Sequence of CARP9_CANAX
EC Number:3.4.23.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
General information:
Sequence
0 MRLNSVALLS LVATALAAKA PFKIDFEVRR GESKDDLSPE DDSNPRFVKR DGSLDMTLTN
60 KQTFYMATLK IGSNEDENRV LEDTGSSDLW VMSHDLKCVS APISKRNERS FGHGTGVKLN
120 ERELMQKRKN LYQPSRTIET DEEKEASEKI HNKLFGFGSI YSTVYITEGP GAYSTFSPLV
180 GTEGGSGGSG GSNTCRSYGS FNTENSDTFK KNNTNDFEIQ YADDTSAIGI WGYDDVTISN
240 VTVKDLSFAI ANETSSDVGV LGIGLPGLEV TTQLRYTYQN LPLKLKADGI IAKSLYSLYL
300 NTADAKAGSI LFGAIDHAKY QGDLVTVKMM RTYSQISYPV RIQVPVLKID VESSSGSTTN
360 ILSGTTGVVL DTGSTLSYVF SDTLQSLGKA LNGQYSNSVG AYVVNCNLAD SSRTVDIEFG
420 GNKTIKVPIS DLVLQASKST CILGVMQQSS SSSYMLFGDN ILRSAYIVYD LDDYEVSLAQ
480 VSYTNKESIE VIGASGITNS SGSGTTSSSG TSTSTSTRHS AGSIISNPVY GLLLSLLISY
540 YVLV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
268331
Monod M.,Hube B.,Hess D.,Sanglard D.
Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.
Microbiology
144
2731-2737
1998
268332
Copping V.M.S.,Barelle C.J.,Hube B.,Gow N.A.R.,Brown A.J.P.,Odds F.C.
Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.
J. Antimicrob. Chemother.
55
645-654
2005
268333
Albrecht A.,Felk A.,Pichova I.,Naglik J.R.,Schaller M.,de Groot P.,Maccallum D.,Odds F.C.,Schafer W.,Klis F.,Monod M.,Hube B.
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.
J. Biol. Chem.
281
688-694
2006
268334
Hornbach A.,Heyken A.,Schild L.,Hube B.,Loffler J.,Kurzai O.
The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.
Infect. Immun.
77
5216-5224
2009
268335
Sorgo A.G.,Heilmann C.J.,Dekker H.L.,Bekker M.,Brul S.,de Koster C.G.,de Koning L.J.,Klis F.M.
Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.
Eukaryot. Cell
10
1071-1081
2011
268336
Aoki W.,Kitahara N.,Miura N.,Morisaka H.,Yamamoto Y.,Kuroda K.,Ueda M.
Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.
J. Biochem.
150
431-438
2011
268337
Bochenska O.,Rapala-Kozik M.,Wolak N.,Bras G.,Kozik A.,Dubin A.,Aoki W.,Ueda M.,Mak P.
Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.
Peptides
48
49-58
2013
268338
Bochenska O.,Rapala-Kozik M.,Wolak N.,Aoki W.,Ueda M.,Kozik A.
The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.
Acta Biochim. Pol.
63
403-410
2016
268339
Ikonomova S.P.,Moghaddam-Taaheri P.,Jabra-Rizk M.A.,Wang Y.,Karlsson A.J.
Engineering improved variants of the antifungal peptide histatin 5 with reduced susceptibility to Candida albicans secreted aspartic proteases and enhanced antimicrobial potency.
FEBS J.
285
146-159
2018
268340
Ikonomova S.P.,Moghaddam-Taaheri P.,Wang Y.,Doolin M.T.,Stroka K.M.,Hube B.,Karlsson A.J.
Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.
Protein Sci.
29
480-493
2020
