Sequence of CASP1_HUMAN
EC Number:3.4.22.36
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/-
Other sequences found for EC No. 3.4.22.36
General information:
Sequence
0 MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS
60 VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN
120 PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT
180 GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR
240 EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG
300 VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY
360 ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
398200
Thornberry N.A.,Bull H.G.,Calaycay J.R.,Chapman K.T.,Howard A.D.,Kostura M.J.,Miller D.K.,Molineaux S.M.,Weidner J.R.,Aunins J.,Elliston K.O.,Ayala J.M.,Casano F.J.,Chin J.,Ding G.J.-F.,Egger L.A.,Gaffney E.P.,Limjuco G.,Palyha O.C.,Raju M.,Rolando A.M.,Salley J.P.,Yamin T.-T.,Lee T.D.,Shively J.E.,McCross M.,Mumford R.A.,Schmidt J.A.,Tocci M.J.
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nature
356
768-774
1992
398201
Cerretti D.P.,Kozlosky C.J.,Mosley B.,Nelson N.,van Ness K.,Greenstreet T.A.,March C.J.,Kronheim S.R.,Druck T.,Cannizzaro L.A.,Huebner K.,Black R.A.
Molecular cloning of the interleukin-1 beta converting enzyme.
Science
256
97-100
1992
398202
Alnemri E.S.,Fernandes-Alnemri T.,Litwack G.
Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.
J. Biol. Chem.
270
4312-4317
1995
398204
Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature
440
497-500
2006
398205
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
398206
Feng Q.,Li P.,Leung P.C.K.,Auersperg N.
Caspase-1 zeta, a new splice variant of caspase-1 gene.
Genomics
84
587-591
2004
398207
Kronheim S.R.,Mumma A.,Greenstreet T.,Glackin P.J.,Van Ness K.,March C.J.,Black R.A.
Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.
Arch. Biochem. Biophys.
296
698-703
1992
398208
Ray C.A.,Black R.A.,Kronheim S.R.,Greenstreet T.A.,Sleath P.R.,Salvesen G.S.,Pickup D.J.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell
69
597-604
1992
398209
Humke E.W.,Shriver S.K.,Starovasnik M.A.,Fairbrother W.J.,Dixit V.M.
ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell
103
99-111
2000
398210
Agostini L.,Martinon F.,Burns K.,McDermott M.F.,Hawkins P.N.,Tschopp J.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Immunity
20
319-325
2004
398211
Lamkanfi M.,Denecker G.,Kalai M.,D'hondt K.,Meeus A.,Declercq W.,Saelens X.,Vandenabeele P.
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.
J. Biol. Chem.
279
51729-51738
2004
398212
Gaggero A.,De Ambrosis A.,Mezzanzanica D.,Piazza T.,Rubartelli A.,Figini M.,Canevari S.,Ferrini S.
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
Oncogene
23
7552-7560
2004
398213
Chae J.J.,Wood G.,Masters S.L.,Richard K.,Park G.,Smith B.J.,Kastner D.L.
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
Proc. Natl. Acad. Sci. U.S.A.
103
9982-9987
2006
398214
Weigert A.,Cremer S.,Schmidt M.V.,von Knethen A.,Angioni C.,Geisslinger G.,Bruene B.
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.
Blood
115
3531-3540
2010
398215
Mishra B.B.,Moura-Alves P.,Sonawane A.,Hacohen N.,Griffiths G.,Moita L.F.,Anes E.
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
Cell. Microbiol.
12
1046-1063
2010
398216
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
398217
Shi J.,Zhao Y.,Wang K.,Shi X.,Wang Y.,Huang H.,Zhuang Y.,Cai T.,Wang F.,Shao F.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Nature
526
660-665
2015
398218
Wang Y.,Ning X.,Gao P.,Wu S.,Sha M.,Lv M.,Zhou X.,Gao J.,Fang R.,Meng G.,Su X.,Jiang Z.
Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.
Immunity
46
393-404
2017
398219
Zheng Y.,Liu Q.,Wu Y.,Ma L.,Zhang Z.,Liu T.,Jin S.,She Y.,Li Y.P.,Cui J.
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.
EMBO J.
37
0-0
2018
398220
Choi Y.J.,Kim S.,Choi Y.,Nielsen T.B.,Yan J.,Lu A.,Ruan J.,Lee H.R.,Wu H.,Spellberg B.,Jung J.U.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Nat. Immunol.
20
276-287
2019
398221
Ball D.P.,Taabazuing C.Y.,Griswold A.R.,Orth E.L.,Rao S.D.,Kotliar I.B.,Vostal L.E.,Johnson D.C.,Bachovchin D.A.
Caspase-1 interdomain linker cleavage is required for pyroptosis.
Life. Sci Alliance
3
0-0
2020
398222
Walker N.P.C.,Talanian R.V.,Brady K.D.,Dang L.C.,Bump N.J.,Ferenz C.R.,Franklin S.,Ghayur T.,Hackett M.C.,Hammill L.D.,Herzog L.,Hugunin M.,Houy W.,Mankovich J.A.,McGuiness L.,Orlewicz E.,Paskind M.,Pratt C.A.,Reis P.,Summani A.,Terranova M.,Welch J.P.,Xiong L.,Moeller A.,Tracey D.E.,Kamen R.,Wong W.W.
Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.
Cell
78
343-352
1994
398223
Rano T.A.,Timkey T.,Peterson E.P.,Rotonda J.,Nicholson D.W.,Becker J.W.,Chapman K.T.,Thornberry N.A.
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
Chem. Biol.
4
149-155
1997
398224
Okamoto Y.,Anan H.,Nakai E.,Morihira K.,Yonetoku Y.,Kurihara H.,Sakashita H.,Terai Y.,Takeuchi M.,Shibanuma T.,Isomura Y.
Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.
Chem. Pharm. Bull.
47
11-21
1999
398225
Romanowski M.J.,Scheer J.M.,O'Brien T.,McDowell R.S.
Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.
Structure
12
1361-1371
2004
398226
Wang K.,Sun Q.,Zhong X.,Zeng M.,Zeng H.,Shi X.,Li Z.,Wang Y.,Zhao Q.,Shao F.,Ding J.
Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.
Cell
180
941-955
2020
398227
Liu Z.,Wang C.,Yang J.,Chen Y.,Zhou B.,Abbott D.W.,Xiao T.S.
Caspase-1 engages full-length Gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage.
Immunity
53
106-114
2020
398228
Robert Hollingsworth L.,David L.,Li Y.,Griswold A.R.,Ruan J.,Sharif H.,Fontana P.,Orth-He E.L.,Fu T.M.,Bachovchin D.A.,Wu H.
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat. Commun.
12
189-189
2021
