQQPDPDMFVRIVEKNDKG
IIVRGAKAHMTGMVNSHEMLIMPTMGMAPDDSDYAVSCAIPVDAPGVIHIFGRQTNDDRK
CEGDIDQGNARYGIVGGECLTVLEDVFVPWDKVFMCGETEFSGLLVERFACYHRQNYGGC
KGGVSDVVIGAAAVMADMSGYGKAGHVKEKINEMIHLTESLYACSIACSAEGKPTASGGY
FVDPLLANVGKHNVTRLIYDIDRLAQDIGGGLTATLPSESDLRHPEIGKYVDKYFKGAAG
VSTEDRMRVARLIENMTGGTALVESMHGAGSPQAQKVMYSKLGNLEHKKKLALHIAGVAA
NKDK
>A0A654M4P7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosocosmicus oleophilus|TrEMBL
MPIKNGSEYIESLRDRNLQVYLFGELVKEPVDHPMIRPSINAVAATYDIAEEDPEIGSAT
SSLTGLKVNRFLHIAESSQDLVNQNRMQRKLGQQTGTCFQRCVGMDALNSLYSTTFEIDK
KYQTPYHERLIEFIKKIQYENHVIGGTMTDAKGDRSLSPSQQEDPDMFVHVVKRDEKGVY
IKGAKAHQTGCINSHWLIVMPTMRMRPEDRDYAIVGAIPVDAKGITYIYGRQSCDTRSME
EGDLDAGNSQFSGQEALIIFDNVFIPNELIFMEGEVEFASMLVERFTCYHRRSYVCKTGL
GDVLIGASAAIAEYNGVSNASHIKDKLIEMTHLNETIFAAGIASSHQAYRTESGNFINDD
MLANVCKHNVTRFPYEIGRLAQDIAGGLMVTMPSEKDFRGPVTGPLLDKYLKGRKGVSTE
DRVRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKLARKLAKVAE
GEDTISNPSLAESSDYFDRIFGIKK
>A0A6N2S0L1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Enterocloster bolteae|TrEMBL
MGVGTYEAYIERMKKMKPNIYLDGKCVDRMGPWNEGGFWVMKQCYDIANDPEYADVCTAT
SHLTGETINRCTHIHHSQDDLLKKQLMTRLVCHRVGGCMQRCMGTDALNAIAVVSYDCDQ
ATGTKYHERFNRYLEYCQKYDLICNCAQTDVKGSRNSKYKRAHQQPDPDMFLHVIKTDVD
GVGIDGKPCKGVIVRGAKICNSCAPYVDEIIATPTKFMGRGDEGYAISFALPADWDGIKL
MALPGLHHKRKHLEAPFNRNGDNESLTIFDDVFVPEERIFLNGYDNEDAVQYAGYLALMF
AHFHRHSYTGCKTAVSEIIASQAALVADVNDIAKAEHVREKICDIIGTAELVFAAGQASA
YRAVEFPNGSWVPDEILTNAGRRLAGHNIYHEYEILADLTGGVCASLPTEESFFAPETAE
LCNKYIMRNPEYTAEETHRVMRMMEDKLCDAFEGAQCVAGVHGGGSPLMETITLMSRYDL
EELKKIAKYLAGFDGVECPRYERATATPRAMLERFKKTQK
>A0A853CND6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Geodermatophilus daqingensis|TrEMBL
MLTGQEYKDSLKDGRKVYFAGRQIEDFATEPALGVPMQVAADGYDKHYSAEPGAVNPLID
GPRSPEELRDKIPVLMEMDLLLNVTYQSLMTLLVAAPRIEGVAPQFVERIHAYVADAKAR
DIRITECITDSKGNRSKHPADQDDPDSYVRVVDRGPDGVVIRGAKMHISAAALGHDLMVM
PTKNMKPGEEDWAICAAVPVNAPGVHITNTTYHPYGRDERDHPTSARESVPDSMCIFDDV
FVPNERIFLDGQAAQAAVFAHSLGLWERLGGTAFMVEQADELVGLAQLIAEANGTAKISH
IREKIDEMMIHATLLRAGLEAALLHAHETPDGYFYPDDMYTNVTKFQGAAQFSKMVRHLH
EIAGGAVLTAPSMSDFDNETLRPYLEKYMSTGDGVSGEYRTKLFHAIRDTTADAYGGWHH
VTNIQSGGGLFAQRLVTRRHYDMTRAKSLALKAAGLAGD
>A0A174BQ24|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Flavonifractor plautii|TrEMBL
MTGEQYIESIRKLNMQVYMFGKKIENLVGY
>A0A087RUW9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-D11|TrEMBL
MANVLKTIRSGEDYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAETYDLALREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDAMNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKGDRSKGPSEQDDPDLFTRIVDTD
EKGVYVSGAKAHQTGCINSHWIILMPTIRLTEADKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGIPKVSHIKDKIIEMTHLNETIFAAGIASSHQGHKMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GVDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKNL
AGITNDVEEPKESSEYFKRVFKTKDSVL
>A0A1V5DFF0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MAIKTREEYYESLKKTHPTTYILGERVDNPHDHPLIKHMVAGVAKTYDLANVAEGKKKLV
TQSDLTGKDTSRFVKFYTGRQDLQDKIEMLKYLSHEIGTCYMRCTGMDAINAVGIETYNC
DRKYKTNYNARFLNWLKMIQENDFTVFSGVTDMKGDRLKRPSEQSDPDMYVHVVDRNDKG
IVVRGAKIHQTGSLCAHWGLIVPTREMLEADKDYALCFALPVDAKGFIHVYGRGSMEARE
LEECDLGNAKYSKFCPMIIFDDVFIPWEHVFLFGEYEFAGDMVRQFGNFHRHSHGGCKCG
VGDVLIGAAAAAAEYNGLKKVSHINTKLAEMTKIIYAMYGCSIAASVTAEPTPSGIYNVD
PILSNTSKLFEGKDLAEVHRMMIEIAGGGVTDLPSDKDFANAEIGHLLSKYFKGADGFAA
HDRVRILRLVEKLAFETRDIVSNIHGGGSPETHRMTLLRNIDIESKKKIAKKLAGIKE
>A0A075GXA6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_204_F10|TrEMBL
MQKTVKPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTEYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPTEQEDPDLFLRIIERD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAVVGAIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFVSMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPKVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEEGEETLENSDYFNRVFKLDNSKE
>A0A080M477|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. BA-91|TrEMBL
MTRDRMLLTSGRLISGAGYRESLRRYTPKVYVDGELIASVADAPTLQPGINALAVSYDFA
LDSDKTPLMTAVQTSSGATVNRMLHINESAGDLLNKLEAVRILCQETGCAQRYLAHDALN
AIHQVSARIDDARGSSEHRARFAAYLEEVQASDWSLGIAMTDAKGDRSKRPHQQANPDTY
VHIVERNPRGIVISGTKAIVTGAPYMHEFLVMPSRNMGPADADFAVCCALPVDAPGLTII
ARPAGRPGEKLEHGAALFSRRYGQSTAVLVFDRVFVPWERVFFAGEWEHSGSLTYHYATH
HRHSCIAARAGFGDLLIGAGALMCEANGFDPGRKASLREPMVELIKITEGFFACGVAASV
YGTPDPYSGSFMPEAVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPATGA
TLAEVLRANPDVPYDKRIEVARFIEDLTASYQGGWYSVISLHGGGSPAAMKQEIWRHYPL
GSKVELVESLLDRGVLHDESRAITRNRQPGRCCDAGCSPPGQTIMVPLPRSGKLS
>A0A2S6R4B0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Alphaproteobacteria bacterium MarineAlpha10_Bin2|TrEMBL
MLMSGEEYRESLRGYSPTVFLDGAQINSVADEPRLAPGVAAVGVTYDFAKLERHQPVMVA
EEQSSSAKVNRFLHINRSSRDLLNKLEAVRLVCQRVGCAQRYLSQDALNAIHQATYRIEA
EAGGDLHQRFGAYLHRVQAEDLTLGVAMTDAKGDRSKRPHEQTNTNAYVHIRERRADGFV
ISGTKAIVTGAPYMHELLVMPGRNMVEADSEFAVCCAVPIDAKGLTIITRPAGRPGDDAA
VFSGRYGQSTGVCVFEDVFVPWQNVFMAGEWQHAQFLTRAYACHHRHSCIGARAGFGDLL
IGASLMMAEANGLDAAGGTHLRERMVELIKIVEGFFACGVASSTYGVPDASGCAEPERIF
ANVGKLLLSTQIYDMQRIAHDLSGGLIVALPGPDEDHNPQTAARLEELWQGKDDIPPERR
RAVARFLGDITASDTAGWFSLISLHGGGSPAATSLEIYRSYPLEDKVALVESLLDRGLLD
SEQSETETGDQPGRCCADGCQAPEEDKATP
>K0IP19|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrososphaera gargensis (strain Ga9.2)|TrEMBL
MPIKNGAEYIQSLRGRKLKVYLFGELVKEPVDHPMIRPSINAVAETYDLAVEEPELASAK
SSLSGIQVNRFLHIAESAQDLVNQNRMQRKLGQLTGTCFQRCVGMDALNSLYSTTFEIDQ
KHGTQYHKRLIEFIKMVQRENLVIGGAMTDVKGDRSLSPSQQEDPDMFVHITKRDSKGVY
ITGAKAHQTGCINSHWIIVMPTMRLKAEDKDYAIVGAIPVDAPGITYIYGRQSCDTRSME
GGEIDAGNVMYSGQEAMVIFKDVFIPNELIFMDGEYEFASMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIADYNGVANASHIKDKLVEMTYLNEAIFGAGIASSYMAHKTASGNWQNDD
MLANVCKHSVTRFPYEIGRMAQDIAGGLMVTMPSEKEFRSPETGPLLEKYLKGRKGVSTE
NRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKAAKKLANVKE
GEAAETAPEQSDYFDKIFGTKDKKKVK
>A0A1V5IG04|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bacteroidetes bacterium ADurb.BinA104|TrEMBL
MALKTGAQYIEEMKKMRPNVYKWGELIEDVTAHPATACHIKNVARWYDNSFDPEKEQIYT
TTSALSGKKAHRWTTLIASADDMLGNANMKRDGYHTCGSCMGPVCAGWTVLNALWGVTYE
MDQELGTDYHERLKNFFAFAEEKALALSGALTDAKGNRALKPGQQDNPDMYLHVVEKRED
GVVIRGFKNQICGVVGSQYIIVMPTTGIGEDEAEYAIAAAVPRDAEGVTIVETRRPSDTR
IEEEGWDGIKSGTTQAYIIFDNVFVPNKHVFMNGEAKYTGKLIGNFTAIYRAAIGACVAG
QGDVMIGAALGMARANGLAQKAFQDKLTQMAVNNETTYGLGIGAMYTGKKHKSGAFYPNP
LLAHVNKVHVATLPYNTKVLAQEISGGIAETGCMPSYKDMMSPIYGEKLIESLRSAVPGE
DRIKMARLVEWLTIGGGVPGCMHGGGSPDTAKMVVKAATKWDNYVDYARVLAQVESPLKE
EKKK
>A0A0D5C4H9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilus adriaticus|TrEMBL
MANVLKTIRTGDDYIESLRGRDLKIYLFGELVKEPVDHPMIRPSINAVAETYDLAVREEE
LASANSSLTGLKVNRFLHIAESAQDLVLQNKMQRKLGQNTGTCFQRCVGMDALNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQKENLVIGGAMTDPKGDRSKGPAEQDDPDLFTRIVDKD
EKGIYVSGAKAHQTGCINSHWIILMPTVRLTENDKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKYGGQEALIILDRVFIPWEKVFMNGEYEFASMLIERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGVPKVSHIKDKIIEMTHLNETIFAAGLASSHQGHKMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GVDIENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKHL
AGITNDVEEPREPSEYFKRVFKTKESVL
>A0A2S9YI27|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Enhygromyxa salina|TrEMBL
MATTWPLTSGAEYIDSLRGRDLAVYLHGERVAEPVDHPIIRPSINAVAETYDLAAREPEL
ATTISPLTGERINRFLHVAASADDLVAQNMMQRKLGQLTGTCFQRCVGMDALNALYSVTF
ELDAKHDTPYHGRLREFIKLVQSRNCVIGGAMTDPKGDRSKAPHQQSDPDLFVHVVERND
EGVVIRGAKAHQTGCINSHWLIVMPTMRLGPEDRDYAVIGAIPVDAPGITYIYGRQSCDT
RSAEPSSLDRGNPRFSGQEALVIFDDVFIPWDRVFMDGEVDFAAMLVERFTCYHRRSYVC
KTGVGDVLIGAAATIADYNGVPKASHIRDKLVEMTHLNETIYGIGIASSHQAQATKSGCY
LNDDMLANVCKHHVTKLPYEIARLAQDLAGGLVATLPSAADLESDAVGALLEKYLKTRDE
VDVRDRWKILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARAMQLDAKKQLAKRLA
DIEDAEPE
>A0A6I7LUH2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|candidate division Zixibacteria bacterium|TrEMBL
MALRTYSEYLDSLRRMRPNIHKFDELINDVTTHPATRNTIEGHGQSYKLLDDPAEREILT
TTSSLTGEPISRYLSIIRAPEDMYANSRLKRHMFQKTGTCTGGRCVGWTALNSMFLTTYE
MDQKLGTDYHVRLLNWLRDAQSRDITVSGALTDPKGDRTKSPMAQDDPDMCLHIVEKRPD
GIVVRGAKVMICGVAASNEIFILPGSGYKEAEKDYALSFVIPRDIENLTIVETRRPSDTR
ETEEGFDIPVKDGGITQAYLLFENVFIPKERVFMAGEYEFALNAVKYFISAYRAAIGGCV
AGQGDVKIGAAVLTARANGLSSKVFNDKLVKMHINNETTYGVGIAAAALGKRHPSGAWVC
DMLLSNVNKIHVATLPYETSLLAQDIAGGIAETGCIPAYKDIVSPKYGHLLKKYLKARHS
AESRVRAARLVEWATIGAGVPGCMHGGGSPDGAKLMIRASENLEEKVQFARRLAGITEEI
PEPEPKK
>A0A1C6AGM6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Roseburia sp|TrEMBL
MAAISTINKPIETAEEYVQSLRDMKTEIWAFGEKVSNIPDHPLFIPHVNAVAKTYEMPFP
VKSHLTGNTINRFNHIHQGPEDLVAKVKMLRALNQQTGCCIQRCAGMDALNATYIVTYEI
DKKYGTNYHERFKKFMTYLQDYNLVTIGGMTDPKGDRSKKANQQKDPDIFLHVVEEREDG
IIVRGAKAHLTGVSGAHELMVFPTENMKEDAKDYAVVFSCPVNTPGITYIFGRQTNDSRK
LDTEYPIDQGNPKYACVGGECLAVFDNVFIPWEDVYMYKEYEFAGMFVEAFATAHRQNYG
ACKGGIADVLIGAVYGIAKVNGVERVGHVKDKIADMINLSETLYAGSIACSYEGHQTESG
AWRADTMLANITKHNTTKFVYDINRIAHDLSGGLLATLPSEADLRHPEIGPLIERFLAGT
DAMSTEDKMRLYRLVETLSGGTAAVESMHGAGSPQSQRIMMLRDAKLEQKLKFAQQLVGC
RGCNGCDGCKQD
>A0A8I2C1R8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bradyrhizobium elkanii|TrEMBL
MLMTAADYRESLRRYKPRVFVNGAAVASVADEPLLAPGVAGVGVTYDFALQPEHVPIMTA
RQGTSGKTVNRMLHINRSSQDLLDKLEAVRLVCRTSGCAQRYLSHDALNGLYQATRLTDD
RHGTDYSQRFLNYLHEVQDQDLTLGVAMTDAKGDRSKRPGLQANTDVYVHIRERRPDGIV
IRGTKAIVTGAPYMHEFLVMPCRTHVPADKDFAVCCAVPVDAPGVTIVARPAGRPGDAAA
KFSAKYGQSVGVVMFDDVFVPHDRVFLAGETEEGGFLTTSYATHHRHSCIGARAGFGDLL
IGAGALMIEANGLDAEKHAHIREAMVELITITESFYACGVASSVYCTKDPAGSVMPDAVF
SNIGKLLLATKIYDMHRVAHYVSGGLIVALPGPDEDHNPETRASLAAVMGGRPDIPAEQR
AEVARLIEDLTVSHEAGWYSVISLHGGGSPEAMKREIWRNYPVMEKAELVENLLGRDLVD
QGQRVSKQPGRCCATGCEVPAPSAAESLL
>A0A835X0N1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MVTMPSEKDFRNPETGPILRKYLAGRKGVDVENRMRILRLIENMTMGRNAVGYLTESMHG
AGSPQAQRIQIARQMQLGYKMNLAKNLASVKDDFQEPTEPSEYFKRVFKIFDKKE
>C6SNM8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Neisseria meningitidis alpha275|TrEMBL
MADLQKTFQTSFRDAMASCAAGVHVITTDGAAGRYGITMTAVAPVTDEPPTVMLCINRSA
RIIPILSENGSLCINMLADEHQDVAEHFAGLTGLSPEERFAYHIWHRGKRDNLK
>Q0K3Y1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)|TrEMBL
MIKTGNQHIAMLRDGREVYLDGKRVTDVTSHPAFRNSIRSYANLYDFQAQPGNIDKMTFQ
PAGTDRRVSRIWELPASYNELVERRQMLEAWTELHYGFMGRSPDHVASCISGMYMGIDVF
EQADPARAGALRDYYRYARDNDLFLTYVIVNPQANQSKSAHEQEDKYLAVGIVDQDAEGI
TVRGAKMLATSGIMANEVFCSCIQPLREGDEMYALSFAVPMNTKGLKVMSRKSYEANATS
VFDNPLASRFDENDAVLYFDDVKVPWERIFVAGDVGLCARQFHATPAHVYQNYQCQVRLM
VKLRFLVGLAHRITEINGTNSFPQVREMLGQLAAEAGMVEAWVYGMEAKGQVGKHGYFVP
DRSMLYGSQVVTQQLYGKVLATLRELAGGGMIMLPSSIEDFANPSLAGIIAKTQKSPVCS
PEERVKFFKLAWDAVGSEFASRHNQYEMFYAGATFVTKGHAYRTYDWQNASGLVDNMLGS
YSLESELAKLPQAA
>A0A2H5V9Q6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|archaeon HR04|TrEMBL
MPLKTQEEFIASLRDGRNVYYNGERVTDVTTHPVLSIFVNHWSLIYKAKHDPKVKDIFVK
RLDEYGEASAYFNIPRNADDLLARAKLIEATTAYCNGQFNIAQAIGTDALFALMSICSEV
DKRYGTRYYQNVLRFYDRCVREDLAMAVAQTDVKGDRSKRPHEQDDPDAYVHIVERRSDG
IVVRGAKVHTTGTQAVNEIIVLPTRNMLAEDRDYAVAFAIPANDKNVKIISRAQASKELG
EFDYPMSVKATAQETLTVFDDVFVPNERIFLAGEYEYAGALARLFALWHRFTAISYKPPI
GDQLLGAAALIAEYNGISKYPHVRSKIVKLIRYVETIRACIRAAAVEHKVYPVGIAVPNP
VYVYIGKYHLADNFHDAAKTVQDLAGGLVITQPTTRDLENPETAKYIEKYLKTRHDVPAK
NRLKVLNYIRDLTASTYTGGYNYVLSVHGEGSLEAQIISTYTEYDVDRCVRYVKSLLNIE
>A0A853CQD6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Geodermatophilus daqingensis|TrEMBL
MLTGEQYKASLDDGRATYFEGERVKDLPGHPVLGQVVQNVADGYDWLAGQSVDGTNPVSG
IPRTPDELRQKVELVHHAGMMAHVNYTSIMTLATAAGRLAGAGPQYVERIQAFTTSAQHS
DIRITQCITDAKGDRSLPPSRQDDPDAYVRVVDRSSDGIVIRGAKLHITAASFGHELMTI
PTKAMKPGEEQYAIAAMIPVNAPGVKIINTTYAPRHPDPRHFPVSGLESFPEGFVIFDDV
FVPNDRVFLDGETEHAAVFAHSLGLWERLGGLTSMADGADVMVGLAQLIAEANGLTRVGH
VKEKIAEMIIHATVVRACLEAALVHAETGVFGAVFPNELYTNAGKYTGAASYNLMVRHLH
DIAGAAVVTAPSLLDLENPEVGPLARKYMSTSKDVDGEYRTRLFHVIRDLTADSYGGWKQ
VTNVQAGGGLYAQRIVTRKHYDMDAAKHAALVVAGLAQDAHGPSKGI
>A0A1C5L5Q0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Megasphaera sp|TrEMBL
MLMTKQQFQDSIRARKPMNVWFLGEKIEDVTTYPPLAASFNAISKIYELQHRPDWQDLIT
VPSHMLDERVSIYNAPLRSAEDANRKTRAARALAEVIGCCTHRCTGSEAFAGLGPACYDM
DHDLGTNYFERFMNFLKYVQQNDLTCTVTVTDVKGLRTAPPHAQADRDSYVHVDEVREDG
IVISGFKCNQTGILFAHEIVIVPTTNMKPEDKDFAVACAVPADTPGLTFVLGRTPQDKRF
FEVEGDIEGIDLGKQYADHQALVYFDHVFVPNERVFLCGETQYVGRLLSYFTAVHRLTAG
GCKAGGCSALCGAASLLADMVGVQKAGHIRTKLTEMAMTAETVYGLSIASGVEGFQHPSG
FWIPNPLMSHTCKYTCTKIPFDAVRYARDILAGFGETAPSELDMRNPEVGELCQRAFNPG
NPKYNAFDRLRASRFIEHMVRGSNWTAMALHGGGNQEASTVMARMYTDWEYLKGLVKVAT
GIETDAQKAEEFIDTIGKRQGRICTTLDLPKVES
>A0A2P9GV76|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophobacter sp. SbD2|TrEMBL
MVFDNVFIPWDRVFLYGETKYCGRLISRFAKTHRMNCGGACKVGFADLIIGATLLAAEFS
GVEKIPHIQDKLIEMVRLSETSHACAIAAAVKGREEPEGSGVFMPDDLFGNVAKLSIAHG
FWEIMKLAGDIGGGLVVTMPRLKDLDHPEVGPLLKKFFQSAAPADKRFRVAKFLQHWTAG
LHGPGTWHGAGAPQTQRVMISYLTDFESKKKMAKKLMRMEED
>A0A1V6AR58|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MALKTPEQYEDSLRKMNFKIYLMGELVKNWVDHPIIRPSMNAVKMTYELAQKLEHEDLMT
VKSHLTGNKINRFTHLHQSPEDLVKKVKMQRLLGQKTAACFQRCVGMDAMNAVDSTTFEM
DQKLGTKYHERFIKFLKMVQDEDLVVDGAMTDVKGDRSLAPHQQADPDMYVHVVEKNDQG
IVVRGAKAHQTGAVNSHWILVMPTIAMGKDDADYAVSFVCPADEKGVYYIYGRQSCDTRK
MEGGTIDVGNAQFGGHEALMVFDNVFIPWENVLMCGEYEFSGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGAAKASHVKDKLIEMTHLNETLFSCGIACSAQGHKTASGTYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGMMVTMASEKDFKNPEIGKVLEKYLKGTANV
SCEDRARVMRLVENLTLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEQKKDLARNIAG
IKEKKK
>A0A1S8QGL8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium beijerinckii|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKAIDNVVDHPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNALYSSTYEI
DKACGTNYHENFNKFLKYVQENDLTVDGAMTDPKGDRGLSPSKQADGDLYLRVVERREDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPNDKDWAISFAVPTDAEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGSKTEAGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGIMVTMPSEADFKDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENICLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
RIKE
>A0A1V4WW82|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaB.Bin047|TrEMBL
MSLMTGSEYIESLRQQKKRIFLGGQTIDNYVDHPIIRPSINACAMTYELSHQPEHRELLT
ATSSLTGKTVNRFTHLHQSAEDLVRKVKMQRLLGQKTGCCFQRCVGFDGFNAVDSVTYEM
DQELGTEYNKRFRSYLEYVQEKDLIVDGAMTDTKGNRRLAPSQQEDPDQFVHVVEKRPDG
IVVRGAKAHQTGAVNSHEILVMPTQTMRPEDADYAVCFATPADAQGILYIYGRQSCDTRR
LEGGSVDVGNAMFGGQEAVIVFSDVFVPWERVFMCGEFQYSGALVERFAGYHRQSYGGCK
SGVGDVLIGAAQAIAKIQGLEKASHIKEKIVEMIHLNETIYSCGIACSAEGRPTTSGTYL
IDLMLANICKLNVTRFPYEISRLAQDVAGGLLVTLPSEKDFSHPEAGPYLEKYLRSDAAY
GTEERCRMQRLIENLTLGMGAVGYLTESMHGAGSPQAQKIMIGRLANLQYKEQVARELAG
IKKN
>A0A1V4WZ67|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaB.Bin047|TrEMBL
MGIKTKNEYIESLRSLKPTAYMFGEKLTNIVDNPRLRAGIEATGATYEMAEIDPGLMITT
SPLINEPVSRFTLPPSTIEDLVARVKVNRRVANHVGTCHQRCTGLDCLTALAIVTYDIDQ
KYNTEYFPRFQEFLKHMQRNDLTGNAGVTDVKGDRSLAPHEQPDKDMFVRVVERKADGIV
VRGAKAHQTGSLSSHEVIVLPSRAMSKDDKDYALAFAVPADTKGLIHVVGRSSLDMRELD
GCDIGNVYYSKYCPTLIFDDVFVPWERVFMCGETEFASDMVVKFSSLHRQSHGGCKSGKI
DCMIGCALTLMDYNGTTKVGHLKQKVIDMIHRAETLYGCCLASSYEGRKQPSGTYFIDTV
LANASKLHEGKEMAEATRLMIDAAGGFVADLPSDRDFSNPEIGDLLKKYLKAVDSVPVEK
RVKMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETNTNDKKKAAKRLAGIDD
>A0A1Q9NHP5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Thorarchaeota archaeon (strain AB_25)|TrEMBL
MSDVGAGAGRPPSILSLFKSMNVNTYRVSLKYRYSIIQVSPPSMELSTMGLKTGEEYIES
LRKRGPLTIYMLGEKIENPIEHPIIRASINSVALTYDLAHDSDYSEIMTAKSVLTGNTIN
RFCHLHTGTEDLQNKVKMQRLLGQLCGTCFQRCVGMDALNAVYLTTYEIDQKFQTNYNQR
FIDYIKQAEAEDWTIDGCMTDPKGDRSKRPSEQKDPDVYVHIAERRDDGVVIRGAKAHQT
GAVNSHEHLIMPTLAMRNEDKDYAICCAVPADAKGLTYYYGRQSCDLRRLDETEAGDVDC
GNPVYGGQECLIVFDDVFVPNERIFMNGESEFCSRLVESFSAYHRQSYGGCKVGVGDVLV
GAAASIAEYNGVEKASHIRDKITEMIHLNETLYSCGIACSAAG
>A0A644Y819|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MASAAFGVETPSGNFLANTLYVNIGKILGIKAVYRSGEIAAEIAGGLICTQPSVADFDNP
ETKDILEKYLVAKQGYSARDRVKVLRFLEYAMGQGSVIPAESLLGGGAPAACRVAIKGAS
NIKYYKQCVKKIIGI
>A0A645C4E1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MSANNNTTYGLGIGAMALGGPHTSGVWISDSQIAHLNKIYVATLPYETKRLCQEIGGGIV
ETGCTPSYTDWNDPRYGEMIRKYVKAGDCSAESRVRAARLSEWLTIGSGVPGCMHGGGSP
DGARMVVKAFTPFEVYADFAKKIAGITENIVDPAADKK
>A0A1S8Q4A5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium beijerinckii|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDNVVDNPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNALYSSTYEI
DKACGTNYHENFNKFLKYVQENDLTVDGAMTDPKGDRGLSPSKQADGDLYLRVVERREDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPNDKDWAISFAVPTDAEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGSKTEAGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGIMVTMPSEADFKDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENICLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
RIEE
>A0A0T5P565|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Roseovarius indicus|TrEMBL
MLMTAQDYRESLRAYSPRVFIDGDRIDSVADEPRLDPGINGVGVTYDFAHRPESERLLTA
TQSSSGKTVNRMLHINESSDDLLQKLEAVRLVCKVSGCAQRYLSHDALNGIYQATHRTDA
THGTDYAQRFMAYLHDVQDRDLTLGVAMTDAKGDRSKRPGQQANPDVYVHIKERRADGIV
IRGTKAIVTGAPYMHEFLVMPCRTHTAEDADYAVCCAVPVDAEGVTIVAKPAGRPGEAAA
KFSARYGQSTGVVIFDDVFVPHDRVFLAGETTEGGFLTTSYATHHRHSCIGARAGFGDLL
IGAGAMMVDANGLDVDRHAHIRDAMVDLITITESFYACGVAASVYCEADPAGSVMPDAVF
SNIGKLLLATKIYDMHRVAHYVSGGLIVALPGPDEDHNPETRADLTAVLGGRPDIPAERR
MEISRMIEDLTVSNQGNWYSVISLHGGGSPEAMKREIWRNYPVAERQELVSDLMDRGVLA
EGRKVSRQPGRCCATGCQPPEKISNTEAAE
>A0A212JIN9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured delta proteobacterium|TrEMBL
MMTGDQYVESIKKINMKIFMFGEQVESAVTNPILRPSLNSVKATYDLAQNPEYEDLMTAK
SHLTGKKINRFTHIHQSTEDLVKKVKMQRLLGQKTAACFQRCVGMDAFNAIFSTTFEIDK
AHGTKYHQNFLKYLAMAQEQDLVTDGAMTDPKGDRGLSPSQQADPDLYLRVVERRPDGVV
VRGAKVHQTGICNSHEVIVMPTIAMRPEDKDYAIAFAVPMDSEGLFMIIGRQSCDTRKLE
GSKMDVGNCEFGGVEALTIFDNVFVPNDRIFLNGETDFAGMMVERFAGYHRQSYGGCKVG
VGDVLIGAAAVAADYNGAHKASHLKDKLIEMTHLNETLYSSGIACSAEGKKTESGNYIID
LLLANVCKQNVTRFPYEITRLAEDIAGGLMVTAPSEKDFRHPKLGPYIDKYLKGVASVST
ENRLKILRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNIEQKKKLAKAIAKIQ
E
>A0A212JB86|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured delta proteobacterium|TrEMBL
MGLMTKDQYIESLRKRKPTVYMFGEKIDNFVDNPRIRAGIEATGATYAMAEMPEYRDLIV
TKSPLINEEVNRFTLPPSSIDDLVHRVKVNRAVANFVGTCHQRCTGLDCMSTLAIVTHAV
DKKYGTKYNENFINFLKYMQKNDFTANAGVTDVKGDRSKGAIDQEDPDMYLRVVEKRADG
IVVRGAKAHQTGSLSSHECIVLPTRAMKADEKDYAVAFAVPMDAPGMIHVVGRSSLDKRE
LDGCDTGNVRYSKYCPTIIFDDVFVPWDRVFLCGETEFAVDLVMRFSAFHRQSHGGCKSG
RIDCMIGTALNMMD
>A0A1V5C0X5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaU1.Bin050|TrEMBL
MGVKTKEEYIESIRALKPTAYMFGERLTNPVDNPRIRAGIEATAATYEMANKPENKDLFI
TMSPLINEPVNRFTLPPSSIEDLVARVKVNRKMANYVGTCHQRCTGLDCLSTLAIVTYDI
DRKYGTNYNKNFTEFLKYMQKNDLTGNACVTDVKGNRSLNPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIALPTRAMGKNDADYALAFAIPSDTKGVIHVVGRSSLDMRE
LDGCDIGNVYYSKYCPTIIFDDVFVPWDRVFMCGETEFASEMVVRFSSFHRQSHGGCKSG
KIDCMIGAALTMMDYNGTAKTSHLKQKVIDMIHRAETLYGCCLASSYEGRKEPSGHYFID
TVLANASKLHEGKEMAEATRLMIDACGGFVADLPSDRDFANPEVGDLLKKYLKAVDTVPV
ENRIKMYRLAEKMAMESADTISDIHGGGSPEAHRVTIFRETDTESKKKSAKRLAGIED
>A0A1V4ICU5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium chromiireducens|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDNVVDHPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNAIFSSTFEL
DKACGTNYHENFKKFLLYVQENDLTVDGAMTDPKGDRGLSPSNQVDGDLFLRVVERRPDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPKDKEWAISFAIPTDTEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLYSCGIACSAMGTKTESGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGIMVTMPSEADFKDETVGPYIEKYLRGVNS
VSTENRMRILRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
KIEE
>A0A060HL93|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrososphaera viennensis EN76|TrEMBL
MPIKNGAEYVESLRGRKLKVYLFGQLVKEPVDHPMIRPSINAVAATYDLANAEPEMAGAK
SSISGLQVNRFLHIAESAEDLVNQNRMQRRLGQLTGTCFQRCVGMDALNSLYSTTYEVDQ
KYKTPYHARLKEFIKMIQRENYVIGGAMTDVKGDRSLSPSQQPDPDMFVHIVKRDKKGVY
ITGAKAHQTGCINSHWILVMPTMRLKAEDKDYAIVGAVPVDAPGITYIYGRQSCDTRSME
EGDIDAGNSKFGGQEAMIIFDNVFIPNELIFLDGEYDYAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIADYNGVASASHIKDKLVEMTHLNETIFGAGIASSYMAHQTASGNWQCDD
MLANVCKHNVTKFPYEISRLAQDIAGGLMVTLPSEKDFRGPETGPLLEKYLKGRKGVSTE
SRVRMLRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKLAKNLASVKE
GETAEIAQENPEYFNKIFGVKKKGKQQ
>A0A174K5C7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Flavonifractor plautii|TrEMBL
MSLMTVEQYIESIRALNLPVYMFGKKRKTQWTTPSSAPPSTRCA
>A0A1V4XAM8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophaceae bacterium PtaB.Bin095|TrEMBL
MRTREQYIQGLRKMRRNIYHDGHKIDRDDEIQQPVLNVMGLTFDAVQDPDLKDLCTAKSH
LTGETINRFCHVHQNTEDLHKKQDMTRALCRKVGLCIQRCMGVDAINAVNAVSFEADRLN
GGKTEYHKNFLKWLERFQSEDLVGSCAQTDMKGERLKRPAQQTDPDMYVHVVEKKSDGIV
VRGCKLHISEASISDEILVVPTRALGPDEKDYAVAFAVPSDHEGVKQVVSIHSQHKRKHF
QRGMNIGYSDSYILFEDCFVPWERVFLCGENDHGGMCALLFALFHRHSYSGCKPAIGDIF
LGLAALAAEYNGIEKTPHVKEMMAEIIKISELGYAAGFTASSMGGPQVMIPGLGNCPYGP
GSYIPNSIYCNVGRCLTGEAVFHEQELICRIAGGIPSTFPYEGDLVHPELQGVLEKYLKR
NPNVPVEDQIKFWMTLGDYTIGTMAGVMNYGNYHGGGSPIMEQIAITSQYDIKARKKMVK
ALAGIKG
>A0A011NJS5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. SK-12|TrEMBL
MNATRPAGLMSGSDYRESLRRYRPTVYLDGHRLDSVADSRELRPGINALAVTYDFAHDPR
QAPLMTALQTSRGRTVNRMLHIDESAADLLNKLEAVRLLCQETGCAQRYLAHDALNAINQ
LCARADAAAGSNERRARFAAYLEHVQDGDLALGIAMTDAKGDRSQRPHRQASRNSYVHIV
ERLAAGVVISGTKAIVTGAPYMHEILVMPSRNMGPADADFAICCALPVDAAGLTMIARPA
GRPGEKLEHGAAPFSRRYGQSTAVLVFDRVFVPWDRVFLAGEWEHSASLTYAYATHHRHS
CIAARAGFGDLLIGAGALMCEANGFDPGTKASLREPMVELIKITEGFFACGVAASVYGAA
DPHSGSFMPEPVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPATAATLAE
VLRASPDVPYDRRIEVARFIEDLTASYQGGWYSVISLHGGGSPAAMKREIWRNYPLGSKV
ELVERLLERGVLHDESRPITRNRQPGRCCAAGCALPGQAMMVALPAAAGCHPTPVDEEPA
AE
>A0A2K5ANW7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosocaldus cavascurensis|TrEMBL
MKSMTIRNGQEYIESLRRRKIKVYLFGELVENPVDHPIIRPSVNAVAETYDLASREPDLA
TAYSPLIGKRVNRFLHITTSADDLVKQNEMQRKLGQLTGTCFQRCVGMDALNALYSVTYE
IDEKYGTQYHKRLVDFIKYVQEENYVIGGAMTDPKGDRSKSPSEQDDPDVFVHIVKQNDE
GIVIRGAKMHQTGCINSHWIVVMPTMRLKPEEKEYAVSCAIPVDDPGLTFVYGRQSCDTR
SMDGNIDVGNAMYAGQEAMIIIDDVFVPWKYVFMCGETEFVPVLVERFTTYHRRSYVCKS
GVGDVLIGAAASIADYNGVLDASHVREKLVEMVFLNEIVYGTGIASSYKARATKAGNYIN
DEILANVCKHHLTKFTFEMARLAQDLTGGIVATLPSEKDLKHPEIGPKLMKYLATKNGVD
PEHRVRMARLIENMTMGRNAVGYLSESLHGAGSPQAQRILIARYMNLEEKMKFAKRLAGI
SDALNGKEEEEEEESATLTSSAPAPSTHSD
>A0A1C6C1X3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Flavonifractor sp|TrEMBL
MALMTGEQYIESIRKIPMEIYMFGKKVENPVDDPILRPSLNSVRMTYDLAQMPEYQDLMT
VVSPETGERINRFTHIHRSTEDLRNKVKMQRLLGQKTAACFQRCVGMDAFNAEYSTTYEV
DKKYGTTYHENFKKFMLYCQENDLTVDGAMTDTKGDRSKAPHEQADPDLFLHVVERRPDG
VVVCGAKAHQTGIINSHEVIVMPTQSMGPDDKDYAISFAVPLDTKGLFMIIGRQSCDTRK
REGSEMDVGNAEFGGVEALTVFDHVFVPNERIFLNGETEFAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAADYNGANKASHVKDKLIEMTHLNETLYCCGIACSAEGYPTESGNYM
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTAPAEADLRDPKLGPVIDKYLRGVNSV
STENRLRILRLIENLSLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLVQKKALAKAIAH
IKE
>E6YZJ9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella schoenbuchensis (strain DSM 13525 / NCTC 13165 / R1)|TrEMBL
MQNHTKDLMPKFQQIATVSSQEYRDTMSCLAGAVHIVTTNGAKGKRGVTVSACCSLSDDP
PMLLVCLMRHNPENKLFMENGNFCVNSLAGKHRSLSEVFSGRCGFTQTERFNTAQWNVLQ
TGAPSLSGALASFDCRLICWHQHATHYILIGEVVAINRNQEKDALMYFNRDYHVLSL
>A0A1V6KG98|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin002|TrEMBL
MCGEIDFTGLLVERFATMHRQNYGGCKGGVSDVIVGATALAAQYQGTSGASHVKDKITEM
MHLAESVYSGSVACSAMGSRTPSGAYYPDPLLANCTKHNITRHIYEISRLAHDVAGGIMA
TMPFDRDLRSPEIGKYVEKYLAGVNGVPAETRMKVLRLIENMTGGTCLVESMHGAGPPQS
QRVMYQRLGNLPQKIKMAKKLAKIDE
>A0A1D3ULU7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Tannerella forsythia|TrEMBL
MKTREEYVESLRKLNLKVYFMGERIHNPVDHPVIRPSLNSIAMTYELAEMEEYKDIMTAT
SNLTGKTVNRFCHLHQSPEDLKKKVKMQRLLGQKTASCFQRCVGMDAFNAIYSTTYEMDQ
VLGTEYHKRFVEYMKYVQDNDLVVDGAMTDPKGDRGLSPSQQEDPDLYVHINEVRPDGIV
VTGAKAHQTGAVNSHEHLIMPTIAMKEADADYAVSFAIESDAEGITMIYGRQSCDTRKME
EGADIDLGNPMFGGHEALVVFDHVFIPNERVFMCKEYQFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGAAALAADYNGVPKASHIKDKLIEMIHLNETLYACGIACSSEGVKMPAGNYMI
DLLLANVCKQNVTRFPYEITRLAEDIAGGLMVTMPSERDLHSEETGDIVRKYLAGAKGKD
TTNRMRILRLIENLTLGTAAVGYRTESLHGAGSPQAQRIMIARQGDLEAKKKMARTIARI
DESLDQ
>A0A7W8M4R4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Catenibacillus scindens|TrEMBL
MPLMTGEQYVESIRKMNMQIYMFGEKIENPVDHPILRPSLNSVRMTYDLAQMPEYEDLMT
ATSHITGEKINRFTHIHQSTDDLCKKVKMQRLCGQKTAACFQRCVGMDGFNAVYSTSYEC
DQAHGTHYHENFLKFVEYCQTNDLVTDGAMTDPKGDRSKAPHAQDDPDMYLHVVERRPDG
IVVRGAKAHQTGIINSHEVLVMPTCSMGEADKDYAVAFAVPSDTEGIYMIIGRQSCDTRK
LEGSSMDVGNPEFGGVEALIVFDDVFVPNDRIFLNGEYEFAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAAEYNGVPKASHIKDKLIEMIHLNETLYCCGIACSAEGEATVSGNYL
INLLLANVCKQNITRFPYEIARLAEDIAGGLMVTAPSEKDLRDPVLGPVVEKYFRGSSSV
STEDRLKILRLIENLTLGTAAVGYRTESMHGAGSPQAQRIMISRQSDLNAKKEMAKALAH
IK
>A0A075GCA9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_107_D09|TrEMBL
MDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFVSMLIERFTCYHRRSYVCKTGVGDV
LIGAAASIADYNGVPKVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGVWQNDEMLA
NVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRKGVDVENKM
RILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNLAKVQEEGE
ETLENSDYFNRVFKLDNSKE
>A0A087S0N9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC RSA3|TrEMBL
MANVLKTIRSGEDYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAETYDLALREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDAMNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKGDRSKGPSEQDDPDLFTRIVDTD
EKGVYVSGAKAHQTGCINSHWIILMPTIRLTEADKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGIPKVSHIKDKIIEMTHLNETIFAAGIASSHQGHKMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GVDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKNL
AGITNDVEEPKESSEYFKRVFKTKDSVL
>A0A840RRF4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Glaciimonas immobilis|TrEMBL
MLMSSSEYRESLRSYKPTVYVNGRKVESVADEAAFLPGINALGVTYDYALEEKYSPIMLA
TQQTSGKQVNRMLHINTSSGDLLNKLEAVRLLCQETGCAQRYLAHDALNAIYQVTHRIDA
DKGTTYGQNFLNYLHEVQDRDLSLGIAMTDAKGDRSKKPHEQANPDSYVHIVERTAKGIV
ISGTKAIVTGAPYMHEFLVMPCRNMSEQDAEFAVCCAVPCDAPGLTIVARPAGRPGEKAA
LFSNKFGQSTGVVIFDKVFVPWERVFYAGEWEHSGYMTYNYATHHRHSCIGARAGFGDLL
IGAGALMCEANGFDPGKENHLREQMVELIKITEGFYACGVAASVYAKLDPGSNSFVPDPV
FSNIGKLLLSTQIYDMHRIAHYVSGGLIVALPGPDEDHNPATAASLADVLRANPDVPYEK
RIQTARFIEDLTASYQGGWYSVISLHGGGSPAAMKQEIYRNYPIGSKVEMVERLLDRGLV
EEPGRAITANKQPGKCCDTGCTAPGTAVMVDMPQTTKKLQVE
>W7W989|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Methylibium sp. T29-B|TrEMBL
MNAPTSIAPPARPATLMSGADYRDSLRRYKPTVYVDGQLVDSVADAPSLRPGVNALAYTY
DFARDPAMAPLALAVQSSRGFTVNRMAHINESAGDLLNKLEAVRLLCQETGCAQRYLMHD
ALNGIAQVSARLDDAKGSTEHRARFQAYLARVQDEDLSLGVAMTDAKGDRSKRPHQQANP
DTYVHVVERNGKGIVISGTKAIVTGAPYMHELLVMPGRNMGAEDADFAVCCAVPIDAPGM
TLVSRPAGRPGDKLEHGAALFSRRYGQATAVVIFDRVFVPWERVFYAGQDGEWEHSGVLT
YSYATHHRHSCIAARAGFGDLLIGAGALMCEANGFDPGEKSNLREPMVELIKITEGFFAC
GVAASVYGTADPYSGSFMPEPVFSNIGKLLMSTQIYDMHRLAHEVSGGLIVALPGPDEDH
NPATAATLSEVLRANPTVPYDKRIEVARFIEDLTASYQGGWYSVISLHGGGSPAALKQEI
WRNYPVGSKVELVERLLDRGVLHDETRAITRNRQPGRCCDTGCTVPGQPVMVALPESTRK
QD
>A0A1V5W3H8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MKTGKEYEESLRKLNLVVYLFGKRVENVVDDPIIRPSMNAVKLTYDLAAMPEYEDLLTAT
SHITGKKINRFTHIHQSKEDLVKKTKMERLLGAQTGCCFQRCVGMDALNALSITTFNIDK
KYGTEYNKRFLKYLEYVQQEDLVCDGAMTDPKGDRSLSPSQQPDKDAFLHVVSEKEDGII
VRGAKAHQTGAVNSHEIIVMPTISMREEDKEYAISFAVPSDTKGITYIYGRQSCDTRKLE
KGTLDRGNQYYGGHEALVVFDDVFVPWERVFMYKEYEFAGELVENFASYHRQSYACKVGV
GDVLIGAAQVAAEYNGAAKASHVKEKIIEMNHLNETLFCGSLACALEGTKQPSGTFLVNT
LLANVCKQNVTRFPYEIARLAQDIAGGLMVTMPSEEDLNSPEVGHWVKKYFKAVANVSTE
NRLRILRLIENITLGTAAVGYLTESMHGAGSPQAQRIMIARQVNMEEKKKIAKKLCGIEE
>A0A1W7LMD9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium beijerinckii|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDKVVDNPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNALYSSTYEI
DKACGTNYHENFNKFLKYVQENDLTVDGAMTDPKGDRGLSPSKQADGDLYLRVVERREDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPNDKDWAISFAVPTDAEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGSKTEAGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGIMVTMPSEADFKDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENICLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
RIEE
>A0A6J4YLH7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Olavius algarvensis Delta 1 endosymbiont|TrEMBL
MKINTTADYLTSLQQLNPTIYYRGKRITDVTRHPATAPHVRSAAMTFSLANNAKYRDLAT
ATSHLTGRTISRFTHVHQSVEDLIKKIKLLRVLGQKTGTCFQRCVGFDGINAVYTVAYEI
DQKLGTDYLERFKKWLIGMQDENRMVVGAMTDPKGDRSKGPAQQSDPDQYVRVVKRTADG
VYIRGAKLHMTGAVNSHEILVMPTTALDEQATDYAIVGAVPIDAEGITMIFGRQANDSRR
DLEERIDSGKPRFGAVGGEAVIVFDDVFIPHEKIFLNGETAYTAAIVYRFAAHHRANYGA
CKTGLMDVLTGAVSYLAQAQGTAKASHIKEKVTEMIHLSETLYSSSIATSAEGWATPSGG
YMVDTMLANVCKQNVTRFHFEIARLALDIAGGFIATLPSEHDLKSEAVGHLVQKYFSGVE
GIPVEDRIKIGRLIEAMTGGTALVESMHGAGSPQAQRVMIFREGDLAGKIKLAKSLAGIP
QRAKK
>A0A1C5VJ09|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Ruminococcus sp|TrEMBL
MLMTKQQFQDSIRARKPMNVWFLGEKIEDVTTYPPLAASFNAISKIYELQHRPDWQDLIT
VPSHMLDERVSIYNAPLRSAEDANRKTRAARALAEVIGCCTHRCTGSEAFAGLGPACYDM
DHDLGTNYFERFMNFLKYVQQNDLTCTVTVTDVKGLRTAPPHAQADRDSYVHVDEVREDG
IVISGFKCNQTGILFAHEIVIVPTTNMKPEDKDFAVACAVPADTPGLTFVLGRTPQDKRF
FEVEGDIEGIDLGKQYADHQALVYFDHVFVPNERVFLCGETQYVGRLLSYFTAVHRLTAG
GCKAGGCSALCGAASLLADMVGVQKAGHIRTKLTEMAMTAETVYGLSIASGVEGFQHPSG
FWIPNPLMSHTCKYTCTKIPFDAVRYARDILAGFGETAPSELDMRNPEVGELCQRAFNPG
NPKYNAFDRLRASRFIEHMVRGSNWTAMALHGGGNQEASTVMARMYTDWEYLKGLVKVAT
GIETDAQKAEEFIDTIGKRQGRICTTLDLPKVES
>A0A075ICG5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote SAT1000_29_H07|TrEMBL
MQKTVKPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEGD
LASAKSSITGEQVNRFLHITESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFERAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAAAIADYNGIPNVSHIKDKLVEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLRKYLKAKK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKRLAKDL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A6C7HPQ7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Salmonella enteritidis PT4 (strain P125109)|TrEMBL
MKPEDFRTDNKRPLTGEEYLKSLQDGREIYIYGERVKDVTTHPAFRNAAASVAQLYDALH
KPSMQDTLCWNTDTGSGGYTHKFFRVAKSADDLRQQRDAIAEWSRLSYGWMGRTPDYKAA
FGCALGANPAFYGQFEQNARNWYTRIQETGLYFNHAIVNPPIDRHKPADEVKDVYIKLEK
ETDAGIIVSGAKVVATNSALTHYNMIGFGSAQVMGENPDFALMFVAPMDAEGVKLISRAS
YEMVAGATGSPFDYPLSSRFDENDAILVMDKVLIPWENVLIYRDFDRCRRWTMEGGFARM
YPLQACVRLAVKLDFITALLKKSLECTGTVEFRGVQADLGEVVAWRNMFWALSDSMCSEA
TPWVNGAWLPDHAALQTYRVMAPMAYAKIKNIIERNVTSGLIYLPSSARDLNNPQIDQYL
AKYVRGSNGMDHVERIKILKLMWDAIGSEFGGRHELYEINYSGSQDEIRLQCLRQAQSSG
NMDKMMAMVDRCLSEYDQNGWTVSHLHNNDDINQLDKLLK
>A0A835XK56|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MPTIRLTENDKDYAIVGAIPADAEGLTYIYGRQSCDTRSMEEGDIDSGNSQYSGQEAMMI
LDNVFIPWEKVFLNGEYEFASMLIERFTCYHRRSYVCKTGLGDVLIGAAATISDYNGIPN
VSHIRDKLVEMTHLNESIFAAGLASSYQSHKLKSGVWLNDDMLANVCKHNVTRFPYEIGR
LAQDIAGGLMVTMPSEKDFRNPETGPILRKYLAGRKGVDVENRMRILRLIENMTMGRNAV
GYLTESMHGAGSPQAQRIQIGRIMQLGYKMNLAKHLAKVKDDFQEPVEPSDYFKRVFKIS
NVKE
>A0A2H1EE69|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosotalea sinensis|TrEMBL
MPIRTAEEYIQSLRGRNMKVYLFGELVKEPVDHPMIKPSINAVAETYALAERDGEMATAK
SSITGLQVNRFLHIAESADDLVNQNKMQRKLGQLTGTCFQRCVGMDALNSLYSVTFEIDE
KYKTNYHKRLTDFIKMIQQENYVIGGAMTDPKGDRSKAPHQQEDPDVFLHVVEKNDKGIF
VTGAKAHQTGCINSHWIIVMPTMRLLEGDKDYAVVGAMPADAPGITYIYGRQSCDTRSME
EDDIDAGNAKFAGQEALIVFDRVFIPWDKVFMFGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAASIADYNGVPDVSHVRDKLVEMTHLNETIYATGIASSSQAHRTKSGVWLNDD
MLANVTKHNVTRFPYEIGRLAQDIAGGLVVTLPSAKDLNNPTTGPILKKYLRGRKGVDVE
NRVRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNLANVKE
NPENDQEQSDYFQRVFKMK
>A0A1E3AX61|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eisenbergiella tayi|TrEMBL
MMTGQEYLESIRNMKMHIFCMGEELETAVGHPILQPSLNSVRMTYDLAQDPEYRELMTAS
SHLTGRTINRFTNLHQSCQDLINKVKMQRILGQKTASCFQRCVGMDAMNAVYSTAYDIDK
KCGTDYFRRFKNFVIHCQDKDLTVDGAMTDPKGDRSLSPHLQQDPDLYLRVVERRSDGVV
VRGAKVHQTGICNSHEVLVMPTISLGEDDKDYAISFAVPTDTEGITMIIGRQSCDTRKLE
CSCLDVGNCKFGGVEALTIFNDVFVPNERIFMNGETQYAGLLVERFAGYHRQSYGGCKVG
VGDVLIGASALAAESNGAEKASHIKDKLIEMTHLNETLYACGIACSCEGYQTPSGIYDIN
TLLANVCKQNVTRFPYEIARLAQDIAGGLMVTAPSEKDLSNPATGPFIEKYLAASSSFSI
RDRLKIFRLIENMTMGASAVGYLTESMHGAGSPQAQRIMISRQGSLEKKKTMAKALLDIQ
>A0A447G3T4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilaceae archaeon|TrEMBL
MKSGVYLNDDMLAQVCKHNVTRFPYEIGRLAQDVAGGLVVTLPSEKDLRNPETGPLLKKY
LAGRKGVDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQLGYKKG
LARKLAGIPGDGEDPPENSEYFERVFKC
>A0A7U9X3C4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Lachnospiraceae bacterium|TrEMBL
MVSLYVLESSTINNVTKGENIMALMTGEEYVESIRKLNLNVYMFGKKIACPADHPILRPS
LNSVKATYDLAQDPQYEELMTATSSLTGKKINRFLHIHQSTKDLMDKVKMQRLLGQQTGA
CFQRCVGMDAFNAVFSTTFETDQKYGSSYHKNFIEYAKYCQENDLTVDGAMTDPKGDRGL
APHAQEDPDLYLRVVERREDGIVVRGAKAHQTGAINSQEMIVMPTVSMKPEDKDYAVAFA
VPTDTEGILMIIGRQSCDTRKMEGSELDVGNSEFGGVEALVVFNDVFVPNERIFLNGETE
YAGVLVERFAGYHRQSYGGCKAGVGDVLIGAAAVAADCNGCAKASHIKDKLIEMTHLNES
LYCCGIACSAEGKPTEAGNYMIDLLLANVCKQNVTRFPYEISRLAEDIAGGIMVTAPSEA
DFRDPVTGPYVEKYLKGAKDVSVEDRIRILRLIENLCLGTAAVGYRTESLHGAGSPQAQR
IMISRQGDLPKKKEMAKKIAKIKD
>A0A0K0NTZ9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Thaumarchaeota archaeon|TrEMBL
GAAATIADYNGVPNVSHIKDKIVEMTHLNETIFAAGIASSHQAHKMESGVYLNEDVLAQV
CRHNVTRFPYEIARLAQDIAGGLVVTLPSEKDFRHPVAGP
>A0A259U5U1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporomusa acidovorans DSM 3132|TrEMBL
MMTGEQYEESLRKMNFKVYLQGELVKNPVDHPIIRPSMNSVKMTYKLAEDTQYADLMTAT
SHLTGKKVNRFCHLHQSTDDLVRKIKMQRLLGQRTAACFQRCVGMDGINAVASTTFEIDQ
KLGTKYHERFNKFLLKMQEEDWTVDGAMTDPKGDRGLAPSKQADPDLFVHVVEKREDGIV
VSGAKAHQTGAINSHWILVMPTIAMTKDDTDYALSFCAPADAEGIYYIYGRQSCDTRKLE
DGDIDVGNKQFGGHEALMVFDHVFIPWENVFMCGEYEFSGMLVERFAGYHRQSYGGCKVG
VGDVLIGAAAVAAEFNGVAKASHIKDKLIEMTHLNETLYACGIACSAEGHKTACGNYLIN
LLLANVCKQNITRFPYEIARLAEDIAGGLMVTMPSEKDLCHPEIGKVVDKYFRGVASVST
ENRMRILRLIENITLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLEGKKQLAKAIAQIK
D
>A0A381IDT3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MLVERFAGYHRQSYGGCKVGVGDVIIGAAGFSS
>A0A645I1G2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MGDVLIGAAAVAAEYNGAAKASHIKDKLIEMIHLNETLFSCGIACSAMGHPTESGNYIID
LLLANVCKQNITRFPYEIVRLAEDISGGLMVTAPSEKDLRDPELGPYVEKYFKGATGVST
ENRLRIMRLVENIALGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEQKKALAKKIAHVQ
E
>A0A650CHP7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sulfurisphaera ohwakuensis|TrEMBL
MAIRTGEQYLDSIKIRNKAEIYVMGKEVKDVTTHPFLKPSVMAFKATFDAAWEEDTKELA
RAWSPFINEEVNRFNHIHRSPEDLAAKVKLLRKLSHKTGACFQRCVGWDALNTLWIMTNI
MAQKGKKEYKDRFVEYLSYVQKKDLALAGAMTDAKGVRTLKPHQQPNKNAYVRIEEVTKD
GIYVSGAKANITGVAATEEIVVLPTRAMGPEDKDYAVAFSIPTDTEGIKIIVGRQLNDAR
RLEGGDIDALPYFYNHEGLVIFDHVFVPMDRVFLMGEYEFTSQLVEVFSAYHRQGYGGCK
AGLGDVIIGASMNLAKQLGVEKASHVQEKLTEMIFLTETMYSAGIAASLNAVKVCDNCWW
VNPMHANVTKHLVARFPAQISQLSIDIAGGIIGTAPSEWDLKNPKLREYIAKYLQGVEGY
TAEDRLRMVRLLENVSLGVAFQIESVHGAGSPAAQRIMFSRLYDLNYAEEVAKRLAGKKT
DLQWKPKAEPWRESETEKLVKS
>C6SNM7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Neisseria meningitidis alpha275|TrEMBL
MFYVRLDEIKNCGCKRPALLYFRRQFRFLD
>A0A8K1Y934|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosotalea sp. TS|TrEMBL
MPIKTGAEYIQSLRGRKMKVYLFGELVKEPVDHPMIRPSINAVAETFDLAVQDGELASAN
SSLSGQQVNRFLHIVESADDLVNQNKMQRKLGQLTGTCFQRCVGMDAINSLYSVTFEIDE
KHKTSYHKRLVEFIKMAQKENFVIGGAMTDPKGDRSKAPFEQDDPDVFMHIVEKNDKGII
VKGAKAHQTGCINSHWILFMPTMRLQENDRDYAIVGAVPADAPGITYIYGRQSCDTRSME
EGDLDSGNSKFAGQEAMIIFDNVFVPWEYVFMNGEYEFASMLVERFTCYHRRSYVCKTGL
GDVLIGASAAIADYNGIPNVSHIKDKLVEMTHLNETIYAAGVASSYQAHRTKSGNWLNDD
MLANVCKHNVTRFPYEIGRLAQDIAGGLMVTLPSEKDFRNPETGPILKKYLKGRKGVDVE
NRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRINIARQMQLDYKKQLAKTLANVKE
DAESTQEPSDYFKRVFKISTRK
>A0A1V5DGP4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MKIKTKEDYVKSLKDQKVVIYYNGELVKDRSTHPAFVPHINSAGKTYELALLPENEDLLT
AKSNITGNKISRFTHIHQSVDDLIKKVQMLRLIAHETASCFQRCVGFDALNALYMTTYEI
DEKYGTKYFTRFVEYLKKIQEENFMLVGGMTDPKGDRSKKPSQQADPDLFTRIVEKRKDG
VVIRGAKAHQTGAVNSSEIMILPTQAMAEGDEAYAIAAAIPLDAKGVTMIFGRQTNEERK
LEGGMDAGNCDFGMVGGEALVVFEDVFVPWERVFMCGEIDFCGLLVERFATLHRQNYGGC
KGGLSDIIIGASAVAAQYQGTLGASHIKDKLVEMMHLAETVYSGSVACSAMGAKTKSGSY
YPDPLLANCTKHNITRNIYEISRLAHDIGGGIMATLPFNNDFKSSAVGKYVEKYMKGVEG
VSTENRMMILRLLENMTGGTALVESMHGAGSPQSQRVMYQRLGRLNDKMKMAKKIAKIKD
>A0A1V5DNV7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MAKIMTIKKPLGTANDYRQSLRDMKTAIWAFGEKITNVPDHPLFIPHVNAVAKTYEVNNP
ATSHLTGKTINRFNHIHQSVDDLVKKVKFLRTINQLTACCIQRCAGQDALNATYVVTYEI
DQKYGTNYHERFKKFMTYLQEYNLVTIGAMTDVKGDRSKKPNQQADPDLFVHVVEERKDG
VVVRGAKAHLTGVSGAHQVIVFMREDSKDYSIVFSCPVNTPGITYIFGRQSNDTRKLEKG
DIDKGNAEFACVGGECVAIFDNVFIPWEDVFMYKEYDFAGMFVEAFASAHRQNYGACKGG
IADVLLGATYGIIKANGLTNASHIRDKVADMINMTETLYAGSLACSYEGHKTPSGAFVAD
TMLANITKHNTTKFVYELNRLSHDICGGLLATLPSEADLRHPEIGPKLEKALAGAAGITA
EEKMRLLRLVDNISGGTACVEAMHGAGPPQSQRIMMLRDAKLEGKLKLAEKLAGIKKDKK
>A0A1C5WBX6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Clostridium sp|TrEMBL
MAIGTYEQYKERLLKMKPNVYLNGKCVDRSNGKEGEERDLADWIKGGTYVMKQCYDVANN
PKYEDVCVTTSHINGERINRCTHIHHSMDDLLKKQLMTRLICQHVGGCMQRCMGTDAMNA
LYSVTYDCDEACGTEYHKRLLAYIEYCQKYDLICNCAQTDVKGSRNPKYKRAHMQPDPDS
FVHVVETDVDGTGVDGKPCKGIIVRGAKICNSCAPYVDEIIVNPTKFMSQDDSDYAVAFA
LPADWDGVKLMALPGLHHKRTHLDAPYAQIGDVESLTIFDDCFVPYDRVFMCGRDHEGVA
RYAGYLALMFAHYHRHSYTGCKTAVSEVIASQAALVADVNDIARESHVREKICDIIQTAE
LVFAAGEAAAHHAMEFPSGQWVPDEVLTNAGRRLAGHNMYHEYETLADLTGGVCASLPTE
ESFFAPETAELCNKYIRRNPAYSAEDTHRVMRMMENKLCDSYEAAQAVAGVHGGGSPLME
TITLMSRYDLEELKKIAKYLAGIPGYEKCPRYERSAHTATPRAMLAKFDAISSKKVNK
>A0A0S3QSA1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)|TrEMBL
MLITKEQYVERLSKREPRVYVNGERVENYVEHPNIKPMIDSIGLTYEMALNEEYKDLTTA
QSQFINEPVNRFLHIYTTKEDLLARLKLARFYSQRLATCNYRCVGSDALNALYTVTYEMD
EELGTEYHKRLVEYIKYAQKNDLALSGALTDVKGDRSKKPHEQDDMYLKIVEKRSDGIVV
KGAKAHQSGAVAADETVVMPTIALKEEDKACAVSFAVPAGTEGLIYVMQNNAFEAKRREN
GEWEIGNPYGVRGTCLMIFDNVFIPWERVFMCEEYKYAAPLVGNFANIHRYVGSGCKAGF
IDTIIGAAELIADYNGVPKASHIQAKITEMIRGCEGCYACALAAGYESTQTKSGVWLPNG
LYSNVSKILGFTAMGDAVVYLADIAGGICVTCPSERDLKNPEIGKYIDHYLRGRADVPTE
ARMKVIKFIEYWVAGPHEGGAVHGGGSPITPNLFINRLAKIEDKIRLVKELLKLQ
>A0A174PGY1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Flavonifractor plautii|TrEMBL
MALMTGEQYIESIRKIPMEIYMFGKKVENPVDNPILRPSLNSVRMTYDLAQMPEYQELMT
AISPETGERINRFTHIHRSTEDLRNKVKMQRLLGQKTAACFQRCVGMDAFNAEYSTTYEI
DKKYGTSYHENFKKFMLYCQENDLTVDGAMTDVKGDRSKAPHAQDDPDMFLHVVERRPDG
VVVCGAKAHQTGIINSHEVIVMPTQSMGPDDKDYAISFAVPLDTKGLFMIIGRQSCDTRK
LEGSEMDVGNSEFGGVEALTVFDHVFVPNDRIFMNGETEYAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAADYNGANKASHIKDKLIEMTHLNETLYCCGIACSAEGAPTESGNYM
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTAPGEADFRDEKLGPVIDKYLKGVSTV
STENRLRILRLIENLSLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLAHKKELAKAIAH
IKE
>A0A835VPK0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MPIRTGDEYIESLRGRDLTIYLFGEKVKDPVDHPMIRPSINAVAETYDLAVREEELATAQ
SSITGQRVNRFLHIAESAQDLVLQNKMQRKMGQNTGTCFQRCVGMDAINSLHSVTYEIDE
KHGTNYHQRLLDFIKMIQKENYVIGGAMTDPKGDRSKGPSEQIDPDMFLRVVKKDDKGVT
IKGAKAHQTGCINSHWIIVMPTLRLTENDKDYAIVGAVPADVKGITYIYGRQSCDTRSME
EGDIDSGNAKYSGQEAMMIFDDVFIPWDKVFMYGEYEFSAMLIERFTCYHRRSYVCKTGL
GDVLIGAASAIADYNGIPHVSHIKDKLVEMTHLNESIFAAGLASSYQSHKLKSGVWLNDD
MLAQVCKHNVTRFPYEIGRLAQDIAGGLMVTMPSEQDFKNPETGPMLNKYLAGRKGVDVE
NRMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKRKLAKHLAGVKE
ADEELNEPSDYFKRVFKINMQEN
>A0A128A0R0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosotalea devanaterra|TrEMBL
MPIKTASEYIQSLRGRDMKVYLFGELVKEPVDHPMIRPSINAVAETYDLAEKESEMATAK
SSITGLQVNRFLHIAESADDLVNQNKMQRKLGQLTGTCFQRCVGMDALNSLYSVTFEIDE
KHKTNYHKRLVDFIKMIQQENFVIGGAMTDPKGDRSKAPHQQEDPDVFLHVVEKNDKGIF
VTGAKAHQTGCINSHWIIVMPTMRLLEGDKDYAVVGAMPADAPGITYIYGRQSCDTRSME
DGDIDAGNAKFAGQEALMVFDRVFIPWDKVFMFGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIADYNGVPDVSHIKDKLVEMTHLNETIYASGIASSSQAHRTKSGVWLNDD
MLANVTKHNVTRFPYEIGRLAQDIAGGLVVTLPSEKDLKNPTTGPILKKYLKGRKGVDVE
SRIRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNLASIKE
NSEPESEQSDYFQRVFKIRK
>A0A080M491|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. SK-02|TrEMBL
MTRDRMLLTSSRLISGAEYRDSLRRYTPKVYVDGEPIASVADAPTLQPGINALAVSYDFA
LDPEKIPLMTAVQTGSGATVNRMLHINESAGDLLNKLEAVRLLCQETGCAQRYLAHDALN
AIHQVSARIDDARGGSEHRARFEAYLEEVQASDWSLGIAMTDAKGDRSKRPHQQANPDTY
VHIVERNPRGIVISGTKAIVTGAPYMHQFLVMPSRNMGPADADFAVCCALPVDAPGLTIV
ARPAGRPGEKLEHGAALFSRRYGQSTAVLVFDRVFVPWERVFFAGEWEHSGSLTYHYATH
HRHSCIAARAGFGDLLIGAGALMCEANGFDPGRQASLREPMVELIKITEGFFACGVAASV
YGTPDPYSGSFMPEAVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPATAA
TLAEVLRAHPDVPYDKRIAVARFIEDLTASYQGGWYSVISLHGGGSPAAMKQEIWRNYPL
GSKVELVERLLDRGVLHDPERAITRNRQPGRCCDAGCSPPGQAIMVPLPRSGKA
>A0A1C6IM32|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Eubacterium sp|TrEMBL
MALMTAAEYIESLRKLNTRVYLFGEKIDNWVDHPIIRPSINCVAMTYALAQNPEYADIMT
VKSNITGKTINRFTHLHQSSDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNAVYSTTFEI
DEKYDTDYHQRFVKFLEMVQEEDLTVDGAMTDPKGDRGKAPHQQEDPDLFLHIVERREDG
IVVRGAKAHQTGSINSHWHIIMPTIAMREADADYAVSFACPSDAEGLYMIYGRQSCDTRK
MEENADIDVGNRKFGGQEALVVFDDVFIPNEYIFMAGEYDFAGMMVERFAGYHRQSYGGC
KVGVGDVVIGAAALAAEYNGCEKASAVKEKLIEMTHLNETLYSCGIACSCEGCKTKAGNY
QIDLLLANVCKQNITRFPYEIVRFAEDIAGGLMVTMPSQKDFESDTVVGKNGETVGDICN
KYFAGRPDVSTENRMRVLRFLENVCLGSAAVGYRTESMHGAGSPQAQRIMIGRQGNIEQK
KEFAKIIAGIK
>A0A2H5ZR32|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bacterium HR31|TrEMBL
MRSPEEYLASLRDGRRVYYRGRRVEDVTTHPHLRKGAGVCALDFQLAHERVDDPTFVVQD
PQTGRRYSRYFHVPRGPDDLLRRRDLIETVTREARSFVPLIKEIGTDALFALLIVCAEMD
RELGTSFLPRVQAFYERCRDGDLAMAVAQTDVKGDRGRRPSEQPHPDLYVRCVRETADGI
VVRGAKAHTTNAVYSNEILVLPTRAMTERDAAYAVAFAVPADTPGLSFVASPRGFGATSP
FDNPLSSRYGITESLTVFDDVFVPWERVFLCGQWAYAGPLAKTFVEFHRFTAISYKTPLL
ELLVGSAAWMAEAQGIAAAGHVRDKLARLVMYAETVRGLTTAAAVEGRTVDGIFVPNVVL
TNAAKYYFARGYHDAVRDVQDIAGGLLVTGPAEEDRNNPELWGLIEPYLQGRAGTSGEAR
LRMMNLIRDLTASDLGGYLEVLAIHAEGSLEAQKLTVLTDYDLERVKRLAARAGGLEA
>A0A075H7M6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_41_D11|TrEMBL
MVIFEKAFIPNELIFMDGEYEFASMLVERFTCYHRRSYVCKTGLGDVLIGAAATIADYNG
VPKVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGVWQNDDMLANVCKHNVTRFPYQ
IGRFAQDIAGGLMVTLPSEAELRSDVTGPLLKKYLKGKKGVDVEDRMRILRLIENMTMGR
NAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKRLAKDLAKIQEEGEETLENSDYFNRVF
KLDNSKE
>A0A1V4XVI4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophus sp. PtaB.Bin001|TrEMBL
MGLKTKEEYIESIRALKPTVYMFGEKLTTSPVDNPRLRAGIEATGATYELASMPENKDLF
VTMSPLINEPVNRFTLPPASIPDLVARVKINRKVANYVGTCHQRCTGLDCLSTLAIVTYD
IDKKYGTHYNENFTEFLKYMQKNDLTGNAGVTDVKGDRSLAPHEQVDKDMFLRVVEKRED
GIVVRGAKSHQTGSLSCHEVIVLPTRAMSKNDGDYAVAFAIPSDTPGLIHVVGRSSLDMR
EIQGFDCGNVFYSKYCPTLIFNDVFVPWNRVFMCGETEFAVDMVVKFSSFHRQSHGGCKS
GKIDCMTGAALTMMDYNGTAKMSHLRQKVIDMIHRAETLYGCCLASSYEGKQQPSGNYFI
DTVLANASKIHEGKEMAEATRLMIDAAGGYVADLPSDRDFDNPEIGGLLKKYLKGVDSVP
VENRVKMFRLIEKMAMESADTISDIHGGGSAEAHRVTILRETDVNAKKKAAKRLAGIVE
>A0A485LZH6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|anaerobic digester metagenome|TrEMBL
MKTAKEYEESLRNLKMNVYMFGQKVENPVDHPVIRPSMNSVAKTYELAFDPRYEELMTAT
SSLTGKKINRFTHLHQSAEDLVKKVKMQRLMGQKTASCFQRCVGLDAFNAVDSTTFEMDR
DLGTQYHQRFRDYLRYVQEEDLTVDGAMTDPKGDRGLRPFQQADPDLFMRVVEKNADGIV
VRGAKCHQTGKKKLARVLVGIDDCARAMAIHRTTLMRKMKRYGL
>A0A075G3Y0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote AD1000_80_D11|TrEMBL
MQKTVRPIRTGEEYIESLKGRDLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVKQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEIDEKHGTEYHKKLLGFIKMVQHENLVIGGAMTDVKGDRSKGPSEQEDPDLFLRIVERN
DKGVYISGAKAHQTGCINSHWMLVMPTMRLTENDKDYAIVGAIPVDAPGITYIYGRQSCD
TRSMEPGDIDQGNSEYGGQEAMVIFDKAFIPNELIFMDGEYEFSSMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGVPKVSHIKDKLIEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQISRFAQDIAGGLMVTLPSEAELRNPITGPLLEKYLKGRK
GVGVESRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKDL
AKIQEKGEETLENADYFKRVFKLDNSKE
>A0A075FN02|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote AD1000_106_A06|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPNVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A1V4WBE9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaB.Bin006|TrEMBL
MGVKTKEEYIESIRALKPTAYMFGERLTNPVDNPRIRAGIEATAATYEMANKPENKDLFI
TMSPLINEPVNRFTLPPSSIEDLVARVKVNRKMANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTNYNKNFTEFLKYMQKNDLTGNACVTDVKGNRSLNPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIALPTRAMGKDDADYALAFAVPSDTKGVIHVVGRSSLDMRE
LDGCDIGNVYYSKYCPTIIFDDVFVPWNRVFMCGETEFASEMVVRFSSFHRQSHGGCKSG
KIDCMIGAALTMMDYNGTAKTSHLKQKVIDMIHRAETLYGCCLASSYEGRKEPSGHYFID
TVLANASKLHEGKEMAEATRLMIDACGGFVADLPSDRDFANPEVGDLLKKYLKAVDTVPV
ENRIKMYRLAEKMAMESADTISDIHGGGSPEAHRVTIFRETDTESKKKSAKRLAGIED
>A0A075GEC6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_153_E08|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPNVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A7X5YAT4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Butyricimonas paravirosa|TrEMBL
MMTKEQYIESLRKLNLKVYFMGELISNPVDHPMIRPSMNSVAMTYELAEKDEYKTLMTAK
SNLTGKTVNRFCHLHQSTEDLINKVKMQRLVGQKTGACFQRCVGMDAFNAIYSTTYEIDQ
AHGTEYHKRFIEYLKYVQDNDLTVDGAMTDPKGDRGLSPSQQEDPDLYLRIKEVRPDGII
VRGAKAHQTGAVNSHEHLIMPTVAMKESDKDYAVSFAVPSDAEGVLMIYGRQSCDTRKME
KDADLDLGNSQFGGHEALVIFDDVFVPNERIFMCKEYEFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGAAALAADYNGVPKANHIKDKLIEMMHLNETLYSCGIACSAEGEPTLAGNYQI
NLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSAQDLRDPYIGGYVKKYLQGATGTD
TENRMRILRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLENKKELAKQIARI
DESKNRK
>A0A1C6GYB2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Clostridium sp|TrEMBL
MALMTGEQYVESMRKLNLQVYMFGKKIDNPVDDPILRPSLNSVKATYDLAQDPEYADLMT
TKSILTGETINRFTHIHQSTDDLIKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTTYET
DEKYGTHYHENFKKFLQYVQEHDYTVDGAMTDPKGDRSLPPHLQADPDLYLRVVERRPDG
IVVRGAKAHQTGFVNSHEVIVMPTQAMGEDDKDYAVAFAVPTDAKGIFMIVGRQSCDTRK
LEGSEIDVGNSQFGGTEALVIFDDVFVPNDRIFLNGENEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAADFNGAQKASHIKDKLIEMTHLNETLYCCGIACSAEGRPTKSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLKDPFLGKYVDKYFRGVNVV
STENRLRIMRLIENLTLGAAAVGYRTESMHGAGSPQAQRIMISRQGNLAMKKKLAKDIAK
ITE
>A0A1V5CZF3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaU1.Bin058|TrEMBL
MALMTSEQYIESLRRVDKRIFLGGEQIDNYVDHPIIRPSINSCAMTYELSAQPEHEELIT
ATSSLTGKKINRFTHLHQSAEDLIKKVKMQRVLGQKTGCCFQRCVGFDGFNAVDSVTYEM
DQELGTDYNDRFRAYLEYVQDNDLVVDGAMTDTKGDRRLAPSEQKDPDQFVHVAERRPGG
IVVRGAKAHQTGAVNSHEILVMPTQTMREADKDYAVCFAIPADAQGILYIYGRQSCDTRR
LEEGDIDVGNAMFGGQEALIVFSDVFVPWERVFMCGEYQYSGALVERFAGYHRQSYGGCK
SGVGDVLIGAAQAISKIQGIEKASHVKDKLVEMTHMNETIYACGVACSAEGKPTPSGTYL
IDLMLANVCKLHVTHLPYLISRLAQDIAGGLVVTMPGEQDFKNPEIGEYLEKYFKSAAAY
STEDRCRMQRLIENLTLGMGAVGYLTESLHGAGSPQAQKIMIGRLANFDYKAELAEELAG
IKR
>A0A2T0B3T8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium liquoris|TrEMBL
MALMTGEQYVESLRKLNLNVYMFGEKIENPVDNPVIRPSMNSVKMTYDLAQMPEYEDLMT
TTSTLTGNKINRFGHIHSSTEDLIKKVKMQRLCGQKTAACFQRCVGMDAFNAEYSTTYEI
DKAYGTDYHEKFKKYLKYVQENDLTVDGAMTDPKGDRGLSPSKQSDPDLYLRVVERRPDG
VVVRGAKAHQTGICNSHEVLVMPTVAMRPEDKDYAISFAVPTDTEGIFMIVGRQSCDSRK
LEAGADIDVGNKVFGGVEALTIFDDVFVPNERIFLDGETEFAGMLVERFAGYHRQSYGGC
KVGVGDVLIGAAALAADYNGANKASHVKDKLIEMTHLNETLYACGIACSAEGYKTESGNY
IIDLLLANVCKQNVTRFPYEIARLAEDIAGGIMVTMPSEKDYRNEKTGPYIEKYLKGIAS
VPTENRMRILRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLGHKKALAKAIA
RIKE
>V6AR86|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosotenuis uzonensis|TrEMBL
MAIRTGQEYIQSLRGRNLKVYLFGELVKEPVDHPMIRPSINAVAETYDLAVREEELAAPM
SKISGKRVNRFLHIAESAQDLVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSVTFEIDE
KYHTNYHKNLLDFIRKMQEENLVIGGAMTDVKGDRSKAPSEQIDEDLFLHVVKRTPEGVY
VTGAKAHQTGCINSHWIIVMPTIRLLEKDKDWAIVGAIPVDAPGITYIYGRQSCDTRSME
EGDIDSGNSKFAGQEAMIIFDNVFIPNNLIFMNGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIADYNGIPDVSHIRDKLVEMTHLNESIYAAGISSSYQAQEMKSGVWLNDD
MLANVCKHNVTRFPYEISRLAQDIAGGIVVTMPSEKDFRHPVTGPLLKKYLAGRKGVDVE
NRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKSLANVKE
DAEDTPENSDYFKRVFKLR
>A0A1C5SNN2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Oscillibacter sp|TrEMBL
MALMTAQEYVESLRKLNTRVYMFGEKIENWVDHPMIRPSINCVAMTYALAQDPQYADLMT
VKSSLTGHTINRFTHLHQSTEDLINKVKMQRLLGQKTASCFQRCVGMDAFNAVFSTTYEI
DEKYGTRYHENFKKFLTFVQDNDLTVDGAMTDPKGDRSKAPSQQADPDMYVHVVERRADG
IVVCGAKCHQTGSINSHWHIFMPTISMGEADKDWAVSFACPTDAEGMYMIYGRQSCDTRK
LEEDASIDVGNAKFGGQEALVVLDHVFIPNEYIFLNGEYEFAGMMVERFAGYHRQSYGGC
KVGVGDTLIGAAALAAEYNGVEKASAVKDKLIEMIHLNETLYCCGIACSSQGFRTKAGNY
QIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLVVTMPSQKDFHSDTVVGRNGETIGEICN
KFFATREGVSTEDRQRILRFIENLCLGAAAVGYRTESMHGAGSPQAQRIMIARQGNLQAK
KQLAKDIAGIEQVQD
>A0A1V5JA73|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MRTKQDYINGLSKMKRNIYFDGQLIDRTDELQMRCLNTIGTTYDEAARPENRELMTAISH
LTGERINRFNHIHQNSDDLHKKQDMTRMLCQKVGGCIQRCMGTDAVNAIYNVSYEADKAN
NGATQYHENFKKWLIRFQKEDLIGCCAQTDVKGDRMLRPADQPNPDVYVHIKERLKDGIV
VEGCKVHISEASVADEVLVLPTRALRPQDKDYAVAFAVPGDWDGLKQVVTIHNLREREYF
PRGFMPGSTDSYMIFENCFVPWERVFLAGEYQHGGVNALLFALFHRHSYSGCKPAIGDVI
LGSAALAAECNNIQKAEHVRKKLAEIIMVTELGYAAGYTASDLGGPQVFMPGKGFVPYGP
GSYIPHSIYCNVGRCLSGEAVWRESEILCDLAGGIVATFPHEKDFVNPETKDALLKYTKR
SPNISVEDQAQFWRFLGDALCSATGGIRNIGAYHGGGSPIMEQIAITTQYDIEARKKLVK
YIAGMSGGDREALAKSNFIKRPKKDK
>A0A2U3LG93|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophobacter sp. SbD1|TrEMBL
MVFEDVFIPWENVFMCGEHEFSGMLVERFAGYHRQSYGGCKVGVGDVLIGAAALAADFNG
VAKASHVKDKIIEMIHLNETLYACGIACSAEGSRTPSGTFIIDLLLANVCKQNVTRFPYE
IARLAEDLAGGLMVTMPSEKDLRHPEIGKVIEKYLRGSSAFPTEHRMRILRLIENITLGT
AAVGYRTESMHGAGSPQAQRIMISRQGNLDRKKQLAMDLAGIA
>A0A835XF09|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MPIRTGQEYIDSLRGRKLKIFLFGEEIKDYVEHPIIRPSINAVAETYDLAVREEELATAQ
SSLSGQRVNRFLHIVEGAQDLVLQNKMQRKMGQNTGTCFQRCVGMDALNALHSVTFEIDE
KHGTNYHKRMLDFIKKMQTENLVIGGAMTDPKGDRSKGPAEQADPDMFLRVVKRDDKGIY
VTGAKAHQTGCINSHWIILMPTLRLTENDKDYAVVGAIPADAPGITYIYGRQSCDTRSME
EGDIDSGNAKYSGQEAMMVLDNVFIAKDKIFMDGEYEFASMLIERFTCYHRRSYVCKTGL
GDVLIGAAATIADYNGIPNVSHIKDKLVEMTHLNESIYAAGIASSYQAHKLKSGVYLNDD
MLAQVCKHNVTRFPYEIGRLAQDIAGGLMVTMPSEKDFRHPEVGPLLKKYLVGRKGVDVE
NKMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKSRLAKHLAGVKE
DDEEIQEPSDYFKRVFKIKVEEN
>A0A836BMT4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MIRPTMNAVAETYDLAVREEELATVQSSLSGQRVNRFLHIVEGAHDLVLQNKMQRKMGQN
TGTCFQRCVGMDAINSLHSVTYEIDEKHGTNYHKRMLDFIKKMQTENLVIGGAMTDPKGD
RSKGPAEQADPDMFLRVVKRDDKGIYVTGAKAHQTGCINSHWIILMPTLRLTENDKDYAV
VGAIPADAPGITYIYGRQSCDTRSMEEGDIDSGNAKYAGQEAMMILDNVFIEKDKIFMDG
EYEFASMLIERFTCYHRRSYVCKTGLGDVLIGAAATIADYNGIPNVSHIKDKLVEMTHLN
ESIFAAGLASSYQAHKLKSGVYLNDDMLAQVCKHNVTRFPYEIGRLAQDIAGGLMVTMPS
EKDFRHPEVGPLLKKYLVGRKGVDVENKVRVLRLIENMTMGRNAVGYLTESMHGAGSPQA
QRIQIARQMQLGYKSRLAKHLAGVKEDDEEIQEPSDYFKRVFKINMSEE
>A0A1C6KPP4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Eubacterium sp|TrEMBL
MTMKTGAQYIESLRKLNTRVYMFGEKVENWVDHPMIRPSINCVAVTYDLAYNPEYEDLMT
AVSHLTGKKINRFAHIHQSAEDLKKKVKMQRLLGQKTGSCFQRCVGMDAFNAVYSTTYEI
DEKYGTHYHQNFKQFLTFVQDHDLIVDGAMTDPKGDRSKAPHQQADADLFVRIKEVREDG
IVVRGAKCHQTGSVNSHWHIVMPTIAMGPDDKDYAVSFACPSDADGIYMIYGRQSCDTRK
LEEKADIDLGNKQYGGQEALVVFDDVFVPNEYVFMAGEYDFAGMLVERFAGFHRQSYGGC
KVGVGDVVIGAAALAAEYNGVEKASAVKEKLIEMTHLNETLYSCGIACSCEGCQTASGGY
IIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTMPSEKDFQSDTPVGREGETIGQICH
KFFAGNGTCSTEDRMRVLRFLENICLGSAAVGYRTESMHGAGSPQAQRIMIARQGNIQGK
KKLAKNLAGIQK
>A0A075H2P0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_45_E05|TrEMBL
MQKTVKPIRTGEEYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAKTYDLAVEEED
LAFPQSSITGERVNRFLHIAESAQDLVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
YEIDEKHGTKYHERLLEFIKMVQHENLVIGGAMTDVKGDRSLAPSEQEDPDLFVHIVDRD
EKGVYITGAKAHQTGTINSHWMIIMPTMRLLENDKDYAIVGAIPVDAPGIKYIYGRQSCD
TRSMEPGDIDVGNSEYGGQETMVILDRVFIPNEMIFMDGEYEFASLLVERFTCYHRRSYV
CKTGLGDVLIGAAAAIADYNGVPKVSHIKDKIIEMTHLNESIYAAGIAASYQGHKMKSGV
FLNDDMLANVCKHNVTRLPYELARLAQDIAGGLLVTLPSEAEFRSPETGPILKKYLKGKS
GAEVENRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKQLAKDL
AKVKEESEEISENSEYFQRVFQLDSKE
>A0A1V6CHA2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin135|TrEMBL
MGIKTKEEYIASIGALKPTAYMFGKKLTSIVDNPRLRAGIEATGATYELANMPENKDLMI
TISPLINEPVSRFTLPPASIEDLVARVKVNRKVANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTNYNKNFTEFLKHMQKNDLTANAGVTDVKGDRSLAPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIVIPTRAMGKNDKDYSVSFAVPSDTKGLIHVVGRSSLDMRE
LDGCDIGNAYYSKYCPTLIFDNVFVPWERVFMCGETEFASEMVIKFSSFHRQSHGGCKSG
KIDCMVGAALTLMDYNGTSKAGHLKQKVIDMIHRAETLYGCCLASSYEGKQQPSGAYFID
TVLANASKIHEGKEMAEATRLMIDACGGFVADLPSDRDFENPDIGDLLKKYLKAVDTVPV
ENRVKMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETDVESKKKAARRLAGIKE
>A0A6N3HGM1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium symbiosum|TrEMBL
MALMTGEQYVESMRKLNLQVYMFGEKIENPVDDPILRPSLNSVKMTYDLAQMPEYEDLMT
STSNLTGEKINRFTNIHMNAQDLVKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTSYEI
DEKYGTHYFENFKKFLQYTQEKDLTVDGAMTDPKGDRSLAPHAQKDPDLFLHVVERRPDG
IVVRGAKAHQTGFVNSHEVIVMPTQSMGPEDRDYAVSFACPTDAEGIFMIVGRQSCDTRK
LEGSDIDVGNSRFGGMEALVIFDNVFIPNDRIFLDGETEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAAAAADYNGAARASHVKDKLIEMTHLNETLYCCGIACSAEGAQTKSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLRDPKLGRYIDKYFRGVNDV
PTEDRMRMMRLVENLTLGSAAVGYRTESMHGAGSPQAQRIMIARQGNIGMKKKLAKDIAG
IKES
>A0A1C5WC58|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Clostridium sp|TrEMBL
MAIGTYEQYKERLLKMKPNVYLNGTCVDRSNGKEGPERDLADWIKGGTYVMKQCYDVAND
PDYADVCITTSHITGEKINRCTHIHHSQEDLLKKQLMTRLICHRVGGCMQRCMGTDAMNA
LFSVTYDCDQACGTEYHQRLLNYIEYCQKYDLICNCAQTDVKGSRNPKYKRAYMQPDPDS
FVHVVDTDVDGIGVDGKPCKGIIVRGAKICNSNAPYVDEIIVNPTKFMGPDDADYAVAFA
LPGDWDGVKLMALPGLHHKRTHLEAPFAKIGDVESLTIFDDCFVPYDRVFMCGRDNEGVP
RYAGYLALMFAHYHRHSYTGCKTAVSEVIASQAALVADVNDIARESHVREKLCDIIQTAE
LVFAAGEASAYHATQFPSGQWVPDEVLTNAGRRLAGHNIYHEYETLADLTGGVCASLPTE
ESFFAPETAELCNKYIRRNPAYSAEDTHRVMRMMENKLCDSYEAAQAVAGVHGGGSPLME
TITMMSRYDLEELKKIAKYLAGIPGYGECPRYERSAHTATPRAMLAKFDAMAAAKKETK
>A0A1V6IR59|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MGLKTADQYEESLRKMNLKVYLLGEQVKCPADHPIIRPSMNSVKMTYALAQSPEHEDLMT
AKSHLTGEKINRFCHLHQSTEDLIKKVKMQRLLGQKTGACFQRCVGMDAINAVDSVTFEM
DKKLGTQYHDRFIRFLKMVQEEDLVVDGAMTDPKGDRSLPPSRQTDPDLYTHVVEKRKDG
IIVRGAKAHQTGAVNSHWILVMPTIAMTKDDADYALSFVAPADADGISYIYGRQSCDTRK
LEGCEIDVGNRQFGGHEALMVFDNLFVPWENVFMCGEYEFSGLLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGAAKASHVKDKLIEMTHLNETLFSCGIACSAQGHRTASGTYL
IDLLLANVCKQNVTRFPYEIARLAEDITGGLMVTMASEKDLRHPEIGKIVEKYFKGIASV
PTEDRCRIMRLVENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEHKKKLAKEIAG
IKD
>A0A1V6IR82|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MRTREQYIERLRKMRRNLYHDGEKIDRDDEIQAPVLNVMGLTFDAVHDPELKDLCTATSH
LTGETINRFCHVHQSTDDLHKKQDMTRALCRKAGMCIQRCMGTDALNAVNAASFEADKVN
NGNTQYHKNFLKWLERFQKEDLVGSCAQTDMKGERLKRPAEQTDPDMYVHVVEKKKDGIV
VRGCKLHISEASISDEIIVVPTRALGPDEKDYAVAFAVPSDYEGVKQVVSIHNQHKRKHI
KRGIDIGYSDSYIIFEDCFVPWERVFLCGENDHGGMCALLFALFHRHSYSGCKPAIGDVF
LGLAALAAEYNGIEKTPHVKEMLAEIIKVSELGYAAGYTASSMGKPEVIIPGLGMCPYGP
GSYIPNSIYCNVGRCLTGEAVFHEQELICRIAGGLPSTFPYEGDLTHPDLKKVLEKYLNR
NPKVPVEDQIKFWMTLGDYTIGTMAGVMNYGNYHGGGSPIMEQIAITSQYDIKDRKKLIK
RLAGIGG
>A0A645E2L3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MVVRGAKAHQTGILNSHEVIVMPTIALGPDDKDYAISFAVPLDTPGLFMIVGRQSCDTRK
TEGSSMDVGNPEFGGVEALTIFEDVFVPNDRIFLNGETEFAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAAVAADYNGANKASHVKDKLIEMTHLNETLYACGIACSCEGKPTASGNYI
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTAPSEKDFRDPKLGPYVEKYLKAASGV
STENRLKILRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLNAKKKLAKAIAH
IKE
>A0A644TU59|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MAIKTKAEYIESLRKLQPVVYMFGERIDNFVDNPRIRAGIEATGETYALAESFEHRDAIT
TNSPLIGEKINRFTLPPASIEDLVARVKNNRLLGGRVGTCYQRCTGMDCLSALAIVTYDI
DRKYGTTYNARFLEFLKYVQKNDLTCNAGVTDVKGDRSLNPAEQADKDLYLRVVEERKDG
IVVRGAKAHQTGSLSSHEIIVLPTRALRKEDKEYAVAFALPIDTPGIIHVVGRSSLDMRE
LQGCDTGNTRYSKYCPTVIFDNVFVPWDRVFLYGETEFAGDLVMRFSSFHRQSHGGCKAG
KIDCMIGAALNMMDYNGTTKAGHLRGKVIDMIHRSETLYGCSLAASYEGKKEPSGTYFVD
PVLVNASKLHEGKEMAEVSRLLMDIAGGFVSDLPSDKDFENPTIGPLLKKYLKGTADTPV
EDRVKMLRLVEKITLESADSVSDIHGGGSPEAHRITIMRESKVGDKKALSKRLAGIEE
>A0A0J1FPX6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfosporosinus acididurans|TrEMBL
MRTRAQYLERLSKMNRNLYSNGEKIDRLDPRQEGALNVMGLTFDAAWDPASKDLCTATSH
ITGETINRFNHIHQNSEDLHKKQDMTRLLCNKVGGCIQRCMGIDAANAINAVSYEAQKSP
KAKTAYHDNFLKWLEWFQSEDLVASCAQTDVKGERLKRPAEQIDPDMYVHVVEERSDGIV
VRGSKVHISEASISDEILVVPNRALQKGEESYAVCFAVPSDYEGIKQVVHYHLNRKRDFF
QKGIETGYTDSYIIFDDCFIPWERVFLCGEIQHGGIAALLFALFHRHSYSGCKPAALDYV
IGMAGLAADINGIDKTHHVREMLSRLIMTGELGYAAGYTASALAKPEVYMPGMGMVPYGP
GSYIPNSIYANVGRCLTGEAVFHEQEILCNIAGGMPATFPFEKDLMNPETKALLEKYLNR
NPKIPIEDQIKFWLNFIDFGLSGYAGTSQYGNYHGGGSPIMEQIAITTQYDLESKKDIVR
EIAGMSQRKK
>A0A087S8Z4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-B03|TrEMBL
MANVLKTIRSGEDYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAETYDLALREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDAMNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKGDRSKGPSEQDDPDLFTRIVDTD
EKGVYVSGAKAHQTGCINSHWIILMPTIRLTEADKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGIPKVSHIKDKIIEMTHLNETIFAAGIASSHQGHKMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GVDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKNL
AGITNDVEEPKESSEYFKRVFKTKDSVL
>A0A6C7IC59|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Salmonella typhimurium (strain D23580)|TrEMBL
MKPEDFRTDNKRPLTGEEYLKSLQDGREIYIYGERVKDVTTHPAFRNAAASVAQLYDALH
KPSMQDTLCWNTDTGSGGYTHKFFRVAKSADDLRQQRDAIAEWSRLSYGWMGRTPDYKAA
FGCALGANPAFYGQFEQNARNWYTRIQETGLYFNHAIVNPPIDRHKPADEVKDVYIKLEK
ETDAGIIVSGAKVVATNSALTHYNMIGFGSAQVMGENPDFALMFVAPMDAEGVKLISRAS
YEMVAGATGSPFDYPLSSRFDENDAILVMDKVLIPWENVLIYRDFDRCRRWTMEGGFARM
YPLQACVRLAVKLDFITALLKKSLECTGTVEFRGVQADLGEVVAWRNMFWALSDSMCSEA
TPWVNGAWLPDHAALQTYRVMAPMAYAKIKNIIERNVTSGLIYLPSSARDLNNPQIDQYL
AKYVRGSNGMDHVERIKILKLMWDAIGSEFGGRHELYEINYSGSQDEIRLQCLRQAQSSG
NMDKMMAMVDRCLSEYDQNGWTVSHLHNNDDINQLDKLLK
>A0A1C5SKE3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Eubacterium sp|TrEMBL
MLMTGEQYIESLRKMKTRVYMFGEEVKDWVDHPIIRPSINCVAVTYDLAQDPEYADLMTA
KSSLTGETINRFAHLHQSTEDLKKKVKMQRLCGQKTASCFQRCVGMDAFNAVFSTTYETD
KKYGTNYHENFKKFLEMVQKNDYVVDGAMTDPKGDRGLAPSAQKDPDLFVHIVERREDGI
VVRGAKAHQTGTINSHWHIVMPTQAMKEADKDFAVSFACPTDAEGMYMIYGRQSCDTRKL
EEGADVDLGNKQFGGQEALVVFDNVFIPNEYIFLAGEYDFAGMMVERFAGYHRQSYGGCK
VGVGDVLIGAAALAAEYNGAQKASHIKDKLIEMIHLNETLYCCGIACSSEGHPTLAGNYE
IDLLLANVCKQNVTRFPYDITRLAEDIAGGLMVTMPSEKDFKSDVKVGSNGETIGEICNK
FFAAAPSCTTEERMRILRFIENICLGSSAVGYRTESLHGAGSPQAQRIMIARQGNLEGKK
ELAKAIAGIK
>A0A6S6XDD8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Ruminococcaceae bacterium BL-6|TrEMBL
MALMTGEQYIESIRNMDIQVYMFGKKIENHVDDPILRPSLNSVRMTYDLAQMPEYEDLMT
AVSPATGHRINRFTHIHQSAGDLVKKVKMQRLLGQKTGACFQRCVGMDAFNAVYSTTYEV
DQKYGTHYHDNFKKFMEYVQENDLTVDGAMTDPKGDRSLPPNKQVDPDLFLRVVERRPDG
IVVRGAKAHQTGVLNSHEVIVMPTISMGPDDKDYTVSFAVPMDTRGLFMIIGRQSCDTRK
LEHSEMDVGNPEFGGVEALTIFDDVFVPNDRIFLNGETEFAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAAEYNGVARASHIKDKLIEMTHLNETLYCCGIACSAEGSPTESGNYM
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTAPSEKDFRDPKLGPYVEKYLRGVAGV
STESRLRVLRLIENLALGTAAVGYRTESMHGAGSPQAQRIMISRQGNIAGKKKLAKALAH
IG
>A0A6J4XFB0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Olavius sp. associated proteobacterium Delta 1|TrEMBL
MKIKTTADYLTSLQKLNPTIYYRGERIKDVTRHPATAPHVRSAAMTFSLANNEKYRDLAT
ATSHLTGNTISRFTHVHQSVEDLIKKIKLLRVLGQKTGTCFQRCVGFDGINAVYTVAYEV
DQKLGTDYLERFKKWLIDVQDENRMVVGAMTDPKGDRSKSPAQQSDPDQYVRVVKRTDDG
VYIRGAKLHMTGAVNSHEILVMPTTALDEQSADYAIVCAIPIDAKGITMIFGRQANDSRR
DNLENIDSGKPRFGAVGGEAVIVFDDVFVPHEKIFLNGEAEYTGAIVYRFAAHHRANYGA
CKTGLMDVLTGAVSYLAQAQGTAKASHIKEKVTEMIHLSETLYSSSIATSAEGWPTPSGG
YMVNTMLANVCKQNVTRFHFEIARLALDIAGGFIATLPSEHDLKSEEVGHLVKKYFSGVE
GIPVEDRIKIGRLIEAMTGGTALVESMHGAGSPQAQRVMIFREGDLTNKIKLAKSLAGIR
QKQKSIK
>A0A1S8T974|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium sp. BL-8|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDNVVDHPIIRPSLNSVAMTYELALMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNAIFSSTYEI
DKACNTNYHENFKEFLKYVQENDLTVDGAMTDPKGDRGLSPSNQADGDLYLRVVERRPDG
VVVRGAKCHQTGMINSHEVVVMPTIALTPNDKDWAISFAVPTDAEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGTKTESGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGLMVTMPSEADFRDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
RIEE
>A0A3B0T7P2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|hydrothermal vent metagenome|TrEMBL
TYIYGRQTNDTRCLEPGTMDEGNARFSGQEAMIVFDNVFVPHAHVFMNGETDFAASLVER
FTTYHRCSYICKTGVGDVLVGAAAEAAELNGVERASHIKDKLVEMVHLNETIAGSALASA
HEAKPLPSGAYINDDMQANVAKQNVTRFPYEIARLAQDIAGGLMVTMPSEADLDHAEAGP
LIRKYLVGRQNTDVTDRLRILRLIENLTLGRNAVGYLTESMHGAGSPQAQRIQIARGAGL
AEKRQLARDLAGSGDR
>A0A381ICT1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MTIGEVCNKYFKASSVASTEERMRILRFLENICLGSSAVGYRTESMHGAGSPQAQRIMIS
RQGNINQKKELAKKIAGIKKEEALNL
>A0A2K5ANV4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosocaldus cavascurensis|TrEMBL
MPLKTQEEFIASLRDGRNVYYNGERVTDVTTHPVLSIFVNHWSLIYKAKHDPKVKDIFVK
RLDEYGEASAYFNIPRNADDLLARAKLIEATTAYCNGQFNIAQAIGTDALFALMSICSEV
DKRYGTRYYQNVLRFYDRCVREDLAMAVAQTDVKGDRSKRPHEQDDPDAYVHIVERRSDG
IVVRGAKVHTTGTQAVNEIIVLPTRNMLAEDRDYAVAFAIPANDKNVKIISRAQASKELG
EFDYPMSVKATAQETLTVFDDVFVPNERIFLAGEYEYAGALARLFALWHRFTAISYKPPI
GDQLLGAAALIAEYNGISKYPHVRSKIVKLIRYVETIRACIRAAAVEHKVYPAGIAVPNP
VYVYIGKYHLADNFHDAAKTVQDLAGGLVITQPTTRDLENPETAKYIEKYLKTRHDVPAK
NRLKVLNYIRDLTASTYTGGYNYVLSVHGEGSLEAQIISTYTEYDVDRCVRYVKSLLNIE
>A0A644ZIB0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MALMTGEQFIESIRKINMQIYLFGEKVENPVDNPVLRPSLNSVRMTYDLAQMPEYQELMT
AVDPDTGKRINRFCHIHRSTEDLMNKVKMQRLCGQKTASCFQRCVGMDAFNAQYSTTYEI
DKTYGTHYRDNFMKFLRYVQDNDLTVDGAMTDPKGDRALAPHEQPDPDMYLHVVERRSDG
IVVRGAKAHQTGIINSHEVIVMPTMAMGPDDKDYAVSFAVPLDTPNLFMIIGRQSCDTRK
LEGGKMDVGNPEFGGVEALTIFDNVFVPNDRIFLNGETEFAGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAALVADYNGANKASHVKDKLIEMTHLNETLYACGIACSAEGKPTESGNYM
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGIMVTAPSEKDFRSEKLGPYVEKYLKAAPGV
TTENRMKLMRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLGAKKKLAKAIAK
IKE
>E6YVE8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella sp. 1-1C|TrEMBL
MSKHKIHLTSKSQSIVPVSSQEYRDTMSHFAGAVHIVTTDGIKGKRGVTISACCSLSDNP
PTLLVCLMRYKTENKLFMENGNFCVNSLTGKHRLLADVFSGRHRFTQNERFAAAEWGILQ
TGAPSLLNALASFDCNLICCHEHPTHYILIGEVVAINRNQEKDALMYFNRDYQTLSLPL
>E6YQW1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella sp. AR 15-3|TrEMBL
MSKHKIYLTSKSQSIVPVSSQEYRDTMSHFAGAVHIVTTDGIKGKRGVTISACCSLSDDP
PTLLVCLMRCNTENKLFMENGNFCVNSLTGKHRLLADVFSGRYSSTQNERFAAAEWGVLQ
TGAPSLSNALASFDCNLICYHEHATHYILIGEVVAIKRNQEKDSLIYFNRNYHTLSLPL
>A0A1E3AJV6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eisenbergiella tayi|TrEMBL
MGLMTGQEYIESLRRLHTKVYLFGKRVENFVDHPIIRPSINSVAMTYDLALDPQYQDIML
AVSNLTGKTINRFCHLHQNEQDLINKVRMQRLLGQKTGACFQRCVGMDAFNAVYSTTFEV
DQKYHTNYHQNFIAFMKEVQEKDLTVDGAMTDPKGDRSLSPGKQKDPDMYLHVVEKNTKG
IYVTGAKAHQTGAVNSHEHLIMPTVAMGENDKEYAVSFAVPSDAEGIKMIYGRQSCDTRK
LEKSGGMDCGNCRFGGQEALVVFEHVFVPWERVFLCEEYEFAGVLVERFAGYHRQSYGGC
KTGVGDVLIGAAAVAAEYNGVQKASHIKDKLIEMIQLNETMYSCGIACSALGTQTAAGNY
QIDNLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEEDFNSPETAEICRKYFKGSAD
ADTVDRMKILRLIENMTLGSAAVGYRTESMHGAGSPQAQRIMINRQGKLEEKKKLAKVIA
GISSEPDK
>A0A075HWE7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_88_C09|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGEQVNRFLHIAESAQDVVKQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGAIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFERAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGIPNVSHIKDKLVEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLRKYLKAKK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKRLAKDL
AKVQEDGDETLENADYFKRVFKLDNSKE
>A0A0F7IDQ3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Geoglobus ahangari|TrEMBL
MINGEQYLERIKSYSREIYVAGKRVDYDHPNIQPVLRAFAFTYDLALERGYSVHSDLVGK
EVNVLNAYYSSPEELMKRYDYQRELSMRLATCNYRCTGADAINAFAAVLKGEERERFLRL
LREIQENDYACTSALTDPKGDRSKRPKEQKEMYVRVVEERDDGIIVEGAKIHQSGAFAAD
INFFLPGQTFKEGEEEFAIAFALKPDDEGVKYILQNTGVQAKQREGGEFEYGNPFGDRTT
CTVVLDRVFVPWERVFVYRDLKAVRNLLMTFANSHRCVGAACKAGFIDSMTGAASLMIKA
NGLEKVSALTSRLGEMSAVAESAYAIAIGSAVKGESVNGTWLPNGLMANAGKIAGVDGFI
KAMRHLAEIAGGIPGTAPSEFDLKSEEVGEYVERFLRGSENFTAEERMRIIKFIEFWLMS
SHYLGALHGGGSVSAAIIFLQYMSDIKSKEEAVRKTINL
>A0A7W9ES06|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sphingopyxis panaciterrulae|TrEMBL
MTHHPREESAADRWARFRPIVTGDDYVESLRGRGVEVWLFGERIDEPVDHPIIRPSINAL
KMTYDLAIEDPDLATAHSDLIDAPVNRFLHIVGSPDDLVMKNRMQRRMGQLTGTCFQRCA
GLDTISVLHSITFDIDAKHGTPYHQRYLEFMRHAQRNNIILGAGMTDPKGDRSKRPHEQA
DPDMFLHVTKRTEAGVYVTGAKAHMTGGLNSHWICVMPTMNMGEADRDFAIVGLVPGDAA
GITYIYGRQSCDTRALEKGDIDQGNARFGGQEVLVVFDNVFIPYEHVLMDGEYEFAQEMV
TRFTAYHRASYVCKTGLGDVMVGAAAQVADYNGAEAASHIKDKLVEMTHLNETIYSSAIA
SSHEAKPLASGIYMNDAMLANVCKHNVTRFPYEISRLAQDLAGGVMVTMPSDADFRHETV
GPILAKYMKGKHNVPVEYRQRILRLIENMTLGRNAVGYLTESLHGAGSPQAQRIQILRGM
EVETKKGLARDLAGIAEDTQS
>A0A1C6D9T3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Flavonifractor sp|TrEMBL
MKTGQEYRDSLRNRNIKVYIKGQLLDSKDVIDHPFIKGHVNSAAMTYELAEDPQFEDLMT
ATSHLTGKKINRFTHIHQSVDDLVKKVKMLRMISLNTGTCYQRCVGLDAVNSIYSVTYEM
DQKLGTNYHERLKKYLLRWQEEDLMVAGAMTDPKGDRSLRPSQQADPDLFVHVVKKDDKG
IYIRGAKAHMTGMVNSHEMLIMPTSGYGEEDKDYAVCCALPVDAPGVIHIFGRQTNDDRK
LEGEIDQGNARYGVVGGECLTILEDVFVPWENVFMCGEYPFSGMLVERFACYHRQNYGGC
KGGVSDIVIGAAATVADMSGYGKATHIKDKLNEMIHLAETLYCCSIACSAEGKPTAAGNY
YVDPLLANVGKHNVTKLIYDIDRLAQDVGGGILATLPSEADFRSPEVGKYVEKYMRGVAS
VPTEDRMRMIRLVEVMTGGVALVESMHGAGSPQAQKIMYSKLSGLESKKKAAMKIAGVDP
SKYSK
>A0A645CEL6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MCKQNVTRFPYEIVRLAEDIAGGLMVTMPSQKDFESDTVVGNNGETISEICNKYFAAHEG
VSTEDRQRVMRFLENMCLGAAAVGYRTESMHGAGSPQAQRIMIARQGNIQGKKQFAKDIS
GIKD
>E6YLM1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella rochalimae ATCC BAA-1498|TrEMBL
MSKHKIHLTSKSQSIVPVSSQEYRDTMSHFAGAVHIVTTDGIKGKRGVTISSCCSLSDNP
PTLLVCLMRYKTENKLFMENGNFCVNSLTGKHRLLADVFSGRHRFTQNERFAAAEWGILQ
TGAPSLLNALASFDCNLICCHEHPTHYILIGEVVAINRNQEKDALMYFNRDYQTLSLPL
>A0A1C5XHJ9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Oscillibacter sp|TrEMBL
MHGAGSPQAQRIMIARQGNLQAKKQMAKEIAGIQN
>E6YHP1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella clarridgeiae (strain CIP 104772 / 73)|TrEMBL
MSKHKTHLISKPQSIAPVSSQEYRDTMSHFAGAVHIVTTDGIKGRRGVTISACCSLSDDP
PTLLVCLMRYNSENKIFMENGNFCVNSLTGKHRLLADVFSGRCGFTQMERFATAQWSVLQ
TGAPSLSGALASLDCNLICWQEYATHYILIGEVVAINRNQEKDALLYFNRDYHTLALSL
>A0A011R406|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Accumulibacter sp. (strain BA-93)|TrEMBL
MNTAQQRASSGQLMSGTDYRESLRRYRPLVYVDGRRIESVADAPELQPGINALAVTYDFA
LDPAKAPLMTARQSWRRSPVNRMLHIDESAGDLLNKLEAVRLLCQETGCAQRYLAHDALN
AIHQVSARIDDARGSSEHRARFAEYLTQVQDKDLSLGIAMTDAKGDRSKRPHQQQNADSY
LHVVERNGQGIVISGAKAIVTGAAYMHEFLVMPCRNMGAEDADFAVCCAVPVDAEGVTIV
SRPAGRPGEKPEHGQPLFSRRYGQATAVVLFERVFVPWERVFYAGDWEHSGVLTYHYATH
HRHSCIAARAGFGDLLIGAGALMCEANGFSDPGAQSNLREAMVELITITESFFACGVAAS
VYAKADEASGSFMPDPVFANIGKLLLATKIYDMHRLAHEVSGGLIVALPGPDEDHNPATA
ASLAEVLRASPDVPYEKRIEVARFMEDLTASYQAGWYSVISLHGGGSPAAMKQEIWRNYP
VGDKVALVERLLDRGLADDPARPISRNRQPGRCCDSGCTQPGQAVMVPLPSPGR
>A0A2H5W4R9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bacterium HR11|TrEMBL
MLRNGAQFLEGLVDGRRVYYRGEPVADVTRHPILQVPARHSALLFDLHFDPELQAELVTT
DDTGEPISTLYRSPTSTDDLLRRSRLIEATTHRSRGVFNIAKVIGSDALFALHIVTAALD
RARGTDYRRRVLEYHRYVAHGDRAVSVAQTDVKGDRSLRPHQQADPDLYVRVRERRSDGI
VVRGAKAHITQAQVADELIVIPCRSLSSEDADYAVAFAVPANAPGITMVTRPMVELESAR
HPLEGPRVRHNTLTEALVVFDDVFVPWERVFLAGETEYASRLALTFALWHRFSAISYRAA
QADLMAALAREIAEANGIADKSHIRRNLVELILLAEVQRMAAHLAAYRCHADPTTGLVYP
DPLCVNLGKLYSNTHYLSATQAFIDCAGGLAATAPSGDDWAHPDLRPVLEKYLTGRATVS
GERRFRLFLLARELVGLLGGYENVTMVHAEGSIEASVIEILRGYDFSAGRRLVEALLGD
>A0A1V6IHF6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin026|TrEMBL
MGLKTKAEYIESIRALKPVVYMFGERITNVVDNPRLRAGIEATGATYEMAEQPENRDLIV
TTSPLINEPVSRFTLPPASIEDLVARVKINRKVANYVGTCHQRCTGLDCLSTLSIVTYDI
DKKYGTNYNKNFLEFLKHMQKNDLTANAGVTDVKGDRSLSPSEQVDKDLFLRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIVLPTRAMGKADKDYSVSFAIPSDTKGLIHVVGRSSLDMRE
IDGADCGNIYYSKYCPTLIFDDVFVPWERVFMCGETEFASEMVIKFSSFHRQSHGGCKAG
KIDCMIGTALTMMDYNGTTKAGHLKQKVIDMIHRAETLYGCCLASSYEGSKQPSGSYFID
TVLANASKIHEGKEMAEATRLMIDVCGGFVADLPSDRDFENPEIGGLLKKYLKGVESVPV
ENRVRMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETDTGAKKKAAKRLAGIKD
>A9IVG4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella tribocorum (strain CIP 105476 / IBS 506)|TrEMBL
MKDMSNHKTCLVPKLQHNITASSQEYRDAMSHFAGAVHIVTTDGIKGKRGVTVSACCSLS
DDPPTLLVCLMRHNLKNHVFMENGIFCVNSLAGKHRPLADIFSGRCNVPQNERFDVAQWR
TLQTGAPSLSDALASFDCRLICWHEHATHCVLVGEVVAINRNHGKDALMYLNRGYHTLPL
>A0A0K0NUL2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Thaumarchaeota archaeon|TrEMBL
ATIADYNGVPNVSHIKDKIVEMTHLNETIFAAGIASSHQAHKMKSGVYLNEDVLAQVCKH
NVTRFPYEIARLAQDIAGGLVVTLPSEKDFRHPVAGPLLKKYL
>A0A3B0SFP6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|hydrothermal vent metagenome|TrEMBL
MAIRTAGEYIESLRNRNLKVYLFGELVEEPVDHPIIRPSIEAVAETYRLAEDDPDLGAAQ
SILTGARVNRFLHVTESVEDVVQQNRMQRVLGQRTGTCFQRCVGQDAINAVFSVTFDIDA
RDGTDYHDRFKSFVTEMQRENFVVGGAMTDPKGDRSRGPSQQSDPDLFLRVVERRPDGVV
LRGAKAHQTGCVNSHWLLAMPTMRLTESDRDYAVVAAMPVDTEGLSYIYGRQSCDARALE
DGDIDAGNAMFGGQEAMIIFEDVFVPNEFIFMDGEVGFAADLVDRFTAYHRRSYVCKAGL
GDVLVGAAATIADYNGVPNASHIRDKIVEMTHLNETIAGCGMAASHESVATDAGNFQPDM
MLANVCKQNVTRFPYEIARLAQDLAGGLMVTMPSQAEFDSPVTGPLLEKYLKGRDGVTVE
NRRRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIVIQRLADVEGKKAMAKKLAGIDE
G
>A0A0H2M565|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax paradoxus|TrEMBL
MNAPLPGTSLMSGADYRESLRRHRPTVFVDGRRVESVADEAAFQPGINAIALTYDYALKK
EYEPLMTAVQHTSGKRVNRLSHINASSGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIA
QVSARIDDARGSTEHTARFLDYLHRIQDQDLTLGVAMTDAKGDRSRRPHEQANVDSYLHV
VERNARGIVISGTKAIVTGAPYVHELLVMPCRNMGKEDADFAVCCAVPLDAPGLTIVARP
AGRPGEKLEHGDALFSRKYGQSTGVCMFDKVFVPWERVFYAGEWEHSGHLTYSYATHHRH
SCIGARAGFGDLLIGAGALMCEANGFDPGKESHLREQMVELITITESFFACGVAASVYGK
ADEHCEVFMPDPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVTLPGPDEDHNPETAARLS
DVLRANPAIPYEQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIWRNYPVGSK
VELVERILERGIAADGSPAAAPYDPARAITKNRQPGKCCDTGCTAPGQPVMVELPASWRP
>A0A841KYQ8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Anaerosolibacter carboniphilus|TrEMBL
MALMTGEQYIESMRKLDVKVYLFGELVENPVDHPIIRPSLNSVAMTYELAHQPEYEDLMT
ATSNLTGEKINRFCHLHQSTDDLRKKVKMQRLLGQKTASCFQRCVGMDAFNAVYSTTYEV
DKAHGTSYHEKFIKYMKYVQENDLTVDGAMTDPKGDRGLAPSKQADPDLFVHVVERRPDG
IVVRGAKAHQTGCVNSHEHLVMPTIAMRPEDKDFAICFAVPTDAEGLFMIYGRQSCDSRK
LEEDADIDVGNKNFGGHEALVVFDNVFVPNDRIFMDGETDFSGMLVERFAGYHRQSYGGC
KVGVGDVLIGATALAADFNGAAKASHVKDKLIEMTHLNETLYCCGIACSLEGYATEAGNY
QIDMLLANICKQNVTRYPYEIARLAEDIAGGLMVTMPSEKDLKNPQIGPYVEKYLKGVSS
VPTEHRMRVLRLIENLTLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEHKKELAKKIA
RIDEQSIAQREAAASEK
>A0A1V5E0U0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MALQTAAQYEESLRKLKLKVYLMGERIVNPVDHPIIRPSMNSVKMTYALAHDPEHEDLMT
ATSHLTGQKINRFCHLHQSTTDLVKKVKMQRLLGQKTGACFQRCVGMDAVNAVDSVTFEM
DKKLGTSYHERFLKFLRRMQDEDMTVDGAMTDPKGDRGLPPSRQADPDLFTHIVERRKDG
IVVRGAKAHQTGAINSHWILVMPTIAMTKEDSDYALSFVAPADAEGISYIYGRQSCDTRK
LEGGNIDVGNYNFGGHEALMVFDNVFVPWENVFMCGEYEFSGLLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGAAKASHVKDKLIEMMHLNETLYACGIACSAEGNKTASGTYL
INLLLANVCKQNVTRLPYEIARLAEDLAGGLMVTLASERDLRHPEIGPVVKKYFRGVASV
STEHRCRIMRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEQKKKLAKDIAG
IKD
>A0A1V5E3G1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophus sp. PtaU1.Bin208|TrEMBL
MGLKTKEEYIESIRALNPVVYMFGERITNVVDNPRIRAGIEATGATYELAGMPENKDLFV
TMSPLINEPVSRFTLPPASIEDLVARVKVNRKVANYVGTCHQRCTGLDCLSTLAIVTYDI
DQKYGTHYNENFLEFLRYMQKNDLTGNAGVTDMKGDRSLAPHEQVDKDLFLRIVEKREDG
IVVRGAKSHQTGSLSCHEVIVLPTRAMGKNDGDYAVAFAIPADTPGLIHVVGRSSLDKRE
LDGFDCGNIYYSKYCPTLIFNDVFVPWNRVFMCGESEFAVDMVVKFSSFHRQSHGGCKSG
KIDCMTGAALTMMDYNGTAKMSHLKQKVIDMIHRAETLYGCCLASSYEGKKQPSGNYFID
TVLANASKIHEGKEMAEATRLMIDAAGGYVADLPSDRDFENPEIGGLLKKYLKGVDSVPV
ENRIKMFRLVEKMAMESADTISDIHGGGSAEAHRVTILRETDVESKKKAAKRLAGIKD
>A0A1U7MI13|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporomusa sphaeroides DSM 2875|TrEMBL
MRTGKEYIESLKQRNIKVYIKGQLLKSEEVVDHPFIRGHVNSAALTFDLAHDPAYEDLMT
TTSHLTGKKINRFTHIHQSVDDLLKKVKMLRMISQKTGTCYQRCVGFDAINALYTVTYEM
DKKLGTEYHERLKKYLINWQENDLMVAGAMTDPKGDRSLRPGQQPDPDMFVRIVEKNDKG
IIVRGAKAHMTGMVNSHEMLIMPTMGMAPDDSDYAVSCAIPVDAPGVIHIFGRQTNDDRK
CEGDIDQGNARYGIVGGECLTVLEDVFVPWDKVFMCGETEFSGLLVERFACYHRQNYGGC
KGGVSDVVIGAAAVMADMSGYGKAGHVKEKINEMIHLTESLYACSIACSAEGKPTASGGY
FVDPLLANVGKHNVTRLIYDIDRLAQDIGGGLTATLPSESDLRHPEIGKYVDKYFKGVAG
VSTEDRMRVARLIENMTGGTALVESMHGAGSPQAQKVMYSKLGNLEHKKKLALHIAGVAA
NKDK
>A0A011NTW2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. BA-92|TrEMBL
MNTSQQGATSGLLMSGSDYRESLRRYRPLVYVDGRQIESVADAPELQPGINALAVTYDFA
LDADKAPVMTARQARRASPVNRMLHINESAGDLLNKLEAVRLLCQETGCAQRYLAHDALN
AIHQVSARIDDARGSSEHRARFAEYLRQVQDRDLSLGIAMTDAKGDRSKRPHQQDNPDAY
LHIVERNGKGIVISGAKAIVTGAAYMHEFLVMPCRNMGAEDADFAVCCAVPVDAEGVTII
SRPAGRPGEKPEHGQPLFSRRYGQATAVVLFERVFVPWERVFYAGDWEHSGVLTYNYATH
HRHSCIAARAGFGDLLIGAGALMCEANGFPDPGAQSNLREAMVELITITESFFACGVAAS
VYGKADEASGSFMPDPVFANIGKLLLATKIYDMHRLAHEVSGGLIVALPGPDEDHNPATA
ASLAEVLRANPEVPYEKRIEVARFMEDLTASYQAGWYSVISLHGGGSPAAMKQEIWRNYP
VGDKVALVERLLDRGLVDDPARPITRNRQPGRCCDSGCTRPGQAVMVPLPAGDGRGRG
>A0A075WDB9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Archaeoglobus fulgidus DSM 8774|TrEMBL
MMNGKEYIESLRKLKPKVYFMGRKIDSVADDPITAPHVNAAAMTYELANDPRYEDVMTAT
SHLTGEKINRFTHIHQSTEDLVKKVRMMRLLGRKTGSCFQRCVGLDALCALYITTYDVDR
KYGTDYHERFKDYLIHVQKNDLMAAGAMTDVKGDRSLRPHQQADPDVYVRVVERREDGIV
VRGAKAHITGAVNSHEIIALPTRAMGEEDKDYAVAFAVPVDAEGVVMIFGRQTNDVRRLD
GDIDCGNAKYATVGGEALIIFNDVFVPWERVFMCGEYDFASELVETFATYHRQNYGGCKV
GVADVLIGASAAIAEYNGVERASHIVDKLTEMVHLAETCWCCSLACSYEGFKTPSGAYMP
NLLLANVTKLNITRFPYEWSRLAQDIVGGLVATTPSELDYKNPETRDLIEKYLKGKADVP
TEHRVRMIRLIENLSIGAELPESMHGAGSPAAQKIMIARRANIDVKKEEAKRVAGILPDE
DYLRVRGFKREGDEGRS
>A0A1C6DMG7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Butyricicoccus sp|TrEMBL
MMTKDQYIESLRKLNLNLYMFGKKVENPVDDPVIRPSLNSFAATYELAEDPQYQDLMTAT
SHISGKKINRFTHMHQSTDDLIKKVKMQRLLGQKTAACFQRCVGMDAMNAVFSSTYEIDE
ACGTKYHENFLKFLTRVQDEDLAVDGAMTDVKGDRSLAPSKQADPDLFLHVVERTADGVY
VTGAKAHQTGFVNSHEVLVMPTISMREGDEDYAISFAVPTDSKGITLIYGRQSCDTRKIE
EYNDIDVGNKVYGGHEVLVIFDRVFVPNDRIFLNGEVKFAGMIVERFAGYHRQSYGGCKV
GVGDVLIGATALAGEMAGSSKASHVKDKLIEMTHLNETLYCCGIACSSQGTKTKAGNYLI
DLLLANVCKQNVTRFPYEIARLAQDLAGGLMVTQPSEADYRNPELKPYIEKYLKGVASVP
TEDRMRLLRLIENMTMGTAAVGYLPESMHGAGSPQAQRIMIARQSNLEMKKELAKKIARI
K
>A0A0F0C9E2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium sp. FS41|TrEMBL
MAIGTYEQYKERLLKMKPNVYLNGTCVDRSNGKEGPERDLADWIKGGTYVMKQCYDVAND
PDYADVCITTSHITGEKINRCTHIHHSQEDLLKKQLMTRLICHRVGGCMQRCMGTDAMNA
LFSVTYDCDQACGTEYHQRLLNYIEYCQKYDLICNCAQTDVKGSRNPKYKRAYMQPDPDS
FVHVVDTDVDGIGVDGKPCKGIIVRGAKICNSNAPYVDEIIVNPTKFMGPDDADYAVAFA
LPGDWDGVKLMALPGLHHKRTHLEAPFAKIGDVESLTIFDDCFVPYDRVFMCGRDNEGVP
RYAGYLALMFAHYHRHSYTGCKTAVSEVIASQAALVADVNDIARESHVREKLCDIIQTAE
LVFAAGEASAYHATQFPSGQWVPDEVLTNAGRRLAGHNIYHEYETLADLTGGVCASLPTE
ESFFAPETAELCNKYIRRNPAYSAEDTHRVMRMMENKLCDSYEAAQAVAGVHGGGSPLME
TITMMSRYDLEELKKIAKYLAGIPGYGECPRYERSAHTATPRAMLAKFDAMAAAKKETK
>A0A075H670|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_41_H02|TrEMBL
MQKTIRPIRNGEEYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVARTYDLAVEEEE
LAFPKSSISGEHVNRFLHIAESAQDLVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEIDEKHNTEYHQRLLEFIKTVQHENLVIGGAMTDVKGDRSLSPSEQEDPDLFVHIVDRD
EKGVYITGAKAHQTGTINSHWMIIMPTMRLQENDKDYAIVGAIPVDAPGIKYIYGRQSCD
TRSMEPGDIDVGNSEYGGQETMVILDRVFIPNEMIFMDGEYEFAAMLVERFTCYHRRSYV
CKTGLGDVLIGAAAAVADYNGVPKVSHIKDKIIEMTHLNESIYAAGISSSYQAQKMKSGV
FLNDDMLANVCKHNVTRFPYEIGRLAQDIAGGLLVTLPSEAEFRSPETGPILKKYLKGKS
GAEVENRMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVKGENEEIKESSEYFERVFKLGND
>W7W785|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Methylibium sp. T29|TrEMBL
MNAPTSIAPPARPATLMSGADYRDSLRRYKPTVYVDGQLVDSVADAPSLRPGVNALAYTY
DFARDPAMAPLALAVQSSRGFTVNRMAHINESAGDLLNKLEAVRLLCQETGCAQRYLMHD
ALNGIAQVSARLDDAKGSTEHRARFQAYLARVQDEDLSLGVAMTDAKGDRSKRPHQQANP
DTYVHVVERNGKGIVISGTKAIVTGAPYMHELLVMPGRNMGAEDADFAVCCAVPIDAPGM
TLVSRPAGRPGDKLEHGAALFSRRYGQATAVVIFDRVFVPWERVFYAGQDGEWEHSGVLT
YSYATHHRHSCIAARAGFGDLLIGAGALMCEANGFDPGEKSNLREPMVELIKITEGFFAC
GVAASVYGTADPYSGSFMPEPVFSNIGKLLMSTQIYDMHRLAHEVSGGLIVALPGPDEDH
NPATAATLSEVLRANPTVPYDKRIEVARFIEDLTASYQGGWYSVISLHGGGSPAALKQEI
WRNYPVGSKVELVERLLDRGVLHDETRAITRNRQPGRCCDTGCTVPGQPVMVALPESTRK
QD
>A0A7Y7IAG6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. SG517|TrEMBL
MNAPLSSASLMSGADYRESLRRYKPTVFVDGRRVDSVADEAAFQPGINAIALTYDYALKK
EYEPLMTAVQHTSGKRVNRLSHINTSAGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIA
QVSARIDDARGSTEHTTRFHEYLHRVQDQELTLGVAMTDAKGDRSRRPHEQANADSYLHV
VERNARGIVISGTKAIVTGAPYVHELLVMPCRNMGKEDADFAVCCAVPLDAPGLTIVARP
AGRPGEKLEHGEALFSRKYGQSTGVCMFDKVFVPWERVFYAGEWEHSGHLTYSYATHHRH
SCIGARAGFGDLLIGAGALMCEANGFDPGKESHLREQMVELITITESFFACGVAASVYGK
ADEHCEVFMPDPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVTLPGPDEDHNPETAARLS
DVLRANPAIPYEQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIWRNYPVGSK
VELVERILERGIAADGSPAATPHDPARAITRNRQPGRCCDTGCTTPGQPVMVDLPASRRA
>A0A081S3F8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-E16|TrEMBL
KHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKGDRSKGPSEQDDPDLFTRIVDTDEKGVY
VSGAKAHQTGCINSHWIILMPTIRLTEADKDWAIVGAIPADAKGVTYIYGRQSCDTRSME
EGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLVERFTCYHRRSYVCKTGL
GDVLIGAAATIADYNGIPKVSHIKDKIIEMTHLNETIFAAGIASSHQGHKMKSGVYLNDD
MLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRKGVDVE
NRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKNLAGITN
DVEEPKESSEYFKRVFKTKDSVL
>A0A381ID68|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVAATYDLAHDPEYADLMT
VTSNITGEKINRFGHLHQSVDDLIKKVKMQRLCGQKTASCFQRCVGMDAFNAVYSTTFEC
DKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLSPSAQPDPDMFLHIVERREDG
IIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVIICSSFRC
>A0A381IDY5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MFHQKVTKQKLETYQIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTMPSEKDFKSDL
KSWNKWNDYWRSM
>A0A1V4XJ24|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophaceae bacterium PtaB.Bin095|TrEMBL
MALKTPEQYEESLRKLNLNVWLMGERVKNVVDHPIIRPSMNSVRMTYALAQEPEHEDLMT
ATSHLTGQKINRFCHLHRSTDDLVKKVKMQRLMGQKTAACFQRCVGMDAINAVDSVTFEM
DRKLGTQYHERFIRFLKKMQDEDWTVDGAMTDPKGDRNLPPGKQADPDLYTRVVKKTREG
IVVRGAKAHQTGAVNSHWILVMPTITMTKEDGDYVLSFVAPADEKGILYIYGRQSCDTRK
LEGGEIDVGNRQFGGHEALMVFDDVFVPWENVFMCGEYEFSGALVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGANRASHIKDKLIEMMHLNETLYACGIACSAEGRPTASGNYL
IDLLLANVCKQNVTRLPYEIARLAEDIAGGLMVTMASERDLRHPEIGKIVEKYLKGIASV
PTEHRCRVLRLIENITLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLDHKKRLAKTIAG
IQN
>A0A1V5DSD3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MKTPEQYEASLRKMNFKIYLLGELVKNPVDHPIIRPSMNSVKMTYALAQDSQYEDLMTAT
SHLTGKKINRFTHLHRSTEDLVKKVKMQRLLGQQTASCFQRCVGMDAMNAVDSTTFEMDK
KLETNYHERFIQFLKMVQKDDLTVDGAMTDVKGDRGLSPRRQADPDLYVHIVEKNEQGIV
VRGAKAHQTGAVNSHWVLVMPTIAMGKDDADYAVSFVAPADAKGIFYIYGRQSCDTRKLE
GVKIDLGNAQFGGHEALMVFDNLFIPWNNVLMCGEYEFSGMLVERFAGYHRQSYGGCKVG
VGDVLIGAAALAADYNGAANASHVKDKLIEMTHLNETLYSCGIACSAQGHKTASGTYLID
LLLANVCKQNVTRFPYEICRLAEDIAGGMMVTMASEKDMKHPEIGKVLEKYLQGKANVTT
EDRCRIMRLVENLTLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEQKKKLAKKIAGIK
E
>A0A075HP77|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_73_E01|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPNVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A1V6IXA5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MTYALAQKPEYEDLMTAKSHLTGNKINRFTHLHQSTDDLIKKVKMQRLLGQQTASCFQRC
VGMDAMNAVDSTTYEMDQKLGTKYHERFIKFLKMVQEEDLTVDGAMTDVKGDRGLAPHQQ
ADPDLYVHIVEKNDKGIVVRGAKAHQTGAVNSHWVLVMPTIAMTKDDADYAVSFVCPADE
KGIFYIYGRQSCDTRKLEGGAIDVGNARFGGHEALMVFDNVFIPWENVLMCGEYEFSGML
VERFAGYHRQSYGGCKVGVGDVLIGAAALAADYNGANKASHIKDKLIEMTHLNETLFSCG
IACSAQGHKTASGTYLIDLLLANVCKQNVTRFPYEICRLAEDIAGGMMVTMASEKDFKNP
ELGKVLEKYLKGNANVSCEDRARIMRLVENLTLGTAAVGYRTESMHGAGSPQAQRIMIAR
QGNLEQKKKLAKNIAGIKEEKK
>A0A075FTT7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote AD1000_30_G09|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPNVSHIKDKLVEMTHLNESIYGTGIASSYQSQK
>A0A1C6HHB6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Flavonifractor sp|TrEMBL
MIRTREEYLKALKAMRPNIYKFGELIEDVTAHPATRKAVEAHARGFDAANTEAEKEIFTT
TSSFTGKPIMRHTSMMTSLEEIMANSRLKRTMYRKTGTCTGGFCVGWNAMNVMWAVTSEM
DQEYGTDYQERLKQWILHAQETGILVAGALTDAKGDRSLKPSEQPNPDSSLHIVEYREDG
VVISGCKAMICGVAASEEIFLLPGSGYKDVDKDYALACVVPRDINGLTIIECRHASDGRD
LEEGSFDAPETGVTQAYLLFDRCFVPRDRVFMAGEAKYSGKVITYFTANYRACIGACVAG
QGDVMIGAGVLMARANGLSIKPFQDKMINMAVNNETTYAVGVAAMAAGKPHASGPWISDS
RLAHTNKIHVATLPYETKRLCQEIGGGIVETGCFPSHKDFTDPKLGALVQKYVKAGKDIS
AETRARAARLSEWLTLGGGVPGCMHGGGSPDGAKMVVHGTTPYEEFAEYAKKVAGITEEV
RDPVKPKK
>A0A645ISJ2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MTQLIYDIDRLAQDIGGGIIATMPSESDLRNPEIGKYVDKYLKGVADVPTEDRMRIGRLI
ENMTGGTALVESMHGAGSPQAQKVMYSKLSNLEKKKEFAAHLAGIHSDKSEEE
>A0A0A2GFV0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Porphyromonas macacae|TrEMBL
MMTKEEYIESLRKLDLKVYLMGKRIENPVDHPMIRPSLNSVAMSYELAQKDEYKDLMTAT
SNLTGKTVNRFCHLHQSPEDLVKKVKMQRLMGQKTAACFQRCVGMDAFNAIFSTTYEMDQ
ALGTEYHKRFRDYMVFVQENDLVVDGAMTDPKGDRGLSPSQQPDPDMYMHVVEVREDGIV
VRGAKAHQTGAVNSHEHLIMPTVAMKEADADYAISFAVPSDAPGVMMIYGRQSCDTRKME
EGADIDLGNNTFGGHEALVVFDNVFVPKERVFMCREYQFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGAAALAADYNGVPKASHIKDKIIEMMHLNETLYACGIACSAEGTKTASGNYII
DLLLANVCKQNVTRLPYEIARLAEDIAGGLMVTMPSEQDYRDPYLGPIVRKYLQGARGKD
TENRMRVLRLIENITLGTAAVGYRTESMHGAGSPQAQRIMISRQGDLEGKKALAAAIAHI
DPSKDKNA
>A0A1V6GQT2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MGKLMNAKEYEESLRKLKLNVYMFGKKVESPVDDPIIRPSMNAVAATYEFAHKPEYEDIM
TVKSHITGKKINRFTHIHQSVDDLVKKSKMGRLLGSLTACCFQRCVGMDALNALSITTHA
IDAKCGTEYNKRFLKYLEYVQENDLTCDGAMTDPKGDRSASPAKQFDPDFFMHVVEERKD
GIVVSGAKAHQTGAVNSHEIIVMPTITMREDDKDYAISFALPSDAQGITYIMGRQSCDTR
KLEGMTFDRGNMHYGGHEALVVFDKVFVPWERVFMYKEYEFSTQLVENFAAYHRQSYACK
VGVGDVLIGAAQTVAEYNGAEKASHVKDKIVEMNHLNETLFCGCIACAAEGHKEPSGTYL
VDVLLANVHKQNVTRFPYEIARLAQDIAGGLMVTCPSAADFASPVVGKWVDKYLKTKTDV
PTEHRIRILRLIENITLGTAAVGYLTESMHGAGSPQAQRIMITRLVNLKQKQKVAKYLCG
IDKER
>A0A087RWV4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-P11|TrEMBL
MANVLKTIRSGEDYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAETYDLALREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDAMNALHSTT
FEIDEKHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKGDRSKGPSEQDDPDLFTRIVDTD
EKGVYVSGAKAHQTGCINSHWILLMPTIRLTEADKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGIPKVSHIKDKIIEMTHLNETIFAAGIASSHQGHQMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GVDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQVGYKKNLAKNL
AGITNDVEEPVESTEYFKRVFKTKDSVL
>A0A0D8HUD5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Rhodococcus sp. (strain AD45)|TrEMBL
MGIRSSDQYRKGLNDDRRVFYRGKKISDVYAEPELTLAVDHSALCYDIADDRPDLAITEV
DGEPVSAFYVAPNSAEDLVRRGALIEEVSRRGGGTIVLKEVGSDALFALLRATTGEGLDN
ARAFYQRVCEGDLSLAVAQTDVKGDRSLAPRQQADPDLYLHIVDEDADSITVRGAKCHTS
FSANADELIVLPTRAMGPDDADYAVSFAIPIDTPGLELYVSPYAAGERNSFEFPISTKHK
LLESLTVFNDVRVPKNRVFLNRQPELAGPLALAFVDYHRFTAINYKLPLLDIMVGAASLI
AEANGISKAGHVKGKITELITWSETVRGLAQLAAVRSKPGAHGVQQPDPLAVNMAKYHFA
HGFHNAVAILTDLSGGLLATGPGGEDWDNPDIRAVLEKYYAAAVPAEKRLRLLNFIADLT
ARDYGGYQSVLATHAEGSLEAEKLQIARSFDSTKARNYVSDLAGISHL
>A0A1E3A0K4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eisenbergiella tayi|TrEMBL
MSLMNGKQYIESLRKLNTKVYLFGKRVDNFVDHPMIRPSINSVAMTYELACDPEYQNLCT
AVSGLTGKKINRFCHLHQSQEDLMKKVKMQRLLGQKTGSCFQRCVGMDAFNAVYSTTFEI
DEKYGTTYHKNFVDYMIYVQEQDLTVDGAMTDPKGDRSLPPSRQEDPDIYLRIVEKNKDG
IIVNGAKAHQTGAVNSHEHLIMPTAAMKEDDKAYAVSFAVPSDAPGISMIYGRQSCDTRK
LEGTGCMDCGNCTFGGQEALVVFDHVFIPWNRVFLCEEYEFAGILVERFAGYHRQSYGGC
KVGVGDVLIGAAACAADYNGVQKAMHIKDKLIEMIQLNETLYSCGIACSALGTETAAGNY
QIDNLLANVCKQNVTRFPYEISRLAEDIAGGLMVTMPSQADFDSPETGEICKKYFKGPKG
TDVMERMKILRLIENITLGAAAVGYRTESMHGAGSPQAQRIMISRQSGLDEKKRLAKKLA
GINT
>F2R414|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)|TrEMBL
MTRSGQEYLEGLRDGRAVWIDGERVEDVTAHPAFRSTAASFAGLFDLADDPVHHPVLVRD
GVRRVHEVPRSYEDLVARRRAFRTTARASYGFLGRTPDYMAAGVAGIAAAPAVLTGDGFD
GAAHALAFHRRLAEGDLHTAFTLNSPARGHGGDDLTLRVVAERDGGIVVSGAKTIGTGAV
FADEILVGTIEPLAADDTAHAVTFSLPLDTPGLTLISRASYEERARSVFDHPLSSRYDEN
DAMLVCQDVLVPWERVLTYRDPAATAAIWWETPAYANLVHQSATRFWTKLEFLTGLAILI
ARSNGTAELPPVTQTVGRLLGMVAQAKAFVLAAEASYEQVDGGRGGVRPGREISFAQRIM
AAELYPRAVQDIKLLAGGALVQLPAGGLDLRHPELGPLVRRYFGTASHPAEDRVKLLKLA
WDALGSEFAGRHEQYERFYHGAPHVHLTMQTWAGAAADCESLAQACLDGYDLGTTR
>A0A8B6LV38|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. SRS16|TrEMBL
MPLKTPEQYVESLRDGRVTYWDGERIDDITTHPRFRMPIDSVKADYRYDDPKYGALRQYQ
TEDGSVAHRIFQIPRDEADLNTRVEMMNHTSIGTLVTGVYMALMSVKDAVEKVNPMYGAN
IERMYRYCRDNDLRAAEVITDPKGDRKRSAAQQDDPDLYLRIVERRKDGIVVRGAKLHIT
AASLVHELVVMPTKGMKAEETDYAVSFSIPVNAPGVKIINRSVAGPDLNPFDYPASSHHG
MPEGFVVFDDVFVPWDRVFLAGEVELASKLAQSLGLWERTGGMVEAVRLSELFVGLAQLV
NEMQGKDSDPVTQNSVAELIAYAEMLRMSLDYACRHYEKTPSGMVFPNTLAINAAKYYYA
ANYHQTVRYLHDLGGGLVLTLPLEADLRNEESGKYIRKYLYTKAGVNVETRMRVYNLIRD
LTADAYGGWQFVVALQAGGGLPAQRVMMRRSYNMDQAKKRALSAAGADASE
>A0A1V6AU96|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MRTKQDFINGLAKMKRNIYYDGQLIDRTDELQMDCINTIGTTYDEAAKPEFEDLMTATSH
LTGEKINRFTHIHQNTTDLHRKQDMTRMLCQKVGGCIQRCMGIDGTNAVYNVSYEADKVK
PGETNYHENFKKWLTRFQREDLVAACAQTDTKGDRMLRPAEQPNPGAYVRIKERLKDGIV
VEGCKLHISEASVSDEIIVLPTRALRADDSDYAVAFAVPGDWDGMTQVVTIHNFRTREHY
KRGFMPGYTDSYLIFDNCFIPWERVFLAGEHMHGGILALLFALFHRHSYSGCKPAIGDVI
LGQAALAAEVNNIYKTEHVREKLAEIIMTIELGYAAGYTASDLGKPEVYIPGMGFVPFGP
GSYIPHSIYCNVGRCLSGEAVYREAEILCDISGGVTATFPHEKDFANPVTGEPLLKYTKR
NPKISAEDQAQFWRYLGDYLCSASGGIMNIGNYHGGGSPIMEQIAITTQYDIESRKKLVR
FIAGMSGGDREALAPKPPKK
>A0A081S2X8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-E16|TrEMBL
MLDTDEKGVYVSGAKAHQTGCINS
>A0A6J4YJS6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Olavius algarvensis Delta 1 endosymbiont|TrEMBL
MPMMTAAQYEESLRRLNLEVYMFGKKLDNVVDDPIIRPSMQAVAKTYDMAQRPEHEDLMT
ATSHISGKKINRFTHIHQSVDDLVKKSKMGRLLGRETGCCFQRCVGMDALNALSIVTYNM
DQKLGTEYNQRFLKYLAYVQENDFTCDGAMTDPKGDRSLPPHKQPDPDHYLHIVEERDDG
IVVRGAKAHQTGAVNSHEIIVMPTIAMREADQDYAVSFALPADADGIIYIMGRQSCDTRK
LEEGMLDRGNIYFGGHEALVVFDDVFVPWERVFMFREFEFVGQLVEKFAAYHRQSYACKV
GVGDVLIGASQTAAEYNNVAGASHVKDKIIEMNHLNETLYCGCLACASEGFKEDCGTYSV
NPLLANIHKQNVTRFPYDISRIAQDTAGGLMVTLPSEQDLKSPETGKWLEKYYTASCDVP
AINRMRVLRLIENMTLGTAAVGYLTESMHGAGSPQAQRIMIARLVNMAEKKRAAKKLSGI
DEE
>A0A0M2GUY7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Microbacterium ketosireducens|TrEMBL
MTLRTADQYRAGLRDGRKVVYRGEEVADILTHPQFIRAVEHSSLGYDIHESHPELAVTEV
DGDPRSFFWNAPRTIDDLIRRGRLIEQVSRLGGGTIVLKEVGSDALFALLRATWGAGNEN
ARRYVEFIAREDLSLAVAQTDVKGNRALGPSQQADPDLYLHIVAEDAESITVRGAKTHTS
FAPNVDEIVVLPTRAMGPDDAAYAVSFAIPVDTPGLTLYVSSFADGEPNEFEHPLSSRHK
LLESLTVFDDVRVPKDRVFLNGVPEHAGPLALAFVDYHRFTAINYKLPLLDQIVGAAILV
AEANGIANAGHVKSKLTELITWAETVRGLAELSALRGAESGNGVFRPDPLTVNMAKYHFA
HGFSAATSHLIDLAGGLLITGPGAGDWAKPEVRAVLEKYYAGAVPGEARLRIANFVSDLT
ARGYGGYQRVLATHAEGSFEAEKLQILRAYDSERAVDYVRGLARVPR
>A0A484I7H0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrosocosmicus franklandus|TrEMBL
MPIKNGSEYIESLRNRNLQVYLFGELVKEPVDHPMIRPSINAVAATYDIAIEDPEIGSAK
STLTGTQVNRFLHIAQSSEDLVNQNKMQRKLGQKTGTCFQRCVGMDALNSLYSTTFEIDK
KYNTQYHTRLLEFIKKIQYENLVIGGTMTDVKGDRSLSPSQQEDPDMFVHIVRRDEKGVY
IRGAKAHQTGCINSHWLIVMPTMRLRPEDKDYAIVGAIPVDAKGITYIYGRQSCDTRSME
DGDLDTGNSQFSGQEALIIFDNVFIPNDLIFMDGEVEFASMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIAEYNGVSNASHIKDKLIEMTHLNETIFAAGIASSHQAYKTPSGNFINDD
MLANVCKHNVTRFPYEIGRLAQDIAGGLMVTMPSEKDFRGAVTGPLLDKYLKGRKGVSTE
DRVRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKLARRLARIPE
GENTTDSTLIAESSDYFDRIFGLKKEKQNNA
>A0A1Q9P5J9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Thorarchaeota archaeon (strain AB_25)|TrEMBL
MKTGDEFLQKLYQMKPNVIIDGKTVGRDDPRLQAVAKVMALTLDKVEEPDFKDLLKVESK
EFGTINRFTHIHQSVDDLLKKQELTRKICRLSGGCVFRCMGIDAMNALSIITHRAEAMTG
QPYNQRFLEYLKFWQENDIVGSCAQTDVKGNRALRPHEQADPDLYLRVVEYRDDGIVVRG
AKNHITAAAVAEEIIVLPTRMLTPEEDEYAVAFAVPGDWDGVKLVTRASGHKREKFDCPA
GDLGDVENFIIFDDVFVPNERVFLGGGKGEHAFGGWTALLFALYHRHSYTGCKPASSEII
LGFSALVSEYSGIEDKKHVQSKLADLISVAELVYAAGIAA
>A0A1C6HDI6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Flavonifractor sp|TrEMBL
MAIMTREQFQASIRARKPMNVWFLGEKVDDLTAFPPLAASFNAISKVYELHSHPDWVDLV
TTKSALNGETVSIYNAPLASPADANKKTRAARALAEVIGCCTHRCTGSEAFAGLGPCTYD
MDHDLGTNYYKRFMNFLDYVQKNDLSCTVTVTDVKGLRTLPPHKQPNKDSYIHVDEIRDD
GIVVSGYKCNQTGILFAHEIIIVPTTNMKPEEKDFALACAIPSDTPGLTFVLGRTPQDKR
FFEVGGDIEGIDLGKPYADHQALVYFDKVFVPNDRVFMCGETEYVGRLLSYFTAVHRLTA
GGCKAGGVSALCGAASLITEMVGVQKAGHIKTKLTEMAMTAETVYALSLASGIEGFKHPS
GFWIPNPLLSHTCKYNCTKMPFEAVRYARDIIAGFGETAPSELDMRSAGVGEICQAAFNP
GNPNYDAFDRLRATRFIEHMVRGSNWTAMALHGGGNQEASTVMARAYTDWNHLQDMVKVA
TGIIKDPDKCDELISDIGKREGRICTTLDLPKAE
>A0A644XLF8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MTDPKGDRGLAPSKQADPDLYLRVVERRPDGVVVRGAKAHQTGICNSHEVLVMPTIAMRP
EDKDYAIAFAVPTDSEGITMIIGRQSCDSRKSEEGADIDVGNKVYGGVEALTIFDNVFVP
NDRIFLNGETEFAGMLVERFAGYHRQSYGGCKVGVGDVLIGAAALAADYNGAQKASHVKD
KLIEMTHLNETLYSSGIACSAEGSKTESGNYIIDLLLANVCKQNVTRFPYEIARLAEDIA
GGLMVTAPSEKDLKDPVVGPYVEKYLKGVNAVSVENRLRILRLIENLTLGTAAVGYRTES
MHGAGSPQAQRIMIARQGNINGKKELAKAIAQITE
>A0A031WIT5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVAATYDLAHDPEYADLMT
VTSNITGEKINRFGHLHQSVDDLIKKVKMQRLCGQKTASCFQRCVGMDAFNAVYSTTFEC
DKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLSPSAQPDPDMFLHIVERREDG
IIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVSFAVPSDAEGVFMIYGRQSCDTRK
LEEGADVDLGNKEFGGQEALVVFDNVFVPNDRIFLCGEWDFSGMLVERFAGYHRQSYGGC
KVGVGDVIIGAAALAADYNGANKASHIKDKLIEMTHLNESLYCCGIACSSEGHKTEAGNY
QIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTMPSEKDFKSDLKVGTSGMTIGEVCN
KYFKASSVASTEERMRILRFLENICLGSSAVGYRTESMHGAGSPQAQRIMISRQGNINQK
KELAKKIAGIKKEEALNL
>A0A1V2W4J6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Burkholderia cenocepacia|TrEMBL
MIKNGTQHIASLRDGRQVYLNGQPVGDVTAHAAFRNSIRSYASLYDYQAENENVEKMTFV
SPDSGNRVSRIWQLPTSYDELVERRAALEAWSELHYGFMGRSPDHVASCLSGMYMGADVF
EQYDPARAGALRDYYRYARDNDLFLTYVIVNPQANQSKAAHEQEDKYLAVGIVDQDAEGI
TVRGAKMLATSGIMANEVFCSCIQPLREGDEMYALSFAVPMNAKGMKIMSRKSYEEHATS
VFDNPLSSRFDENDAVLYFDDVKVPWERIFVAGNTAMCAKQFHATPAHVYQNYQCQVRLM
TKLRFLVGLGLKISEVNGTNAFPQVRETLGQLAAEASMVEAWVYGMEAKGTVVNGFYVPD
RNMLYGSQVVTQQLYSKVLNTLRELAGGGMIMLPSSVRDFENPDLLRIIEKTQKSPVCSS
EDRVKFFKLAWDAVGSEFASRHNQYELFYAGASFVTKGHAYRTYDWQRASHLVDSMLGSY
SLNQELSTPRAA
>A0A1V5DKI3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MGIKTKEEYIESIRALKPTAYMFGERLTNPVDNPRIRAGIEATAATYEMANKPENKDLFI
AMSPLINEPVNRFTLPPASIEDLVARVKVNRKMANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTNYNKNFTEFLKYMQKNDLTGNACVTDVKGNRSLNPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIALPTRAMGKNDADYALAFAVPSDTKGVIHVVGRSSLDMRE
LDGCDIGNVYYSKYCPTIIFDDVFVPWNRVFMCGETEFAAEMVVRFSSFHRQSHGGCKSG
KIDCMIGAALTMMDYNGTAKTSHLKQKVIDMIHRAETLYGCCLASSYEGKKEPSGYYFID
TVLANASKLHEGKEMAEATRLMIDACGGFVADLPSDRDFANPEIGGLLKKYLKAVDSVPV
ENRIKMYRLTEKMAMESADTISDIHGGGSPEAHRVTIFRETDIESKKKAAKRLAGIEE
>A0A6N2S4P2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Enterocloster bolteae|TrEMBL
MGIGTYEAYRERLSKMKPNVYLDGKCVDRNGDWIEGGCYVMKVCYDMANDPKFADVCTVK
SHLTGEIINRCTHIHQSQDDLLKKQLMTRLICHRVGGCMQRCMGTDALNAIAVVSYDCDQ
ATGTNYYERFNKYLRYCQENDLVCNCAQTDVKGSRNSKYKRAHQQPDPDMFVHIIKTDVD
GIGVDGKPCKGVIVRGAKICNSNAPYVDEIIVNPTKFMGKGDEGYAVSFALPADWDGVKL
MALPGLHHKRKHLEAPFSKIGDVESLTIFDDVFVPEDRLFLNGYDNPDVVQYAGYLALMF
AHFHRHSYTGCKAAVSEIIAAQAALVADVNDIAKAEHVREKICDIIGTAELVFAAGQASA
YRSVRFPNGSWVPDEILTNAGRRLAGHNIYHEYEILADLTGGVCASLPTEESFFAPETAE
LCNKYIMRNPEYTAEETHRVMRMMEDKLCDAFEGAQCVAGVHGGGSPLMETITLMSRYDL
EELKKIAKYLAGFDGVECPRYERKTATPRAMLERFQKTQRQDGM
>A0A075H3L7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_47_A04|TrEMBL
MQKTVKPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTEYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPTEQEDPDLFLRIIERD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAVVGAIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFVSMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPKVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEEGEETLENSDYFNRVFKLDNSKE
>A0A1G4FKR1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporanaerobacter sp. PP17-6a|TrEMBL
MKTGSQYRESLKRLHPIIYCNGRRIEDVVDDKMTKPHVNSAAMTYDLAFEPKYEDLMTAT
SSLTGKKINRFTHIPQSTGDLVKKVKMLRMISQHTGTCYQRCVGMDALNATFITTYEIDR
DCHTNYHERFKEYYKYVQQNDLMIAGSMTDVKGDRSKKPSQQADPDLYVHIVDKRKDGIV
VRGAKAHQTGMANSHEMLILPTTNLGPEDKDYAVACAIPVDAPGVIHIFGRQTNDQRRLD
GDIDCGNSEFAIVGGETLTILNDVFVPWERVFMCNEYPYAQKYVETFASYHRQNYGGCKV
GLADVIIGTAAAVADCNGVLNKSHIKDKLVEMTFLAETMHCCSLACSSEGFKTPAGSYYV
NTLFANAAKLNCTRTMYEISRLAHDIAGGFIATLPYEADYKSKEVGQYIDKYLAANPKYS
TEERIRMARLLENMTGGTALAESMHGAGSPQAMRIMIYRQANLEHKMDIAKKLAKIDKME
G
>A0A485M3W5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|anaerobic digester metagenome|TrEMBL
MTIKAVKEPAGFQAREQRRHSMRTREQYIEGLRKMRKNLYYNGSRIDRDDELQQPALNVM
GVTFDAVRDPELKDLCTATSHLTGQTINRFCHIHQNPDDLHKKQNMTRALCRKVGFCIQR
CMGIDAVNAVNAVSFEADRSNGGNTEYHKNFLKWLEYFQTGDLVGACAQTDVKGERLKRP
IQQTDPDMYLHVVEKKSDGIVVRGCKLHISEASIADEIMVIPTRALGPDEKEYAVAFAIP
ADHEGVKQVLSIHNFRGRKYYKKGFVGGYTDSYLIFDNVFVPWERVFLCGENDHGGVCAL
LFALFHRHSYSGCKPAIGDVLTGMASLAARHNGIRKTSHVREMLSEFIKITELGYAAGYT
ASALGKPEVYIPGMGSVPYGPGSCIPNSIYANVGRCLTGEAVFKEQEMLCSIAGGLPATF
PNEGDLTDPELKPLLEKYLMRNPDVPIEDQIKFWMLYIDYSCSGFAGPMNYGNYHGGGSP
IMEQIAITSQYNIKLRENIVNSIAGIEELKAGTLTSL
>A0A0L6ZBL6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium homopropionicum DSM 5847|TrEMBL
MAMMTGEQYVESLRKLKLNVYMFGKKIENVVDNPIIRPSMNSVKMTYDLAEKPEYEELMT
TVSNITGEKINRFTNIHQSTEDLVKKVKMQRLCGQKTAACFQRCVGMDAFNAEYSTTFEI
DKEYGTNYHERFKKFMAYVQENDLTVDGAMTDPKGDRALSPAKQADPDLYLHIVERREDG
IVVRGAKSHQTGITNSHEVLVMPTVAMRPEDKDYAVSFAVPTDSQGITIIMGRQSCDTRK
SEEGADIDVGNFNYGGHEALVVFDNVFVPNDRIFLNGETEFAGMLVERFAGYHRQSYGGC
KVGVGDVLIGATALAADYNGAHKVSHIKDKLIEMTHLNETLYACGIACSAEGHKTESGNY
LINLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEKDFRSEEVGHYIEKYLKGVAS
VSTENRMRILRLIENITLGTAAVGYRTESMHGAGSPQAQRIMISRQSNLAHKKALAKAIA
RIKE
>A0A1V6ET33|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Alphaproteobacteria bacterium ADurb.Bin100|TrEMBL
MTAVQHTSGKVVNRLSHINMSSGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIGQVSAR
IDDARGTTEHTARFLNYLHRVQDQDLTLGVAMTDAKGDRSRRPFEQNNPDSYVHIVERNA
MHNGRRGIVISGTKAIVTGAPYMHELLVMPCRNMGREDADFAVCCAVPIDAPGLTIVARP
AGRPGETLEHGDALFSRKYGQSTGVCLFERVFVPMDDVFYAGEWEHSGHLTYSYATHHRH
TCIGARAGFGDLLIGAGALMCEANGFDPGKETHLREQMVELITITESFFACGVAASVYAK
PDEHSHSFMPDPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVTLPGPDEDHNPETAAKLS
DVLRASPDVPYEQRIQTARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIYRNYPIGSK
VELVERLLQRGVAADGTPAAAPHDPARAITRNRQPGKCCDTGCTVPGAPVMVDLPTLEQT
LPSRSEPGSTL
>A0A0K0NU66|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Thaumarchaeota archaeon|TrEMBL
GAAATIADYNGVPNVXHIKDKIVEMTHXNETIFAAGIASSHQAHKMKSGVYXNEDVLAQV
CKHNVTRFPYEIARLAQDIAGGXVVTLPXEKDFRHPVAGP
>A0A081S348|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-E16|TrEMBL
MANVLKTIRSGEDYIESLRGRDLKVYLFGELVKEPVDHPMIRPSINAVAETYDLALREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDAMNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQQENLVIGGAMTDPKG
>A0A7Y0LSA1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridioides difficile|TrEMBL
MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVAATYDLAHDPEYADLMT
VTSNITGEKINRFGHLHQSTDDLIKKVKMQRLCGQKTASCFQRCVGMDAFNAVYSTTFEC
DKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLSPSAQPDPDMFLHIVERREDG
IIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVSFAVPSDAEGVFMIYGRQSCDTRK
LEEGADVDLGNKEFGGQEALVVFDNVFVPNDRIFLCGEWDFSGMLVERFAGYHRQSYGGC
KVGVGDVIIGAAALAADYNGANKASHIKDKLIEMTHLNESLYCCGIACSSEGHKTEAGNY
QIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTMPSEKDFKSDLKVGTSGMTIGEVCN
KYFKASSVASTEERMRILRFLENICLGSSAVGYRTESMHGAGSPQAQRIMISRQGNINQK
KELAKTIAGIKKEEALNL
>A0A1V4WG46|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaB.Bin027|TrEMBL
MGIKTKEEYIASIGALKPTAYMFGKKLTSIVDNPRLRAGIEATGATYELANMPENKDLMI
TISPLINEPVSRFTLPPASIEDLVARVKVNRKVANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTNYNKNFTEFLKHMQKNDLTANAGVTDVKGDRSLAPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIVIPTRAMGKNDKDYSVSFAVPSDTKGLIHVVGRSSLDMRE
LDGCDIGNAYYSKYCPTLIFDNVFVPWERVFMCGETEFASEMVIKFSSFHRQSHGGCKSG
KIDCMVGAALTLMDYNGTSKAGHLKQKVIDMIHRAETLYGCCLASSYEGKQQPSGAYFID
TVLANASKIHEGKEMAEATRLMIDACGGFVADLPSDRDFENPDIGDLLKKYLKAVDTVPV
ENRVKMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETDVESKKKAARRLAGIKE
>A0A1V5DRQ3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MPVYVMGEKVKNVDHPIIWPSINSVGMTYEIAQDPQYEDLATAKSHITGKKINRFTHIHQ
SIDDLVRKIKLLRLMGQKTASCFQRCAGLDGMNALNAITFEMDAEMKTEYHQRFLNFMRI
IQEEDLVCDTALTDPKGDRSLAPGKQKDPDMYLHIVKKDAKGIVVRGCKAHQTGATNSHW
IAVFPTSAMKEEDKDYAVSFVTPSNAKGITYVFGRQSCDTRKLEKGKIDVGNLNFGGQEA
YIIFDDVFVPWENVLIGGETQYAGRVVEIFANYHRTSYGGCKIGVADVLIGATSLLTKCN
GTSKASHVRDKLTEMVHLAETCYSCALSAQTEGSRHASGGYLVNGLIANVCKLNITRFPA
EISRLSQDLAGAVVGTTPSEKDFDIPGGIGELLKKYLKGAADFSWEERVRCIRLIENITM
GTGAVAFFTEAIHGAGSPQAQRVMISRYSNLDMKEKLAKNIAGIQEK
>A0A090JPF5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Peptoniphilus sp. ING2-D1G|TrEMBL
MARKTGAQYEESIRALNMNVYMFGEKIEKPLDHPILRPSFNSVKATYEFADSKSKDLFVA
NSPFIEGEVNRFNHIHESADDLVKKVTMQRFLGQKTAACFQRCVGMDGMNAVFSTTYEID
DKYSTRYHERFVKYLKYIQENDLVVDGAMTDPKGDRGKSPSAQDDPDLYLHVVERREDGI
VVRGAKAHQTGATNSHEILVMPTVSMKPEDKDYSVSFAVPVDAPGIVMIIGRQSCDTRKL
EDSPMDVGNLRYGGMEALIVFDDVFVPNDRIFMDGETDFSGMLVERFAGYHRQSYACKTG
VGDVLIGAAALAADYNGVPKASHIKDKLIEMNHLNETIWSSALACSYSGWKTSSGNYMCD
LLLANVCKQNVTRFPYEISRLAQDIAGGMMVTTPSEKDFKSEAVGKYVEKYLKGVSDIST
EDRIRIMRLIENLSLGTAAVGYLTESMHGAGSPQAQRIMIARQSNMEEKKRFAKHIAMIK
KS
>A0A3S4V6C6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Fusobacterium varium|TrEMBL
MALKTPQEYLDSLRKLNLEVYLLGERVKDPVDNPIIRPSLNSVIMTYELAQDPKYADLMV
VNSHLTGEKINRFTHIHQSTEDLVKKVKMQRLLGQKTGSCFQRCVGMDAFNAVYSTTYET
DQKYGTEYHARFKKFLEYVQKEDLTVDGAMTDPKGDRGLSPSKQEDPDLFLHIVEKRKDG
IVVRGAKVHQTGIVNSHEVLVMPTISMTEEDKEYAVAFSVPTDTKGIKIIYGRQSCDTRK
LEEGTLDRGNPKFGGHEALVIFDNVFVPTERIFMCEEYDFSGMLVERFAGFHRQSYGGCK
VGVGDVLIGAAALIADYNGTKKASHVKDKIIEMIHLNETLYCAGIACSSEGHPTVAGSYE
IDMLLANICKQNVTRFPYEIARLAEDIAGGLFVTMPSEKDYRDPVLGAYIDKYLKGVAAV
PTIDRMKVLRLIENLTLGTAAVGYRTESMHGAGSPQAQRIMISRQSNLEVKKQFVKDILD
IKD
>A0A1V5C4I0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdaceae bacterium PtaU1.Bin034|TrEMBL
MGLKTKKEYIESVAALTPTAYMFGQKLTNIIDNPRIRAGIEATAATYELAEKEENRDLFT
TVSPLLNERVSRFTLPPASIEDLVARVKVNRKVANYVGTCHQRCTGLDCLSSLAIVTYDV
DQKYGTSYNRNFLEFLKHMQKNDLTGNAGVTDVKGDRSLNPADQVDKDMFLHVVEKRDDG
IVVRGAKAHQTGSLSSHEIIVLPTRAMTKADSDYAVSFAIPSDTAGLIHVVGRSTLDMRE
LDGADCGNVYYSKYCPTLIFDNVFVPWNRVFLCGESEFAQDLVVKFSSFHRQSHGGCKSG
KIDCMIGCALTLMDYNGTAKAAHLKQKVIDMIHRAETLYACCLASSYEGKKQPSGAYFID
TVLANASKIHEGKELAEAIRLMIDACGGFVADLPSDRDFNNPEIGGLLKKYLKGVDSVPV
ENRVKMYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETDINSKKKAAKRLAGVES
>A0A7W5D6C5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. Sphag1AA|TrEMBL
MNAPLNPAALMSGQDFRESLRRYHPTVYVDGRLVDSVADERAFQPGINAIALTYDHALKT
QYEPVMTAVQHTSGKRVNRFSHINTSSGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIA
QVSARIDDARGTRENSGRFTEYLHRIQDQDLTLGVAMTDAKGDRSKRPHEQANADSYVHI
VERNAVHNGVRGIVISGTKAIVTGAPYVHELLVMPCRNMGKEDADFSVCCAVPLDAPGLT
IIARPAGRPGEKLEHGEALFSRKYGQSTGVCIFDRVFVPWDNVFYAGEWEHSSHLTYSYA
THHRHSCIGARAGFGDLLIGAGALMCEANGFDPGRETHLREQMVELITITESFFACGVAA
SVYAKADEHCEVFMPEPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVALPGPDEDHNPAT
AARLADVLRANPDVPYEQRIETARFIEDLTAGYQGGWYSTISLHGGGSPAAMKQEIYRNY
PVGSKVELVERILERGVGADGSPSAAPHDPTRPITRNRQPGKCCDTGCTAPGQPVMVDLP
LPHGGTDRSR
>A0A0K1DZR5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Pyrobaculum sp. WP30|TrEMBL
MLRTGEQYVEGIRERRHAKIYVMGKRVTDVTTNLFLKPSVLAFKATFDAAFQEDTRDLAR
AFSPFINEEVNRFVHIHQGPQDLVAKVKLLRRLSHKTGTCFQRCVGWDALNTLYIVTGKM
AERGDGVYRERFLKYLEHVQRRDLALAGAMTDVKGVRTLRPSEQPNPDAYVRVVEERDDG
IVVSGAKANITGVAAVDEVVVLPTRAMTEQDAAYAVSFAVPLDTPGVVVVVGRQINDARR
MEGGDIDGVPYMAHHEGLIIFNNVFVPWDRVFMYKDWRWTGPLVEIFASFHRQGYGGCKS
GLGDVIIGATYELAKTIGVDNKPNVADKLAEMVFLNESMYSAGLAASWEGSKLLKEGGWW
VNPMYANVTKHLVARFPYEISKLAHDIAGGIVGTAPSEFDLKNEEIKNLLEKYLQGVPEI
PAEERLRLVRLLENVSVSVGFLIESVHGAGSPAAQKIMFNRLYDYEKAGEIAKALSRIKV
TVKWPKAPEPRRPSESEKL
>A0A4U9YKC5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Gordonia terrae|TrEMBL
MAIRDPQAYREGLRDNRRVVYRGERIDDVTAFDEFADAIAHSSLAYEISRTEPDLAVADD
GDGPYTAFYRVPRTAEDISNRGRLIETLSRMGAGTIVLKEVGSDALFALLRALSGDSLAK
AQAFYRYCCENDVALAVAQTDVKGDRSLPPHRQPDPDHYLRIVDEDADSITVSGAKVHTS
FSANADELIVLPTRAMSEADRDWAVSFAIPVDTEGLTLYVSPYLHGDHHAFEHPISSRHK
LLESLTVFDRVRVPKERVFLNREPELAGPLALAFVDYHRFTAVNYKLPILDLLVGAAIGI
AEANGIAGAGHVKTKLTELITYAETVRGFAELAAVRARNGGNGIHLPDPLAVNMAKYHFA
HGFHQAAATLLDLAGGLVVTGPGGHDWDDPEVRAVLEKYFAAARPAEERLRLIHLIGDLT
AGQWGGYQSVLATHAEGSLEAEKMQIARAYDSTRARAAVDAVLRAAAETPIPGTELDAPV
GAAR
>A0A7W6T3F8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bradyrhizobium sp. SBR1B|TrEMBL
MDQEVVAPASAGMPNRIRSGAEYIESLRGRRLAVYLMGELVDEPVDHPVIRPSINAVART
YDLANEDPALASAISSLTGTNVNRFLHISGSPADLVMQNKMQRRLGQLTGTCFQRCVGMD
ALNSLHSVTYDLDTKYNTPYHARFTQFLARMQSLNLVIGGAMTDVKGDRGQSPSQQADPD
LFLHVVRRTPEGVYVRGAKAHQTGCLNSHWLIVMPTMRLEAVDRDYAIVGAIPVDAAGIT
YIYGRQSCDTRSTEGGDIDVGNAQFAGQEAMIIFEDVFIPNEHVFLDGEFEFASTLVERF
TCYHRRSYVCKTGVGDVLIGAAATVADYNGVERASHIRDKLVEMTHLNETIYGAGIAASH
QGTAMNSGAYLPDEMLANVCKHHVTRLPYEIGRLAQDLGGGLMVTLPSEHELRHEKIGPM
IEKYLKGRPEIKTEDRIRILRLVENMTLGRNAVGYLTESMHGAGSPQAQRIQIARSMQIE
FKKDLAKALAGISSASRGKIESDLSTYMARVFAPISN
>A0A7W0HL83|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfosalsimonas propionicica|TrEMBL
MKTGKEYEDSLRKLNLKVFLFGQRVENIVDDPVIRPSMNAVKLTYDLAHQPEYEDLMTAT
SHITGKKINRFTHIHQNTTDLVKKSKMGRLLGSLTGCCFQRCVGMDAINALSITTFNIDE
KYQTGYYKRFLQYLEYVQEQDLVCDGAMTDPKGDRSLPPSRQPDPDAFLHVIAENDDGIV
VRGAKAHQTGAVNSHEIIVMPTIAMREDDKDYAVSFALPADAEGISYIYGRQSCDMRKLE
DGMIDRGNQHYGGHEALVVFDDVFVPWDRVFMCREHEFAGELVEHFASYHRQSYACKAGV
GDVLIGATQLAADYNGAEKASHVKDKIIEMNHLNETLFCGSLACAGEGGAKPSGTYCVNA
LLANVSKQNVTRFPYEIARLAQDIAGGLMVTCPSEQDLRNPDTGKWMEKYYKTKTDVPTE
NRIRILRLIENLTLGTAAVGYLTESMHGAGSPQAQRIMISRLVNMEAKKNVAKKLCGIDQ
>A0A7W0C8T2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfosalsimonas propionicica|TrEMBL
MMTARQYEESLRKLNIVVYMFGERISNPVDHPIIRPSMNAVAKTYELAHQPEHEDLMTAT
SHLTGKKINRFTHIHQSVSDLVKKTKMGRLLGAHTGCCFQRCVGMDALNAISIVSHDIDA
EYDTDYKDRFLKYLKYVQENDLTCDGAMTDPKGDRSLPPHKQPDSDMYVHVVKETEEGMV
VRGAKAHQTGAVNSHEIIVMPTIAMREQDRDYAVCFALPSDAEGITYIMGRQSCDTRKTE
QTRLDTGNPAFGGHEALVIFDDVFVPWDRVFMFREHEFAGVLVEKFAGYHRQSYACKSGV
GDVLIGATQTVAEYNGTQGASHVKDKIIEMNHLNETLFCGSLSCAAEGRREPSGTYSVNT
LLANVSKQNVTRFPYEIARLAQDVAGGLMVTLPSAADFASSETAHWLEKYYGASANVPTE
NRRRILRLIENLTLGTAAVGYLTESMHGAGSPQAQRIMIARQVNMQQKQQMAKNLCGIEE
>A9IVJ0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bartonella tribocorum (strain CIP 105476 / IBS 506)|TrEMBL
MKSFVEQSPIIVGGGIAGLSTALALAHKGIASTIIEKYQKLETIGAGIQLTPNATSILAH
WNLLNKLTEVATIPHFLELKDGISLKIRLHAHLINLTEKHWKAPYITIHRAALQKVLYDA
VIENPLIQYKAGETIVSSTQSVTSIDITTIKTDTVTKQLYSTPLLIGCDGVWSTLRQQSP
FYEKANFSGFIAWRATTTCDNLPQNFYSSLHNMKTITAWMGPNNHLVIYPIQSSEKVVNF
VAITHGKNPEEGWAHKGDKEKLKSLFKGWNSKILQIFDHIDEWKYWPLFHMKQNRFLGLD
RQVFVGDCAHAALPFAAQGAAMAIEDAATLAEALSLKDLSLTKALSLYEKTRTPRIVEVK
KRTNFNRLAYHATGPIAIARNLMMKIRTPESIMSSLNWLYRYDAINSIKNRDKNL
>A0A1S8S0X5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium beijerinckii|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDNVVDHPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNALYSSTYEI
DKACGTNYHENFNKFLKYVQENDLTVDGAMTDPKGDRGLSPSKQADGDLYLRVVERREDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPNDKDWAISFAIPTDTEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGTKTESGNY
YIDNLLANVCKQNVTRLPYEICRLAEDIAGGLMVTMPSEADFKDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENLCLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
KIEE
>A0A2H5ZWP3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bacterium HR32|TrEMBL
MRTAEQYLASLRDGRRVYYRGERVEDVTSHPHLRKGAGVCAVDFRLAHEHAQDPTFTVRD
PQTGQVYSRYFHVPRGPEDLLRRRDLIERVTREARSFVPLIKEIGTDALFALHIVCAQMD
RDLGTSFLPRVQAFYERCRDGDLAMAVAQTDVKGDRGKRPADQPHPDLYVRCVRETADGI
VVRGAKAHTTNAVYSNEVLVLPTRAMTERDAAYAVAFAVPADTPGLTFVASPRGFGATSA
FDNPLSSRYAITESLTVFDDVFVPWERVFLCGQWAYAGPLAKTFVEFHRFTAISYKTPLL
ELLVGAAAWMAEAQGIAGAGHVRDKLARLVMYAETVRGLSTAAAVEGRFEEGIFVPNVVL
TNAAKYAFARGYHDGVRDVQDIAGGLVVTGPAEEDRANPELWRLIEPYLQGRAGVSGEAR
LRMMNLIRDLVASDLGGYLEVLAIHAEGSLEAQKLTVLMDYDLDRVKRLAAQAGGLEV
>A0A1Q9NZP7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Heimdallarchaeota archaeon LC_3|TrEMBL
MFKGPITSGEEYIKSLQGRKLKVYLFGEIIENIVDHPVIRPSINAMAKTFDLANSDENLA
TVYSSLSNQKINRFLHIAEKSEDLVFQNKMQRRLGQLTGTCFQRCVGMDAINALHSVTYE
IDEKYHTKYHQKFLKFVEMAQKSNFVLGGAMTDVKGDRSKRPFEQDDSDMFVHVIKRDGK
GVYISGAKAHQTGALNSHWLIVMPTMRMTEQDKDYTIVGAIPVDTPGVTYIYGRQSNDLR
HLEGFPIDTGNHFFSGQEALVIFENVFIPTDLIFMNGEYEFATMLVDRFTNYHRRSYVCK
SGVSDVLIGAAATIADYNGVSNASHIRDKLVEMTHLNETIYATGIASSYQSYKMKSGVWM
NDDMLANVCKQNVTRFPYELGRLAQDLAGGLMVTLPSEKDLKHDELGPLLDKYLKGKNEI
STEDRVRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRINIYRLMQIEFKKNLAKYLAG
IDISEKELSRFENFYERVFS
>A0A1V5DXV6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MITKEQYRERMFKMKPNICIGSKMVRRDDPRLIPGLNVLEVTYDLAHDPKWKGLATATST
ITGEEISRWAHLPQNPYDLMQKQKLIRLAARRVGGCIQRCMGHDALNALAICTKEIDMAK
KTDYHKRFMDYMKIYHQKGWDGCCAQTDSKGDRMKRPSQQDNPDAHVHIVEERKDGIVVS
GFKMSITQAAYADEIFVVPTRALMEDDRDFAVAFAVPADCEGLTLVTRPVWLREKDDADC
PPYCRYGVSDSVLIFDKVFVPKERVFMCGEWEFGRRVALLFADSHRHSYSGCKPAVSDML
CGVTALAAEANGIQKVAHVREKLTEFASTAELAYAAGIASAVFGEKTASGVFFPNSIYAN
VGRRMTGELIYHEYNMLTEIAGGISVTMPFKEDFEFGPFKEQLMKFIVRNPKISADDSLK
IWRLVENVGASPMASWFEIAGVHGGGSPIMETIALGIEYDYETRKKLGRYLAGISPELDD
SADLLREPTFGDGLITERPVSKK
>A0A1C5YH17|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Clostridium sp|TrEMBL
MALMTGEQYVESMRKLNLQVYMFGEKIENPVDDPILRPSLNSVKMTYDLAQMPEYEDLMT
STSNLTGEKINRFTNIHMNAQDLVKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTSYEI
DEKYGTHYFENFKKFLQYTQEKDLTVDGAMTDPKGDRSLAPHAQKDPDLFLHVVERRPDG
IVVRGAKAHQTGFVNSHEVIVMPTQSMGPEDRDYAVSFACPTDAEGIFMIVGRQSCDTRK
LEGSDIDVGNSRFGGMEALVIFDNVFIPNDRIFLDGETEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAAAAADYNGAARASHVKDKLIEMTHLNETLYCCGIACSAEGAQTKSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLRDPKLGRYIDKYFRGVNDV
PTEDRMRMMRLVENLTLGSAAVGYRTESMHGAGSPQAQRIMIARQGNIGMKKKLAKDIAG
IKES
>A0A653A3B3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Desulfatiglans sp|TrEMBL
MGLKTKEEYIESLRRMNPTAYMFGQKLTDVVDNPRLRAGIEATAATYEVAELDDFKDLAV
TQSPLINEPVNRFTLPPSSIEDLVARVKLNRKLGAYVGTCHQRCTGLDCLSTLSIVTYDI
DQKYGTHYYDNFVEFLKYMQKNDLTANAGVTDVKGDRSKGPKDQEDKDMYVHVVEKRDDG
IVVRGAKAHQTGSLSSHEIIVLPTRAMRKGDEDYALSFAVPADAPGLIHVVGRSSLDMRE
LDGYDVGNIRYSKYCPTLIFNDVFVPWERVFMCGETEFAVEMVVRFSSFHRQSHGGCKSG
KIDCMIGTALTMMEYNGTSKAGHLKQKVIDMIHRAETLYGCCLASSYEGKQEPSGTYFID
TVLANASKIHEGKEMAEAIRLMVDVCGGFVADMPSDRDFENPEIGPLVKKYMKGADGVPI
DNRIKLYRLAEKLALESADTISDIHGGGSPEAHRVTIFRETNIDRKKDAAKRLAGIES
>A0A0A2FFU8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Porphyromonas crevioricanis|TrEMBL
MMTSQEYIESMRKLNLKVYFMGERIENPVDHPMIRPSLNSVAMTYELAEKPEYQEVMTAI
SNLTGKRINRFCHLHQSTEDLKNKVKMQRLLGQKTASCFQRCVGMDAFNAIYSTTYEMDQ
ELGTSYHARFVEYLKYVQDNDLVVDGAMTDPKGDRGLSPSQQEDPDMYLHIVEVREDGIV
VRGAKAHQTGAVNSHEHLIMPTVAMKEGDKDYAVSFAVPGDTEGLFMIYGRQSCDTRKTE
AGAEIDLGNPTFGGHEALVVFDNVFVPNERVFMCKEYQYAGMMVERFAGYHRQSYGGCKV
GVGDVLIGAAALAAEYNGVPKVSHIKDKLIEMIHLNETLYACGIACSSEGKPTASGNYLI
DLLLANVCKQNVTRLPYEIARLAEDIAGGLMVTMPSEQDLRDPELGPVVKKYLKGAVGKD
TTNRMRILRLIENMTLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLEAKKQMAREIARI
DTSLDK
>S0G7I5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MLRTKEQYHEDLFAMRPNIFIGGKPVGRDDPRLRPGINVLDITFDLAQTPEWKGLATAVS
TVTGAEINRWAHLPQNPQDLLQKQKLIRLGARRAGGCIQRCMGHDAINALAICTREMDDA
NGTEYHRRFLDYLKVYHEKDLDGCCAQTDSKGDRMKRPSEQSDPDAYLHIKEEREDGIVV
SGFKMSITQAAYADEIIVLPTRALIASDRNYAVAFAVPGDAEGMSLITRPVWLRENDKEG
AAPFCTYGVSDCVVFFDNVFVPKERVFMCGEWQFGRRLALLFADSHRHSYSGCKPAVSDI
LCGTTCLAAEANNIANASHVKEKLSEFAGAAELAFAAGVAAAVYGKKTDSGVFFPNEIYA
NVGRRLTGEMIYHEYNILTEIAGGISVTMPFDEDFEQGKNAEAMKRFIIRNPNLSVEDSL
KIWQLVEHIGASSMASWYKIAGVHGGGSPIMETIALNLGYDFEDKKRLARYLAGIDNDLD
DSKMRDQIAKIDTQI
>A1K6V5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Azoarcus sp. (strain BH72)|TrEMBL
MSSAVLEAPLSAEAFRRGMRRLALPTAVVTTAHDGERGGLTVSSLCSVSTDPPRLLVCIN
TAASAFPLLRASGVLAVNMLAEGQGALCMRFGSSRCSGEARFAEGRWETARTGAPLLADA
LASFDCRVVEMHESATHAIVIADVVELRTAPDAMPLLYRDGAFARLHMEAAP
>A0A1V5J725|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MALKTGKEYEDSLRNMKFKVYLMGEKVDNPVDHPIIRPSMNSVKMTYELAHDPAHEDLMT
VKSHLDGKKVNRFCHLHQNTEDLVKKVKMQRLLGQKTAACFQRCVGMDAMNAVDSVTYEM
DQKLGTEYHKRFTKFMKMVQDNDFTVDGAMTDPKGDRGVSPSKQADPDLYTHVVEKRKDG
IVVRGAKAHQTGAINSHWVLVMPTVSMGKEDADYALSFACPADADGITYIYGRQSCDTRK
LEGGEIDVGNCRFGGHEALMVFDNVFVPWENVFMCGEYEFSGMLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGASKASHIKDKLIEMIHLNETLFSCGIACSAQGHKTVSGTYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEKDLRHPEIGKIVDKYFKGVNGV
PTENRCRIMRLVENITLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLEQKKKLAKEIAG
IKD
>A0A1V5JBN5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MKTKKDYIKRLSKMKRNVYFDGQLIDRTDELHMDCIDTIGTTYDEAEKPENQELMTAISH
LTGERINRFNHIHQNTTDLHNKQDMTRMLCQKVGGCIQRCMGIDGTNSVYNVSYEADKSN
KGATQYHENFKKWLTRFQKEDLVGCCAQTDVKGDRMLRPADQPNPGAYVRIKERLKDGIV
VEGCKVHISEASVADEVLVIPTRALREKDKDYAVAFAVPGDWDGMKQVVTIHNLRPREIY
KRGFMPGATDSYVIFDNCFVPWERVFLAGEHQHGGVLALLFALFHRHSYSGCKPAIGDIL
LGSAALAAEVNNIHKESHVREKLAEIIMTTELGYAAGYTASDLGKPEVYIPGVGFVPYGP
GSYIPNSIYCNVGRCLTGEAVYREQEILCDISGGVTATFPHEKDFANKDVGDLLFKYTKR
NPNMPAEDQAQFWRFLGDTLCSSTGGLMNVANYHGGGSPIMEQIAITTQYDIESRKKLVK
YIAGMSGGDREALAPKAAKQKTK
>A0A836BJ40|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MGIRTGQEYIQSLRGRKMKVYLFGELVEEPVDHPLIRPSINAVAETYDIAVREEELATAQ
SSITGQRVNRFLHIAESVQDVVLQNKMQRKLGQNTGTCFQRCVGMDALNSLHSVTFEMDE
KHGTNYHKRLLDFIKMLQTENFVIGGAMTDPKGDRSKGPAEQVDPDMFVHVVKKDDKGIY
LTGAKAHQTGCINSHWIIIMPTMRLTEDDKEYAIVGAIPADAEGITYIYGRQSCDTRSME
EGDLDAGNSQYSGQEAMIVLENVFIPWDKVFMNGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAATIADYNGIPNVTHIKDKLIEMTHLNESIFAAGIASSYQSHKMKSGVWMNEE
MLANVCKHNVTRFPYEIARLAQDIAGGLMVTMPSEKDFKNPETGPMLRKYLAGRKGVDVE
NRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKMNLAKNLAKVKD
DFLEPTEPSDYFKRVFKISNKEE
>A0A011QSA3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. BA-94|TrEMBL
MNPCQSATVPNRALMSGSDYRESLRRYRPTVHLDGRLLESVADSRELQPGINALAVTYDF
ARDPQKAPLMTALQASRGQTVNRMLHVDESAADLLNKLEAVRLLCQETGCAQRYLAHDAL
NAINQLCARVDAEAGSNERRARFAAYLEHVQDDDLALGIAMTDAKGDRSQRPHQQANRNS
YVHIVERLASGIVIAGTKAIVTGAPYMHEVLVMPSRNMGPADADFAVCCALPVDAPGLTM
VARPAGRPGEMLEHGAALFSRRYGQSTAVLVFDRVFVPWERVFLAGEWEHSASLTYHYAT
HHRHSCIAARAGFGDLLIGAGALMCEANGFDPGRKASLREPMVELIKITEGFFACGVAAS
VYGAPDPHSGSFMPEPVFANIGKLLLATXLLLATQIYDMHRLAHEVSGGLIVALPGPDED
HNPATAATLAEVLRASPDVPYDKRIEVARFIEDLTASYQGGWYSVISLHGGGSPAAMKQE
IWRNYPLGSKVDLVERLLERGVLHDESRPITRNRQPGRCCDAGCSPPGQAIMVPLPATPA
CRSTPDEDKRPTD
>A0A1V4Y3L4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophus sp. PtaB.Bin138|TrEMBL
MGLKTKEEYIESLRALKPTVYMFGEKITNVVDNPRIRAGIEATGATYELASMPENKDLFV
TISPLINEPVSRFTLPPASITDLVARVKINRKVANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTHYNENFLEFLKHMQKNDLTGNAGVTDVKGDRSLAPHEQVDKDMFLRIVEKREDG
IVVRGAKSHQTGSLSSHEIIVLPTRAMGKNDGDYAVAFAIPADSPGLIHVVGRSSLDKRE
LDGYDCGNMYYSKYCPTLIFNDVFVPWNRVFMCGETEFAVDMVVKFSSFHRQSHGGCKSG
KIDCMTGAALTMMDYNGTAKLSHLKQKVIDMIHRAETLYGCCLASSYEGKQQPSGNYFID
TVLANASKIHEGKEMAEATRLMIDIAGGFVADLPSDRDFENPEIGGLLKKYLKGVDSVPV
ENRIRMFRLVEKMALESADTISDIHGGGSAEAHRVTIFRETDTESKKKAAKRLAGIKD
>A0A6P2EK90|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. PBL-E5|TrEMBL
MMNAPSAAPALMSGHEFRESLRRYSPTVFVDGRRVDSVADEPAFQPGINAIALTYDYALK
AQYAPLMTAVQHTSGKRVNRLSHINTSSGDLLNKLEAVRLVCQETGCAQRYLTHDALNAI
AQVSARIDDARGGSEHRERFTAYLHRIQDQDLTLGVAMTDAKGDRSRRPHEQANVDSYVH
IVERNAVRNGVRGIVISGTKAIVTGAPYVHELLVMPCRNMGREDADFAVCCAVPLDAAGL
TIIARPAGRPGEKLEHGDALFSRKYGQSTGVCLFDRVFVPWENVFYAGEWEHSGHLTYSY
ATHHRHSCIGARAGFGDLLIGAGALMCEANGFDPGRETHLREQMVELITITESFFACGVA
ASVYAKADTHCEVFMPDAVFSNIGKLLLATRIYDMHRIAHYVSGGLIVTLPGPDEDHNPE
TAARLSEVLRANPDVPYAQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIYRN
YPLGSKVELVERILERGIAADGSPAAAPHDPARAITRNRQPGKCCDTGCTTPGQPVMVDL
PVLPSLAARPN
>A0A1V5I012|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Spirochaetes bacterium ADurb.BinA120|TrEMBL
MKNDRIALKTAEEYEESLRKLNLVVYMFGERVKNVVDDSIIRPSMNAVAMTYKLAHMPEY
EDLMTATSHITGKRINRFCHIHQSVDDLVKKSKMGRLLGSLTGCCFQRCVGMDALNALSM
VTYDIDKKYGTQYNKRFLKYLEYVQNNDLVCDGAMTDPKGNRGLAPHQQADPDLFLHVVE
EKKDGIVVRGAKAHQTGAVNSHEIIVMPTISMREEDKDFAVSFALPSDTEGITYIMGRQS
CDTRKLEEGAIDRGNQLFGGHEALVVFDNVFVPWDRVFMYKEYDFSGQLVEQFASYHRQS
YACKVGVGDVLIGAAQTAAEYNGAEKASHVKDKIIEMNHLNETLYCGCIACAAEGHREPS
GTYYVNTLLANVHKQNITRFPYEIARLAQDIAGGLLVTLPSEKDFKSPLVGNWLNKYYRG
RADVPTENRCRILRLIENITMGTAAVGYLTESMHGAGSPQAQRIMIARQVNLKQKQKVAK
RLCGIEE
>A0A0C5BXW1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilus piranensis|TrEMBL
MANVLKTIRTGEDYIESLRGRDLKVYLFGELVKEPVDHPIIRPSINAVAETYDLAVREEA
LASADSSITGLKVNRFLHIAESAEDLVLQNKMQRKLGQNTGTCFQRCVGMDALNSLHSTT
FEIDEKHGTDYHKRFLEFVKMVQKENLVIGGAMTDPKGDRSKGPSEQEDPDLFTRIVDTD
ENGVYVSGAKAHQTGCINSHWIILMPTIRLTEDDKDWAIVGAIPADAKGVTYIYGRQSCD
TRSMEEGDIDDGNAKFGGQEALIILDRVFIPWDKVFMHGEYEFASMLIERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGVPKVSHIKDKIIEMTHLNETIFAAGIASSHQGQKMKSGV
YLNDDMLAQVCKHNVTRFPYEISRLAQDIAGGLVVTLPSEKDFRHPEAGPLLKKYLAGRK
GTDVENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIQRQMQIGYKKNLAKNL
AGIKNDIVEPSEPSEYFKRVFKTKDSVL
>A0A8B6LI78|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax sp. SRS16|TrEMBL
MMNAPSAAPALMSGHEFRESLRRYSPTVFVDGRRVDSVADEPAFQPGINAIALTYDYALK
AQYAPLMTAVQHTSGKRVNRLSHINTSSGDLLNKLEAVRLVCQETGCAQRYLTHDALNAI
AQVSARIDDARGGSEHRERFTAYLHRIQDQDLTLGVAMTDAKGDRSRRPHEQANVDSYVH
IVERNAVRNGVRGIVISGTKAIVTGAPYVHELLVMPCRNMGREDADFAVCCAVPLDAAGL
TIIARPAGRPGEKLEHGDALFSRKYGQSTGVCLFDRVFVPWENVFYAGEWEHSGHLTYSY
ATHHRHSCIGARAGFGDLLIGAGALMCEANGFDPGRETHLREQMVELITITESFFACGVA
ASVYAKADAHCEIFMPDAVFSNIGKLLLATRIYDMHRIAHYVSGGLIVTLPGPDEDHNPE
TAARLSEVLRANPDVPYAQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIYRN
YPLGSKVELVERILERGIAADGSPAATPHDPARAITRNRQPGKCCDTGCTTPGQPVMVDL
PVLPSVATRPS
>A0A0K0NTZ0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Thaumarchaeota archaeon|TrEMBL
AAATIADYNGVPNVSHIKDKIVEMTHLNETIFAAGIASSHQAHKMKSGVYLNEDVLAQVC
KHNVTRFPYEIARLAQDIAGGLVVTLPSEKDFRHPVAGPLLKKY
>A0A0K2J684|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Porphyromonas gingivalis AJW4|TrEMBL
MMTSEQYVESLRKLNLKVYFMGERIENPVDHPMIRPSMNSVAMTYKLAEMDEYKHLMTAT
SNLTGKQVNRFCHLHQSTEDLKDKVKMQRLMGQKTASCFQRCVGMDAFNAIYSTTYEMDQ
ALGTTYHKRFIEYMKYVQDNDLVVDGAMTDPKGDRGLSPSEQADPDLYLHIVEVREDGIV
VSGAKAHQTGAVNSHEHLIMPTIAMREADADYAVSFAVPSDAEGVIMIYGRQSCDTRKME
EGADIDLGNSEFGGHEALVVFDRVFVPNERVFMCKEYQFAGMMVERFAGYHRQSYGGCKV
GVGDVLIGAAALAADYNGVPKASHIKDKLIEMIHLNETLYACGIACSSEGTQMKAGNYMI
DLLLANVCKQNITRLPYEIARLAEDIAGGLMVTMPSQQDFRHPEIGPIVKKYLAGATGKS
TENRMRVLRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGDLEGKKKLARAIAHI
DESLDK
>A0A380WAD6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Afipia felis|TrEMBL
MLMSAADFRESLRAYKPRVFVNGNAVESVADEPLLAPGIAGVGVTYDFALRAEHAPLMTA
RQGTSGKVVNRMLHIDENSQDLLYKLEAVRLVCKTSGCAQRYLAHDALNGLYQSTRLTDE
RYGTDYSQRFLAYLHHVQDNDLTLGIAMTDAKGDRSKRPGKQINPDVYVHIKERRRDGIV
IRGTKAIVTGAPYMHEFLVMPCRTHAPEDKDFAVCCAVPCDAPGVTIIARPAGRPGEAVA
KFSAKYGQSVGVVIFDDVFVPHDRVFLAGETEEGGFLTTSYATHHRHSCIGARAGFGDLL
IGAGALMIEANGLDAERHSHIREAMVELITITESFYACGVASSVYCTKDPAGSVMPDAVF
SNIGKLLLATKIYDMHRVAHYVSGGLIVALPGPDEDHNPETMASLAAVMGGRPDIPTEQR
AEVARFIEDLTVSHEAGWYSVISLHGGGSPEAMKREIWRNYPVMEKVELVESLLDRGVLD
EGQRVSKQPGRCCATGCEVPEPLQQAELSPLNGAAE
>A0A3B1D8V1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|hydrothermal vent metagenome|TrEMBL
MSVKTAQEYRESLAKRKPLKVYWNGGKLEDPIQHPIVKSSVNSVALTYELAHDPQHQHLL
REKSSLTGDTINRFCHLHQSTDDLLKKIQMQRLLGQKCGTCFQRCVGMDAMNAVFSITFL
IDKKHNTDYHQRFKKYVQKAQDEDLVIDGCMTDPKGDRSKRPSEQKDPDLYVHVVERRED
GVVIRGAKAHQTGAINSHYHLIMPTTAMREGDEEYAVCCSVAADHPGITYIYGRQSCDLR
KLDESKAGDIDSGNPCFGGQECLVVFDNVFVPNEDIFMDGEIEFTGSLVESFAGYHRQSY
CCKTGVGDVMIGAAACMAQYNGTTKASHIKDKIVEMNLMNETIYSCGVAAAVLGKKTEAG
NYLIDLLSANICKQHVTRYPYEIARLLQDIAGGLMVTLPSAKDFDNAETKSLLEKYLVGA
EGVDIFDRVKMLRLIENLTLGRAAVGYLTESLHGAGSPQAQRIMISRLVNLKEKMDMAKN
LVQ
>A0A679IZB6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax paradoxus|TrEMBL
MNAPLPSASLMSGADYRESLRRYQPTVFVDGRRVESVADEPAFQPGINAIALTYDYALKQ
AHEPLMTAVQHTSGKRVNRLSHLNASAGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIA
QVSARIDDARGSTEHTARFHEYLHRVQDQDLTLGVAMTDAKGDRSRRPHEQANVDSYLHV
VERNTRGIVISGTKAIVTGAPYVHELLVMPCRNMGKEDADFAVCCAVPLDAPGLTIVARP
AGRPGEKLEHGDALFSRKYGQSTGVCMFDKVFVPWERVFYAGDNGTWEHSGHLTYSYATH
HRHSCIGARAGFGDLLIGAGALMCEANGFDPGKESHLREQMVELITITESFFACGVAASV
YGKADEHCEVFMPDPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVTLPGPDEDHNPETAA
RLSDVLRANPAIPYEQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIWRNYPV
GSKVELVERILERGIAADGSPAAAPHDPARAITRNRQPGKCCDTGCTTTGRPVMVDLPAS
RHA
>A0A1V4XGF0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophaceae bacterium PtaB.Bin095|TrEMBL
MRTEQAYRDSIRAMKPVVYAFGERVEQVCDHPAFAPTLNAIGLTFRMARETKNETLMTAR
SPFTGAMVNRFFHVMQSPEELIQRGELGKFFTPFHGACIGARCAGTAALNALYASTWDMD
QKLGTDYHRRLVNFLEFAQREDLAVSGAVTDPKGNRALSPGQQADPDLYLRVVETRADGI
VVRGAKAHQSGAVLANFALVAPTVSLKETERQYAVSFAVPPDAPGLIHIAEAPAPNARRL
NNGDEMDFGNYAYGVHGSTHMIFNDVFIPSERVFMCGEYLFAGELAAMFGHLQRLASACC
KSGHCDLTCGAAAVAADYNGCERMAHIRDKIVEMSFQSALAYGTALASAYKGRAHASGVY
VPDPLLVNAAKLQAVEAVWLSSKLATEIAGGVICTIPSQKDFSHPDTAKYVDKYFRGRDD
VSTENRARITRLVEYLVGQGSIIPTESSHGAGPAAVQRLVMRQSNNLNYFKERAMKMAGI
KK
>A0A2S9YMN7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Enhygromyxa salina|TrEMBL
MSTHTSWPLRSGADYIASLRGRDLDVYLLGERVDEPVDHPIIRPSINAVAETYDLAAREP
ELATAISSLTGERVNRFLHIAHSAQDLVEQNHMQRKLGQLTGTCFQRCVGMDALNALYSV
TYEIDQAHATPYHARLREFIALVQSRNCVIGGAMTDPKGDRSKAPHQQTDPDLFLRVVAR
TDEGVVIRGAKAHQTGCINSHYLIVMPTMRLGPEDRDYAIIGALPVEAPGITYIYGRQSC
DTRSLEPSALDRGNPQYAGQEALVIFDDVFIPWERVFMHGEVEFASMLVERFTCYHRRSY
VCKTGVGDVLIGAAATVAEYNGVAKASHIRDKLVEMTHLNETIYGTGIASSHQAKPTLSG
AYLNDDMLANVCKHHVTKLPYELGRLAQDLAGGLVATLPSAADLESDAVGALLEKFLKTR
DDVDVRDRWKILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARGMQLELKQQLAKR
LAQIEEP
>A0A6J5DNM3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Paraburkholderia solisilvae|TrEMBL
MLMSSGDYKESLRQYRPKIFVDGQRVISVADEPAFRPGVNAVGLTYDYALRAEYAPIMTA
TQGSSGRVVNRFLHINTSSGDLLNKLKAVRLVCQETGCAQRYLTHDALNAIHQVSARLDD
AKGKTEHLDRFTAYLHDVQDRDLTLGVAMTDAKGDRSKRPHQQRNPDAYVHITHRDSKGI
SISGTKAIVTGAPYMHEFLVMPCRNMSREEADFAICCAVPVDADGVTIIARPAGRPGEKA
ALFSNKYGQSTGVVVFQDVFVPWDRVFYAGDWEHSGHMTYNYATHHRHSCIGARAGFGDL
LIGAGALMCEANGFDPAEEHHLRDQMVELIKITEGFYACGVAASVYATLDKAANSFVPDP
VFANIGKLLLATQIYDMHRIAHYVSGGLIVALPGPDEDHNPQTQATLQDVLRANANIPYD
KRIETARFIEDLTASYQGGWYSVISLHGGGSPEAMKREIYRNYPVGSKVQLVERLLNRGL
TDDPDRAITRNTLPGKCCSQGCTMPGAAAIVNLPELPSKRAGTF
>A0A652ZTZ6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Spirochaetes bacterium|TrEMBL
MAIKTKAEYIESLRKLQPVVYMFGERIDNFVDNPRIRAGIEATGETYALAESFEHRDAIT
TNSPLIGEKINRFTLPPASIEDLVARVKNNRLLGGRVGTCYQRCTGMDCLSALAIVTYDI
DRKYGTTYNARFLEFLKYVQKNDLTCNAGVTDVKGDRSLNPAEQADKDLYLRVVEERKDG
IVVRGAKAHQTGSLSSHEIIVLPTRALRKEDKEYAVAFALPIDTPGIIHVVGRSSLDMRE
LQGCDTGNTRYSKYCPTVIFDNVFVPWDRVFLYGETEFAGDLVMRFSSFHRQSHGGCKAG
KIDCMIGAALNMMDYNGTTKAGHLRGKVIDMIHRSETLYGCSLAASYEGKKEPSGTYFVD
PVLVNASKLHEGKEMAEVSRLLMDIAGGFVSDLPSDKDFENPTIGPLLKKYLKGTADTPV
EDRVKMLRLVEKITLESADSVSDIHGGGSPEAHRITIMRESKVGDKKALSKRLAGIEE
>A2R1N0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Aspergillus niger (strain CBS 513.88 / FGSC A1513)|TrEMBL
MDPIRAEAIHNERHVKVVCVGAGASGLCLAYKLQRSFQNYDLTIYEKNPEISGTWYENRY
PGCACDVPSHNYVYSFEPKADWSSVYAGSREIRGYFNDFANKYGLRKYIHTSHVVTETNW
IEESGQWQVTATDLTTGHTVHDWCHILIHATGYLNKPAWPEIPGLADFKGTKLHSAMYDE
SVSLEGKNVLLIGAGSSAVQILPAIQPIVNRVKIFIRSPTWLLPDISTEAGKFPEEQIEH
FVNNPESVTALRKDNERTMNSIFRTAMYLKDTVLQEQAKGLLTSVMKNAFQDQEMEDRLI
PNFSVGCKRVVPSGFRYLNTLKKENVDVVYGGVTAVTPSGCVSEDGNEHQGDIIICATGF
DTSYIPRYPVIGPNGRNLQTEWAESIMGYMGIGISEFPNTFTMLGPYTPVSNGPTMVAIE
AQADYICSFIDRYQTEPIHSMALKGDVCAEFKEHVGSFMEKAVWTDNCRNSHNNHTIGGR
VPTTWPGSTLHYLEAMREPRADDWDIKYKGNRFSWLGIGVSQTEWDPTADLGYYIRQSDD
GPWHSRRKRNLVIAKTGSMAPRPLHRQPKLAAKEKAQSIKADVSEQMPRAQAEPVSEATA
>A0A533QPZ3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp|TrEMBL
MNASQSATPPSHGLMSGNDYRESLRRYRPTVHLDGRLLESVADSRELQPGINALAVTYDF
ARDPRKAPLMTALQTSRGQTVNRMLHIDESAADLLNKLEAVRLLCQETGCAQRYLAHDAL
NAINQLCARVDAEIGSNERRARFAAYLEHVQDSDLALGIAMTDAKGDRSQRPHQQVNRNS
HVHIVERLANGIVIAGTKAIVTGAPYMHEILVMPSRNMGPADADFAVCCALPVDAPGLTM
VARPAGRPGEKLEHGAALFSRRYGQSTAVLVFDRVFVPWDRVFLAGEWEHSASLTYHYAT
HHRHSCIAARAGFGDLLIGAGALMCEANGFDPGRKASLREPMVELIKITEGFFACGVAAS
VYGTPDPHSGSFMPEPVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPATA
ATLAEVLRASPDVPYDKRIEVARFVEDLTASYQGGWYSVISLHGGGSPAAMKQEIWRNYP
LGSKVELVERLLERGVLHDESRPITRNRQPGRCCDAGCSTPGQAMMVPLPATAGCRSIAG
GEEPPAA
>A0A1X6ZGS3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Roseovarius gaetbuli|TrEMBL
MLMTAEEYRESLRAYDPRVFINGKRVESVADEPLLRPGINGVGVTYDFAHQPATERLLTA
TQGSSGKVVNRMLHINETSQDLLTKLEAVRTVCKVSGCAQRYLSHDALNGIFQSTALTDA
NHGTDYHQRFMAYLHEVQDRDLTLGVAMTDAKGDRSLRPGQQENRDVYVHIKERRPDGIV
IRGTKAIVTGAPYMHEFLVMPCRTHLPEDADFAVCCAVPIDAEGITIVSKPAGRPNEAAA
KFSATYGQATGVVIFDDVFVPHERVFQAGEVEEAGFMTTSYATHHRHSCIGARAGFGDLL
IGAGAMMIKANGLDPDRHGHIRDAMVDLITITESFYACGVAASVYCRDDPAGSVMPDPVF
SNVGKLLLATKIYDMHKAAHYVSGGLIVALPGPDEDHNPETRASLEAVLGGRGDVPMERR
MEISRFLEDLTVSHQAGWYSLISLHGGGSPEAMKREIWRNYPVDDNVDLVSQLIDRGVYD
MGQKVSKQPGRCCAKGCEVPEPLLPGKAAE
>S0G554|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MKIKTSSDYMSSLQSINPVIYYKGEKIKDVTLHPATAPHVRAAAMTYALASQAEHHDLAT
ATSHLTGRKISRFTHVHQNVEDLLKKVKLLRILGQKTGTCFQRCVGFDGINAVYSVVYEV
DEKLGTDYLERFKQWLTYIQDENLMVVGAMTDPKGDRSKNPSEQPDPDQFVRVVERRNDG
IVVRGAKLHMTGAVNSHEILIMPTMAMDEKSKDYAFVGAIPVDAPGIIMVFGRQAGDDRR
DKLETIDVGKPRFGSVGGEAMIIFDDVFIPNERVFLDGETEFTASIVYRFAAHHRSNYGA
CKTGLMDVLTGAVSYLCQIQGAAKGSHVRDKVTEMIHLSETLYSSSIACSAEGVPTESGA
YMVDTMLANVCKQNVTRFHFEVARLAVDLAGGFIATLPSEHDLKSDEVGHLVKKYFTGVA
DIPVEERIKIGRLIEAMTGGTALVESMHGAGSPQAQRIMIFREGDLTKKVSLAKALAGIP
SVKPKQEAS
>A0A075HFL0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_67_H03|TrEMBL
MQKTVRPIRTGEEYIESLRGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPTEQEDPDLFLHIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAVRLTEKDKDYAIVGCIPVDAPGITYIYGRQSCD
TRSMESGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFVSMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGIPNVSHIKDKLVEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLRKYLKAKK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKDL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A4Y7RP80|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Pelotomaculum propionicicum|TrEMBL
MALKTREDYLKSLKAMRPNVYKFGKLIEDVTTDPATRRTVESHARAFDAAHDPEYADAFT
AVSDFTGEKILRWNGMMDSLEDIVANSVFKRWMYRFTGTCNGGLCVGWNSQNVMWNVTAL
IDKDCGTNYQERLKKWIIGAQEKGLVVAGALTDAKGDRSMKPSQQPELDANVHIKEVRAD
GVVISGVKAMICGVAASNEIFLLPGSGYKEEDKAFALACVVPRDIEGLTIVETRRPSDGR
ELEEEGWDIPETAITQAYLIFEDCFVPNERVFMCQEFKYSGKVIEYFTANYRACIGACVA
GQGDIMIGAAALMARTNGLAAGTFSGKMVDMAINNETTYAVGIGAMAVGKPGPGGMWVSD
SLLAHTNKVHVATLPYETKRLCQDIGGGIVETGCFPSYKDFQDPKYGKKIESVVKASVRF
SAESRARAARLSEWLTLGAGVPGCMHGGGSPDGAKLVVRAFTPVDKFAQMASKIAGITEE
ITEPEKKKK
>A0A075HFL5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_65_A09|TrEMBL
MQKTVRPIRTGEEYIESLKGRDLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVKQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEIDEKHGTKYHKKLLEFIKMVQHENLVIGGAMTDVKGDRSKGPSEQEDPDLFLRIVERN
DKGVYISGAKAHQTGCINSHWMLVMPTMRLTENDKDYAIVGAIPVDAPGITYIYGRQSCD
TRSMEPGDIDQGNSEYGGQEAMVIFDKAFIPNESIFMDGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGVPKVSHIKDKLIEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQISRFAQDIAGGLMVTLPSEAELRNPITGPLLEKYLKGRK
GVNVESRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKDL
AKIQEQGEETIENADYFKRVFKLDNSKE
>A0A075MNM8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Nitrososphaera evergladensis SR1|TrEMBL
MPIKNGAEYVESLRGRKLKVYLFGQLVKEPVDHPMIRPSINAVAATYDLANAEPEMAGAK
SSISGLQVNRFLHIAESAEDLVNQNKMQRRLGQLTGTCFQRCVGMDALNSLYSTTYEIDQ
KHNTKYHSRLKEFIKMIQRENYVIGGAMTDVKGDRSLSPSQQPDPDMFVHIVKRDKKGVY
ITGAKAHQTGCINSHWILVMPTMRLKGEDKDYAIVGAVPVDAPGITYIYGRQSCDTRSME
EGDIDAGNSKFGGQEAMIIFDNVFIPNELIFMDGEYDYAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAAAIADYNGVASASHIKDKLVEMTHLNETIFGAGIASSYMAHQTASGNWQCDD
MLANVCKHNVTKFPYEISRLAQDIAGGLMVTLPSEKDFRGPETGPLLEKYLKGRKGVSTE
SRVRMLRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKLAKNLASVKE
GETAEISQENSEYFNKIFGVRKKGKQQ
>A0A4P6LW20|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Blautia producta|TrEMBL
MGFMTAKEYIESLRKMKTVVYLLGERVENFVDHPIIRPSVHSVAMTYALAQNPEYKDLMT
AVSGLTGERVNRFCHIHRSTEDLINKVKMQRLLGQKTGACFQRCVGMDALNAIYSTTFEV
DKKYGTDYFKKFCTYMKYVQENDLTVDGAMTDPKGDRGRSPSQQDDPDMYLHIVEKREDG
IVVTGAKAHQTGAVNSHEQLIMPTIAMKEEDKAYAVSFAVPSDAEGITMIYGRQSCDTRK
LENTGCMDCGNCKFGGQEALVVFDRVFVPWDRVFLCEEYEFAGVLVERFAGYHRQSYGGC
KAGVGDVLIGASATAADYNGVSKASHIKDKLIEMMHLNETLYCCGIACSAEGSPTQSGNY
QIDNLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEKDFESPEVGEMCRKYFKGNSQ
TDVMDRMKILRLIENMTLGTAAVGYRTESLHGAGSPQAQRIMIGRQGKLAEKQRLAKSIA
GIKE
>A0A0J1FCM3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Peptococcaceae bacterium CEB3|TrEMBL
MRTRAEYIERLGKMNHNLYFNGEKIDRLDERQEGAINVMGLTFDAVWDPASKDLCTATSH
LTGETISRFNHIHQSVEDLHKKQDMTRLLVNKVGQCIQRCMGIDAANAIHAVSYEAQKSP
KAKTAYHDNWLKWLERFQREDLVASCAQTDVKGERLKRPAEQIDPDMYVHVMEERSDGII
VRGCKVHISEASISDEILVVPNRALQKGEEAYALAFAVPSDYEGVKQVVHFHNYRKRDTY
ERGIEYGYTDSYVIFDDCFIPWERVFLCGETQHGGIAALLFALFHRHSYSGCKPAMLDYV
IGLAALAAEINGIEKTPHVRKMLSELIMTGELGYAAGYTASDLGKPEVYMPGMGLVPYGP
GSYIPNSIYANVGRCLTGEAVFHEQEILCNIAGGMPATFPYEKDLTNPETKALLEKYLNR
NPKIPIEEQIKFWLNFIDFGLSGSTGSVQYGSYHGGGSPIMEQIAITSQYDLESKKDIVR
AIAGMEPRPKKK
>A0A084Y148|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Candidatus Accumulibacter sp. SK-01|TrEMBL
MTDSNGNGRPSSRLISGAEYRDSLRRYTPKVYVDGEPIASVADAPTLQPGINALAVSYDF
ALDPEKIPLMTAVQTGSGATVNRMLHINESAGDLLNKLEAVRILCQETGCAQRYLAHDAL
NAIHQVSARIDDARGGNEHRARFAAYLEEVQASDWSLGIAMTDAKGDRSKRPHQQANPDT
YVHIVERNPRGIVISGTKAIVTGAPYMHQFLIMPSRNMGPADADFAVCCALPVDAPGLTI
VARPAGRPGDKLEHGAALFSRRYGQSTAVLVFDRVFVPWERVFFAGEWEHSGSLTYHYAT
HHRHSCIAARAGFGDLLIGAGALMCEANGFDPGRKASLREPMVELIKITEGFFACGVAAS
VYGTPDPYSGSFMPEAVFANIGKLLLATQIYDMHRLAHEVSGGLIVALPGPDEDHNPATA
ATLAEVLRAHPDVPYDKRIAVARFIEDLTVSYQGGWYSVISLHGGGSPAAMKQEIWRNYP
LGSKVELVERLLDRGVLHDAARAITRNRQPGRCCDAGCSPPGQAIMVPLPRSGKA
>A0A0F0CE52|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium sp. FS41|TrEMBL
MAIGTYEQYKERLLKMKPNVYLNGKCVDRSNGKEGEERDLADWIKGGTYVMKQCYDVANN
PKYEDVCVTTSHINGERINRCTHIHHSMDDLLKKQLMTRLICQHVGGCMQRCMGTDAMNA
LYSVTYDCDEACGTEYHKRLLAYIEYCQKYDLICNCAQTDVKGSRNPKYKRAHMQPDPDS
FVHVVETDVDGTGVDGKPCKGIIVRGAKICNSCAPYVDEIIVNPTKFMSQDDSDYAVAFA
LPADWDGVKLMALPGLHHKRTHLDAPYAQIGDVESLTIFDDCFVPYDRVFMCGRDHEGVA
RYAGYLALMFAHYHRHSYTGCKTAVSEVIASQAALVADVNDIARESHVREKICDIIQTAE
LVFAAGEAAAHHAMEFPSGQWVPDEVLTNAGRRLAGHNMYHEYETLADLTGGVCASLPTE
ESFFAPETAELCNKYIRRNPAYSAEDTHRVMRMMENKLCDSYEAAQAVAGVHGGGSPLME
TITLMSRYDLEELKKIAKYLAGIPGYEKCPRYERSAHTATPRAMLAKFDAILSKKENK
>A0A1V5DGW2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophus sp. PtaU1.Bin005|TrEMBL
MGLKTKEEYIESLRALKPTVYMFGEKITNVVDNPRIRAGIEATGATYELASMPENKDLFV
TISPLINEPVSRFTLPPASITDLVARVKINRKVANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTHYNENFLEFLKHMQKNDLTGNAGVTDVKGDRSLAPHEQVDKDMFLRIVEKREDG
IVVRGAKSHQTGSLSSHEIIVLPTRAMGKNDGDYAVAFAIPADSPGLIHVVGRSSLDKRE
LDGYDCGNMYYSKYCPTLIFNDVFVPWNRVFMCGETEFAVDMVVKFSSFHRQSHGGCKSG
KIDCMTGAALTMMDYNGTAKLSHLKQKVIDMIHRAETLYGCCLASSYEGKQQPSGNYFID
TVLANASKIHEGKEMAEATRLMIDIAGGFVADLPSDRDFENPEIGGLLKKYLKGVDSVPV
ENRIRMFRLVEKMALESADTISDIHGGGSAEAHRVTIFRETDTESKKKAAKRLAGIKD
>A0A6J4XDJ0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Olavius sp. associated proteobacterium Delta 1|TrEMBL
MPMMTAEQYEKGLRKLNLVVYMFGKQLDNVVDDPIIRPSMQAVAKTYDMAHRPEHEDLMT
ATSHITGNKINRFTHIHQSVEDLVKKSKMGRLLGRETGCCFQRCVGMDALNVLSIVTYNM
DQKLGTDYNQRFLKYLEYVQESDFTCDGAMTDPKGDRSLPPHKQPDPDHYLHVVEERDEG
IVVRGAKAHQTGAVNSHEIIVMPTIAMRQEDRDYAVSFALPADAEGIVYIMGRQSCDTRK
LEAGLLDRGNIFFGGHEALVVFDDVFVPWDRVFMYKEFEFVGQLVEKFAAFHRQSYACKV
GVGDVLIGASQTAAEYNNVAGASHIKDKIIEMNHLNETLYCGCIACASEGFKEDCGTYSV
NSLLANIHKQNVTRFPYDISRLAQDIAGGLMVTLPSEQDLISPETGKWLEKYYTAGCDVP
AINRMRILRLIENMTLGTAAVGYLTESMHGAGSPQAQRIMISRLINMAEKKRAAKKLCGI
DEE
>A0A1V5CIN6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Syntrophorhabdus sp. PtaU1.Bin002|TrEMBL
MGVKTKEEYIESIRALKPTAYMFGERLTNPVDNPRIRAGIEATAATYEMANKPENKDLFI
TMSPLINEPVNRFTLPPSSIEDLVARVKVNRKMANYVGTCHQRCTGLDCLSTLAIVTYDI
DKKYGTNYNKNFTEFLKYMQKNDLTGNACVTDVKGNRSLNPHEQVDKDMFVRVVEKRDDG
IVVRGAKAHQTGSLSSHEIIALPTRAMGKNDADYALAFAVPSDTKGVIHVVGRSSLDMRE
LDGCDIGNVYYSKYCPTIIFDDVFVPWNRVFMCGETEFASEMVVRFSSFHRQSHGGCKSG
KIDCMIGAALTMMDYNGTAKTSHLKQKVIDMIHRAETLYGCCLASSYEGRKEPSGHYFID
TVLANASKLHEGKEMAEATRLMIDACGGFVADLPSDRDFANPEVGDLLKKYLKAVDTVPV
ENRIKMYRLAEKMAMESADTISDIHGGGSPEAHRVTIFRETDTESKKKSAKRLAGIED
>A0A1V5DUU5|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MALITSEEYLASVRKMKPRVYIGGKWLSNLLENPVTKSMVMANAAVYDLAQDQEYREIMV
AASHLTGEPVSRNLHVARSIHDLDMRQEMALLTSQVLGTCNYRCVGCDALNSLASTTWEM
DRELGTKYNERFSNWLKTAQSQDLAVSGAITDAKGDRKKRPPQQENRDVYLHLVEKRKDG
IVVRGYKVSQSGAIGAHETIVLPGGGLKDDEADFALAFAVQNSSPGLSYICQYNAYSAER
EMCGNDIDELGNPVYGQRETSTMVFDNVFIPWERVFLCGETKYAGRIVTRFAKAHRMNCG
GACKVGFADLIIGATMLAAEYTGVEKVPHIQEKIIDMVRLSETSHACAIASAMRGREEPK
GSGVFLPDDLFGNAAKLNIAHGFWEIIKNAGDIGGGLVVTMPRLKDLEDPEVGPVLQKAF
GAAAPAEKRLKVAKFLQHWTSGLHGVGTWHGAGAPQAQRFMFTVLTDFDKKKKMAKKLMG
LKEK
>A0A1V6IVQ0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MRTKEQYIEGLRKMRRNIYHDGHLMDRDDEIQEPVLNVMGLTFDAVNDPELKDLCTAKSH
LTGETINRFCHVHQSTDDLHKKQDMTRALCRKAGMCIQRCMGTDALNAVNAASFEADKVN
RGNTEYHKNFLKWLERFQKEDLVGSCAQTDMKGERLKRPAEQTDPDMYVHVVEKKSDGIV
VRGCKLHISEASISDEIMVVPTRALGPDEKDYAVAFAVPSDYEGVKQVVSIHSQYKRKHF
MRGMNIGYSDSYIIFEDCFVPWERVFLCGENDHGGMCALLFALFHRHSYSGCKPAIGDVF
LGLAALAAEYNGIEKTPHVKEMLAEIIKVSELGYAAGYTASSMGKPEVIIPGLGMCPYGP
GSYIPNSIYCNVGRCLTGEAVFHEQELICRIAGGIPSTFPYEGDLTHPDLKAVLEKYLNR
NPKVPVKDQIKFWMTLGDYTIGTMAGVMNYGNYHGGGSPIMEQIAITSQYDIKDRKKLIK
RLAGISS
>A0A136WC62|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Anaerotignum neopropionicum|TrEMBL
MTTTAKLMTPKEYIESLRKMNTRVYMFGKKIDNWVDDPIIRPSINCVAMTYAMAQDPQHK
DLMTVKSSLTGHTINRFTHLHQSSEDLIYKIKMLRLLGQKTASCFQRCVGMDAFNAVFST
TFEVDQAHGTDYHENFKKFLTMVQDNDFTVDGAMTDAKGDRSKAPHEQSDPDMYLRVVER
REDGIVVSGAKCHQTGSINSHWHIFMPTIAMSEADKDWAISFACPSDAEGMYMIYGRQSC
DTRKLEDAAIDVGNVKFCGQEALVILDHVFIPNENIFLNGEHEFTGMMVERFAGYHRQSY
GGCKVGVGDVIIGATALAAEYNGVEKASAVKDKLIEMTHLNETLYSCGIACSCEGCATKA
GNYQIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTMPSEKDFKSDLPVGREGETISQ
ICNKYFATREGVSAEDRQRVMRFLENICLGAAAVGYRTESLHGAGSPQAQRIMIARQGNI
QGKKQLAKNIVGIKE
>A0A645FWM8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|bioreactor metagenome|TrEMBL
MEKASAVKDKLIEMTHLNETLYSCGIACSCEGKPTKAGNYQIDLLLANVCKQNVTRFPYE
IVRLAEDIAGGLMVTLPSERDFKSGTEVGRNGETIGEICEKYFKTREEVPTEDRARVLRF
LENICLGAAAVGYRTESMHGAGSPQAQRVMIARQGNIEGKKQLAKSIAGISEEHK
>A0A075G5D3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_06_B11|TrEMBL
MQKTVRPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTKYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDLFLRIVDRD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAIVGGIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFASMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPNVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRVLRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEQGEETLENADYFKRVFKLDNSKE
>A0A1C6JUH1|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Oscillibacter sp|TrEMBL
MALMTAQEYVESLRKLNTRVYMFGEKIENWVDHPMIRPSINCVAMTYALAQDPQYADLMT
VKSSLTGHTINRFTHLHQSTEDLINKVKMQRLLGQKTASCFQRCVGMDAFNAVFSTTYEI
DEKYGTRYHENFKKFLTFVQDNDLTVDGAMTDPKGDRSKAPSQQADPDMYVHVVERRADG
IVVCGAKCHQTGSINSHWHIFMPTISMGEADKDWAVSFACPTDAEGMYMIYGRQSCDTRK
LEEDASIDVGNAKFGGQEALVVLDHVFIPNEYIFLNGEYEFAGMMVERFAGYHRQSYGGC
KVGVGDTLIGAAALAAEYNGVEKASAVKDKLIEMIHLNETLYCCGIACSSQGFRTKAGNY
QIDLLLANVCKQNVTRFPYEIVRLAEDIAGGLVVTMPSQKDFHSDTVVGRNGETIGEICN
KFFATREGVSTEDRQRILRFIENLCLGAAAVGYRTESMHGAGSPQAQRIMIARQGNLQAK
KQMAKEIAGIQN
>A0A835X3A2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Nitrosopumilales archaeon|TrEMBL
MPIRTGEDYIESLRGRNLKIYLFGELVKEPVDHPLIRPSINAVAETYDLAVREQDLATVE
SSISGQRVNRFLHIVQSAEDLVLQNKMQRKLGQNTGTCFQRCVGMDALNSLHSVTYEMDE
KYKTNYHKRLLDFIKMAQTENLIIGGAMTDPKGDRSKGPHEQEDPDMFVHVVEKNDKGII
INGAKAHQTGCINSHWIIVMPTMRLAEADAEFAVVGAVPADAPGITYIYGRQSCDTRSME
EGDLDSGNAKYSGQEAMMIFDHVFIPWEKVFMNGEYEFAAMLVERFTCYHRRSYVCKTGL
GDVLIGAAATIADYNGVPNVSHIKDKLVEMTHLNESIYAAGIASSYQSRPLKSGVWLNDD
MLANVCKHNVTRFPYELGRMAQDIAGGLLVTLPSEKDFRNPETGPLLKKYLRGRKGVDVE
NRMKILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKSKLAKNLANIKD
DEEGRPEHSEYFERVFKIGGYENN
>A0A3S4GTS9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Paracoccus haematequi|TrEMBL
MLMSAADYRDSLRAYKPRVFVSGQAVESVADEPLLAPGIAGVGVTYDFALQEQHARIMTA
RQGTSGKTVNRMLHINETSQDLLDKLEAVRLVCRTSGCAQRYLTHDALNGLWQATHLIDA
NHGTDYGQRFLAYLHDIQDRDLTLGVAMTDAKGDRSLRPGKQVNPDVYVHITERRKDGIV
IRGTKAIVTGAPYMHEFLVMPCRTHMPEDSAFAVCCAVPCDAPGVTIISRPAGQPGNAAA
KFSAKYGQAVAMVVFDDVFVPHDRVFLAGETEEGGFLTTSYATHHRHSCIGARAGFGDLL
IGAGALMIEANGLDADRHGHIRDQMVELITITESFYACGVASSVYCTKDAAGSIMPDAVF
SNIGKLLLATKIYDMHRVAHYVSGGLIVALPGPDEDHNPETAASIAAVMGGRADIPFEQR
VEVARFIEDLTVSHEAGWYSVISLHGGGSPEAMKREIWRNYPVMEKVELVESLLDRGLLN
DGRRVSKQPGRCCTIGCETPELTPPSGTAASSLAMERSV
>A0A075HAF3|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured marine thaumarchaeote KM3_47_A03|TrEMBL
MQKTVKPIRTGEEYIESLKGRNLKVYLFGELVKEPVDHPIIRPSINAVAKTYDLAVEEED
LASAKSSITGERVNRFLHIAESAQDVVLQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEMDEKHGTEYHKRLLEFIKMVQHENLVIGGAMTDVKGDRSKGPTEQEDPDLFLRIIERD
DKGVYISGAKAHQTGCINSHWMIVMPAIRLTEADKDYAVVGAIPVDAPGITYIYGRQSCD
TRSMEPGDMDQGNSQFSGQEAMVIFDRAFIPNELIFMDGEYEFVSMLIERFTCYHRRSYV
CKTGVGDVLIGAAASIADYNGVPKVSHIKDKLVEMTHLNESIYGTGIASSYQSQKMKSGV
WQNDEMLANVCKHNVTRFPYQIGRFAQDIAGGLMVTLPSEAEFRSPETGPLLKKYLKGRK
GVDVENKMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKKLAKNL
AKVQEEGEETLENSDYFNRVFKLDNSKE
>A0A087S533|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Marine Group I thaumarchaeote SCGC AAA799-D07|TrEMBL
MQKTVRPIRTGEEYIESLKGRELKVYLFGELVKEPVDHPMIRPSINAVAKTYDLAVEEED
LASAKSSITGELVNRFLHIAESAQDVVKQNKMQRKLGQLTGTCFQRCVGMDALNSLHSTT
FEIDEKHGTEYHKKLLEFIKMVQHENLVIGGAMTDVKGDRSKGPAEQEDPDMFVRIVERN
DKGVYISGAKAHQTGCINSHWMLVMPTMRLTENDKDYAIVGAIQVDAPGITYIYGRQSCD
TRSMEPGDIDQGNSQYGGQEAMVIFDRAFIPNELLFMDGEYEFASMLVERFTCYHRRSYV
CKTGLGDVLIGAAATIADYNGVPKVSHIKDKLIEMTHLNESIYGTGIASSYQSHKMKSGV
WQNDDMLANVCKHNVTRFPYQISRFAQDIAGGLMVTLPSEAELRNPITGPLLEKYLKGRK
GVDVESRMRILRLIENMTMGRNAVGYLTESMHGAGSPQAQRIQIARQMQLGYKKRLAKDL
AKVQEEGDETLENSDYFERVFKLDNSKE
>A0A2H5V9P2|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|archaeon HR04|TrEMBL
MKSMTIRNGQEYIESLRRRKIKVYLFGELVENPVDHPIIRPSVNAVAETYDLASREPDLA
TAYSPLIGKRVNRFLHITTSADDLVKQNEMQRKLGQLTGTCFQRCVGMDALNALYSVTYE
IDEKYGTQYHKRLVDFIKYVQEENYVIGGAMTDPKGDRSKSPSEQDDPDVFVHIVKQNDE
GIVIRGAKMHQTGCINSHWIVVMPTMRLKPEEKEYAVSCAIPVDDPGLTFVYGRQSCDTR
SMDGNIDVGNAMYAGQEAMIIIDDVFVPWKYVFMCGETEFVPALVERFTTYHRRSYVCKS
GVGDVLIGAAASIADYNGVLDASHVREKLVEMVFLNEIVYGTGIASSYKARATKAGNYIN
DEILANVCKHHLTKFTFEMARLAQDLTGGIVATLPSEKDLKHPEIGPKLMKYLATKDGVD
PEHRVRMARLIENMTMGRNAVGYLSESLHGAGSPQAQRILIARYMNLEEKMKFAKRLAGI
SDALNGKEEEEEEESATLTSSAPAPSTHSD
>A0A1C5M7Y4|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|uncultured Megasphaera sp|TrEMBL
MTLMTGEQYIESMRKLNLQVYMFGKKVECPVDDPILRPSLNSVRMTYDLAQMPEYQDLMT
VMSPYTGERVNRFTHIHQSTTDLMNKVKMQRLLGQKTASCFQRCVGMDAFNAVFSTTYDI
DQKYGTHYHDNFMTFMKRVQTQDLTVDGAMTDPKGDRGLAPHAQEDPDLYLHVVERRPDG
VVVRGAKAHQTGFINSHEVIVMPTIAMGEDDKDYAISFSCPTDAEGIFMIVGRQSCDTRK
LEGAEMDTGNPEFGGTEALVIFDNVFIPNENIYLNGEYEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGCPKASHIKDKLIEMQHLNETLYACGIACSALGTKTASGNYL
IDLLLANVCKQNVTRFPYEIVRLAEDIAGGLMVTAPSEKDLRDPKIGPYVEKYLRGVSSV
STENRLKVLRLIENLSLGTAAVGYRTESMHGAGSPQAQRIMISRQGNLRMKKQLAKAIAH
IED
>A0A0K0H9L7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Salmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)|TrEMBL
MAKSADDLRQQRDAIAEWSRLSYGWMGRTPDYKAAFGCALGANPAFYGQFEQNARHWYTR
IQETGLYFNHAIVNPPIDRHKPADEVKDVYIKLEKETDAGIIVSGAKVVATNSALTHYNM
IGFGSAQVMGENPDFALMFVAPMDAEGVKLISRASYEMVAGATGSPFDYPLSSRFDENDA
ILVMDNVLIPWENVLIYRDFDRCRRWTMEGGFARMYPLQACVRLAVKLDFITALLKKSLE
CTGTVEFRGVQADLGEVVAWRNMFWALSDSMCSEATPWVNGAWLPDHAALQTYRVMAPMA
YAKIKNIIERNVTSGLIYLPSSARDLNNPHIDQYLAKYVRGSNGMDHVERIKILKLMWDA
IGSEFGGRHELYEINYSGSQDEIRLQCLRQAQSSGNMDKMMAMVDRCLSEYDQHGWTVSH
LHNNDDINQLDKLLK
>A0A174A005|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium symbiosum|TrEMBL
MALMTGEQYVESMRKLNLQVYMFGKKIENPVDDPILRPSLNSVKMTYDLAQMPEYEDLMT
STSNLTGEKINRFTNIHMNAQDLVKKVKMQRLCGQKTAACFQRCVGMDAFNAVYSTSYEI
DEKYGTHYFENFKKFLQYTQEKDLTVDGAMTDPKGDRSLAPHAQKDPDLFLHVVERRPDG
IVVRGAKAHQTGFVNSHEVIVMPTQSMGPEDRDYAVSFACPTDAEGIFMIVGRQSCDTRK
LEGSDIDVGNSRFGGMEALVIFDNVFIPNDRIFLAGETEFAGVLVERFAGYHRQSYGGCK
VGVGDVLIGAAAAAADYNGAARASHVKDKLIEMTHLNETLYCCGIACSAEGAQTKSGNYL
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTAPSEKDLRDPKLGRYIDKYFRGVNDV
PTEDRMRMMRLVENLTLGSAAVGYRTESMHGAGSPQAQRIMIARQGNIGMKKKLAKDIAG
IKES
>A0A7Y9D6L9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Clostridium beijerinckii|TrEMBL
MPLKTKEQYIESLRKLNLKVYMFGKPVDNVVDNPIIRPSLNSVAMTYELAQMPEYEDLMT
ATSNLTGEKVNRFAHLHQSTDDLIKKVKMQRLLGQKTASCFQRCVGMDAFNALYSSTYEI
DKACGTNYHENFNKFLKYVQENDLTVDGAMTDPKGDRGLSPSKQADGDLYLRVVERREDG
VVVRGAKCHQTGMLNSHEVVVMPTIALTPNDKDWAISFAVPTDAEGIIHIYGRQSCDTRK
LEPGADIDLGNAEFGGQETLTIFDNVFVPNERIFLNGETDFAGMIVERFAGYHRQSYGGC
KVGVGDVLIGAAAVAADYNGAHKASHVKDKLIEMTHLNETLFSCGIACSAMGSKTEAGNY
YIDNLLANVCKQNVTRFPYEICRLAEDIAGGIMVTMPSEADFKDEKIGPYIDKYLRGVNS
VSTENRMRILRLIENICLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLAAKKKIAKKIA
RIKE
>A0A1V5IFX6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Bacteroidetes bacterium ADurb.BinA104|TrEMBL
MALKTGAQYIEEMKKMRPNVYKWGELIEDVTEHPATASHIRNVAKWYDNSFDPEKEQLYT
NTSFLSGNKAHRWNTLITSADDMLGNANMKRDGYHTCGSCMGPVCAGWTVLNALWSVTFD
MDQEFGTDYHERLKNFCIFAENNALALSGALTDAKGNRALKPSQQDNPDMYLHVVEKRED
GVVIRGFKNQICGTVGSQYIMVMPTTGMGEDEGDYAIAAAVPRDAEGVTIVETRRPSDTR
IEEEGWDGIKSGTTQAYIIFDNVFVPSKHVFMNGETKYTGKLIGNFTAIYRAAIGACVAG
QGDVMIGAALGMARANGLAQKAFQDKLTKMAINNETTYGLGIGAMYTGKKHKSGAFYPNP
LLAHVNKVHVATLPYDTKVLAQEISGGITETGCMPSYKDMMSPLYGEKLIESLRSAVPGE
DRIKMARLVEWLTIGGGVPGCMHGGGSPDTAKMVVKAATKWDNYVDYARALAQVESPLKE
EKKK
>A0A143XZW8|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Eubacteriaceae bacterium CHKCI004|TrEMBL
MAIMTKEQFQDSIRAREPMNVWFLGEKIEDLTTFPVLSASFNAVSKVYELHNHPDWEDLL
TVESDLNGEKVSIYNAPLHSPEDANRKTRAARALAEVIGCCTHRCTGSEAFAGLGPCTYD
MDQDLGTDYFKRFTNFIDYVQKNDLSCTVTVTDVKGLRTLPPHKQPNRDNYIHIDEIRED
GIIISGFKCNQTGILFAHEIIIIPTTNMKPEDEDFALACAIPADAPNITYVLGRTPQDKR
FFEVGGDIEGIDLGKKYADHQALVYFDKVFVPKERVFMCGETKYVGRMLSYFTAVHRLTA
GGCKAGGCSALCGAASLITEMVGVQKAGHIRTKLTEMAMTAETVYALSLASGVEGFKHPS
GYWIPNPLLSHTCKYTCTKMPFEAVRYARDIIAGFGETAPSEIDMRSEAVGKLCQDAFNP
GNPDYDAFDRLRAVRFVEHMVRGSNWTAMALHGGGNQEASTVMARAYTDWKHLQDIARAA
TGIVKDEEKCEEIISDIGKREGRICTTLDLPKEQ
>A0A1V5DS46|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Smithella sp. PtaU1.Bin162|TrEMBL
MSSYEAYKERLLKMKPNIYVGGEKIGRNDPRVEAGMNMIRVSYDAETDPQFKDKAIVKSS
LTGKNISLYTHVPQNTEDLLKRQKLTRDLCGLCGGCFQRCMANDTISGISIATKEMDDDL
GTEYHQRFFNYLKYYQKNNLCGNAGQTDIKGDRSKRPHEQVDPDLYLRVVEKRKDGIVVC
GSKAHNTIAPYADEIIVVPTRAMTKDDADWAVSFAIPSDAEGISLIARASQPRARTHIKA
PFNERGVMDSLTVFDNVFVPWERVFMCGEWQYAGRLALLFANYHRFSYCGCKPAMTDVFI
GATAMVAEYNGVGNAPHIKDDLAKLMVTAELVYAAGIAAAVTGKKSSSGTFEPNFMYSNA
GRYHAGVNIFHEYDILSATAGGWPATMPYEEDFYNKDIKGFLDKYSMRKPGISAEDQHRL
FRFISDFSCSAWSGVWQYAGVHGGGSPIMEMIGIRSNYDLKAKKDLVKHLAGIKD
>A0A517DNW9|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Sporomusa termitida|TrEMBL
MALKTAAQYEESLRKLNFKVYLQGELVEKPVDHPIIRPSMNSVKMTYELAQDPQYEELMT
ATSHLTGKKVNRFCHLHQSSDDLVKKVKMQRLLGQKTAACFQRCVGMDAINAVDSVTFEM
DQKLGSNYHERFNKFLLQMQEEDWTVDGAMTDPKGDRSLSPSKQVDPDLFVHIVEKRADG
IIVSGAKAHQTGAINSHWILVMPTIAMGKDDVDYAVSFCAPADAQGIFYIYGRQSCDTRK
LEGGDIDVGNKQFGGHEALMVFDHVFIPWDNVFMCGEFEFSGALVERFAGYHRQSYGGCK
VGVGDVLIGAAALAADYNGANKASHVKDKLIEMMHLNETLYACGIACSAEGHKTASGNYI
IDLLLANVCKQNVTRFPYEIARLAEDIAGGLMVTMPSEKDLRSPEIGKVVEKYFRGVAGV
STENRMRILRLIENITLGTAAVGYRTESMHGAGSPQAQRIMIARQGNLEQKKELAKSIAG
IVQK
>A0A840FRP0|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Variovorax guangxiensis|TrEMBL
MNAPLPGTSLMSGADYRESLRRYKPTVFVDGRRVDSVADEAAFQPGINAIALTYDYARRS
EHEPLMTAVQHTSGKRVNRLSHINTSAGDLLNKLEAVRLVCQETGCAQRYLTHDALNAIA
QVSARIDDARGSTEHAARFHEYLHRVQDQDLTLGVAMTDAKGDRSRRPHEQADVDSYLHV
VERNARGIVISGTKAIVTGAPYVHELLVMPCRNMGKEDADFAVCCAVPLDAPGLTIVARP
AGRPGEKLEHGDALFSRKYGQSTGVCMFDRVFVPWERVFYAGEWEHSGHLTYSYATHHRH
SCIGARAGFGDLLIGAGALMCEANGFDPGKESHLREQMVELITITESFFACGVAASVYGK
ADEHCEVFMPDPVFSNIGKLLLATKIYDMHRIAHYVSGGLIVTLPGPDEDHNPETAARLS
DVLRANPAIPYEQRIETARFIEDLTAGYQGGWYSVISLHGGGSPAAMKQEIWRNYPVGSK
VELVERILERGIAADGSPAAAPHDPARAITRNRQPGKCCDTGCTAPGQAVMVELPVSRRA
>A4YGC7|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)|TrEMBL
MVVRTGEQYLQSISNRSKVEIYVMGREVKDVTKHPFLKPSVMSFKATFDAAWEEDTKELG
RAWSPYLEEEINRFNHIHRSPDDLAAKVKLLRKLSHKTGACFQRCVGWDSLNTLHIVTTM
MAKKGKTEVRDRFVEYLKYVQKNDLALAGAMTDAKGIRNLKPSQQPNKNAYLRITEVTKD
GIYVSGAKANITGVAATEEMVVLPTRAMGPEDKDYAVAFAIPTDTEGVKIVVGRQLNDAR
RMEEGEIDGLPYFYNHEGLVIFDNVFVPMNRVFLAGEWEYTGTLVEIFSAYHRQGYGGCK
AGLGDVIIGASADLAKQIGVDRASHVQDKLTEMIFLTETMYSAGIAASLNAVKMCDNCWW
VNPMHANVTKHLVARFPSQIAQLSIDLAGGIVGTAPSEWDLKNPKLKEYISRYLQGAEDF
TAEDRLRMVRLVENVSMGVAFQIESVHGAGSPAAQRIMFSRLYDLNFAQEVAKKLAGRKS
EVKFTSKAEPWRESQSEAEAKEAGLKS
>A8AA25|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)|TrEMBL
MGLRKPEEYISALREKSKRAEIYVLGERVEDVTKHPFTLPAVKAFEWTYKAPWDPYFYDK
EMGVHLAKAYSPFINEEINRFNHIHQSPQDLAIKVKYFRKLSHKAGSCFQRCVGWDAINT
ISIISYDIDKWYEQKGEKPEHFEHFGTYYERFLKFLKYVQKEDIALAGVMTDAKGVRSLR
PHEQPNKDVYVHVKEVADEGIIVRGAKANITGVVASEEMIVMPTRAMTEKDKDFAIAFAA
PIDAEGVTLVVGRYTNDTRRFEEPNVDALPGVFPAEAIVIFDDVFVPWERVFMFREYQFA
AELVEIFSSYHRQAYGGCKPGLADVIIGGAYHLAKQMGIANKCHIREKLTEMIFLTEAMH
AGGLAAAWEGKKAASGTYYVDQMKANVTKQMVTRFPYEIARLAHDIAGGLIGTLPSYKDL
MHEKIGKYLQQYLQCLPDYPAEWRHRVLRLLENITLSVEFLIESVHGAGSPEAQRIWMRR
FYPLEEMEDVALSLAGINPEEKPERKKQKEQT
>B1YBY6|4-hydroxybutanoyl-CoA dehydratase|EC 4.2.1.120|Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)|TrEMBL
MGLRTGDQYVEGLRNRKHVKVYVMGKRVEDVTTNLFMKPSLLSFKATFDAAFQEDTRDLA
RAYSPFINEEINRFVHIHQGPQDLVAKVKLLRALSHKTGSCFQRCVGWDGLNTMYIITGK
LAEKGKPVYRERFLKYLEEVQRRDLALAGAMTDARGVRSLRPHEQPNPDAYVRVVEERDD
GIIVRGAKANITGVALVDEVIVMPTRAMTEKDAPYAVAFAVPLDSPGVTVVVGRQINDVR
KAEGDIDGLPYMSHHEGLIIFEDVFVPWDRVFLYQEWQWAGPLVEVFSAFHRQGYAGCKS
GLGDVIIGAAYNLAKQIGVADKPNIVDKLTEMVFLNESMYSAGLAASWEGKKLLKDGGWW
VNPMYANVTKHLVSRFPYEISRLSHDIAGGIIGTAPSEFDLKNSEIRQLVEKYLQGVPEF
TAEDRLRMLRLLENVSVSVGFLIESVHGAGSPAAQKIVFSRLYDFQGAEAVAKRLARMRG
PEPPGTPEPHKKSDVEK