Sequence of RDH16_HUMAN
EC Number:1.1.1.315
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH + H+
General information:
Sequence
0 MWLYLAVFVG LYYLLHWYRE RQVLSHLRDK YVFITGCDSG FGKLLARQLD ARGLRVLAAC
60 LTEKGAEQLR GQTSDRLETV TLDVTKTESV AAAAQWVKEC VRDKGLWGLV NNAGISLPTA
120 PNELLTKQDF VTILDVNLLG VIDVTLSLLP LVRRARGRVV NVSSVMGRVS LFGGGYCISK
180 YGVEAFSDSL RRELSYFGVK VAMIEPGYFK TAVTSKERFL KSFLEIWDRS SPEVKEAYGE
240 KFVADYKKSA EQMEQKCTQD LSLVTNCMEH ALIACHPRTR YSAGWDAKLL YLPMSYMPTF
300 LVDAIMYWVS PSPAKAL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
293290
Gough W.H.,VanOoteghem S.,Sint T.,Kedishvili N.Y.
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.
J. Biol. Chem.
273
19778-19785
1998
293291
Jurukovski V.,Markova N.G.,Karaman-Jurukovska N.,Randolph R.K.,Su J.,Napoli J.L.,Simon M.
Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes.
Mol. Genet. Metab.
67
62-73
1999
293292
Cain J.M.,Zaino R.,Shearer D.,Bennett R.A.,Olt G.,Weisz J.
Expression of a retinol dehydrogenase (hRoDH-4), a member of the retinol/steroid dehydrogenase family implicated in retinoic acid biosynthesis, in normal and neoplastic endometria.
Am. J. Obstet. Gynecol.
186
675-683
2002
293293
Lapshina E.A.,Belyaeva O.V.,Chumakova O.V.,Kedishvili N.Y.
Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: characterization of the holo-CRBP dehydrogenase activity of RoDH-4.
Biochemistry
42
776-784
2003
293294
Persson B.,Kallberg Y.,Bray J.E.,Bruford E.,Dellaporta S.L.,Favia A.D.,Duarte R.G.,Joernvall H.,Kavanagh K.L.,Kedishvili N.,Kisiela M.,Maser E.,Mindnich R.,Orchard S.,Penning T.M.,Thornton J.M.,Adamski J.,Oppermann U.
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
Chem. Biol. Interact.
178
94-98
2009
293295
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
293296
Fiandalo M.V.,Stocking J.J.,Pop E.A.,Wilton J.H.,Mantione K.M.,Li Y.,Attwood K.M.,Azabdaftari G.,Wu Y.,Watt D.S.,Wilson E.M.,Mohler J.L.
Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade.
Oncotarget
9
11227-11242
2018
