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Sequence of UCHL3_HUMAN

EC Number:3.4.19.12

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ubiquitinyl hydrolase 1
P15374
Homo sapiens
230
26183
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12

General information:

Sequence
show sequence in fasta format
  0 MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE
 60 KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK
120 KFLEESVSMS PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL
180 YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
372703
Wilkinson K.D.,Lee K.,Deshpande S.,Duerksen-Hughes P.,Boss J.M.,Pohl J.
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.
Science
246
670-673
1989
372706
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
372707
Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.
The DNA sequence and analysis of human chromosome 13.
Nature
428
522-528
2004
372709
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
372710
Wada H.,Kito K.,Caskey L.S.,Yeh E.T.H.,Kamitani T.
Cleavage of the C-terminus of NEDD8 by UCH-L3.
Biochem. Biophys. Res. Commun.
251
688-692
1998
372711
Nam M.J.,Madoz-Gurpide J.,Wang H.,Lescure P.,Schmalbach C.E.,Zhao R.,Misek D.E.,Kuick R.,Brenner D.E.,Hanash S.M.
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
Proteomics
3
2108-2115
2003
372712
Mason D.E.,Ek J.,Peters E.C.,Harris J.L.
Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry.
Biochemistry
43
6535-6544
2004
372713
Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science
316
1160-1166
2007
372714
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
372715
Popp M.W.,Artavanis-Tsakonas K.,Ploegh H.L.
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
J. Biol. Chem.
284
3593-3602
2009
372716
Setsuie R.,Sakurai M.,Sakaguchi Y.,Wada K.
Ubiquitin dimers control the hydrolase activity of UCH-L3.
Neurochem. Int.
54
314-321
2009
372717
Setsuie R.,Suzuki M.,Tsuchiya Y.,Wada K.
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
Neurochem. Int.
56
911-918
2010
372718
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
372719
Dennissen F.J.,Kholod N.,Hermes D.J.,Kemmerling N.,Steinbusch H.W.,Dantuma N.P.,van Leeuwen F.W.
Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
FEBS Lett.
585
2568-2574
2011
372720
Iphofer A.,Kummer A.,Nimtz M.,Ritter A.,Arnold T.,Frank R.,van den Heuvel J.,Kessler B.M.,Jansch L.,Franke R.
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.
ChemBioChem
13
1416-1420
2012
372721
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
372722
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
372723
Johnston S.C.,Larsen C.N.,Cook W.J.,Wilkinson K.D.,Hill C.P.
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8-A resolution.
EMBO J.
16
3787-3796
1997
372724
Misaghi S.,Galardy P.J.,Meester W.J.N.,Ovaa H.,Ploegh H.L.,Gaudet R.
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.
J. Biol. Chem.
280
1512-1520
2005