Sequence of CARP8_CANAX
EC Number:3.4.23.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
General information:
Sequence
0 MVSIITFTKN VLVTLAFALL AQGLAIPEDI DKRAEKVVSL DFTVTRKPFN ATAHGQHHQS
60 QQQQQQQQQQ PAQKRGTVQT SLINEGPSYA ATITVGSNKQ QQTVIVDTGS SDLWVVDSAA
120 VCQVTYPGQS PTFCKQDGTY KPSSSTTSQN LGKAFSIRYE DGSSSQGTVY KDTIGLGGAS
180 ITNQQFADVT TTSVDQGILG IGFTGDESSP TYDNVPVTLK KQGIINKNAY SLYLNSASAS
240 SGTIIFGGVD NAKYTGSLTA LPITSSNELR VQLSTINIAG TTVSASTTPV LDSGTTLTYF
300 SQTIADKLAA AVGAKWNSYY QLYTSSCNLA GNIVFNFAKG VTISVPLSEF VLQDGNSCYF
360 GVSRDSATIL GDNFLRRAYA VYDLDGNTIS LAQVKYTTSS SISTL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
268325
Monod M.,Hube B.,Hess D.,Sanglard D.
Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.
Microbiology
144
2731-2737
1998
268326
Aoki W.,Kitahara N.,Miura N.,Morisaka H.,Yamamoto Y.,Kuroda K.,Ueda M.
Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.
J. Biochem.
150
431-438
2011
268327
Ramage G.,Coco B.,Sherry L.,Bagg J.,Lappin D.F.
In vitro Candida albicans biofilm induced proteinase activity and SAP8 expression correlates with in vivo denture stomatitis severity.
Mycopathologia
174
11-19
2012
268328
Puri S.,Kumar R.,Chadha S.,Tati S.,Conti H.R.,Hube B.,Cullen P.J.,Edgerton M.
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.
PLoS ONE
7
E46020-E46020
2012
268329
Bochenska O.,Rapala-Kozik M.,Wolak N.,Bras G.,Kozik A.,Dubin A.,Aoki W.,Ueda M.,Mak P.
Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.
Peptides
48
49-58
2013
268330
Bochenska O.,Rapala-Kozik M.,Wolak N.,Aoki W.,Ueda M.,Kozik A.
The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.
Acta Biochim. Pol.
63
403-410
2016
