Sequence of HEXB_DOTSN
EC Number:2.3.1.86
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
fatty-acyl-CoA synthase system
M2XHU6
Dothistroma septosporum (strain NZE10 / CBS 128990)
1904
210940
Reaction
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+
General information:
Sequence
0 MGSQHQSQHN SALIQAARDG EATLSVAFGG QGPSNLNCFN DLLELNKTYG STLRPLIHTA
60 DATLSELASL PHRSGFHEDE GFETLDWLQD PKQAPSREYL ALSPMSFPIN TLLSLCNYCV
120 TLRALRLDPG QFRSSLHNVV GHSQGIFAAA AIAKADSWES FLEAAEIALK ISFWVGLESH
180 TAAPPSHISA AAVQDCVEHG EGQPSSMLGI TGLNRAQVEM LVERVNKSLS DDDRHVCLAL
240 ANSRDKYTIA GPPHSLRAVC VQIREIRAAD GVDQSRILFN KRKQEVDALF LPISAPYHSQ
300 YLKQVSNNVL DALDVDLVGS ELGIPLLHTQ SGQNLQDWKS KSIIKAIVCA VTTDMVEWPD
360 VCQRLGSSYI LGFGPGNIGN LIHESTEGTG VRVIQMNDRS PGSRGIGARA ELFSEEMPPQ
420 ALDWKQTFGP RLVLDHRGDV QIQTRMTQLL NAPPVMVAGM TPTTVTWDFV SCVMQAGYHV
480 ELAGGGYSSE ARFEEALRRL AASIPIYRGI TCNLLYANPQ TIAWQVAVLR RLIKEGISIE
540 GVTIGAGVPS PDVIKEYIAI GLKHISFKPG SIAAIDEVIE IAQAHPQFPI GLQWTGGRAG
600 GHHSHEDLHL PILKTYARIR RCSNIVLIAG SGFGGGSDTY PYISGDWSKS LSYPPMPFDG
660 ILLGSRVMVA KEAHTSPQAK QLIVQTEGVG DNDWHTSFET PTGGVITITS EHGQPIHMLA
720 TRGVMLWKEF DKRIFSIKDA AKRLSYIRAH REEIITRLNK DYQKPWFGVN GDGQNVDLDR
780 MTYREVLGRM CQLMSRGDNG WTDPSWLAMV KDFVEIAGER FGCQVDAHAT KAPEVRTAFE
840 ATLGGSVDET LYPEDVALVL ELLRRRGRKP PPFVPALDEN FETWCKKDSL WQSEDVDSLV
900 GKDVQRACII QGPVAVRHST IHDEPVQDIL DNICNFHIES LLQSGETPGV ARKQDLGRPN
960 SIKKSVPGVQ ITTEKTTIRY QVHKTDKLPP EMDTLIEHIV GPAADCWTHH CLKDEWVFRD
1020 QARLRNPIRA AFLRQIQPGE VIEVRLSRDG NTQAIALKTA LFGKSSLQTV LRIASTDGKS
1080 IKVALTPPSF LSDKPLGLQF AYQLSRKSRG SKLVEVTPNR LDAIKGFYAQ LWVDSNQDVK
1140 EAGLNSEFWG EPTTLLAQDV QNYTAVVSRS TSPQLQAWNP TGSVPVDYCI VLAWTALTKP
1200 LTIPALQCDL LNLLHRSVNF KYAANARPLR LGDVTQTVSR ITSLTIQPTG KLVEVSAELR
1260 RNDETVVTIT TEFFIVGQFE DYETQFKSFE EPLFEVRVHS VTRQALLQSR KWLVLDDPSM
1320 DLAGLTLAFK LNTHTTFDHE GKVGALQVTG SVSRVESTGF DTRIGKVYFK KDSCNGNPVV
1380 DFLNRHGYPR VTRQPLENPG WNEGSTVLMK APAKSNQYAM ASKDTNPLHV CGVFARYAGL
1440 PDTVVHGMHT SAIVRRAVEW AVGDSDRSRF KKWQVSFEGM VRPNDRLKIQ LQHTAMEHGR
1500 MIMKVQAFND ETGDKVIEAE AEVEQPRTGY VFCGQGSQEK GMGMSLYNAR PEAKALWDRG
1560 DQFLREQYGF SLLSLVRENP TTLTINFGGR RGKRIRDNYL AMTKKTSLKA DAKDVCIVQG
1620 LTPTSTSHTF SETKGLLFST QFSQPAIALM EMVEHEHLFA KGVVQPSALF AGHSLGEYAA
1680 LGACTTFMPF ESLLTLIFYR GLKMQNALER DANGRTDYSM MAADPSRVGK AGFDERAFQC
1740 LVELVNEETG LLMEIVNHNV RSQQYVCAGH FRALWILGKV CDDLAKHPKI HLLSMQDLKD
1800 MVTTHVPAAG KLTNDIVLTR GKATIPLNGI DIPFHSTMLR GEIEHFRRYL LTKVNVPDIK
1860 PNELVGKWIP NVVGRPFSLD RSYIEHVQSV TGSEPLQKML KAMA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
235478
de Wit P.J.G.M.,van der Burgt A.,Oekmen B.,Stergiopoulos I.,Abd-Elsalam K.A.,Aerts A.L.,Bahkali A.H.,Beenen H.G.,Chettri P.,Cox M.P.,Datema E.,de Vries R.P.,Dhillon B.,Ganley A.R.,Griffiths S.A.,Guo Y.,Hamelin R.C.,Henrissat B.,Kabir M.S.,Jashni M.K.,Kema G.,Klaubauf S.,Lapidus A.,Levasseur A.,Lindquist E.,Mehrabi R.,Ohm R.A.,Owen T.J.,Salamov A.,Schwelm A.,Schijlen E.,Sun H.,van den Burg H.A.,van Ham R.C.H.J.,Zhang S.,Goodwin S.B.,Grigoriev I.V.,Collemare J.,Bradshaw R.E.
The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.
PLoS Genet.
8
E1003088-E1003088
2012
235479
Ohm R.A.,Feau N.,Henrissat B.,Schoch C.L.,Horwitz B.A.,Barry K.W.,Condon B.J.,Copeland A.C.,Dhillon B.,Glaser F.,Hesse C.N.,Kosti I.,LaButti K.,Lindquist E.A.,Lucas S.,Salamov A.A.,Bradshaw R.E.,Ciuffetti L.,Hamelin R.C.,Kema G.H.J.,Lawrence C.,Scott J.A.,Spatafora J.W.,Turgeon B.G.,de Wit P.J.G.M.,Zhong S.,Goodwin S.B.,Grigoriev I.V.
Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.
PLoS Pathog.
8
E1003037-E1003037
2012
235480
Bradshaw R.E.,Bhatnagar D.,Ganley R.J.,Gillman C.J.,Monahan B.J.,Seconi J.M.
Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes.
Appl. Environ. Microbiol.
68
2885-2892
2002
235481
Bradshaw R.E.,Jin H.,Morgan B.S.,Schwelm A.,Teddy O.R.,Young C.A.,Zhang S.
A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.
Mycopathologia
161
283-294
2006
235482
Zhang S.,Schwelm A.,Jin H.,Collins L.J.,Bradshaw R.E.
A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.
Fungal Genet. Biol.
44
1342-1354
2007
235483
Schwelm A.,Bradshaw R.E.
Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.
Toxins
2
2680-2698
2010
235484
Chettri P.,Ehrlich K.C.,Cary J.W.,Collemare J.,Cox M.P.,Griffiths S.A.,Olson M.A.,de Wit P.J.,Bradshaw R.E.
Dothistromin genes at multiple separate loci are regulated by AflR.
Fungal Genet. Biol.
51
12-20
2013
235485
Bradshaw R.E.,Slot J.C.,Moore G.G.,Chettri P.,de Wit P.J.,Ehrlich K.C.,Ganley A.R.,Olson M.A.,Rokas A.,Carbone I.,Cox M.P.
Fragmentation of an aflatoxin-like gene cluster in a forest pathogen.
New Phytol.
198
525-535
2013
235486
Chettri P.,Ehrlich K.C.,Bradshaw R.E.
Regulation of the aflatoxin-like toxin dothistromin by AflJ.
Fungal Biol.
119
503-508
2015
