Sequence of CASP1_MOUSE
EC Number:3.4.22.36
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/-
Other sequences found for EC No. 3.4.22.36
General information:
Sequence
0 MADKILRAKR KQFINSVSIG TINGLLDELL EKRVLNQEEM DKIKLANITA MDKARDLCDH
60 VSKKGPQASQ IFITYICNED CYLAGILELQ SAPSAETFVA TEDSKGGHPS SSETKEEQNK
120 EDGTFPGLTG TLKFCPLEKA QKLWKENPSE IYPIMNTTTR TRLALIICNT EFQHLSPRVG
180 AQVDLREMKL LLEDLGYTVK VKENLTALEM VKEVKEFAAC PEHKTSDSTF LVFMSHGIQE
240 GICGTTYSNE VSDILKVDTI FQMMNTLKCP SLKDKPKVII IQACRGEKQG VVLLKDSVRD
300 SEEDFLTDAI FEDDGIKKAH IEKDFIAFCS STPDNVSWRH PVRGSLFIES LIKHMKEYAW
360 SCDLEDIFRK VRFSFEQPEF RLQMPTADRV TLTKRFYLFP GH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
398242
Nett-Fiordalisi M.A.,Cerretti D.P.,Berson D.R.,Gilbert D.J.,Jenkins N.A.,Copeland N.G.,Black R.A.,Chaplin D.D.
Molecular cloning of the murine IL-1 beta converting enzyme cDNA.
J. Immunol.
149
3254-3259
1992
398243
Molineaux S.M.,Casano F.J.,Rolando A.M.,Peterson E.P.,Limjuco G.,Chin J.,Griffin P.R.,Calaycay J.R.,Ding G.J.-F.,Yamin T.-T.,Palyha O.C.,Luell S.,Fletcher D.,Miller D.K.,Howard A.D.,Thornberry N.A.,Kostura M.J.
Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.
Proc. Natl. Acad. Sci. U.S.A.
90
1809-1813
1993
398244
Casano F.J.,Rolando A.M.,Mudgett J.S.,Molineaux S.M.
The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE).
Genomics
20
474-481
1994
398245
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
398246
van de Craen M.,Vandenabeele P.,Declercq W.,van den Brande I.,van Loo G.,Molemans F.,Schotte P.,van Criekinge W.,Beyaert R.,Fiers W.
Characterization of seven murine caspase family members.
FEBS Lett.
403
61-69
1997
398247
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
398248
Broz P.,von Moltke J.,Jones J.W.,Vance R.E.,Monack D.M.
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
Cell Host Microbe
8
471-483
2010
398249
Guo A.,Gu H.,Zhou J.,Mulhern D.,Wang Y.,Lee K.A.,Yang V.,Aguiar M.,Kornhauser J.,Jia X.,Ren J.,Beausoleil S.A.,Silva J.C.,Vemulapalli V.,Bedford M.T.,Comb M.J.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Mol. Cell. Proteomics
13
372-387
2014
398250
Wang Y.,Ning X.,Gao P.,Wu S.,Sha M.,Lv M.,Zhou X.,Gao J.,Fang R.,Meng G.,Su X.,Jiang Z.
Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.
Immunity
46
393-404
2017
398251
Choi Y.J.,Kim S.,Choi Y.,Nielsen T.B.,Yan J.,Lu A.,Ruan J.,Lee H.R.,Wu H.,Spellberg B.,Jung J.U.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Nat. Immunol.
20
276-287
2019
398252
Wang K.,Sun Q.,Zhong X.,Zeng M.,Zeng H.,Shi X.,Li Z.,Wang Y.,Zhao Q.,Shao F.,Ding J.
Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.
Cell
180
941-955
2020
398253
Lee S.,Karki R.,Wang Y.,Nguyen L.N.,Kalathur R.C.,Kanneganti T.D.
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Nature
597
415-419
2021
