Sequence of AMACR_MYCTU
EC Number:5.1.99.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
alpha-methylacyl-CoA racemase
O06543
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
360
38685
Reaction
(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA
General information:
Sequence
0 MAGPLSGLRV VELAGIGPGP HAAMILGDLG ADVVRIDRPS SVDGISRDAM LRNRRIVTAD
60 LKSDQGLELA LKLIAKADVL IEGYRPGVTE RLGLGPEECA KVNDRLIYAR MTGWGQTGPR
120 SQQAGHDINY ISLNGILHAI GRGDERPVPP LNLVGDFGGG SMFLLVGILA ALWERQSSGK
180 GQVVDAAMVD GSSVLIQMMW AMRATGMWTD TRGANMLDGG APYYDTYECA DGRYVAVGAI
240 EPQFYAAMLA GLGLDAAELP PQNDRARWPE LRALLTEAFA SHDRDHWGAV FANSDACVTP
300 VLAFGEVHNE PHIIERNTFY EANGGWQPMP APRFSRTASS QPRPPAATID IEAVLTDWDG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
241868
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
241869
Bhaumik P.,Kursula P.,Ratas V.,Conzelmann E.,Hiltunen J.K.,Schmitz W.,Wierenga R.K.
Crystallization and preliminary X-ray diffraction studies of an alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis.
Acta Crystallogr. D
59
353-355
2003
241870
Ouazia D.,Bearne S.L.
A continuous assay for alpha-methylacyl-coenzyme A racemase using circular dichroism.
Anal. Biochem.
398
45-51
2010
241871
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
M111.011627-M111.011627
2011
241872
Lu R.,Schmitz W.,Sampson N.S.
Alpha-methyl acyl CoA racemase provides Mycobacterium tuberculosis catabolic access to cholesterol esters.
Biochemistry
54
5669-5672
2015
241873
Pal M.,Easton N.M.,Yaphe H.,Bearne S.L.
Potent dialkyl substrate-product analogue inhibitors and inactivators of alpha-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis by rational design.
Bioorg. Chem.
77
640-650
2018
241874
Savolainen K.,Bhaumik P.,Schmitz W.,Kotti T.J.,Conzelmann E.,Wierenga R.K.,Hiltunen J.K.
Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.
J. Biol. Chem.
280
12611-12620
2005
241875
Bhaumik P.,Schmitz W.,Hassinen A.,Hiltunen J.K.,Conzelmann E.,Wierenga R.K.
The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface.
J. Mol. Biol.
367
1145-1161
2007
241876
Sharma S.,Bhaumik P.,Schmitz W.,Venkatesan R.,Hiltunen J.K.,Conzelmann E.,Juffer A.H.,Wierenga R.K.
The enolization chemistry of a thioester-dependent racemase: the 1.4 A crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations.
J. Phys. Chem. B
116
3619-3629
2012
