Sequence of UBA1_SCHPO
EC Number:6.2.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
E1 ubiquitin-activating enzyme
O94609
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
1012
112949
Reaction
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
General information:
Sequence
0 MSNNMNIDQT DQNTIDEGLY SRQLYVLGHE AMKQMSQSNV LIIGCKGLGV EIAKNVCLAG
60 VKSVTLYDPQ PTRIEDLSSQ YFLTEDDIGV PRAKVTVSKL AELNQYVPVS VVDELSTEYL
120 KNFKCVVVTE TSLTKQLEIN DFTHKNHIAY IAADSRGLFG SIFCDFGENF ICTDTDGNEP
180 LTGMIASITD DGVVTMLEET RHGLENGDFV KFTEVKGMPG LNDGTPRKVE VKGPYTFSIG
240 SVKDLGSAGY NGVFTQVKVP TKISFKSLRE SLKDPEYVYP DFGKMMRPPQ YHIAFQALSA
300 FADAHEGSLP RPRNDIDAAE FFEFCKKIAS TLQFDVELDE KLIKEISYQA RGDLVAMSAF
360 LGGAVAQEVL KATTSKFYPL KQYFYFDSLE SLPSSVTISE ETCKPRGCRY DGQIAVFGSE
420 FQEKIASLST FLVGAGAIGC EMLKNWAMMG VATGESGHIS VTDMDSIEKS NLNRQFLFRP
480 RDVGKLKSEC ASTAVSIMNP SLTGKITSYQ ERVGPESEGI FGDEFFEKLS LVTNALDNVE
540 ARMYVDRRCV FFEKPLLESG TLGTKGNTQV VVPHLTESYG SSQDPPEKSF PICTLKNFPN
600 RIEHTIAWAR DLFEGLFKQP IDNVNMYLSS PNFLETSLKT SSNPREVLEN IRDYLVTEKP
660 LSFEECIMWA RLQFDKFFNN NIQQLLFNFP KDSVTSTGQP FWSGPKRAPT PLSFDIHNRE
720 HFDFIVAAAS LYAFNYGLKS ETDPAIYERV LAGYNPPPFA PKSGIKIQVN ENEEAPETAA
780 NKDKQELKSI ADSLPPPSSL VGFRLTPAEF EKDDDSNHHI DFITAASNLR AMNYDITPAD
840 RFKTKFVAGK IVPAMCTSTA VVSGLVCLEL VKLVDGKKKI EEYKNGFFNL AIGLFTFSDP
900 IASPKMKVNG KEIDKIWDRY NLPDCTLQEL IDYFQKEEGL EVTMLSSGVS LLYANFQPPK
960 KLAERLPLKI SELVEQITKK KLEPFRKHLV LEICCDDANG EDVEVPFICI KL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
306689
Azad A.K.,Tani T.,Shiki N.,Tsuneyoshi S.,Urushiyama S.,Ohshima Y.
Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe.
Mol. Biol. Cell
8
825-841
1997
306690
Wood V.,Gwilliam R.,Rajandream M.A.,Lyne M.H.,Lyne R.,Stewart A.,Sgouros J.G.,Peat N.,Hayles J.,Baker S.G.,Basham D.,Bowman S.,Brooks K.,Brown D.,Brown S.,Chillingworth T.,Churcher C.M.,Collins M.,Connor R.,Cronin A.,Davis P.,Feltwell T.,Fraser A.,Gentles S.,Goble A.,Hamlin N.,Harris D.E.,Hidalgo J.,Hodgson G.,Holroyd S.,Hornsby T.,Howarth S.,Huckle E.J.,Hunt S.,Jagels K.,James K.D.,Jones L.,Jones M.,Leather S.,McDonald S.,McLean J.,Mooney P.,Moule S.,Mungall K.L.,Murphy L.D.,Niblett D.,Odell C.,Oliver K.,O'Neil S.,Pearson D.,Quail M.A.,Rabbinowitsch E.,Rutherford K.M.,Rutter S.,Saunders D.,Seeger K.,Sharp S.,Skelton J.,Simmonds M.N.,Squares R.,Squares S.,Stevens K.,Taylor K.,Taylor R.G.,Tivey A.,Walsh S.V.,Warren T.,Whitehead S.,Woodward J.R.,Volckaert G.,Aert R.,Robben J.,Grymonprez B.,Weltjens I.,Vanstreels E.,Rieger M.,Schaefer M.,Mueller-Auer S.,Gabel C.,Fuchs M.,Duesterhoeft A.,Fritzc C.,Holzer E.,Moestl D.,Hilbert H.,Borzym K.,Langer I.,Beck A.,Lehrach H.,Reinhardt R.,Pohl T.M.,Eger P.,Zimmermann W.,Wedler H.,Wambutt R.,Purnelle B.,Goffeau A.,Cadieu E.,Dreano S.,Gloux S.,Lelaure V.,Mottier S.,Galibert F.,Aves S.J.,Xiang Z.,Hunt C.,Moore K.,Hurst S.M.,Lucas M.,Rochet M.,Gaillardin C.,Tallada V.A.,Garzon A.,Thode G.,Daga R.R.,Cruzado L.,Jimenez J.,Sanchez M.,del Rey F.,Benito J.,Dominguez A.,Revuelta J.L.,Moreno S.,Armstrong J.,Forsburg S.L.,Cerutti L.,Lowe T.,McCombie W.R.,Paulsen I.,Potashkin J.,Shpakovski G.V.,Ussery D.,Barrell B.G.,Nurse P.
The genome sequence of Schizosaccharomyces pombe.
Nature
415
871-880
2002
306691
Olsen S.K.,Lima C.D.
Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Mol. Cell
49
884-896
2013
306692
Kochanczyk T.,Hann Z.S.,Lux M.C.,Delos Reyes A.M.V.,Ji C.,Tan D.S.,Lima C.D.
Structural basis for transthiolation intermediates in the ubiquitin pathway.
Nature
633
216-223
2024
